PL3838333T3 - Zastosowanie zmiennych pól elektrycznych w celu zwiększenia przepuszczalności błon komórkowych - Google Patents
Zastosowanie zmiennych pól elektrycznych w celu zwiększenia przepuszczalności błon komórkowychInfo
- Publication number
- PL3838333T3 PL3838333T3 PL20212074.7T PL20212074T PL3838333T3 PL 3838333 T3 PL3838333 T3 PL 3838333T3 PL 20212074 T PL20212074 T PL 20212074T PL 3838333 T3 PL3838333 T3 PL 3838333T3
- Authority
- PL
- Poland
- Prior art keywords
- cell membrane
- electric fields
- alternating electric
- membrane permeability
- increase cell
- Prior art date
Links
- 210000000170 cell membrane Anatomy 0.000 title 1
- 230000005684 electric field Effects 0.000 title 1
- 230000035699 permeability Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/025—Digital circuitry features of electrotherapy devices, e.g. memory, clocks, processors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36002—Cancer treatment, e.g. tumour
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
- A61N1/36034—Control systems specified by the stimulation parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Radiology & Medical Imaging (AREA)
- Biophysics (AREA)
- Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Electrotherapy Devices (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862693811P | 2018-07-03 | 2018-07-03 | |
| US201862728255P | 2018-09-07 | 2018-09-07 | |
| US201962795136P | 2019-01-22 | 2019-01-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3838333T3 true PL3838333T3 (pl) | 2023-06-12 |
Family
ID=67441670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL20212074.7T PL3838333T3 (pl) | 2018-07-03 | 2019-07-03 | Zastosowanie zmiennych pól elektrycznych w celu zwiększenia przepuszczalności błon komórkowych |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20200009376A1 (ja) |
| EP (7) | EP3900775B1 (ja) |
| JP (3) | JP7055906B2 (ja) |
| KR (2) | KR20230151039A (ja) |
| CN (7) | CN116173401A (ja) |
| AU (2) | AU2019299533B2 (ja) |
| BR (1) | BR112020025760A2 (ja) |
| CA (1) | CA3100859A1 (ja) |
| DK (1) | DK3838333T3 (ja) |
| ES (3) | ES2934978T3 (ja) |
| IL (1) | IL279465A (ja) |
| MX (1) | MX2020012673A (ja) |
| NZ (1) | NZ770871A (ja) |
| PL (1) | PL3838333T3 (ja) |
| SG (1) | SG11202012597UA (ja) |
| WO (1) | WO2020010188A1 (ja) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10779875B2 (en) | 2013-05-06 | 2020-09-22 | Novocure Gmbh | Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment |
| US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
| US10821283B2 (en) | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
| EP4147747A1 (en) | 2016-06-30 | 2023-03-15 | Novocure GmbH | Arrays for longitudinal delivery of ttfields to a body |
| CN110178029B (zh) | 2017-01-19 | 2021-11-16 | 诺沃库勒有限责任公司 | 用于在施加TTFields的同时在显微镜下观察细胞培养物的系统 |
| WO2019133608A1 (en) | 2017-12-26 | 2019-07-04 | Gala Therapeutics, Inc. | Optimization of energy delivery for various applications |
| ES2934978T3 (es) * | 2018-07-03 | 2023-02-28 | Univ Leland Stanford Junior | Uso de campos eléctricos alternos para aumentar la permeabilidad de la membrana celular |
| MX2020013427A (es) | 2018-07-10 | 2021-05-27 | Novocure Gmbh | Inhibicion de infecciones virales usando campos electricos alternos. |
| CA3103075A1 (en) | 2018-07-18 | 2020-01-23 | Novocure Gmbh | Using power loss density and related measures to quantify the dose of tumor treating fields (ttfields) |
| EP3895643B1 (en) | 2018-08-23 | 2023-10-11 | Novocure GmbH | Using alternating electric fields to increase permeability of the blood brain barrier |
| JP2022501098A (ja) | 2018-09-07 | 2022-01-06 | ノボキュア ゲーエムベーハー | Ｔ細胞の増殖を低減する交流電場を使用する自己免疫性疾患の治療 |
| US11986647B2 (en) | 2018-09-07 | 2024-05-21 | Novocure Gmbh | Treating autoinflammatory and mitochondrial diseases using an alternating electric field |
| EP3984590B1 (en) | 2018-10-15 | 2022-12-07 | Novocure GmbH | Generating tumor treating fields (ttfields) with high uniformity throughout the brain |
| CN112955208A (zh) | 2018-10-25 | 2021-06-11 | 吉夫·波姆桑 | 向受试者的脊柱解剖结构递送交变电场（例如，ttfields） |
| WO2020104921A1 (en) | 2018-11-19 | 2020-05-28 | Novocure Gmbh | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
