PL3773291T3 - Zastosowanie przemiennych pól elektrycznych do zwiększania przepuszczalności bariery krew-mózg - Google Patents

Zastosowanie przemiennych pól elektrycznych do zwiększania przepuszczalności bariery krew-mózg

Info

Publication number
PL3773291T3
PL3773291T3 PL19780002T PL19780002T PL3773291T3 PL 3773291 T3 PL3773291 T3 PL 3773291T3 PL 19780002 T PL19780002 T PL 19780002T PL 19780002 T PL19780002 T PL 19780002T PL 3773291 T3 PL3773291 T3 PL 3773291T3
Authority
PL
Poland
Prior art keywords
electric fields
brain barrier
blood brain
alternating electric
increase permeability
Prior art date
Application number
PL19780002T
Other languages
English (en)
Inventor
Carsten Hagemann
Mario LOHR
Almuth F. KESSLER
Malgorzata BUREK
Carola Forster
Catherine BRAMI
Hadas Sara Hershkovich
Tali Voloshin-Sela
Original Assignee
Novocure Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novocure Gmbh filed Critical Novocure Gmbh
Publication of PL3773291T3 publication Critical patent/PL3773291T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37217—Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36002—Cancer treatment, e.g. tumour
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/0007—Special media to be introduced, removed or treated introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
    • A61M2205/054—General characteristics of the apparatus combined with other kinds of therapy with electrotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0693—Brain, cerebrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2250/00—Specially adapted for animals
PL19780002T 2018-08-23 2019-08-22 Zastosowanie przemiennych pól elektrycznych do zwiększania przepuszczalności bariery krew-mózg PL3773291T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862722100P 2018-08-23 2018-08-23
EP19780002.2A EP3773291B1 (en) 2018-08-23 2019-08-22 Using alternating electric fields to increase permeability of the blood brain barrier
PCT/IB2019/057091 WO2020039390A1 (en) 2018-08-23 2019-08-22 Using alternating electric fields to increase permeability of the blood brain barrier

Publications (1)

Publication Number Publication Date
PL3773291T3 true PL3773291T3 (pl) 2022-01-31

Family

ID=68104708

Family Applications (3)

Application Number Title Priority Date Filing Date
PL21170598.3T PL3892219T3 (pl) 2018-08-23 2019-08-22 Zastosowanie przemiennych pól elektrycznych w celu zwiększenia przepuszczalności bariery krew-mózg
PL19780002T PL3773291T3 (pl) 2018-08-23 2019-08-22 Zastosowanie przemiennych pól elektrycznych do zwiększania przepuszczalności bariery krew-mózg
PL20212126T PL3804648T3 (pl) 2018-08-23 2019-08-22 Zastosowanie przemiennych pól elektrycznych do zwiększania przepuszczalności bariery krew-mózg

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL21170598.3T PL3892219T3 (pl) 2018-08-23 2019-08-22 Zastosowanie przemiennych pól elektrycznych w celu zwiększenia przepuszczalności bariery krew-mózg

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL20212126T PL3804648T3 (pl) 2018-08-23 2019-08-22 Zastosowanie przemiennych pól elektrycznych do zwiększania przepuszczalności bariery krew-mózg

Country Status (16)

