DK4074367T3 - Arrays til levering af tumorbehandlingsfelter (tt-felter) med individuelt tilgængelige elektrodeelementer og temperatursensorer - Google Patents
Arrays til levering af tumorbehandlingsfelter (tt-felter) med individuelt tilgængelige elektrodeelementer og temperatursensorer Download PDFInfo
- Publication number
- DK4074367T3 DK4074367T3 DK22177344.3T DK22177344T DK4074367T3 DK 4074367 T3 DK4074367 T3 DK 4074367T3 DK 22177344 T DK22177344 T DK 22177344T DK 4074367 T3 DK4074367 T3 DK 4074367T3
- Authority
- DK
- Denmark
- Prior art keywords
- fields
- arrays
- delivery
- temperature sensors
- electrode elements
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36002—Cancer treatment, e.g. tumour
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
- A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
- A61N1/36031—Control systems using physiological parameters for adjustment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
- A61N1/403—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00059—Material properties
- A61B2018/00071—Electrical conductivity
- A61B2018/00077—Electrical conductivity high, i.e. electrically conducting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/0016—Energy applicators arranged in a two- or three dimensional array
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00172—Connectors and adapters therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00666—Sensing and controlling the application of energy using a threshold value
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00791—Temperature
- A61B2018/00815—Temperature measured by a thermistor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/0091—Handpieces of the surgical instrument or device
- A61B2018/00916—Handpieces of the surgical instrument or device with means for switching or controlling the main function of the instrument or device
- A61B2018/00922—Handpieces of the surgical instrument or device with means for switching or controlling the main function of the instrument or device by switching or controlling the treatment energy directly within the hand-piece
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
- A61N1/0492—Patch electrodes
- A61N1/0496—Patch electrodes characterised by using specific chemical compositions, e.g. hydrogel compositions, adhesives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Physiology (AREA)
- Surgery (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Otolaryngology (AREA)
- Plasma & Fusion (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Electrotherapy Devices (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962955664P | 2019-12-31 | 2019-12-31 | |
| EP20829225.0A EP4054701A1 (en) | 2019-12-31 | 2020-12-21 | Arrays for delivering tumor treating fields (ttfields) with individually accessible electrode elements and temperature sensors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK4074367T3 true DK4074367T3 (da) | 2023-05-22 |
Family
ID=74004134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK22177344.3T DK4074367T3 (da) | 2019-12-31 | 2020-12-21 | Arrays til levering af tumorbehandlingsfelter (tt-felter) med individuelt tilgængelige elektrodeelementer og temperatursensorer |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US11878163B2 (da) |