| BR112021004336A2 (pt) | 2018-11-29 | 2021-08-17 | Novocure Gmbh | matrizes de transdutor com flexibilidade melhorada para entregar ttfields (campos de tratamento de tumor) |
| EP3961565A1 (en) | 2019-01-08 | 2022-03-02 | Novocure GmbH | Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (ttfields) |
| KR20240013279A (ko) | 2019-02-26 | 2024-01-30 | 노보큐어 게엠베하 | 표적 암세포들의 전기적 특징에 기초한 종양처리장 요법의 주파수 결정 |
| US11471676B2 (en) | 2019-02-27 | 2022-10-18 | Novocure Gmbh | Delivering tumor treating fields (TTFields) using implantable transducer arrays |
| EP3977991A1 (en) | 2019-03-29 | 2022-04-06 | Novocure GmbH | Methods for reducing viability of ttfields-resistant cancer cells |
| EP3960232B1 (en) | 2019-04-17 | 2023-01-04 | Novocure GmbH | Uploading data from an isolated system without compromising isolation |
| JP7382422B2 (ja) * | 2019-04-22 | 2023-11-16 | ボストン サイエンティフィック サイムド，インコーポレイテッド | 癌の併用電気化学療法 |
| EP4378519A1 (en) | 2019-04-22 | 2024-06-05 | Boston Scientific Scimed, Inc. | Electrical stimulation devices for cancer treatment |
| JP2022529374A (ja) | 2019-04-23 | 2022-06-21 | ボストン サイエンティフィック サイムド，インコーポレイテッド | がん治療のための電気刺激用電極 |
| CN113766950A (zh) | 2019-04-23 | 2021-12-07 | 波士顿科学国际有限公司 | 带有热治疗或热监测的电刺激 |
| US11607542B2 (en) | 2019-04-23 | 2023-03-21 | Boston Scientific Scimed, Inc. | Electrical stimulation for cancer treatment with internal and external electrodes |
| EP4085967B1 (en) | 2019-07-31 | 2023-09-06 | Novocure GmbH | Applying tumor treating fields (ttfields) via electrodes embedded into skull implants |
| WO2021024170A1 (en) * | 2019-08-05 | 2021-02-11 | Voloshin Sela Tali | Increasing cancer cells' sensitivity to tumor treating fields (ttfields) by inhibiting il11 activity |
| WO2021038510A1 (en) | 2019-08-30 | 2021-03-04 | Novocure Gmbh | Delivering tumor treating fields (ttfields) to the neck |
| WO2021102356A1 (en) * | 2019-11-20 | 2021-05-27 | Berg Llc | Combination therapy of a coenzyme q10 compound and radiation therapy for treatment of glioma |
| EP4074369A1 (en) | 2019-12-31 | 2022-10-19 | Novocure GmbH | High voltage, high efficiency sine wave generator that prevents spikes during amplitude adjustments and switching of channels |
| FI4074367T3 (fi) | 2019-12-31 | 2023-06-21 | Novocure Gmbh | Ryhmiä tuumorihoitokenttien (ttfields) toimittamiseksi yksilöllisesti käytettävissä olevien elektrodielementtien ja lämpöanturien avulla |
| US11883655B2 (en) | 2020-02-24 | 2024-01-30 | Boston Scientific Scimed, Inc. | Systems and methods for treatment of pancreatic cancer |
| WO2021198864A1 (en) * | 2020-03-30 | 2021-10-07 | Novocure Gmbh | Intravenous / intra-spinal / intra-cavity / intraventricular delivery of ttfields (tumor treating fields) for treating cancer and metastases |
| US11818943B2 (en) | 2020-06-25 | 2023-11-14 | Novocure Gmbh | Fabricating organic light emitting diodes (OLEDs) using tubulin |
| KR20230112130A (ko) | 2020-11-25 | 2023-07-26 | 노보큐어 게엠베하 | 절반 미만의 시간동안 피크 강도에서 종양 치료 필드(TTField)를 인가하여 종양 치료 필드의 효능 향상 |
| WO2022130183A2 (en) | 2020-12-17 | 2022-06-23 | Novocure Gmbh | Pyroelectric-based temperature sensing of transducer arrays for applying tumor treating fields (ttfields) |
| IT202100000119A1 (it) * | 2021-01-05 | 2022-07-05 | Telea Electronic Eng Srl | Dispositivo e farmaco antitumorale per il trattamento di cellule neoplastiche |
| US20230009366A1 (en) | 2021-06-30 | 2023-01-12 | Novocure Gmbh | Using Alternating Electric Fields at Different Frequencies to Increase Permeability of the Blood Brain Barrier and also to Provide Other Benefits |
| US11877838B2 (en) * | 2021-08-14 | 2024-01-23 | Nano Hesgarsazan Salamat Arya | Preventing cytokine storm in COVID-19 patients by suppressing clonal expansion in activated lymphocytes using alternating electric fields |
| TW202333820A (zh) | 2021-12-29 | 2023-09-01 | 瑞士商諾沃庫勒有限責任公司 | 在使用交流電場治療受試者時藉由使用較大陰極和較小陽極來降低電知覺 |
| WO2023126855A1 (en) | 2021-12-30 | 2023-07-06 | Novocure Gmbh | Selecting values of parameters for treatment using tumor treating fields (ttfields) |
| US20230310877A1 (en) | 2022-03-30 | 2023-10-05 | Novocure Gmbh | Reducing Electrosensation Whilst Treating a Subject Using Alternating Electric Fields by Pairing Transducer Arrays Together |
