JP5280600B2 - 分裂中の細胞を破壊するための方法および装置 - Google Patents
分裂中の細胞を破壊するための方法および装置 Download PDFInfo
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- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/147—Electrodes transferring energy by capacitive coupling, i.e. with a dielectricum between electrode and target tissue
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Description
本発明は、迅速に分裂中の細胞の選択的な破壊に関し、とりわけ分裂中の細胞を選択的に破壊するための方法および装置に関する。
腫瘍、特に悪性腫瘍またはガン性腫瘍は、正常組織と比較して非常に非制御的に増殖することが、当該技術分野で知られている。そのような促進した増殖は、腫瘍が過剰増殖する空間を占有し、そこに隣接する組織を損傷または破壊することを可能にする。さらに、特定のガンは、転移性ガン細胞がさらなる腫瘍に増殖する部位に、単一の細胞または小細胞クラスター(転移)を含むガン性「種(seeds)」を伝播する能力によって特徴付けされる。
単細胞生物および非分裂細胞を含む、分裂中の細胞の間を適切に区別し、非分裂中の細胞または生物には実質的に影響しないで、分裂中の細胞または生物を選択的に破壊可能である分裂中の細胞を殺す方法は、当該技術分野で必要とされており、これまで入手されていない。
本発明は、増殖および分裂を経験している細胞を選択的に破壊するための新規な方法と装置を提供する。これは、生存中の組織および単細胞生物における細胞、特に腫瘍細胞を含む。本発明の方法と装置は、そのような生存中の組織または生物の増殖を除去または制御する。
細胞分裂工程の各種の段階を模式的に説明する図1A−1Eが参照される。図1Aは正常な形状の細胞10を示し、それは一般的に当該技術分野で知られているように、球状(図面に示されているような)、楕円状、シリンダー状、「パンケーキ」状、またはいずれかの他の細胞の形状であっても良い。図1B−1Dは、分裂工程の各種の段階の間の細胞10を示し、それは図1Eに示されているように、二つの新たな細胞18と20の形成を引き起こす。
図4は、電場を印加しない場合の、典型的な細胞分裂を示す所定の期間に得られた多数の連続的な顕微鏡写真フレームを表す。この実施態様では、細胞はBHK(ベビーハムスター腎臓)細胞である。顕微鏡写真は、40分の期間で撮られた。細胞は、標準的培養培地(DMEM)で培養された。時間と分(時:分)の用語で写真の上部に時間が示されている。細胞分裂をより鮮明に示すために、写真は500倍の倍率で得られる。興味ある領域を強調するために、各写真に楕円が与えられている。フレームAは、分裂工程の前の分裂中の細胞の位置を示す。非分裂中の細胞は、通常組織培養プレートにへばりついている。この状態では、細胞は写真のフレームにおける隣の細胞から区別できない。フレームBでは、分裂について細胞自体を準備するように細胞を見て、より球状の形状で写真を撮ることができる。細胞はこの一般的な形状を当然採用するので、細胞は隣の細胞からより明確に区別される。分裂工程が継続すると、分裂中の細胞はフレームCに示されている裂け目を形成し、フレームDに示されているように砂時計上の形状を採用するように進行する。フレームEでは、分裂中の細胞は二つの別個の細胞にちぎれ、フレームFでは細胞は互いから遠ざかって移動する。娘細胞がフレームGで平らになり始め、フレームHでは最終的に消える。
【図面の簡単な説明】
【図1】図1A−1Eは、細胞分裂工程の各種の段階の、単純化した模式的な断面図である。
【図2】図2Aと2Bは、本発明の実施態様に従った、電場にかけられた非分裂中の細胞の模式図である。
【図3】図3A、3B、および3Cは、本発明の実施態様に従った、細胞の破壊を引き起こす電場にかけられた分裂中の細胞(図3C)の模式図である。
【図4】図4は、典型的な細胞分裂工程を説明する各時点で得られる、一連の連続的な顕微鏡写真フレームである。
【図5】図5は、分裂工程を完成することができない細胞を引き起こす、本発明の方法に従った電場にかけられている分裂中の細胞を説明する、一連の連続的な顕微鏡写真フレームである。
【符号の説明】
10:細胞
11:細胞膜
12:裂け目
14:サブ細胞
16:サブ細胞
18:新たな細胞
20:新たな細胞
22:ブリッジ、ネック
24:オルガネラ
26:オルガネラ
28:電極(陽極)
30:オルガネラ
32:電極(陰極)
Claims (20)
- 生存組織において、非分裂中の細胞または生物には実質的に影響しないで、分極可能な細胞内成分(24、26)を有する分裂中の細胞(10)を選択的に破壊する、または分裂中の細胞(10)の増殖を制御する装置であって、
第一および第二の絶縁電極(28、32)(ここで第一および第二の電極(28、32)は、処理される前記生存組織の近傍に配置される);
第一および第二の電極(28、32)を横切って交流電位を印加し、交流電場を生成するための電場供給源であって、
前記電位が、終後期または終期における分裂中の細胞(10)内に、分裂中の細胞(10)の切断溝(22)の領域で一般的に収束し、そこで増大した密度の電場を規定する電場線を有する不均一な電場を供給する10kHzから1MHzの間の周波数を有する電場供給源を含み、
前記分裂中の細胞(10)内で発生した前記不均一な電場が、前記細胞内成分(24、26)が前記切断溝(22)を破壊し、前記分裂中の細胞(10)の破壊または分裂中の細胞(10)の増殖制御を引き起こすまで、切断溝(22)に向けて前記細胞内成分(24、26)を移動させる、装置。
- 前記電場が、脈動する電場である、請求項1に記載の装置。
- 前記電場を消散することにより前記電場から感受性領域を遮蔽するためのシールドをさらに含む、請求項1に記載の装置。
- 所望の部位に前記電場を配向するよう位置しうる金属電極をさらに含む、請求項1に記載の装置。
- 所望の部位に前記電場を配向する導波管をさらに含む、請求項1に記載の装置。
- 前記電位が前記生存組織に対して回転されている、請求項1に記載の装置。
- 前記電場供給源が、2時間未満の所定の期間に亘り前記電位を印加する、請求項1に記載の装置。
- 前記電場供給源が、所定の期間に亘り前記電位を除去し、所定の期間が経過した後、前記電位を再印加する、請求項1に記載の装置。
- 前記電場が、前記分裂中の細胞(10)を通過する前は実質的に均一な電場である、請求項1に記載の装置。
- 最初に言及された前記電場供給源により印加される前記電場に対して反対分極のさらなる電場を印加し、最初に言及された前記電場供給源により印加される前記電場を所望の部位で消失させ、それにより所望の部位で遮蔽するためのさらなる電場供給源をさらに含む、請求項1に記載の装置。
- 生存組織において、非分裂中の細胞または生物には実質的に影響しないで、分極可能な細胞内成分(24、26)を有する分裂中の細胞(10)の増殖を制御する装置であって、
第一および第二の絶縁電極(28、32)(ここで第一および第二の電極(28、32)は、処理される前記生存組織の近傍に配置される);
第一および第二の電極(28、32)を横切って交流電位を印加し、交流電場を生成するための電場供給源であって、
前記電位が、終後期または終期における分裂中の細胞(10)内に、分裂中の細胞(10)の切断溝(22)の領域で一般的に収束し、そこで増大した密度の電場を規定する電場線を有する不均一な電場を供給する10kHzから1MHzの間の周波数を有する電場供給源を含み、
前記分裂中の細胞(10)内で発生した前記不均一な電場が、前記細胞内成分(24、26)が前記切断溝(22)を破壊し、前記分裂中の細胞(10)の増殖制御を引き起こすまで、切断溝(22)に向けて前記細胞内成分(24、26)を移動させる、装置。