Country Link
US (4) US11351349B2 (pl)
EP (5) EP3878389A1 (pl)
JP (1) JP6974671B2 (pl)
KR (2) KR20240042240A (pl)
CN (6) CN113908432A (pl)
AU (2) AU2019324585C1 (pl)
BR (1) BR112020025422A2 (pl)
CA (1) CA3100817A1 (pl)
DK (3) DK3804648T3 (pl)
ES (3) ES2898090T3 (pl)
HU (3) HUE056950T2 (pl)
IL (1) IL279466A (pl)
MX (1) MX2020013519A (pl)
PL (3) PL3892219T3 (pl)
SG (1) SG11202012592WA (pl)
WO (1) WO2020039390A1 (pl)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10779875B2 (en) 2013-05-06 2020-09-22 Novocure Gmbh Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment
US10188851B2 (en) 2015-10-28 2019-01-29 Novocure Limited TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements
US10821283B2 (en) 2016-04-04 2020-11-03 Novocure Gmbh Reducing motility of cancer cells using tumor treating fields (TTFields)
CA3029468A1 (en) 2016-06-30 2018-01-04 Zeev Bomzon Arrays for longitudinal delivery of ttfields to a body
WO2018134733A1 (en) 2017-01-19 2018-07-26 Moshe Giladi System for viewing cell cultures under a microscope whilst applying ttfields
CN116603165A (zh) * 2018-07-03 2023-08-18 斯坦福大学托管董事会 使用交变电场提高细胞膜通透性
CA3103070C (en) 2018-07-10 2024-01-09 Novocure Gmbh Inhibiting viral infection using alternating electric fields
JP7233453B2 (ja) * 2018-08-23 2023-03-06 ノボキュア ゲーエムベーハー 血液脳関門の透過性を向上させるための交流電界の使用
DK3804648T3 (da) * 2018-08-23 2022-04-11 Novocure Gmbh Anvendelse af elektriske vekseltrømsfelter til forøgelse af permeabilitet af blodhjernebarrieren
JP2022501098A (ja) 2018-09-07 2022-01-06 ノボキュア ゲーエムベーハー Ｔ細胞の増殖を低減する交流電場を使用する自己免疫性疾患の治療
EP3984590B1 (en) 2018-10-15 2022-12-07 Novocure GmbH Generating tumor treating fields (ttfields) with high uniformity throughout the brain
EP3870271A1 (en) 2018-10-25 2021-09-01 Zeev Bomzon Delivering alternating electric fields (e.g., ttfields) to a subject's spinal anatomy
MX2021002624A (es) 2018-11-19 2021-05-12 Novocure Gmbh Arreglos para suministrar campos de tratamiento de tumores (ttfields) con subelementos direccionables selectivamente.
CA3110453C (en) 2018-11-29 2024-02-27 Novocure Gmbh Enhanced-flexibility transducer arrays for delivering ttfields (tumor treating fields)
EP3961565A1 (en) 2019-01-08 2022-03-02 Novocure GmbH Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (ttfields)
CN113573774A (zh) 2019-02-26 2021-10-29 诺沃库勒有限责任公司 基于靶向癌细胞的电特性确定TTfield治疗的频率
CN113453638A (zh) 2019-02-27 2021-09-28 诺沃库勒有限责任公司 使用可植入换能器阵列递送肿瘤治疗场（TTFields）
JP7419391B2 (ja) 2019-03-29 2024-01-22 ノボキュア ゲーエムベーハー ＰＴＧＥＲ３阻害剤によりＴＴＦｉｅｌｄｓ－耐性がん細胞におけるＴＴＦｉｅｌｄｓに対する感受性を回復させるための方法
PL3960232T3 (pl) 2019-04-17 2023-05-15 Novocure Gmbh Załadowanie danych z układu izolowanego bez naruszania izolacji
WO2021019403A1 (en) 2019-07-31 2021-02-04 Yoram Wasserman Applying tumor treating fields (ttfields) via electrodes embedded into skull implants
JP2022545794A (ja) 2019-08-30 2022-10-31 ノボキュア ゲーエムベーハー 頸部への腫瘍治療電界（ＴＴＦｉｅｌｄｓ）の印加
CA3152250A1 (en) 2019-09-10 2021-03-18 Novocure Gmbh A method of reducing viability of cancer cells by applying alternating electric fields and administering checkpoint inhibitors to the cancer cells
CN114901344A (zh) 2019-12-31 2022-08-12 诺沃库勒有限责任公司 具有可单独访问的电极元件和温度传感器的用于传递肿瘤治疗场（tt场）的阵列
KR20220122679A (ko) 2019-12-31 2022-09-02 노보큐어 게엠베하 채널들의 스위칭 및 진폭 조정 중 스파이크들을 방지하는 고전압, 고효율 사인파 생성기