| EP (3) | EP4054701A1 (da) |
| JP (2) | JP2023508585A (da) |
| KR (1) | KR20220123079A (da) |
| CN (2) | CN114901344B (da) |
| AU (1) | AU2020416669A1 (da) |
| BR (1) | BR112022012409A2 (da) |
| CA (1) | CA3163316A1 (da) |
| DK (1) | DK4074367T3 (da) |
| ES (1) | ES2950234T3 (da) |
| FI (1) | FI4074367T3 (da) |
| HU (1) | HUE061733T2 (da) |
| IL (1) | IL294386B2 (da) |
| MX (1) | MX2022006136A (da) |
| PL (1) | PL4074367T3 (da) |
| TW (2) | TWI888461B (da) |
| WO (1) | WO2021137094A1 (da) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017289870B2 (en) | 2016-06-30 | 2021-12-23 | Novocure Gmbh | Arrays for longitudinal delivery of TTFields to a body |
| US11986647B2 (en) | 2018-09-07 | 2024-05-21 | Novocure Gmbh | Treating autoinflammatory and mitochondrial diseases using an alternating electric field |
| CN118925056A (zh) | 2018-10-15 | 2024-11-12 | 诺沃库勒有限责任公司 | 生成遍及大脑具有高均匀性的肿瘤治疗场(ttfields) |
| US11369790B2 (en) | 2018-10-25 | 2022-06-28 | Novocure Gmbh | Delivering alternating electric fields (e.g., TTFields) to a subject's spinal anatomy |
| SG11202101810SA (en) | 2018-11-29 | 2021-03-30 | Novocure Gmbh | Enhanced-flexibility transducer arrays for delivering ttfields (tumor treating fields) |
| CN113330485B (zh) | 2019-01-08 | 2025-09-26 | 诺沃库勒有限责任公司 | 评估将图像分割成不同类型组织的质量,用于使用肿瘤治疗场(TTField)来计划治疗 |
| EP3924039B1 (en) | 2019-04-17 | 2023-11-22 | Novocure GmbH | Uploading data from an isolated system without compromising isolation |
| EP4223364B1 (en) | 2020-09-25 | 2024-04-24 | Novocure GmbH | Varying the metallization area on individual electrode elements in a tumor treating fields system to maximize current without overheating |
| US11759628B2 (en) * | 2020-12-09 | 2023-09-19 | Lifebridge Innovations, Pbc | Insulated electrode for delivering tumor treating electromagnetic fields |
| WO2022175803A1 (en) * | 2021-02-17 | 2022-08-25 | Novocure Gmbh | Arrays for delivering tumor treating fields (ttfields) with sets of electrode elements having individually adjustable active areas |
| WO2022190068A1 (en) | 2021-03-12 | 2022-09-15 | Novocure Gmbh | Methods of treating disease by skewing macrophage phenotype with alternating electric fields |
| JP2024513854A (ja) | 2021-03-31 | 2024-03-27 | ノボキュア ゲーエムベーハー | 腫瘍治療電場(TTFields)システムの電極を使用したインピーダンス断層撮影法 |
| CN113368389B (zh) * | 2021-06-08 | 2023-03-14 | 湖南安泰康成生物科技有限公司 | 利用电场抑制肿瘤增殖的设备及其控制方法和装置 |
| JP2024523598A (ja) * | 2021-06-30 | 2024-06-28 | ノボキュア ゲーエムベーハー | 腫瘍治療電場(TTfields)を印加するためのトランスデューサアレイにおける電流を調整するためのキャパシタの使用 |
| EP4376939A1 (en) * | 2021-09-14 | 2024-06-05 | Novocure GmbH | Temperature independent method and system for applying ttfields |
| WO2023116670A1 (zh) * | 2021-12-22 | 2023-06-29 | 江苏海莱新创医疗科技有限公司 | 肿瘤电场治疗系统及其交流电信号施加方法 |
| US12502548B2 (en) | 2021-12-29 | 2025-12-23 | Novocure Gmbh | Reducing electrosensation whilst treating a subject using alternating electric fields by using larger cathodes and smaller anodes |
| JP2024545019A (ja) | 2021-12-30 | 2024-12-05 | ノボキュア ゲーエムベーハー | 腫瘍治療フィールド(ttfield)を使用した治療のためのパラメータ値の選択 |
