PL92086B1 - - Google Patents
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- Publication number
- PL92086B1 PL92086B1 PL1974175144A PL17514474A PL92086B1 PL 92086 B1 PL92086 B1 PL 92086B1 PL 1974175144 A PL1974175144 A PL 1974175144A PL 17514474 A PL17514474 A PL 17514474A PL 92086 B1 PL92086 B1 PL 92086B1
- Authority
- PL
- Poland
- Prior art keywords
- acid
- formula
- compounds
- hydrochloride
- reaction
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19732354002 DE2354002A1 (de) | 1973-10-27 | 1973-10-27 | Neue n-(methoxymethyl-furylmethyl)6,7-benzomorphane und -morphinane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL92086B1 true PL92086B1 (instruction) | 1977-03-31 |
Family
ID=5896658
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1974175144A PL92086B1 (instruction) | 1973-10-27 | 1974-10-26 | |
| PL1974175142A PL92053B1 (instruction) | 1973-10-27 | 1974-10-26 | |
| PL1974175143A PL92052B1 (instruction) | 1973-10-27 | 1974-10-26 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1974175142A PL92053B1 (instruction) | 1973-10-27 | 1974-10-26 | |
| PL1974175143A PL92052B1 (instruction) | 1973-10-27 | 1974-10-26 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US3981874A (instruction) |
| JP (1) | JPS5738590B2 (instruction) |
| AT (6) | AT335634B (instruction) |
| BE (1) | BE821505A (instruction) |
| BG (3) | BG27903A3 (instruction) |
| CA (1) | CA1056377A (instruction) |
| CH (6) | CH609340A5 (instruction) |
| CS (3) | CS171196B2 (instruction) |
| DD (1) | DD115909A5 (instruction) |
| DE (1) | DE2354002A1 (instruction) |
| DK (1) | DK138325C (instruction) |
| ES (6) | ES431055A1 (instruction) |
| FI (1) | FI62079C (instruction) |
| FR (1) | FR2248838B1 (instruction) |
| GB (1) | GB1482552A (instruction) |
| HU (1) | HU176479B (instruction) |
| IE (1) | IE41528B1 (instruction) |
| IL (1) | IL45938A (instruction) |
| NL (1) | NL7413980A (instruction) |
| NO (1) | NO140859C (instruction) |
| PH (1) | PH11894A (instruction) |
| PL (3) | PL92086B1 (instruction) |
| RO (5) | RO65656A (instruction) |
| SE (1) | SE422791B (instruction) |
| SU (6) | SU510999A3 (instruction) |
| YU (5) | YU36950B (instruction) |
| ZA (1) | ZA746790B (instruction) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1513961A (en) * | 1975-02-25 | 1978-06-14 | Acf Chemiefarma Nv | 6,7-benzomorphans method for their preparation and intermediates |
| US4208523A (en) * | 1978-11-30 | 1980-06-17 | Sterling Drug Inc. | 11-Lower-alkyl-, 11-phenyl-lower-alkyl- and 11-cyclo-lower-alkyl-lower-alkyl-hexahydro-2,6-methano-3-benzazocines |
| JP5470557B2 (ja) | 2007-07-26 | 2014-04-16 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤の合成 |
| JP5769970B2 (ja) * | 2007-11-16 | 2015-08-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用 |
| EP2229368A1 (en) | 2007-12-11 | 2010-09-22 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| EP2252601B1 (en) | 2008-01-24 | 2012-12-19 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US20110028445A1 (en) * | 2008-02-12 | 2011-02-03 | Boehringer Ingelheim International Gmbh | Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| JP5730021B2 (ja) | 2008-02-15 | 2015-06-03 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロアルキルラクタム誘導体 |
| EP2291371B1 (en) | 2008-05-01 | 2015-06-10 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CN102089300B (zh) | 2008-05-01 | 2014-06-18 | 生命医药公司 | 11β-羟基类固醇脱氢酶1的环状抑制剂 |
| EP2291370B1 (en) | 2008-05-01 | 2013-11-27 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| JP5711115B2 (ja) | 2008-05-13 | 2015-04-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンゾモルファン及び関連骨格のアリサイクリックカルボン酸誘導体、そのような化合物を含有する医薬及びその使用 |
| JP5777030B2 (ja) | 2008-07-25 | 2015-09-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤 |
| WO2010011314A1 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
| UA109255C2 (ru) | 2009-04-30 | 2015-08-10 | Берінгер Інгельхайм Інтернешнл Гмбх | Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1 |
| JP5656986B2 (ja) | 2009-06-11 | 2015-01-21 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １，３−オキサジナン−２−オン構造に基づく１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤 |
| TWI531571B (zh) | 2009-11-06 | 2016-05-01 | 維它藥物公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物 |
| JP5860042B2 (ja) | 2010-06-16 | 2016-02-16 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | 置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用 |