- 前記電場が、脈動する電場である、請求項11に記載の装置。
- 前記電場を消散することにより前記電場から感受性領域を遮蔽するためのシールドをさらに含む、請求項11に記載の装置。
- 所望の部位に前記電場を配向するよう位置しうる金属電極をさらに含む、請求項11に記載の装置。
- 所望の部位に前記電場を配向する導波管をさらに含む、請求項11に記載の装置。
- 前記電位が前記生存組織に対して回転されている、請求項11に記載の装置。
- 前記電場供給源が、2時間未満の所定の期間に亘り前記電位を印加する、請求項11に記載の装置。
- 前記電場供給源が、所定の期間に亘り前記電位を除去し、所定の期間が経過した後、前記電位を再印加する、請求項11に記載の装置。
- 前記電場が、前記分裂中の細胞(10)を通過する前は実質的に均一な電場である、請求項11に記載の装置。
- 最初に言及された前記電場供給源により印加される前記電場に対して反対分極のさらなる電場を印加し、最初に言及された前記電場供給源により印加される前記電場を所望の部位で消失させ、それにより所望の部位で遮蔽するためのさらなる電場供給源をさらに含む、請求項11に記載の装置。
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US18329500P | 2000-02-17 | 2000-02-17 | |
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PCT/IB2001/000202 WO2001060994A1 (en) | 2000-02-17 | 2001-02-16 | Method and apparatus for destroying dividing cells |
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Families Citing this family (107)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7089054B2 (en) * | 2002-10-02 | 2006-08-08 | Standen Ltd. | Apparatus and method for treating a tumor or the like |
US7016725B2 (en) | 2001-11-06 | 2006-03-21 | Standen Ltd. | Method and apparatus for destroying dividing cells |
US8175698B2 (en) | 2000-02-17 | 2012-05-08 | Novocure Ltd. | Treating bacteria with electric fields |
US7599746B2 (en) | 2000-02-17 | 2009-10-06 | Standen Ltd | Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases |
US7136699B2 (en) * | 2002-10-02 | 2006-11-14 | Standen, Ltd. | Apparatus for destroying dividing cells |
US8447395B2 (en) | 2000-02-17 | 2013-05-21 | Novocure Ltd | Treating bacteria with electric fields |
US7599745B2 (en) * | 2000-02-17 | 2009-10-06 | Standen Ltd | Treating a tumor or the like with an electric field |
US7146210B2 (en) | 2000-02-17 | 2006-12-05 | Standen Ltd. | Apparatus and method for optimizing tumor treatment efficiency by electric fields |
US6868289B2 (en) | 2002-10-02 | 2005-03-15 | Standen Ltd. | Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor |
AU3399801A (en) | 2000-02-17 | 2001-08-27 | Yoram Palti | Method and apparatus for destroying dividing cells |
PT2345451T (pt) * | 2004-12-07 | 2018-04-19 | Novocure Ltd | Eléctrodos para aplicar um campo eléctrico in-vivo ao longo de um extenso período de tempo |
WO2006085150A2 (en) * | 2004-12-27 | 2006-08-17 | Standen Ltd. | Treating a tumor or the like with electric fields at different orientations |
US20070021803A1 (en) | 2005-07-22 | 2007-01-25 | The Foundry Inc. | Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction |
CN101321555B (zh) * | 2005-10-03 | 2020-12-08 | 诺沃库勒有限责任公司 | 优化电场特征以增加电场在增殖细胞上的效果 |
US8019414B2 (en) | 2006-04-05 | 2011-09-13 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with other treatment regimens |
US7680543B2 (en) * | 2006-09-14 | 2010-03-16 | Lazure Technologies, Llc | Tissue ablation and removal |
JP2010534056A (ja) * | 2007-02-16 | 2010-11-04 | イオジェニックス・プロプライエタリー・リミテッド | 水生生物の培養を改善するための方法 |
WO2009044289A1 (en) * | 2007-03-06 | 2009-04-09 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with photodynamic therapy |
EP2183024B1 (en) | 2007-08-14 | 2019-05-15 | Novocure Ltd. | Treating parasites with electric fields |
WO2009036471A1 (en) * | 2007-09-14 | 2009-03-19 | Lazure Technologies, Llc | Prostate cancer ablation |
US8562602B2 (en) * | 2007-09-14 | 2013-10-22 | Lazure Technologies, Llc | Multi-layer electrode ablation probe and related methods |
WO2009036459A1 (en) * | 2007-09-14 | 2009-03-19 | Lazure Technologies, Llc | Multi-tine probe and treatment by activation of opposing tines |