EP4138988A1 (en) * 2020-04-24 2023-03-01 Novocure Gmbh Using alternating electric fields to increase permeability of the blood brain barrier
US11818943B2 (en) 2020-06-25 2023-11-14 Novocure Gmbh Fabricating organic light emitting diodes (OLEDs) using tubulin
US20220161028A1 (en) 2020-11-25 2022-05-26 Novocure Gmbh Increasing the Efficacy of Tumor Treating Fields (TTFields) by Applying the TTFields at Peak Intensity Less Than Half the Time
WO2022130183A2 (en) 2020-12-17 2022-06-23 Novocure Gmbh Pyroelectric-based temperature sensing of transducer arrays for applying tumor treating fields (ttfields)
CN113008403B (zh) * 2021-02-08 2022-08-12 清华大学 电场发生装置及测温电极装置
EP4319864A1 (en) * 2021-04-08 2024-02-14 Novocure GmbH Methods of treating neurodegenerative disorders with alternating electric fields
CN113509641A (zh) * 2021-06-29 2021-10-19 北京康源嘉成生物科技有限公司 一种非药物且非侵入性开放血脑屏障的装置和方法
US20230009366A1 (en) 2021-06-30 2023-01-12 Novocure Gmbh Using Alternating Electric Fields at Different Frequencies to Increase Permeability of the Blood Brain Barrier and also to Provide Other Benefits
WO2023053044A1 (en) 2021-09-30 2023-04-06 Novocure Gmbh Reducing electrosensation whilst treating a subject using alternating electric fields
US20230201616A1 (en) 2021-12-29 2023-06-29 Novocure Gmbh Reducing Electrosensation Whilst Treating a Subject Using Alternating Electric Fields by Using Larger Cathodes and Smaller Anodes
US20230218912A1 (en) 2021-12-30 2023-07-13 Novocure Gmbh Selecting Values of Parameters for Treatment Using Tumor Treating Fields (TTFields)
US20230310877A1 (en) 2022-03-30 2023-10-05 Novocure Gmbh Reducing Electrosensation Whilst Treating a Subject Using Alternating Electric Fields by Pairing Transducer Arrays Together
US20230310848A1 (en) 2022-03-30 2023-10-05 Novocure Gmbh Using Interleaved Cooling Periods to Increase the Peak Intensity of Tumor Treating Fields
US20230398367A1 (en) 2022-06-13 2023-12-14 Novocure Gmbh Systems and methods for increasing intestinal absorption of therapeutic agents
WO2024003713A1 (en) 2022-06-27 2024-01-04 Novocure Gmbh Using a closed-loop technique to reduce electrosensation while treating a subject using alternating electric fields
WO2024003791A1 (en) 2022-06-30 2024-01-04 Novocure Gmbh Electrode assembly for applying tumor treating fields (ttfields) that includes a plurality of thermally linked but electrically isolated graphite sheets
KR102637878B1 (ko) * 2022-09-02 2024-02-19 주식회사 뉴로스피어 대뇌병변 산화철의 전자-펜톤효과를 이용한 전기장 대뇌자극치료기기
WO2024069523A1 (en) 2022-09-30 2024-04-04 Novocure Gmbh Changing the orientation of tumor treating fields (ttfields) by adjusting the amplitudes of two or more electric fields that are all in-phase with each other
WO2024069504A1 (en) 2022-09-30 2024-04-04 Novocure Gmbh Reducing electrosensation while treating a subject using alternating electric fields by controlling ramp-up characteristics
US20240108887A1 (en) 2022-09-30 2024-04-04 Novocure Gmbh Reducing Electrosensation While Treating a Subject Using Alternating Electric Fields by Deactivating Selected Electrode Elements
WO2024069321A1 (en) 2022-09-30 2024-04-04 Novocure Gmbh Compositions, systems, and methods for reducing electrosensation and/or skin irritation

