PT1015444E - Derivados de pirimidina e processos para a sua preparacao - Google Patents

Derivados de pirimidina e processos para a sua preparacao

Info

Publication number
PT1015444E
PT1015444E PT98911242T PT98911242T PT1015444E PT 1015444 E PT1015444 E PT 1015444E PT 98911242 T PT98911242 T PT 98911242T PT 98911242 T PT98911242 T PT 98911242T PT 1015444 E PT1015444 E PT 1015444E
Authority
PT
Portugal
Prior art keywords
processes
preparation
pyrimidine derivatives
pyrimidine
derivatives
Prior art date
Application number
PT98911242T
Other languages
English (en)
Portuguese (pt)
Inventor
Jong Wook Lee
Bong Yong Lee
Chang Seop Kim
Seung Kyu Lee
Keun Seog Song
Song Jin Lee
Woo Jeon Shim
Man Soon Hwang
Original Assignee
Yuhan Corp Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp Ltd filed Critical Yuhan Corp Ltd
Publication of PT1015444E publication Critical patent/PT1015444E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT98911242T 1997-03-27 1998-03-24 Derivados de pirimidina e processos para a sua preparacao PT1015444E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR19970010863 1997-03-27
KR19970010862 1997-03-27

Publications (1)

Publication Number Publication Date
PT1015444E true PT1015444E (pt) 2003-10-31

Family

ID=26632616

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98911242T PT1015444E (pt) 1997-03-27 1998-03-24 Derivados de pirimidina e processos para a sua preparacao

Country Status (21)

