MX2020013427A - Inhibicion de infecciones virales usando campos electricos alternos. - Google Patents

Inhibicion de infecciones virales usando campos electricos alternos.

Info

Publication number
MX2020013427A
MX2020013427A MX2020013427A MX2020013427A MX2020013427A MX 2020013427 A MX2020013427 A MX 2020013427A MX 2020013427 A MX2020013427 A MX 2020013427A MX 2020013427 A MX2020013427 A MX 2020013427A MX 2020013427 A MX2020013427 A MX 2020013427A
Authority
MX
Mexico
Prior art keywords
alternating electric
target region
electric field
electric fields
viral infection
Prior art date
Application number
MX2020013427A
Other languages
English (en)
Inventor
Moshe Giladi
Tali VOLOSHIN-SELA
Noa Kaynan
Eilon D Kirson
Original Assignee
Novocure Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novocure Gmbh filed Critical Novocure Gmbh
Publication of MX2020013427A publication Critical patent/MX2020013427A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/40Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/03Electric current
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/05General characteristics of the apparatus combined with other kinds of therapy
    • A61M2205/054General characteristics of the apparatus combined with other kinds of therapy with electrotherapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medical Informatics (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Electrotherapy Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Las infecciones virales en una región objetivo se pueden inhibir al imponer un campo eléctrico alterno en la región objetivo por un período de tiempo. El campo eléctrico alterno tiene una frecuencia y una intensidad de campo de tal manera que, cuando el campo eléctrico alterno se impone en la región objetivo por el período de tiempo, el campo eléctrico alterno inhibe la infección de las células en la región objetivo por el virus. Opcionalmente, la inhibición de infecciones virales usando el procedimiento de campo eléctrico alterno se puede combinar con la administración de un agente antivírico a la región objetivo, de tal manera que una dosis terapéuticamente eficaz del agente antiviral esté presente en la región objetivo mientras se imponen los campos eléctricos alternos.
MX2020013427A 2018-07-10 2019-07-09 Inhibicion de infecciones virales usando campos electricos alternos. MX2020013427A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862695925P 2018-07-10 2018-07-10
PCT/IB2019/055852 WO2020012364A1 (en) 2018-07-10 2019-07-09 Inhibiting viral infection using alternating electric fields

Publications (1)

Publication Number Publication Date
MX2020013427A true MX2020013427A (es) 2021-05-27

Family

ID=67998511

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020013427A MX2020013427A (es) 2018-07-10 2019-07-09 Inhibicion de infecciones virales usando campos electricos alternos.

Country Status (13)