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1206353A (zh) * 1995-11-21 1999-01-27 E·N·勒纳 提高有机体内生物活性物质和化合物释放的装置
US6678558B1 (en) 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
US7412285B2 (en) * 1999-04-09 2008-08-12 Oncostim, Inc. Method and device for treating cancer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
US20030078499A1 (en) 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US7146210B2 (en) 2000-02-17 2006-12-05 Standen Ltd. Apparatus and method for optimizing tumor treatment efficiency by electric fields
US8447395B2 (en) 2000-02-17 2013-05-21 Novocure Ltd Treating bacteria with electric fields
US8175698B2 (en) 2000-02-17 2012-05-08 Novocure Ltd. Treating bacteria with electric fields
US7089054B2 (en) 2002-10-02 2006-08-08 Standen Ltd. Apparatus and method for treating a tumor or the like
US7599746B2 (en) * 2000-02-17 2009-10-06 Standen Ltd Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases
JP5280600B2 (ja) 2000-02-17 2013-09-04 パルティ、ヨーラム 分裂中の細胞を破壊するための方法および装置
US7016725B2 (en) 2001-11-06 2006-03-21 Standen Ltd. Method and apparatus for destroying dividing cells
US6868289B2 (en) 2002-10-02 2005-03-15 Standen Ltd. Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor
US7136699B2 (en) 2002-10-02 2006-11-14 Standen, Ltd. Apparatus for destroying dividing cells
US6546290B1 (en) * 2000-04-12 2003-04-08 Roamitron Holding S.A. Method and apparatus for electromedical therapy
US7332313B2 (en) 2001-06-05 2008-02-19 Applied Biophysics, Inc. Electrical wounding assay for cells in vitro
US6904322B2 (en) 2002-02-15 2005-06-07 Kalaco Scientific, Inc. Transcranial electrostimulation apparatus and method
US20030171738A1 (en) 2002-03-06 2003-09-11 Konieczynski David D. Convection-enhanced drug delivery device and method of use
US10912712B2 (en) 2004-03-25 2021-02-09 The Feinstein Institutes For Medical Research Treatment of bleeding by non-invasive stimulation
JP4750784B2 (ja) 2004-04-23 2011-08-17 ノヴォキュアー・リミテッド 異なる周波数の電界による腫瘍等の治療
PT2364748T (pt) * 2004-12-07 2018-03-26 Novocure Ltd Eléctrodos para aplicar um campo eléctrico in-vivo ao longo de um extenso período de tempo
EP1833554A2 (en) 2004-12-27 2007-09-19 Standen Ltd. Treating a tumor or the like with electric fields at different orientations
US8788044B2 (en) 2005-01-21 2014-07-22 Michael Sasha John Systems and methods for tissue stimulation in medical treatment
US20100049117A1 (en) 2005-04-18 2010-02-25 Pantec Biosolutions Ag Microporator for Porating a Biological Membrane and Integrated Permeant Administering System
EP3804809B1 (en) 2005-10-03 2023-12-27 Novocure GmbH Optimizing characteristics of an electric field to increase the field's effect on proliferating cells
US8019414B2 (en) 2006-04-05 2011-09-13 Novocure Ltd. Treating cancer using electromagnetic fields in combination with other treatment regimens
PT2167194T (pt) 2007-03-06 2017-06-15 Novocure Ltd Tratamento do cancro utilizando campos electromagnéticos em combinação com terapia fotodinámica
PT2183024T (pt) 2007-08-14 2019-08-01 Novocure Ltd Tratando parasitas com campos elétricos
US8715203B2 (en) 2007-09-17 2014-05-06 Novocure Limited Composite electrode
DE102008018170B4 (de) 2008-04-03 2010-05-12 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Mikrofluidisches System und Verfahren zum Aufbau und zur anschließenden Kultivierung sowie nachfolgender Untersuchung von komplexen Zellanordnungen
