PL4219487T3 - Agoniści receptora GLP-1 i ich zastosowania - Google Patents

Agoniści receptora GLP-1 i ich zastosowania

Info

Publication number
PL4219487T3
PL4219487T3 PL23155747.1T PL23155747T PL4219487T3 PL 4219487 T3 PL4219487 T3 PL 4219487T3 PL 23155747 T PL23155747 T PL 23155747T PL 4219487 T3 PL4219487 T3 PL 4219487T3
Authority
PL
Poland
Prior art keywords
glp
receptor agonists
agonists
receptor
Prior art date
Application number
PL23155747.1T
Other languages
English (en)
Inventor
Gary Erik Aspnes
Scott W. Bagley
John M. Curto
David James EDMONDS
Mark E. Flanagan
Kentaro Futatsugi
David A. Griffith
Kim HUARD
Yajing Lian
Chris Limberakis
Allyn T. Londregan
Alan M. Mathiowetz
David W. Piotrowski
Roger B. Ruggeri
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of PL4219487T3 publication Critical patent/PL4219487T3/pl

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/40—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton with quaternised nitrogen atoms bound to carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/02—Formic acid
    • C07C53/06—Salts thereof
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pulmonology (AREA)
PL23155747.1T 2018-06-13 2019-06-11 Agoniści receptora GLP-1 i ich zastosowania PL4219487T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862684696P 2018-06-13 2018-06-13
US201962846944P 2019-05-13 2019-05-13
US201962851206P 2019-05-22 2019-05-22

Publications (1)

Publication Number Publication Date
PL4219487T3 true PL4219487T3 (pl) 2025-03-31

Family

ID=67003576

Family Applications (2)

Application Number Title Priority Date Filing Date
PL19733151.5T PL3806955T3 (pl) 2018-06-13 2019-06-11 Agoności receptora GLP-1 i ich zastosowania
PL23155747.1T PL4219487T3 (pl) 2018-06-13 2019-06-11 Agoniści receptora GLP-1 i ich zastosowania

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL19733151.5T PL3806955T3 (pl) 2018-06-13 2019-06-11 Agoności receptora GLP-1 i ich zastosowania

Country Status (40)

Country Link
US (6) US10934279B2 (pl)
EP (2) EP4219487B9 (pl)
JP (1) JP6916968B1 (pl)
KR (1) KR102542199B1 (pl)
CN (4) CN112533674B (pl)
AU (1) AU2019285491B2 (pl)
BR (1) BR112020024470A2 (pl)
CA (1) CA3045644C (pl)
CL (1) CL2020003222A1 (pl)
CO (1) CO2020015305A2 (pl)
CR (1) CR20200612A (pl)
CU (1) CU20200099A7 (pl)
CY (1) CY1126097T1 (pl)
DK (2) DK3806955T3 (pl)
EC (1) ECSP20078651A (pl)
ES (2) ES3012643T3 (pl)
FI (2) FI3806955T3 (pl)
GE (1) GEP20237453B (pl)
HR (2) HRP20250099T1 (pl)
HU (2) HUE063074T2 (pl)
IL (1) IL279300B2 (pl)
LT (2) LT3806955T (pl)
MA (1) MA64510B1 (pl)
MD (2) MD3806955T3 (pl)
MX (1) MX389121B (pl)
MY (1) MY199157A (pl)
NI (1) NI202000091A (pl)
NZ (1) NZ770240A (pl)
PE (2) PE20240584A1 (pl)
PH (1) PH12020552069A1 (pl)
PL (2) PL3806955T3 (pl)
PT (2) PT4219487T (pl)
RS (2) RS64323B9 (pl)
SG (1) SG11202011465QA (pl)
SI (2) SI3806955T1 (pl)
TW (1) TWI707683B (pl)
UA (1) UA124371C2 (pl)
UY (1) UY38261A (pl)
WO (1) WO2019239319A1 (pl)
ZA (1) ZA202007572B (pl)

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TWI707683B (zh) 2018-06-13 2020-10-21 美商輝瑞股份有限公司 Ｇｌｐ－１受體促效劑及其用途
PL3806855T3 (pl) 2018-06-15 2023-07-24 Pfizer Inc. Agoniści receptora GLP-1 oraz ich zastosowania
MA54555A (fr) * 2018-11-22 2021-09-29 Qilu Regor Therapeutics Inc Agonistes de glp-1r et leurs utilisations
US10954221B2 (en) 2019-04-12 2021-03-23 Qilu Regor Therapeutics Inc. GLP-1R agonists and uses thereof
WO2020234726A1 (en) * 2019-05-20 2020-11-26 Pfizer Inc. Combinations comprising benzodioxol as glp-1r agonists for use in the treatment of nash/nafld and related diseases
TWI751585B (zh) * 2019-06-28 2022-01-01 美商美國禮來大藥廠 類升糖素肽1受體促效劑
EP4048664A1 (en) 2019-10-25 2022-08-31 Gilead Sciences, Inc. Glp-1r modulating compounds
WO2021116874A1 (en) * 2019-12-10 2021-06-17 Pfizer Inc. Solid forms of 2-((4-((s)-2-(5-chloropyridin-2-yl)-2-methylbenzo[d] [1,3]dioxol-4-yl)piperidin-1-yl)methyl)-1-(((s)-oxetan-2-yl)methyl)-1h-benzo[d] imidazole-6-carboxylic acid, 1,3-dihydroxy-2-(hydroxymethyl)propan-2-amine salt
PE20230183A1 (es) 2019-12-10 2023-02-01 Lilly Co Eli Procesos e intermediario para la preparacion de oxetan-2-ilmetanamina
SI4097097T1 (sl) * 2020-01-29 2025-04-30 Gilead Sciences, Inc. Spojine, ki modulirajo glp-1r
CN119874775A (zh) 2020-02-07 2025-04-25 加舒布鲁姆生物公司 杂环glp-1激动剂
TW202144340A (zh) * 2020-04-03 2021-12-01 大陸商江蘇恆瑞醫藥股份有限公司 稠合咪唑類衍生物、其製備方法及其在醫藥上的應用
CN113493447B (zh) * 2020-04-03 2024-06-11 轩竹(北京)医药科技有限公司 Glp-1受体激动剂
EP4143183B1 (en) * 2020-04-29 2025-10-22 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
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RS66418B9 (sr) 2025-05-30
SI3806955T1 (sl) 2023-08-31
MA64510B1 (fr) 2025-03-28
JP6916968B1 (ja) 2021-08-11
CN112533674A (zh) 2021-03-19
ECSP20078651A (es) 2021-01-29
ES2949954T9 (es) 2023-11-23
PE20240584A1 (es) 2024-03-21
DK3806955T3 (da) 2023-06-26
EP4219487A1 (en) 2023-08-02
RS64323B1 (sr) 2023-08-31
CN119431342A (zh) 2025-02-14
DK4219487T3 (da) 2025-02-03
PT3806955T (pt) 2023-07-20
PT4219487T (pt) 2025-02-18
CY1126097T1 (el) 2023-11-15
TWI707683B (zh) 2020-10-21
CA3045644A1 (en) 2019-12-13
CR20200612A (es) 2021-01-20
CO2020015305A2 (es) 2021-03-08
UY38261A (es) 2020-01-31
US20240059679A1 (en) 2024-02-22
PE20211601A1 (es) 2021-08-18
RS64323B9 (en) 2023-11-30
NZ770240A (en) 2023-07-28
UA124371C2 (uk) 2021-09-01
US20250340544A1 (en) 2025-11-06
MD4219487T2 (ro) 2025-04-30

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