Country Link
US (2) US11583675B2 (es)
EP (2) EP3984591A1 (es)
JP (2) JP7366990B2 (es)
KR (1) KR20210030971A (es)
CN (1) CN112469465A (es)
AU (1) AU2019301956B2 (es)
BR (1) BR112020025692A2 (es)
CA (1) CA3103070C (es)
IL (1) IL279252A (es)
MX (1) MX2020013427A (es)
NZ (1) NZ770868A (es)
SG (1) SG11202012564SA (es)
WO (1) WO2020012364A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112020025269A2 (pt) 2018-07-18 2021-03-09 Novocure Gmbh Uso de densidade de perda de energia e medidas relacionadas para quantificar a dose dos campos de tratamento de tumor (ttfields)
EP3892219B1 (en) 2018-08-23 2022-06-01 Novocure GmbH Using alternating electric fields to increase permeability of the blood brain barrier
US11020585B2 (en) 2018-09-07 2021-06-01 Novocure Gmbh Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells
HUE061361T2 (hu) 2018-10-15 2023-06-28 Novocure Gmbh Az egész agyban nagy egyenletességû tumorkezelõ mezõk (TT-mezõk) generálása
US11395916B2 (en) 2018-11-19 2022-07-26 Novocure Gmbh Arrays for delivering tumor treating fields (TTFields) with selectively addressable sub-elements
BR112021004336A2 (pt) 2018-11-29 2021-08-17 Novocure Gmbh matrizes de transdutor com flexibilidade melhorada para entregar ttfields (campos de tratamento de tumor)
US11601067B2 (en) 2019-12-31 2023-03-07 Novocure Gmbh High voltage, high efficiency sine wave generator that prevents spikes during amplitude adjustments and switching of channels
KR20220123079A (ko) 2019-12-31 2022-09-05 노보큐어 게엠베하 개별적으로 접근 가능한 전극 요소들 및 온도 센서들을 가지는 종양 처리 필드(종양 치료 필드)를 전달하는 어레이들
WO2021255523A1 (en) * 2020-06-19 2021-12-23 Novocure Gmbh Ttf generated proliferation of cytotoxic t cells to create a specific pro-inflammatory response
US11818943B2 (en) 2020-06-25 2023-11-14 Novocure Gmbh Fabricating organic light emitting diodes (OLEDs) using tubulin
CN115175730A (zh) 2020-06-30 2022-10-11 诺沃库勒有限责任公司 用于施加肿瘤治疗场(ttfield)的具有聚合物绝缘层的柔性换能器阵列
IT202000017644A1 (it) * 2020-07-21 2022-01-21 Andrea Riba Dispositivo per il trattamento di malattie causate da coronavirus mediante l’applicazione di campi elettrici al corpo umano
US20220088403A1 (en) * 2020-09-18 2022-03-24 Novocure Gmbh Methods And Compositions For Treating Coronavirus
US11877838B2 (en) * 2021-08-14 2024-01-23 Nano Hesgarsazan Salamat Arya Preventing cytokine storm in COVID-19 patients by suppressing clonal expansion in activated lymphocytes using alternating electric fields
KR20240047135A (ko) 2022-10-04 2024-04-12 박원일 전자기파 인가형 바이러스 제거 치료 장치
KR20240065533A (ko) 2022-11-01 2024-05-14 박원일 활동 공간 치료용 전자기장 인가 장치 및 이를 가진 활동 공간용 인공 구조물