US20100100093A1 (en) * | 2008-09-16 | 2010-04-22 | Lazure Technologies, Llc. | System and method for controlled tissue heating for destruction of cancerous cells |
US8728139B2 (en) | 2009-04-16 | 2014-05-20 | Lazure Technologies, Llc | System and method for energy delivery to a tissue using an electrode array |
US9526911B1 (en) | 2010-04-27 | 2016-12-27 | Lazure Scientific, Inc. | Immune mediated cancer cell destruction, systems and methods |
US8684901B1 (en) | 2010-11-22 | 2014-04-01 | Jacob Zabara | Electromagnetic radiation treatment for cancer and pathological genetic regulations |
US9233257B1 (en) | 2010-11-22 | 2016-01-12 | Jacob Zabara | Electromagnetic radiation treatment |
US9031701B2 (en) | 2011-02-15 | 2015-05-12 | Hemosonics Llc | Characterization of blood hemostasis and oxygen transport parameters |
GB2522583B (en) * | 2012-10-26 | 2019-03-27 | E Sandstrom Robert | Apparatus for treating a tumor with free radical lifetimes enhanced by persistant low strength magnetic field |
US9789328B2 (en) * | 2012-10-26 | 2017-10-17 | Robert E. Sandstrom | Tumor treatment with free radical lifetimes enhanced by persistent low strength magnetic field |
US9655669B2 (en) | 2013-05-06 | 2017-05-23 | Novocure Limited | Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment |
US10779875B2 (en) | 2013-05-06 | 2020-09-22 | Novocure Gmbh | Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment |
US9833617B2 (en) | 2014-07-25 | 2017-12-05 | Loyalty Based Innovations, LLC | Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields |
US20190117963A1 (en) | 2014-07-25 | 2019-04-25 | Loyalty Based Innovations, LLC | Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields |
US9726647B2 (en) | 2015-03-17 | 2017-08-08 | Hemosonics, Llc | Determining mechanical properties via ultrasound-induced resonance |
US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
US10821283B2 (en) | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
WO2018002879A1 (en) | 2016-06-30 | 2018-01-04 | Zeev Bomzon | Arrays for longitudinal delivery of ttfields to a body |
WO2018134733A1 (en) | 2017-01-19 | 2018-07-26 | Moshe Giladi | System for viewing cell cultures under a microscope whilst applying ttfields |
US11338135B2 (en) | 2017-10-23 | 2022-05-24 | Cardiac Pacemakers, Inc. | Medical devices for cancer therapy with electric field shaping elements |
CO2018001283A1 (es) | 2018-02-07 | 2019-08-09 | Panacea Quantum Leap Tech Llc | Método de estimulación de tejidos con campos eléctricos y magnéticos por barrido en frecuencia |
US10953209B2 (en) | 2018-03-28 | 2021-03-23 | Board Of Regents Of The University Of Texas System | Treating tumors using TTFields combined with a PARP inhibitor |
WO2019197973A1 (en) | 2018-04-09 | 2019-10-17 | Moshe Giladi | Treating tumors with ttfields and an aurora kinase inhibitor |
EP3775956B1 (en) | 2018-04-10 | 2022-03-23 | Novocure GmbH | Low frequency (<1 mhz) ac conductivity estimates derived from two mri images having different repetition times |
SG11202012597UA (en) | 2018-07-03 | 2021-01-28 | Edwin Chang | Using alternating electric fields to increase cell membrane permeability |
US11179322B2 (en) | 2018-07-10 | 2021-11-23 | Novocure Gmbh | Methods and compositions for treating tumors with TTFields and sorafenib |
WO2020012364A1 (en) | 2018-07-10 | 2020-01-16 | Novocure Gmbh | Inhibiting viral infection using alternating electric fields |
US11911612B2 (en) | 2018-07-18 | 2024-02-27 | Novocure Gmbh | Using power loss density and related measures to quantify the dose of tumor treating fields (TTFields) |