| TWI537258B (zh) | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物 |
| JP2014524438A (ja) | 2011-08-17 | 2014-09-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | インデノピリジン誘導体 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3632591A (en) * | 1968-07-19 | 1972-01-04 | Sterling Drug Inc | 1 2 3 4 5 6 - hexahydro-3-(cycloaliphatic or cycloaliphatic 11-dimethyl-2 alkyl)-66-methano-3-benzazocines |
| US3833595A (en) * | 1968-12-26 | 1974-09-03 | Sumitomo Chemical Co | 2-aroylalkyl benzomorphans |
| CS166802B2 (instruction) * | 1971-02-08 | 1976-03-29 | Boehringer Sohn Ingelheim |
-
1973
- 1973-10-25 SU SU2069684A patent/SU510999A3/ru active
- 1973-10-25 SU SU2069691A patent/SU511005A3/ru active
- 1973-10-27 DE DE19732354002 patent/DE2354002A1/de not_active Withdrawn
-
1974
- 1974-01-25 RO RO7480315A patent/RO65656A/ro unknown
- 1974-10-02 CS CS6769A patent/CS171196B2/cs unknown
- 1974-10-02 CS CS6767A patent/CS171194B2/cs unknown
- 1974-10-02 CS CS6768A patent/CS171195B2/cs unknown
- 1974-10-15 US US05/514,474 patent/US3981874A/en not_active Expired - Lifetime
- 1974-10-16 ES ES431055A patent/ES431055A1/es not_active Expired
- 1974-10-16 ES ES431059A patent/ES431059A1/es not_active Expired
- 1974-10-16 AT AT829074A patent/AT335634B/de not_active IP Right Cessation
- 1974-10-16 ES ES431057A patent/ES431057A1/es not_active Expired
- 1974-10-16 AT AT828874A patent/AT335076B/de active
- 1974-10-16 AT AT828674A patent/AT335632B/de not_active IP Right Cessation
- 1974-10-16 AT AT828774A patent/AT335633B/de not_active IP Right Cessation
- 1974-10-16 AT AT828974A patent/AT336202B/de not_active IP Right Cessation
- 1974-10-16 AT AT828574A patent/AT335631B/de not_active IP Right Cessation
- 1974-10-16 ES ES431056A patent/ES431056A1/es not_active Expired
- 1974-10-16 ES ES431058A patent/ES431058A1/es not_active Expired
- 1974-10-16 ES ES431054A patent/ES431054A1/es not_active Expired
- 1974-10-24 CH CH1426574A patent/CH609340A5/xx not_active IP Right Cessation
- 1974-10-24 YU YU2856/74A patent/YU36950B/xx unknown
- 1974-10-24 PH PH16448A patent/PH11894A/en unknown
- 1974-10-24 YU YU2851/74A patent/YU36951B/xx unknown
- 1974-10-24 YU YU2854/74A patent/YU36949B/xx unknown
- 1974-10-24 YU YU2853/74A patent/YU36952B/xx unknown
- 1974-10-24 YU YU02852/74A patent/YU36519B/xx unknown
- 1974-10-24 CH CH1426374A patent/CH609047A5/xx not_active IP Right Cessation
- 1974-10-24 CH CH1426474A patent/CH609048A5/xx not_active IP Right Cessation
- 1974-10-24 CH CH1426274A patent/CH609046A5/xx not_active IP Right Cessation
- 1974-10-25 HU HU74BO1521A patent/HU176479B/hu unknown
- 1974-10-25 SU SU2069689A patent/SU508192A3/ru active
- 1974-10-25 SU SU2070713A patent/SU512707A3/ru active
- 1974-10-25 SU SU2070657A patent/SU508193A3/ru active
- 1974-10-25 BG BG028038A patent/BG27903A3/xx unknown
- 1974-10-25 BE BE149902A patent/BE821505A/xx not_active IP Right Cessation
- 1974-10-25 SU SU7402069685A patent/SU578870A3/ru active
- 1974-10-25 CH CH1436974A patent/CH609685A5/xx not_active IP Right Cessation
- 1974-10-25 DK DK559874A patent/DK138325C/da not_active IP Right Cessation
- 1974-10-25 RO RO7480318A patent/RO65659A/ro unknown
- 1974-10-25 GB GB46323/74A patent/GB1482552A/en not_active Expired
- 1974-10-25 CH CH1437074A patent/CH609686A5/xx not_active IP Right Cessation
- 1974-10-25 IE IE2206/74A patent/IE41528B1/en unknown
- 1974-10-25 NO NO743845A patent/NO140859C/no unknown
- 1974-10-25 RO RO7480314A patent/RO65655A/ro unknown
- 1974-10-25 FR FR7435890A patent/FR2248838B1/fr not_active Expired
- 1974-10-25 IL IL45938A patent/IL45938A/en unknown
- 1974-10-25 NL NL7413980A patent/NL7413980A/xx unknown
- 1974-10-25 SE SE7413485A patent/SE422791B/xx unknown
- 1974-10-25 FI FI3141/74A patent/FI62079C/fi active
- 1974-10-25 RO RO7480317A patent/RO65658A/ro unknown
- 1974-10-25 CA CA212,340A patent/CA1056377A/en not_active Expired
- 1974-10-25 RO RO7480316A patent/RO65657A/ro unknown
- 1974-10-25 JP JP12261074A patent/JPS5738590B2/ja not_active Expired
- 1974-10-25 BG BG028037A patent/BG27902A3/xx unknown
- 1974-10-25 ZA ZA00746790A patent/ZA746790B/xx unknown
- 1974-10-25 DD DD181929A patent/DD115909A5/xx unknown
- 1974-10-25 BG BG028036A patent/BG27901A3/xx unknown
- 1974-10-26 PL PL1974175144A patent/PL92086B1/pl unknown
- 1974-10-26 PL PL1974175142A patent/PL92053B1/pl unknown
- 1974-10-26 PL PL1974175143A patent/PL92052B1/pl unknown
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