US10245098B2 (en) * 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
WO2010118387A1 (en) 2009-04-09 2010-10-14 Virginia Tech Intellectual Properties, Inc. Integration of very short electric pulses for minimally to noninvasive electroporation
CA2771169A1 (en) 2009-08-24 2011-03-03 Ron L. Alterman Apparatus for trans-cerebral electrophoresis and methods of use thereof
CN103328038A (zh) * 2010-12-01 2013-09-25 史拜诺莫度雷森公司 向神经解剖结构直接递送药剂
US20150126964A1 (en) * 2012-05-13 2015-05-07 Corporation De L'ecole Polytechnique De Montreal Drug delivery across the blood-brain barrier using magnetically heatable entities
US20120323214A1 (en) 2012-05-16 2012-12-20 Totada R Shantha Alzheimer's disease treatment with multiple therapeutic agents delivered to the olfactory region through a special delivery catheter and iontophoresis
ES2898374T3 (es) * 2012-09-06 2022-03-07 Covidien Lp Sistema de tratamiento neurológico
US9020605B2 (en) * 2012-10-25 2015-04-28 Oncosec Medical Incorporated Electroporation device
US9682066B2 (en) 2012-12-04 2017-06-20 University Of Cincinnati Methods of treating primary brain tumors by administering letrozole
US9655669B2 (en) 2013-05-06 2017-05-23 Novocure Limited Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment
US10779875B2 (en) 2013-05-06 2020-09-22 Novocure Gmbh Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment
CN108024803B (zh) 2015-04-10 2021-10-19 安吉戴尼克公司 使用热控电极进行不可逆电穿孔的系统和方法
US11167133B2 (en) 2015-05-14 2021-11-09 London Health Sciences Centre Research Inc. Intratumoral modulation therapy
US9910453B2 (en) 2015-09-25 2018-03-06 Novocure Limited High voltage, high efficiency sine wave generator with pre-set frequency and adjustable amplitude
US10188851B2 (en) 2015-10-28 2019-01-29 Novocure Limited TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements
US10821283B2 (en) * 2016-04-04 2020-11-03 Novocure Gmbh Reducing motility of cancer cells using tumor treating fields (TTFields)
CA3029468A1 (en) 2016-06-30 2018-01-04 Zeev Bomzon Arrays for longitudinal delivery of ttfields to a body
US20180008708A1 (en) 2016-07-10 2018-01-11 Novocure Limited Synchronizing Tumor Cells to the G2/M Phase Using TTFields Combined with Taxane or Other Anti-Microtubule Agents
EP4218907A1 (en) 2016-08-18 2023-08-02 Novocure GmbH Temperature measurement in arrays for delivering tumour treating fields
CN116236696A (zh) 2016-12-13 2023-06-09 诺沃库勒有限责任公司 使用具有用可变形模板优化过的电极位置的TTField治疗患者
WO2018134733A1 (en) 2017-01-19 2018-07-26 Moshe Giladi System for viewing cell cultures under a microscope whilst applying ttfields
EP3764931A4 (en) * 2018-03-12 2021-12-08 Tel Hashomer Medical Research Infrastructure And Services Ltd. METHOD OF MODIFYING THE PERMEABILITY OF THE BRAIN BARRIER
US10953209B2 (en) 2018-03-28 2021-03-23 Board Of Regents Of The University Of Texas System Treating tumors using TTFields combined with a PARP inhibitor
JP7139448B2 (ja) 2018-04-09 2022-09-20 ノボキュア ゲーエムベーハー ＴＴＦｉｅｌｄｓ及びオーロラキナーゼ阻害剤による腫瘍の治療
KR20200141478A (ko) 2018-04-10 2020-12-18 지브 봄존 서로 다른 반복 시간을 가지는 두 개의 MRI 이미지들로부터 얻어진 1MHz 미만 저주파 교류 전도도 추산치
CN116603165A (zh) 2018-07-03 2023-08-18 斯坦福大学托管董事会 使用交变电场提高细胞膜通透性
CA3103070C (en) 2018-07-10 2024-01-09 Novocure Gmbh Inhibiting viral infection using alternating electric fields
DK3804648T3 (da) * 2018-08-23 2022-04-11 Novocure Gmbh Anvendelse af elektriske vekseltrømsfelter til forøgelse af permeabilitet af blodhjernebarrieren