DK3804648T3 (da) | 2018-08-23 | 2022-04-11 | Novocure Gmbh | Anvendelse af elektriske vekseltrømsfelter til forøgelse af permeabilitet af blodhjernebarrieren |
US11160977B2 (en) | 2018-09-04 | 2021-11-02 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the infratentorial brain |
US11986647B2 (en) | 2018-09-07 | 2024-05-21 | Novocure Gmbh | Treating autoinflammatory and mitochondrial diseases using an alternating electric field |
EP3846894A1 (en) | 2018-09-07 | 2021-07-14 | Novocure GmbH | Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells |
US11241577B2 (en) | 2018-10-15 | 2022-02-08 | Novocure Gmbh | Generating tumor treating fields (TTFields) with high uniformity throughout the brain |
JP7148722B2 (ja) * | 2018-10-25 | 2022-10-05 | ゼーヴ・ボンゾン | 被験者の脊椎構造体に対する交番電界(例えばTTField)の送達 |
EP3922301B1 (en) | 2018-11-19 | 2024-02-21 | Novocure GmbH | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
EP4019081B1 (en) | 2018-11-29 | 2024-04-03 | Novocure GmbH | Enhanced-flexibility transducer arrays for delivering ttfields (tumor treating fields) |
WO2020144582A1 (en) | 2019-01-08 | 2020-07-16 | Novocure Gmbh | Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (ttfields) |
CN113573774A (zh) | 2019-02-26 | 2021-10-29 | 诺沃库勒有限责任公司 | 基于靶向癌细胞的电特性确定TTfield治疗的频率 |
EP3954314A1 (en) | 2019-02-27 | 2022-02-16 | Novocure GmbH | Delivering tumor treating fields (ttfields) using implantable transducer arrays |
JP7419391B2 (ja) | 2019-03-29 | 2024-01-22 | ノボキュア ゲーエムベーハー | PTGER3阻害剤によりTTFields-耐性がん細胞におけるTTFieldsに対する感受性を回復させるための方法 |
WO2020212824A1 (en) | 2019-04-17 | 2020-10-22 | Yoram Wasserman | Uploading data from an isolated system without compromising isolation |
EP3958954B1 (en) | 2019-04-22 | 2024-04-24 | Boston Scientific Scimed Inc. | Electrical stimulation devices for cancer treatment |
EP4397361A3 (en) | 2019-04-22 | 2024-08-28 | Boston Scientific Scimed, Inc. | Devices for administering electrical stimulation to treat cancer |
JP2022529374A (ja) | 2019-04-23 | 2022-06-21 | ボストン サイエンティフィック サイムド,インコーポレイテッド | がん治療のための電気刺激用電極 |
WO2020219517A2 (en) | 2019-04-23 | 2020-10-29 | Boston Scientific Scimed, Inc. | Electrical stimulation for cancer treatment with internal and external electrodes |
JP7476231B2 (ja) | 2019-04-23 | 2024-04-30 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 温熱療法又は熱モニタと共に行われる電気刺激 |
CN114364432A (zh) | 2019-07-31 | 2022-04-15 | 诺沃库勒有限责任公司 | 经由埋入颅骨植入物中的电极施加肿瘤治疗场(TTField) |
EP4021559B1 (en) | 2019-08-30 | 2023-10-25 | Novocure GmbH | Delivering tumor treating fields (ttfields) to the neck |
EP4038035A1 (de) | 2019-09-30 | 2022-08-10 | TDK Electronics AG | Polykristalliner keramischer festkörper, dielektrische elektrode mit dem festkörper, vorrichtung mit der elektrode und verfahren zur herstellung |
US11534601B2 (en) | 2019-11-08 | 2022-12-27 | Novocure Gmbh | Perforated hydrogel configurations and methods of production and use thereof |
JP2023508584A (ja) | 2019-12-31 | 2023-03-02 | ノボキュア ゲーエムベーハー | 画像セグメンテーションのための方法、システム、および装置 |
EP4054705A2 (en) | 2019-12-31 | 2022-09-14 | Novocure GmbH | High voltage, high efficiency sine wave generator that prevents spikes during amplitude adjustments and switching of channels |
DK4074367T3 (da) | 2019-12-31 | 2023-05-22 | Novocure Gmbh | Arrays til levering af tumorbehandlingsfelter (tt-felter) med individuelt tilgængelige elektrodeelementer og temperatursensorer |
US11458298B2 (en) | 2020-01-22 | 2022-10-04 | Novocure Gmbh | Assemblies containing two conductive gel compositions and methods of production and use thereof |
EP4110455B1 (en) | 2020-02-24 | 2024-05-22 | Boston Scientific Scimed, Inc. | Systems for treatment of pancreatic cancer |
