MX2021014771A - Tratamiento combinado con un agonista de tlr7 y un inhibidor de montaje de capsida de hbv. - Google Patents

Tratamiento combinado con un agonista de tlr7 y un inhibidor de montaje de capsida de hbv.

Info

Publication number
MX2021014771A
MX2021014771A MX2021014771A MX2021014771A MX2021014771A MX 2021014771 A MX2021014771 A MX 2021014771A MX 2021014771 A MX2021014771 A MX 2021014771A MX 2021014771 A MX2021014771 A MX 2021014771A MX 2021014771 A MX2021014771 A MX 2021014771A
Authority
MX
Mexico
Prior art keywords
tlr7 agonist
capsid assembly
hbv capsid
combined treatment
assembly inhibitor
Prior art date
Application number
MX2021014771A
Other languages
English (en)
Inventor
Lu Gao
Lue Dai
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2021014771A publication Critical patent/MX2021014771A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se dirige a composiciones y métodos para tratar infección de virus de hepatitis B virus. En particular, la presente invención se dirige a una terapia de combinación que comprende administración de un agonista de TLR7 y un inhibidor de montaje de cápsida de HBV para el uso en el tratamiento de paciente con hepatitis B crónica.
MX2021014771A 2016-09-13 2019-03-07 Tratamiento combinado con un agonista de tlr7 y un inhibidor de montaje de capsida de hbv. MX2021014771A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2016098892 2016-09-13

Publications (1)

Publication Number Publication Date
MX2021014771A true MX2021014771A (es) 2022-01-18

Family

ID=59859071

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019002678A MX2019002678A (es) 2016-09-13 2017-09-11 Tratamiento combinado con un agonista de tlr7 y un inhibidor de montaje de capsida de hbv.
MX2021014771A MX2021014771A (es) 2016-09-13 2019-03-07 Tratamiento combinado con un agonista de tlr7 y un inhibidor de montaje de capsida de hbv.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2019002678A MX2019002678A (es) 2016-09-13 2017-09-11 Tratamiento combinado con un agonista de tlr7 y un inhibidor de montaje de capsida de hbv.

Country Status (14)

Country Link
US (1) US11337982B2 (es)
EP (2) EP3970750A1 (es)
JP (2) JP7101663B2 (es)
KR (1) KR102497701B1 (es)
CN (1) CN109715214B (es)
AU (1) AU2017326400B2 (es)
BR (1) BR112019004560A2 (es)
CA (1) CA3034185A1 (es)
ES (1) ES2894605T3 (es)
IL (2) IL264926B (es)
MX (2) MX2019002678A (es)
PL (1) PL3512556T3 (es)
TW (1) TWI720250B (es)
WO (1) WO2018050571A1 (es)

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CA2979490C (en) 2015-03-16 2023-07-18 F. Hoffmann-La Roche Ag Combined treatment with a tlr7 agonist and an hbv capsid assembly inhibitor
EP3645516A4 (en) 2017-06-27 2021-07-07 Janssen Pharmaceutica NV HETEROARYLDIHYDROPYRIMIDE DERIVATIVES AND METHODS OF TREATMENT OF HEPATITIS B INFECTIONS
WO2019155042A1 (en) 2018-02-12 2019-08-15 F. Hoffmann-La Roche Ag Novel sulfone compounds and derivatives for the treatment and prophylaxis of virus infection
KR20200128414A (ko) * 2018-02-28 2020-11-12 에프. 호프만-라 로슈 아게 간암의 치료 및 예방을 위한 7-치환된 설폰이미도일퓨린온 화합물 및 유도체
US11554120B2 (en) 2018-08-03 2023-01-17 Bristol-Myers Squibb Company 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor
US11053235B2 (en) 2018-08-09 2021-07-06 Janssen Sciences Ireland Unlimited Company Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases
WO2020125729A1 (en) 2018-12-20 2020-06-25 Janssen Pharmaceutica Nv Heteroaryldihydropyrimidine derivatives and methods of treating hepatitis b infections
WO2020193459A1 (en) 2019-03-25 2020-10-01 F. Hoffmann-La Roche Ag Solid forms of a compound of hbv core protein allosteric modifier
TW202122392A (zh) * 2019-07-31 2021-06-16 愛爾蘭商健生科學愛爾蘭無限公司 二氫嘧啶衍生物及其於治療ｈｂｖ感染或ｈｂｖ誘發的疾病之用途
CN114423430A (zh) * 2019-09-20 2022-04-29 豪夫迈·罗氏有限公司 使用核心蛋白别构调节剂治疗hbv感染的方法

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CA2979490C (en) * 2015-03-16 2023-07-18 F. Hoffmann-La Roche Ag Combined treatment with a tlr7 agonist and an hbv capsid assembly inhibitor
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Also Published As

Publication number Publication date
PL3512556T3 (pl) 2021-12-27
EP3512556B1 (en) 2021-08-18
CN109715214B (zh) 2022-03-04
ES2894605T3 (es) 2022-02-15
BR112019004560A2 (pt) 2019-07-02
EP3970750A1 (en) 2022-03-23
IL287545B (en) 2022-10-01
US20190298726A1 (en) 2019-10-03
JP7101663B2 (ja) 2022-07-15
KR20190053219A (ko) 2019-05-17
WO2018050571A1 (en) 2018-03-22
IL287545B2 (en) 2023-02-01
IL287545A (en) 2021-12-01
MX2019002678A (es) 2019-05-20
CN109715214A (zh) 2019-05-03
EP3512556A1 (en) 2019-07-24
AU2017326400B2 (en) 2023-03-30
IL264926B (en) 2021-12-01
JP2022130672A (ja) 2022-09-06
CA3034185A1 (en) 2018-03-22
KR102497701B1 (ko) 2023-02-09
US11337982B2 (en) 2022-05-24
AU2017326400A1 (en) 2019-02-21
TW201811371A (zh) 2018-04-01
TWI720250B (zh) 2021-03-01
JP2019526610A (ja) 2019-09-19

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