| CN114534091B (zh) * | 2022-02-17 | 2022-09-09 | 湖南安泰康成生物科技有限公司 | 利用电场抑制肿瘤增殖的设备及其控制装置 |
| CN119013076A (zh) | 2022-03-30 | 2024-11-22 | 诺沃库勒有限责任公司 | 通过将换能器阵列配对在一起来使用交流电场治疗受试者的同时减少电敏 |
| CA3255022A1 (en) | 2022-03-30 | 2023-10-05 | Novocure Gmbh | USE OF INTERLACED COOLING PERIODS TO INCREASE THE MAXIMUM INTENSITY OF TUMOR TREATMENT FIELDS |
| JP2025533794A (ja) * | 2022-09-30 | 2025-10-09 | ノボキュア ゲーエムベーハー | Tt場用途システム用のシングルワイヤ温度測定ソリューション、ならびにその製造方法および使用方法 |
| WO2024090939A1 (ko) * | 2022-10-25 | 2024-05-02 | 주식회사 필드큐어 | 전기장 전달 시스템 및 방법 |
| CN115980490B (zh) * | 2022-12-30 | 2024-04-19 | 江苏海莱新创医疗科技有限公司 | 电极片的质量检测系统及方法、转接器、电场发生器 |
| CN115970166B (zh) * | 2022-12-30 | 2024-03-19 | 江苏海莱新创医疗科技有限公司 | 肿瘤电场治疗系统、肿瘤治疗设备及电极片温度检测方法 |
| CN115845260B (zh) * | 2022-12-30 | 2024-07-05 | 江苏海莱新创医疗科技有限公司 | 肿瘤电场治疗系统及其电极片、温度检测方法 |
| US12268863B2 (en) | 2023-02-06 | 2025-04-08 | Novocure Gmbh | Shiftable transducer array with anisotropic material layer |
| KR20240129583A (ko) | 2023-02-20 | 2024-08-27 | 주식회사 필드큐어 | 대상체에 전기장을 전달하는 임베디드 전극 |
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| TW202528013A (zh) | 2023-09-29 | 2025-07-16 | 瑞士商諾沃庫勒有限責任公司 | 使用振幅和頻率的交錯變化來改善交變電場治療期間的電感覺 |
| CN120501498B (zh) * | 2025-07-22 | 2025-09-16 | 苏州元科医疗器械有限公司 | 对消化道进行电场治疗的装置及电极阵列膜 |
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| US11109773B2 (en) | 2016-12-13 | 2021-09-07 | Novocure Gmbh | Treating patients with TTFields with the electrode positions optimized using deformable templates |
| WO2018134733A1 (en) | 2017-01-19 | 2018-07-26 | Moshe Giladi | System for viewing cell cultures under a microscope whilst applying ttfields |
| CN106823145A (zh) * | 2017-03-24 | 2017-06-13 | 长沙普特斯科技有限公司 | 一种采用调幅电场治疗肿瘤的装置 |
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| US10953209B2 (en) | 2018-03-28 | 2021-03-23 | Board Of Regents Of The University Of Texas System | Treating tumors using TTFields combined with a PARP inhibitor |
| US11298422B2 (en) | 2018-04-09 | 2022-04-12 | Novocure Gmbh | Treating tumors with TTFields and an aurora kinase inhibitor |
| PL3775956T3 (pl) | 2018-04-10 | 2022-10-10 | Novocure Gmbh | Szacunki przewodności ac o niskiej częstotliwości (< 1 mhz) pozyskane z dwóch obrazów mri o różnych czasach repetycji |
| CN116603165A (zh) | 2018-07-03 | 2023-08-18 | 斯坦福大学托管董事会 | 使用交变电场提高细胞膜通透性 |
| US11179322B2 (en) | 2018-07-10 | 2021-11-23 | Novocure Gmbh | Methods and compositions for treating tumors with TTFields and sorafenib |
| CA3103070C (en) | 2018-07-10 | 2024-01-09 | Novocure Gmbh | Inhibiting viral infection using alternating electric fields |
| MX2020013431A (es) | 2018-07-18 | 2021-05-27 | Novocure Gmbh | Uso de densidad de perdida de potencia y mediciones relacionadas para cuantificar la dosis de campos de tratamiento de tumores (ttfield). |
| KR20250069692A (ko) | 2018-08-23 | 2025-05-19 | 카스텐 하게만 | 뇌-혈액 장벽 투과성을 향상시키기 위한 교번 전기장의 이용 |
| US11160977B2 (en) | 2018-09-04 | 2021-11-02 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the infratentorial brain |
| CN112770806B (zh) | 2018-09-07 | 2025-12-05 | 诺沃库勒有限责任公司 | 使用交变电场治疗自身免疫性疾病以减少t细胞的增殖 |
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| CN113164525B (zh) | 2018-10-23 | 2025-03-14 | 利兰·斯坦福青年大学托管委员会 | 在基于干细胞的疗法中使用交变电场预防和治疗畸胎瘤形成 |