| WO2023187689A1 (en) | 2022-03-30 | 2023-10-05 | Novocure Gmbh | Using interleaved cooling periods to increase the peak intensity of tumor treating fields |
| CN114891777B (zh) * | 2022-05-19 | 2024-05-14 | 江苏大学 | 利用高压电场放电刺激提高微藻胞外多糖分泌的装置及方法 |
| WO2023248139A1 (en) | 2022-06-20 | 2023-12-28 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using tumor treating fields and vegf inhibitors |
| US20230407282A1 (en) * | 2022-06-21 | 2023-12-21 | Novocure Gmbh | Systems and methods for treating conditions and diseases using alternating electric fields and crispr-cas system |
| WO2024003791A1 (en) | 2022-06-30 | 2024-01-04 | Novocure Gmbh | Electrode assembly for applying tumor treating fields (ttfields) that includes a plurality of thermally linked but electrically isolated graphite sheets |
| US20240108699A1 (en) | 2022-09-30 | 2024-04-04 | Novocure Gmbh | Compositions, systems, and methods for reducing electrosensation and/or skin irritation |
| WO2024079719A1 (en) * | 2022-10-14 | 2024-04-18 | Novocure Gmbh | Method and apparatus for delivering alternating electric fields to a target tissue |
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| US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
| US10821283B2 (en) | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
| EP4147747A1 (en) | 2016-06-30 | 2023-03-15 | Novocure GmbH | Arrays for longitudinal delivery of ttfields to a body |
| US20180008708A1 (en) | 2016-07-10 | 2018-01-11 | Novocure Limited | Synchronizing Tumor Cells to the G2/M Phase Using TTFields Combined with Taxane or Other Anti-Microtubule Agents |
| JP7148495B2 (ja) | 2016-08-18 | 2022-10-05 | ノボキュア ゲーエムベーハー | Ｔｔフィールドを送達するためのアレイにおける温度測定 |
| EP3528732B1 (en) | 2016-10-20 | 2023-06-21 | Retrovascular, Inc. | Device for enhanced composition delivery |
| AU2017377003B2 (en) * | 2016-12-13 | 2022-05-19 | Novocure Gmbh | Treating patients with TTFields with the electrode positions optimized using deformable templates |
| CN110178029B (zh) | 2017-01-19 | 2021-11-16 | 诺沃库勒有限责任公司 | 用于在施加TTFields的同时在显微镜下观察细胞培养物的系统 |
| US20190117969A1 (en) * | 2017-10-23 | 2019-04-25 | Cardiac Pacemakers, Inc. | Medical devices for treatment of cancer with electric fields |
| US10953209B2 (en) | 2018-03-28 | 2021-03-23 | Board Of Regents Of The University Of Texas System | Treating tumors using TTFields combined with a PARP inhibitor |
| EP3773726B1 (en) * | 2018-04-09 | 2024-06-05 | Novocure GmbH | Treating tumors with ttfields and an aurora kinase inhibitor |
| EP3832335A1 (en) | 2018-04-10 | 2021-06-09 | Zeev Bomzon | Low frequency (< 1 mhz) ac conductivity estimates derived from two mri images having different repetition times |
| ES2934978T3 (es) | 2018-07-03 | 2023-02-28 | Univ Leland Stanford Junior | Uso de campos eléctricos alternos para aumentar la permeabilidad de la membrana celular |
| EP3895643B1 (en) * | 2018-08-23 | 2023-10-11 | Novocure GmbH | Using alternating electric fields to increase permeability of the blood brain barrier |
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2019
- 2019-07-03 ES ES21175486T patent/ES2934978T3/es active Active
- 2019-07-03 KR KR1020237035475A patent/KR20230151039A/ko not_active Application Discontinuation
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- 2019-07-03 CN CN202310342594.3A patent/CN116173401A/zh active Pending
- 2019-07-03 KR KR1020217003330A patent/KR102592927B1/ko active IP Right Grant
- 2019-07-03 CN CN202310341169.2A patent/CN116159242A/zh active Pending
- 2019-07-03 CA CA3100859A patent/CA3100859A1/en active Pending
- 2019-07-03 CN CN202310342595.8A patent/CN116236688A/zh active Pending
- 2019-07-03 WO PCT/US2019/040479 patent/WO2020010188A1/en unknown
- 2019-07-03 MX MX2020012673A patent/MX2020012673A/es unknown
- 2019-07-03 DK DK20212074.7T patent/DK3838333T3/da active
- 2019-07-03 ES ES21175485T patent/ES2934669T3/es active Active
- 2019-07-03 US US16/502,255 patent/US20200009376A1/en active Pending
- 2019-07-03 ES ES20212074T patent/ES2943672T3/es active Active
- 2019-07-03 EP EP21175486.6A patent/EP3900775B1/en active Active
- 2019-07-03 CN CN202310341198.9A patent/CN116139400A/zh active Pending
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