WO2021223684A1 (zh) * | 2020-05-02 | 2021-11-11 | 电冷科学有限公司 | 一种避免活性非消融电极附近组织损伤的装置 |
TW202200232A (zh) | 2020-05-06 | 2022-01-01 | 瑞士商諾沃庫勒有限責任公司 | 用於產生腫瘤治療電場之導電襯墊以及生產和使用其之方法 |
WO2021257967A1 (en) | 2020-06-19 | 2021-12-23 | The Methodist Hospital Dba Houston Methodist Hospital | Method and apparatus for oncomagnetic treatment |
US11818943B2 (en) | 2020-06-25 | 2023-11-14 | Novocure Gmbh | Fabricating organic light emitting diodes (OLEDs) using tubulin |
DE102020133165B9 (de) | 2020-12-11 | 2024-06-06 | Tdk Electronics Ag | Keramikelektrode, Baugruppe mit der Keramikelektrode, Anordnung mit der Keramikelektrode und Verfahren zur Herstellung einer Keramikelektrode |
CN116782980A (zh) | 2020-12-21 | 2023-09-19 | 诺沃库勒有限责任公司 | 复合电极的优化 |
JP2024514045A (ja) | 2021-03-12 | 2024-03-28 | ノボキュア ゲーエムベーハー | 電極アレイ、ならびにその製造および使用方法 |
EP4271466A2 (en) | 2021-03-18 | 2023-11-08 | Novocure Gmbh | Constructing a 3d phantom with liquid hydrogel |
JP2024524745A (ja) | 2021-07-21 | 2024-07-05 | ノボキュア ゲーエムベーハー | 腫瘍治療フィールドを発生させる伝導性パッド、ならびに、その生産および使用の方法 |
US11877838B2 (en) * | 2021-08-14 | 2024-01-23 | Nano Hesgarsazan Salamat Arya | Preventing cytokine storm in COVID-19 patients by suppressing clonal expansion in activated lymphocytes using alternating electric fields |
WO2023042080A1 (en) | 2021-09-14 | 2023-03-23 | Novocure Gmbh | Temperature independent method and system for applying ttfields |
US20230102915A1 (en) | 2021-09-30 | 2023-03-30 | Novocure Gmbh | Method and system for applying tumor treating fields interfacing with hair follicles |
WO2023095111A1 (en) | 2021-11-29 | 2023-06-01 | Novocure Gmbh | Methods of reducing ciliogenesis with alternating electric fields |
US20230173288A1 (en) | 2021-12-07 | 2023-06-08 | Novocure Gmbh | Compact dc system for delivering a square wave ac signal |
US20230181897A1 (en) | 2021-12-10 | 2023-06-15 | Novocure Gmbh | Compression garment assembly for applying ttfields and methods of production and use thereof |
US20230173265A1 (en) | 2021-12-10 | 2023-06-08 | Novocure Gmbh | Garment providing a biasing force on a transducer array |
US20230181898A1 (en) | 2021-12-10 | 2023-06-15 | Novocure Gmbh | Compression garment assembly for applying ttfields and methods of production and use thereof |
US20230398367A1 (en) | 2022-06-13 | 2023-12-14 | Novocure Gmbh | Systems and methods for increasing intestinal absorption of therapeutic agents |
WO2023248139A1 (en) | 2022-06-20 | 2023-12-28 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using tumor treating fields and vegf inhibitors |
US20230407282A1 (en) | 2022-06-21 | 2023-12-21 | Novocure Gmbh | Systems and methods for treating conditions and diseases using alternating electric fields and crispr-cas system |
WO2024052877A1 (en) | 2022-09-08 | 2024-03-14 | Novocure Gmbh | Constructing a 3d phantom with a matrix material having conductive particles dispersed therein |
US20240103041A1 (en) | 2022-09-27 | 2024-03-28 | Novocure Gmbh | Ingestible implantable device to measure internal ttfield intensity |
CA3180284A1 (en) | 2022-09-29 | 2024-03-29 | Novocure Gmbh | Transducer array having a temperature sensor isolation layer between a temperature sensor and external environment |
WO2024069501A1 (en) | 2022-09-29 | 2024-04-04 | Novocure Gmbh | System and method for maintaining ttfields during battery changes |
WO2024069321A1 (en) | 2022-09-30 | 2024-04-04 | Novocure Gmbh | Compositions, systems, and methods for reducing electrosensation and/or skin irritation |