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2062631U (zh) * 1989-11-24 1990-09-26 余定福 治腹泻特效电子装置
US5983130A (en) * 1995-06-07 1999-11-09 Alza Corporation Electrotransport agent delivery method and apparatus
US7089054B2 (en) 2002-10-02 2006-08-08 Standen Ltd. Apparatus and method for treating a tumor or the like
US7146210B2 (en) 2000-02-17 2006-12-05 Standen Ltd. Apparatus and method for optimizing tumor treatment efficiency by electric fields
US7599746B2 (en) 2000-02-17 2009-10-06 Standen Ltd Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases
US7136699B2 (en) 2002-10-02 2006-11-14 Standen, Ltd. Apparatus for destroying dividing cells
CN1416466A (zh) 2000-02-17 2003-05-07 约朗姆·帕尔蒂 破坏正在分裂的细胞的方法和装置
US6868289B2 (en) 2002-10-02 2005-03-15 Standen Ltd. Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor
US8175698B2 (en) 2000-02-17 2012-05-08 Novocure Ltd. Treating bacteria with electric fields
US7016725B2 (en) 2001-11-06 2006-03-21 Standen Ltd. Method and apparatus for destroying dividing cells
US8447395B2 (en) 2000-02-17 2013-05-21 Novocure Ltd Treating bacteria with electric fields
EP1740268A2 (en) 2004-04-23 2007-01-10 Standen Ltd. Treating a tumor or the like with electric fields at different frequencies
ES2660829T3 (es) 2004-12-07 2018-03-26 Novocure Limited Electrodos para aplicar un campo eléctrico in vivo durante un período de tiempo
JP5559460B2 (ja) 2004-12-27 2014-07-23 スタンデン・リミテッド 異なる配向の電界を用いて腫瘍またはその類似物を処理する方法
US8007440B2 (en) * 2005-02-08 2011-08-30 Volcano Corporation Apparatus and methods for low-cost intravascular ultrasound imaging and for crossing severe vascular occlusions
CN104771830B (zh) 2005-10-03 2018-10-26 诺沃库勒有限公司 优化电场特征以增加电场在增殖细胞上的效果
US8019414B2 (en) * 2006-04-05 2011-09-13 Novocure Ltd. Treating cancer using electromagnetic fields in combination with other treatment regimens
US7988875B2 (en) * 2007-02-08 2011-08-02 Applied Materials, Inc. Differential etch rate control of layers deposited by chemical vapor deposition
US20080190918A1 (en) 2007-02-09 2008-08-14 Scholle Corporation Shipping container for flowable material and flexible tank therefor
WO2009044289A1 (en) 2007-03-06 2009-04-09 Novocure Ltd. Treating cancer using electromagnetic fields in combination with photodynamic therapy
CN101820947A (zh) 2007-08-14 2010-09-01 诺沃库勒有限公司 用电场治疗寄生物
US8715203B2 (en) 2007-09-17 2014-05-06 Novocure Limited Composite electrode
US9504824B2 (en) * 2009-06-23 2016-11-29 Board Of Regents, The University Of Texas System Noninvasive therapies in the absence or presence of exogenous particulate agents
GB201006841D0 (en) 2010-04-26 2010-06-09 Thomsen Lars Method, device and system for targetted cell lysis
US20170128127A1 (en) * 2011-05-06 2017-05-11 Minerva Surgical, Inc. Gynecological treatment methods
US10779875B2 (en) 2013-05-06 2020-09-22 Novocure Gmbh Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment
US9655669B2 (en) 2013-05-06 2017-05-23 Novocure Limited Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment
US9910453B2 (en) 2015-09-25 2018-03-06 Novocure Limited High voltage, high efficiency sine wave generator with pre-set frequency and adjustable amplitude
US10188851B2 (en) 2015-10-28 2019-01-29 Novocure Limited TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements
US10821283B2 (en) 2016-04-04 2020-11-03 Novocure Gmbh Reducing motility of cancer cells using tumor treating fields (TTFields)
CA3029468A1 (en) 2016-06-30 2018-01-04 Zeev Bomzon Arrays for longitudinal delivery of ttfields to a body
US20180008708A1 (en) 2016-07-10 2018-01-11 Novocure Limited Synchronizing Tumor Cells to the G2/M Phase Using TTFields Combined with Taxane or Other Anti-Microtubule Agents
WO2018033842A1 (en) 2016-08-18 2018-02-22 Yoram Wasserman Temperature measurement in arrays for delivering ttfields
PL3554631T3 (pl) 2016-12-13 2022-09-12 Novocure Gmbh Leczenie pacjentów polami ttfields ze zoptymalizowanymi pozycjami elektrod z wykorzystaniem odkształcalnych matryc
US11573221B2 (en) 2017-01-19 2023-02-07 Novocure Gmbh System for viewing cell cultures under a microscope whilst applying TTFields
EP3773726B1 (en) 2018-04-09 2024-06-05 Novocure GmbH Treating tumors with ttfields and an aurora kinase inhibitor
CN112424626A (zh) 2018-04-10 2021-02-26 吉夫·波姆桑 从具有不同重复时间的两个mri图像导出的低频(<1mhz)ac电导率估计
ES2934669T3 (es) 2018-07-03 2023-02-23 Univ Leland Stanford Junior Uso de campos eléctricos alternos para aumentar la permeabilidad de la membrana celular
US11179322B2 (en) 2018-07-10 2021-11-23 Novocure Gmbh Methods and compositions for treating tumors with TTFields and sorafenib
BR112020025269A2 (pt) 2018-07-18 2021-03-09 Novocure Gmbh Uso de densidade de perda de energia e medidas relacionadas para quantificar a dose dos campos de tratamento de tumor (ttfields)
EP3892219B1 (en) 2018-08-23 2022-06-01 Novocure GmbH Using alternating electric fields to increase permeability of the blood brain barrier
US11160977B2 (en) 2018-09-04 2021-11-02 Novocure Gmbh Delivering tumor treating fields (TTFields) to the infratentorial brain
US11020585B2 (en) 2018-09-07 2021-06-01 Novocure Gmbh Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells
US20200108031A1 (en) 2018-10-05 2020-04-09 Novocure Gmbh Treating Tumors Using TTFields Combined with ABT-751