Country Link
US (1) US6352993B1 (show.php)
EP (1) EP1015444B1 (show.php)
JP (1) JP3176379B2 (show.php)
KR (1) KR100278857B1 (show.php)
CN (1) CN1118464C (show.php)
AR (1) AR012181A1 (show.php)
AT (1) ATE241613T1 (show.php)
AU (1) AU720385B2 (show.php)
BR (1) BR9808070A (show.php)
CA (1) CA2284795C (show.php)
DE (1) DE69815126T2 (show.php)
DK (1) DK1015444T3 (show.php)
ES (1) ES2200324T3 (show.php)
HU (1) HUP0000851A3 (show.php)
IN (1) IN188411B (show.php)
PT (1) PT1015444E (show.php)
RU (1) RU2203894C2 (show.php)
TR (1) TR199902383T2 (show.php)
TW (1) TW542831B (show.php)
UY (1) UY24938A1 (show.php)
WO (1) WO1998043968A1 (show.php)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100272471B1 (ko) 1998-11-17 2000-11-15 김선진 신규의 피리미딘 유도체 및 그의 제조방법
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
AR038368A1 (es) 2002-02-01 2005-01-12 Novartis Ag Compuestos n-pirimidin-2-il-aminas sustituidas como inhibidores de ige, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de un medicamento
WO2004012659A2 (en) 2002-08-01 2004-02-12 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
US20070161637A1 (en) * 2003-07-22 2007-07-12 Neurogen Corporation Substituted pyridin-2-ylamine analogues
JP4800216B2 (ja) * 2003-10-24 2011-10-26 エグゼリクシス， インコーポレイテッド ｐ７０Ｓ６キナーゼモジュレーターおよび使用方法
AU2004285394B2 (en) 2003-11-03 2009-01-08 Astrazeneca Ab Imidazo (1,2-A) pyridine derivatives for the treatment of silent gastro-esophageal reflux
KR101122376B1 (ko) * 2005-03-09 2012-03-26 주식회사유한양행 신규의 5,6-다이메틸피리미딘 유도체 및 그의 제조방법
US20090124645A1 (en) * 2005-10-14 2009-05-14 Neurosearch A/S Novel Pyrimidine-2,4-Diamine Derivatives and their Use as Modulators of Small-Conductance Calcium-Activated Potassium Channels
JP4946482B2 (ja) 2007-02-08 2012-06-06 船井電機株式会社 緩衝用梱包材及びｔｖ受像機の緩衝用梱包材
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
PL2308877T3 (pl) 2008-08-05 2014-07-31 Daiichi Sankyo Co Ltd Pochodne imidazopirydyn-2-onu
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
AU2011331301A1 (en) 2010-11-15 2013-05-23 Katholieke Universiteit Leuven Antiviral condensed heterocyclic compounds
MX337477B (es) * 2011-02-25 2016-03-07 Yuhan Corp Derivados de diaminopiridina y procesos para su preparacion.
MX2014009933A (es) * 2012-02-17 2015-12-16 Abbvie Inc Diaminopirimidinas utiles como inhibidores del virus sincitial respiratorio humano (rsv).
JP6316282B2 (ja) 2012-05-29 2018-04-25 モメンティブ パフォーマンス マテリアルズ ゲーエムベーハー イソシアナートシランの作製
SG10201600149VA (en) 2012-11-21 2016-02-26 Ptc Therapeutics Inc Substituted reverse pyrimidine bmi-1 inhibitors
BR112015022545A2 (pt) 2013-03-13 2017-07-18 Constellation Pharmaceuticals Inc compostos de pirazolo e os usos disso
WO2015030847A1 (en) * 2013-08-30 2015-03-05 Ptc Therapeutics, Inc. Substituted pyrimidine bmi-1 inhibitors
CN104903312B (zh) * 2013-10-07 2019-01-29 卡德门企业有限公司 Rho激酶抑制剂
WO2015076800A1 (en) 2013-11-21 2015-05-28 Ptc Therapeutics, Inc. Substituted pyridine and pyrazine bmi-1 inhibitors
JP2018502900A (ja) * 2014-10-22 2018-02-01 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム ジスコイジンドメイン受容体１を標的化する小分子阻害剤およびその使用
CN105669642B (zh) * 2014-11-19 2020-06-09 江苏天士力帝益药业有限公司 一种盐酸洛氟普啶的制备方法
HUE058871T2 (hu) * 2016-01-04 2022-09-28 Merck Serono Sa Hidroxipropil-tiazolidin-karboxamid származék L-valinátja, ennek sója és kristályformája
WO2018184978A1 (de) * 2017-04-05 2018-10-11 Bayer Cropscience Aktiengesellschaft 2-amino-5-oxyalkyl-pyrimidinderivate und deren verwendung zur bekämpfung unerwünschten pflanzenwachstums
CA3109386A1 (en) 2018-08-17 2020-03-19 Ptc Therapeutics, Inc. Use of 5-fluoro-2-(6-fluoro-2-methyl-1h-benzo(d)imidazol-1-yl)-n4-(4-(trifluoromethyl)phenyl)pyrimidine-4,6-diamine in the treatment of pancreatic cancer
CN114685369B (zh) * 2022-05-17 2024-02-02 河南省科学院高新技术研究中心 一种利用离子液体制备1-甲基-1,2,3,4-四氢异喹啉的方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1182584A (en) 1966-03-31 1970-02-25 Ici Ltd Pyrimidine derivates and the use thereof as fungicides
US3980781A (en) 1966-03-31 1976-09-14 Imperial Chemical Industries Limited Fungicidal composition and method containing 2-amino-pyrimidines
US4000138A (en) 1966-03-31 1976-12-28 Imperial Chemical Industries Limited Organic compounds and compositions containing them
GB1383409A (en) 1972-09-09 1974-02-12 Pfizer Ltd Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them
US4044136A (en) 1972-09-09 1977-08-23 Pfizer Inc. Aminoquinazoline therapeutic agents
US3956495A (en) 1973-10-30 1976-05-11 Eli Lilly And Company 2,4-Diaminoquinazolines as antithrombotic agents
US4755218A (en) 1985-12-31 1988-07-05 Monsanto Company Haloacyl 1-substituted-1,2,3,4-tetrahydro-isoquinolines as herbicide antidotes
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds
IL88507A (en) * 1987-12-03 1993-02-21 Smithkline Beckman Intercredit 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them
US4966622A (en) 1988-04-12 1990-10-30 Ciba-Geigy Corporation N-phenyl-N-pyrimidin-2-ylureas
HU206337B (en) * 1988-12-29 1992-10-28 Mitsui Petrochemical Ind Process for producing pyrimidine derivatives and pharmaceutical compositions
DE3901448A1 (de) 1989-01-19 1990-07-26 Basf Ag Emulsionscopolymerisate
ES2081863T3 (es) 1989-03-22 1996-03-16 Ciba Geigy Ag Plaguicidas.
GB8910722D0 (en) 1989-05-10 1989-06-28 Smithkline Beckman Intercredit Compounds
CA2015981A1 (en) * 1989-05-10 1990-11-10 Thomas H. Brown Compounds
GB9012592D0 (en) 1990-06-06 1990-07-25 Smithkline Beecham Intercredit Compounds
DK0556310T3 (da) 1990-11-06 1995-08-21 Pfizer Quinazolinderivater til forhøjelse af antitumoraktivitet
AU653601B2 (en) * 1991-04-17 1994-10-06 Pfizer Inc. Pyrimidine derivatives for enhancing antitumor activity
US5276186A (en) 1992-03-11 1994-01-04 Ciba-Geigy Corporation Process for the production of guanidine derivatives
KR0144833B1 (ko) * 1992-12-28 1998-07-15 김태훈 신규의 퀴나졸린 유도체 및 그의 제조방법
IL110643A (en) * 1993-08-12 1998-07-15 Astra Ab Amidine derivatives their preparation and pharmaceutical compositions containing them
ES2114662T3 (es) 1993-08-26 1998-06-01 Ono Pharmaceutical Co Derivados de la 4-aminopirimidina.
WO1995010506A1 (en) 1993-10-12 1995-04-20 The Du Pont Merck Pharmaceutical Company 1n-alkyl-n-arylpyrimidinamines and derivatives thereof
DE69530989T2 (de) 1994-08-13 2004-05-19 Yuhan Corp. Neue pyrimidinderivate und verfahren zu ihrer herstellung
DE69706981T2 (de) 1996-05-04 2002-06-06 Yuhan Corp., Seoul/Soul Verfahren zur herstellung von pyrimidin-derivaten