US20240108704A1 (en) | 2022-09-30 | 2024-04-04 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using alternating electric fields and apoptotic cancer cell vaccination |
US20240110174A1 (en) | 2022-09-30 | 2024-04-04 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using alternating electric fields and dendritic cells |
WO2024069539A1 (en) | 2022-09-30 | 2024-04-04 | Novocure Gmbh | Single wire temperature measurement solution for a ttfield application system and methods of production and use thereof |
CN115845254B (zh) * | 2022-11-23 | 2024-02-02 | 湖南安泰康成生物科技有限公司 | 小细胞肺癌治疗系统以及交变电场发生装置 |
US20240173544A1 (en) | 2022-11-30 | 2024-05-30 | Novocure Gmbh | Transducer arrays having alternative array materials |
WO2024127192A1 (en) | 2022-12-13 | 2024-06-20 | Novocure Gmbh | Wireless transducer arrays applying tumor treating fields and systems and methods of use thereof |
WO2024141995A1 (en) | 2022-12-28 | 2024-07-04 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using tumor treating fields and anti-vegfr-2 antibodies |
Family Cites Families (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR446660A (fr) * | 1911-09-02 | 1912-12-12 | Gottlieb Schuettel | Dispositif pour métiers continus à anneaux pour monter les curseurs sur les anneaux |
BE794566A (fr) | 1972-01-28 | 1973-07-26 | Esb Inc | Regenerateur et stimulateur bioelectrochimique et procedes d'application in vivo d'energie electrique a des cellules et des tissus. |
US3991770A (en) | 1974-01-24 | 1976-11-16 | Leveen Harry H | Method for treating benign and malignant tumors utilizing radio frequency, electromagnetic radiation |
US4016886A (en) * | 1974-11-26 | 1977-04-12 | The United States Of America As Represented By The United States Energy Research And Development Administration | Method for localizing heating in tumor tissue |
US4121592A (en) | 1975-08-04 | 1978-10-24 | Critical Systems, Inc. | Apparatus for heating tissue |
JPS5547870A (en) | 1978-02-24 | 1980-04-05 | Lawrence Joseph L | Medical treatment method |
DE2813068A1 (de) * | 1978-03-25 | 1979-10-04 | Philips Patentverwaltung | Verfahren und vorrichtung zur ermittlung von inneren koerperstrukturen |
GB2043453A (en) | 1979-02-22 | 1980-10-08 | Electrochem Tech Corp | Improvements in or relating to an electrode |
US4472506A (en) * | 1981-01-13 | 1984-09-18 | Liburdy Robert P | Method for determining cell membrane dielectric breakdown |
US4467809A (en) * | 1982-09-17 | 1984-08-28 | Biolectron, Inc. | Method for non-invasive electrical stimulation of epiphyseal plate growth |
US4622952A (en) | 1983-01-13 | 1986-11-18 | Gordon Robert T | Cancer treatment method |
CA1244889A (en) * | 1983-01-24 | 1988-11-15 | Kureha Chemical Ind Co Ltd | HYPERTHERMIA DEVICE |
DE3323415C2 (de) * | 1983-06-29 | 1985-04-25 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Verwendung eines Verfahrens und einer Vorrichtung zur Bestimmung von Zellinhaltstoffe sezernierenden Zellen |
SE455920B (sv) | 1986-01-29 | 1988-08-22 | Hans Wiksell | Anordning for hypertermibehandling av tumorer |
US4923814A (en) * | 1986-05-09 | 1990-05-08 | Electropore, Inc. | High speed, high power apparatus for vesicle prealignment, poration, loading and fusion in uniform electric fields and method therefor |
CN86103803B (zh) | 1986-06-05 | 1987-11-18 | 北京信息工程学院 | 静电场治疗装置 |
US4822470A (en) * | 1987-10-09 | 1989-04-18 | Baylor College Of Medicine | Method of and apparatus for cell poration and cell fusion using radiofrequency electrical pulses |
US4936303A (en) * | 1987-11-20 | 1990-06-26 | Ultrathermics | Ultrasonic heating apparatus and method |
JPH0629196B2 (ja) * | 1987-12-01 | 1994-04-20 | 甲子郎 梅村 | 超音波による腫瘍治療用生理作用増強剤 |