Also Published As

Publication number Publication date
KR102651496B1 (ko) 2024-03-25
EP3895643A1 (en) 2021-10-20
AU2019324585A1 (en) 2021-01-14
EP3895643B1 (en) 2023-10-11
EP3804648A1 (en) 2021-04-14
SG11202012592WA (en) 2021-01-28
DK3773291T3 (da) 2021-11-15
HUE059062T2 (hu) 2022-10-28
US10967167B2 (en) 2021-04-06
EP3892219A1 (en) 2021-10-13
AU2019324585C1 (en) 2023-04-27
KR20210071964A (ko) 2021-06-16
CN112469352B (zh) 2021-10-08
US20200269037A1 (en) 2020-08-27
PL3804648T3 (pl) 2022-06-06
US20200061361A1 (en) 2020-02-27
HUE056950T2 (hu) 2022-03-28
CN113908430A (zh) 2022-01-11
EP3773291A1 (en) 2021-02-17
EP3773291B1 (en) 2021-10-27
HUE058160T2 (hu) 2022-07-28
CN112469352A (zh) 2021-03-09
JP2021522957A (ja) 2021-09-02
AU2022268405A1 (en) 2023-01-05
CN113908431A (zh) 2022-01-11
NZ770867A (en) 2023-11-24
WO2020039390A1 (en) 2020-02-27
US11351349B2 (en) 2022-06-07
EP3892219B1 (en) 2022-06-01
EP3895643C0 (en) 2023-10-11
CN112618956A (zh) 2021-04-09
EP3804648B1 (en) 2022-01-19
ES2898090T3 (es) 2022-03-03
ES2911526T3 (es) 2022-05-19
PL3892219T3 (pl) 2022-10-03
IL279466A (en) 2021-01-31
EP3878389A1 (en) 2021-09-15
JP6974671B2 (ja) 2021-12-01
US20200061360A1 (en) 2020-02-27
MX2020013519A (es) 2021-05-12
ES2922576T3 (es) 2022-09-16
AU2019324585B2 (en) 2022-12-08
CN113908432A (zh) 2022-01-11
US11400269B2 (en) 2022-08-02
DK3892219T3 (da) 2022-06-27
DK3804648T3 (da) 2022-04-11
BR112020025422A2 (pt) 2021-03-16
US20220265982A1 (en) 2022-08-25
CN113908433A (zh) 2022-01-11
CA3100817A1 (en) 2020-02-27
KR20240042240A (ko) 2024-04-01

Similar Documents

Publication Publication Date Title
IL279466A (en) Using alternating electric fields to increase the permeability of the blood-brain barrier
IL279465A (en) Using alternating electric fields to increase cell membrane permeability
GB2561312B (en) Microfluidic model of the blood brain barrier
IL279252A (en) Inhibition of viral infection using alternating electric fields
PL3244965T3 (pl) Leczenie bólów głowy za pomocą stymulacji elektrycznej
EP2968940A4 (en) TRANSCUTANEAL ELECTRICAL STIMULATION AT SEVERAL SPOTS OF THE BACKMARK FOR MOTION RELIEF
IL262522A (en) Medicinal peptides of neurygiolin for the treatment or prevention of heart failure
IL246384B (en) Blood-brain barrier shuttle
IL260349B (en) Device for non-invasive electrical stimulation of the spinal cord
IL261224A (en) A system for non-invasive electrical brain stimulation
GB201613187D0 (en) Blood brain barrier model
GB2546139B (en) Improvements relating to the manufacture of medical devices
EP3058985A4 (en) Electric or magnetic stimulation device for treatment of circulatory disease
IL259490A (en) Vaccine with mica/b alpha 3 domain for cancer treatment
SG10201700022QA (en) Intradermal Administration Of Immunoglobulin G Preparation
HK1223280A1 (zh) 用於心力衰竭的預防或治療的人
EP3860638A4 (en) USE OF VEGF AT MULTIPLE DOSE TO INCREASE PERMEABILITY OF THE BLOOD-BRAIN BARRIER
GB201712881D0 (en) Alternate between usage of the left or right brain
GB201503816D0 (en) Non-invasive deep brain stimulation
GB201503818D0 (en) Non-invasive deep brain stimulation
TWM533345U (en) Structure improvement of electric connector
TWM533475U (en) Improved structure of filter
GB201401287D0 (en) Bernard's theory of inertia applied to the human brain
GB201401290D0 (en) Bernard's theory of ingenuity applied to the brain
ITBA20140017U1 (it) "cassettiera blindata multifunzione"