Also Published As

Publication number Publication date
EP1015444B1 (en) 2003-05-28
BR9808070A (pt) 2000-03-08
TR199902383T2 (xx) 2000-06-21
KR19980080789A (ko) 1998-11-25
CN1118464C (zh) 2003-08-20
TW542831B (en) 2003-07-21
ES2200324T3 (es) 2004-03-01
AU6523998A (en) 1998-10-22
IN188411B (show.php) 2002-09-21
JP2000513014A (ja) 2000-10-03
HUP0000851A3 (en) 2002-04-29
CA2284795C (en) 2004-01-20
CA2284795A1 (en) 1998-10-08
AR012181A1 (es) 2000-09-27
DK1015444T3 (da) 2003-08-18
CN1251586A (zh) 2000-04-26
ATE241613T1 (de) 2003-06-15
HK1026418A1 (en) 2000-12-15
JP3176379B2 (ja) 2001-06-18
HUP0000851A1 (hu) 2001-04-28
KR100278857B1 (ko) 2001-01-15
EP1015444A1 (en) 2000-07-05
DE69815126T2 (de) 2004-04-08
RU2203894C2 (ru) 2003-05-10
WO1998043968A1 (en) 1998-10-08
DE69815126D1 (de) 2003-07-03
AU720385B2 (en) 2000-06-01
UY24938A1 (es) 2001-01-31
US6352993B1 (en) 2002-03-05

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