US5389069A (en) * | 1988-01-21 | 1995-02-14 | Massachusetts Institute Of Technology | Method and apparatus for in vivo electroporation of remote cells and tissue |
FR2627987B3 (fr) | 1988-03-04 | 1990-02-02 | Indiba Sa | Appareil electronique pour la therapie medicale et cosmetique |
US5158071A (en) | 1988-07-01 | 1992-10-27 | Hitachi, Ltd. | Ultrasonic apparatus for therapeutical use |
GB8904998D0 (en) | 1989-03-04 | 1989-04-19 | Matthews Tony | Anaesthetising apparatus |
US5099756A (en) * | 1989-06-01 | 1992-03-31 | Harry H. Leveen | Radio frequency thermotherapy |
US5441746A (en) | 1989-12-22 | 1995-08-15 | Molecular Bioquest, Inc. | Electromagnetic wave absorbing, surface modified magnetic particles for use in medical applications, and their method of production |
US5236410A (en) | 1990-08-02 | 1993-08-17 | Ferrotherm International, Inc. | Tumor treatment method |
WO1992007621A1 (en) * | 1990-11-05 | 1992-05-14 | Bsd Medical Corporation | Urethral inserted applicator for prostate hyperthermia |
CA2109084C (en) | 1991-05-03 | 2004-02-24 | John William Fisher Costerton | Biofilm reduction method |
US5441532A (en) * | 1991-06-26 | 1995-08-15 | Massachusetts Institute Of Technology | Adaptive focusing and nulling hyperthermia annular and monopole phased array applicators |
US5697909A (en) * | 1992-01-07 | 1997-12-16 | Arthrocare Corporation | Methods and apparatus for surgical cutting |
US5468223A (en) | 1992-11-30 | 1995-11-21 | C.N.R.S. Paris | Electrochemotherapy |
US5386837A (en) * | 1993-02-01 | 1995-02-07 | Mmtc, Inc. | Method for enhancing delivery of chemotherapy employing high-frequency force fields |
FR2703253B1 (fr) | 1993-03-30 | 1995-06-23 | Centre Nat Rech Scient | Applicateur d'impulsions electriques pour traitement de tissus biologiques. |
US5458597A (en) * | 1993-11-08 | 1995-10-17 | Zomed International | Device for treating cancer and non-malignant tumors and methods |
IL108775A (en) | 1994-02-25 | 2003-09-17 | Univ Ramot | Method for efficient incorporation of molecules into cells |
US5704355A (en) * | 1994-07-01 | 1998-01-06 | Bridges; Jack E. | Non-invasive system for breast cancer detection |
AU6639596A (en) | 1995-07-28 | 1997-02-26 | James R. Gray | Use of a polarizing field to modify the efficacy of a bioactive agent |
US5606971A (en) * | 1995-11-13 | 1997-03-04 | Artann Corporation, A Nj Corp. | Method and device for shear wave elasticity imaging |
US5718246A (en) | 1996-01-03 | 1998-02-17 | Preferential, Inc. | Preferential induction of electrically mediated cell death from applied pulses |
US5984882A (en) | 1996-08-19 | 1999-11-16 | Angiosonics Inc. | Methods for prevention and treatment of cancer and other proliferative diseases with ultrasonic energy |
US5869326A (en) | 1996-09-09 | 1999-02-09 | Genetronics, Inc. | Electroporation employing user-configured pulsing scheme |
US6055453A (en) * | 1997-08-01 | 2000-04-25 | Genetronics, Inc. | Apparatus for addressing needle array electrodes for electroporation therapy |
AU9472998A (en) | 1997-09-04 | 1999-03-22 | Science Research Laboratory, Inc. | Cell separation using electric fields |
US6027488A (en) | 1998-06-03 | 2000-02-22 | Genetronics, Inc. | Flow-through electroporation system for ex vivo gene therapy |
US5976092A (en) * | 1998-06-15 | 1999-11-02 | Chinn; Douglas O. | Combination stereotactic surgical guide and ultrasonic probe |
US6319901B1 (en) | 1998-10-15 | 2001-11-20 | Ichor Medical Systems, Inc. | Methods for prolonging cell membrane permeability |