Also Published As

Publication number Publication date
AU2019301956A1 (en) 2021-01-07
NZ770868A (en) 2023-12-22
US12011588B2 (en) 2024-06-18
US20230173266A1 (en) 2023-06-08
CA3103070A1 (en) 2020-01-16
CA3103070C (en) 2024-01-09
IL279252A (en) 2021-01-31
JP2023184550A (ja) 2023-12-28
KR20210030971A (ko) 2021-03-18
WO2020012364A1 (en) 2020-01-16
US11583675B2 (en) 2023-02-21
EP3820562A1 (en) 2021-05-19
EP3984591A1 (en) 2022-04-20
SG11202012564SA (en) 2021-01-28
BR112020025692A2 (pt) 2021-03-16
JP7366990B2 (ja) 2023-10-23
CN112469465A (zh) 2021-03-09
US20200016399A1 (en) 2020-01-16
JP2022511220A (ja) 2022-01-31
AU2019301956B2 (en) 2023-04-13

Similar Documents

Publication Publication Date Title
NZ770868A (en) Inhibiting viral infection using alternating electric fields
MX2022011756A (es) Tratamiento combinado con un agonista de tlr7 y un inhibidor del ensamblaje de la capsida del vhb.
MX2018005230A (es) Terapia de combinacion de un inhibidor del ensamble de la capside del hbv y un interferon.
PH12018502489A1 (en) Antiviral therapy
MX2020006864A (es) Modalidades combinadas para inhibidores de nucleosidos y/o nadph oxidasa (nox) como agentes antivirales especificos de mieloides.
WO2017027350A3 (en) Rnai therapy for hepatitis b virus infection
JOP20180008A1 (ar) مركبات لعلاج إصابة بعدوى فيروس الالتهاب الكبدي b
MX2021014771A (es) Tratamiento combinado con un agonista de tlr7 y un inhibidor de montaje de capsida de hbv.
MX2018009126A (es) Vectores virales oncoliticos y usos de estos.
MX2020000993A (es) Vectores virales oncolíticos y usos de estos.
MX2020005054A (es) Combinacion de dos agentes antivirales para el tratamiento de hepatitis c.
MX2022009352A (es) Sal de hemisulfato de nucleotido para el tratamiento del virus de hepatitis c.
PH12019500513A1 (en) Mast cell stabilizers for treatment of hypercytokinemia and viral infection
MX2016004492A (es) Inhibidores de la replicacion del virus de inmunodeficiencia humana (vih).
MX2016012799A (es) Metodos para tratar el virus de la hepatitis c.
IN2014MN01548A (es)
IN2013MU01696A (es)
MX2018000240A (es) Metodos para tratar el vhc.
MX2017013795A (es) Combinaciones terapeuticas de tratamientos antivirales y antiinflamatorios.
PH12015502128A1 (en) Novel dosing regimens of celgosivir for the treatment of dengue
MX2016012722A (es) Metodos para tratar el virus de la hepatitis c.
WO2016090107A3 (en) Treatment of hepatitis delta virus infection
MX2019013014A (es) Tratamiento de carcinoma hepatocelular.
JO3769B1 (ar) علاج RNAi لعدوى فيروس التهاب الكبد B
WO2014140680A8 (en) Dosing regimen for use of celgosivir as an antiviral therapeutic for dengue virus infection