ATE298536T1 (de) | 1999-03-09 | 2005-07-15 | Thermage Inc | Vorichtung zur behandlung von gewebe |
US6678558B1 (en) | 1999-03-25 | 2004-01-13 | Genetronics, Inc. | Method and apparatus for reducing electroporation-mediated muscle reaction and pain response |
US6366808B1 (en) | 2000-03-13 | 2002-04-02 | Edward A. Schroeppel | Implantable device and method for the electrical treatment of cancer |
US6853864B2 (en) | 2000-02-02 | 2005-02-08 | Catholic University Of America, The | Use of electromagnetic fields in cancer and other therapies |
US6868289B2 (en) | 2002-10-02 | 2005-03-15 | Standen Ltd. | Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor |
US8175698B2 (en) | 2000-02-17 | 2012-05-08 | Novocure Ltd. | Treating bacteria with electric fields |
US7016725B2 (en) | 2001-11-06 | 2006-03-21 | Standen Ltd. | Method and apparatus for destroying dividing cells |
US7136699B2 (en) | 2002-10-02 | 2006-11-14 | Standen, Ltd. | Apparatus for destroying dividing cells |
US7599745B2 (en) | 2000-02-17 | 2009-10-06 | Standen Ltd | Treating a tumor or the like with an electric field |
US7146210B2 (en) | 2000-02-17 | 2006-12-05 | Standen Ltd. | Apparatus and method for optimizing tumor treatment efficiency by electric fields |
AU3399801A (en) | 2000-02-17 | 2001-08-27 | Yoram Palti | Method and apparatus for destroying dividing cells |
US7599746B2 (en) | 2000-02-17 | 2009-10-06 | Standen Ltd | Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases |
US7089054B2 (en) | 2002-10-02 | 2006-08-08 | Standen Ltd. | Apparatus and method for treating a tumor or the like |
US6546290B1 (en) | 2000-04-12 | 2003-04-08 | Roamitron Holding S.A. | Method and apparatus for electromedical therapy |
US6994706B2 (en) * | 2001-08-13 | 2006-02-07 | Minnesota Medical Physics, Llc | Apparatus and method for treatment of benign prostatic hyperplasia |
DE102004028156A1 (de) | 2004-06-09 | 2006-01-05 | Kalbe, Jochen, Dr. | Kombination von Radiowellen mit pharmakologisch aktiven Substanzen |
PT2345451T (pt) | 2004-12-07 | 2018-04-19 | Novocure Ltd | Eléctrodos para aplicar um campo eléctrico in-vivo ao longo de um extenso período de tempo |
WO2006085150A2 (en) | 2004-12-27 | 2006-08-17 | Standen Ltd. | Treating a tumor or the like with electric fields at different orientations |
ES2651812T3 (es) | 2005-06-08 | 2018-01-29 | Novocure Limited | Aparato para tratar el cáncer con campos eléctricos que se guían a las localizaciones deseadas dentro de un cuerpo |
CN101321555B (zh) | 2005-10-03 | 2020-12-08 | 诺沃库勒有限责任公司 | 优化电场特征以增加电场在增殖细胞上的效果 |
US8019414B2 (en) | 2006-04-05 | 2011-09-13 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with other treatment regimens |
WO2009044289A1 (en) | 2007-03-06 | 2009-04-09 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with photodynamic therapy |
EP2183024B1 (en) | 2007-08-14 | 2019-05-15 | Novocure Ltd. | Treating parasites with electric fields |
US8715203B2 (en) | 2007-09-17 | 2014-05-06 | Novocure Limited | Composite electrode |
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2001
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- 2001-02-16 US US12/199,498 patent/USRE43618E1/en not_active Expired - Lifetime
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AU3399801A (en) | 2001-08-27 |
CA2400526C (en) | 2013-04-23 |
US7333852B2 (en) | 2008-02-19 |
JP2004505604A (ja) | 2004-02-26 |
EP2335776A1 (en) | 2011-06-22 |
EP1259596A1 (en) | 2002-11-27 |
WO2001060994A1 (en) | 2001-08-23 |
CN1416466A (zh) | 2003-05-07 |
USRE43618E1 (en) | 2012-08-28 |
EP1259596A4 (en) | 2004-12-22 |
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