| US11369790B2 (en) | 2018-10-25 | 2022-06-28 | Novocure Gmbh | Delivering alternating electric fields (e.g., TTFields) to a subject's spinal anatomy |
| US20200146586A1 (en) | 2018-11-14 | 2020-05-14 | Novocure Gmbh | Creating Accurate Computational Head Models of Patients Using Datasets Combining MRI and CT Images |
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| KR102747887B1 (ko) | 2018-11-19 | 2024-12-27 | 노보큐어 게엠베하 | 선택적으로 주소 지정 가능한 하위 요소를 하지는 종양 치료장 제공을 위한 어레이 |
| SG11202101810SA (en) | 2018-11-29 | 2021-03-30 | Novocure Gmbh | Enhanced-flexibility transducer arrays for delivering ttfields (tumor treating fields) |
| CN113330485B (zh) | 2019-01-08 | 2025-09-26 | 诺沃库勒有限责任公司 | 评估将图像分割成不同类型组织的质量,用于使用肿瘤治疗场(TTField)来计划治疗 |
| KR20210130765A (ko) | 2019-02-22 | 2021-11-01 | 노보큐어 게엠베하 | Xelox, folfox 또는 이들의 각 구성 요소와 ttfield를 조합한 위암 치료 |
| US11554262B2 (en) | 2019-02-26 | 2023-01-17 | Novocure Gmbh | Determining a frequency for TTFields treatment based on an electrical characteristic of targeted cancer cells |
| EP3954314B1 (en) | 2019-02-27 | 2025-01-08 | Novocure GmbH | Delivering tumor treating fields (ttfields) using implantable transducer arrays |
| EP3988099B1 (en) | 2019-03-29 | 2023-06-07 | Novocure GmbH | Methods for restoring sensitivity to ttfields in ttfields-resistant cancer cells with ptger3 inhibitors |
| EP3924039B1 (en) | 2019-04-17 | 2023-11-22 | Novocure GmbH | Uploading data from an isolated system without compromising isolation |
| CN114364432B (zh) | 2019-07-31 | 2025-10-31 | 诺沃库勒有限责任公司 | 经由埋入颅骨植入物中的电极施加肿瘤治疗场(TTField) |
| US12343336B2 (en) | 2019-08-05 | 2025-07-01 | Novocure Gmbh | Increasing cancer cells' sensitivity to tumor treating fields (TTFields) by inhibiting IL11 activity |
| US11890467B2 (en) | 2019-08-30 | 2024-02-06 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the neck |
| EP4028052A1 (en) | 2019-09-10 | 2022-07-20 | Novocure GmbH | A method of reducing viability of cancer cells by applying alternating electric fields and administering checkpoint inhibitors to the cancer cells |
-
2020
- 2020-12-21 DK DK22177344.3T patent/DK4074367T3/da active
- 2020-12-21 WO PCT/IB2020/062309 patent/WO2021137094A1/en not_active Ceased
- 2020-12-21 AU AU2020416669A patent/AU2020416669A1/en active Pending
- 2020-12-21 ES ES22177344T patent/ES2950234T3/es active Active
- 2020-12-21 HU HUE22177344A patent/HUE061733T2/hu unknown
- 2020-12-21 EP EP20829225.0A patent/EP4054701A1/en active Pending
- 2020-12-21 PL PL22177344.3T patent/PL4074367T3/pl unknown
- 2020-12-21 US US17/129,088 patent/US11878163B2/en active Active
- 2020-12-21 CN CN202080091024.6A patent/CN114901344B/zh active Active
- 2020-12-21 EP EP23161354.8A patent/EP4212203A1/en active Pending
- 2020-12-21 JP JP2022540519A patent/JP2023508585A/ja active Pending
- 2020-12-21 CN CN202512046031.1A patent/CN121695416A/zh active Pending
- 2020-12-21 BR BR112022012409A patent/BR112022012409A2/pt unknown
- 2020-12-21 KR KR1020227026417A patent/KR20220123079A/ko active Pending
- 2020-12-21 MX MX2022006136A patent/MX2022006136A/es unknown
- 2020-12-21 EP EP22177344.3A patent/EP4074367B1/en active Active
- 2020-12-21 IL IL294386A patent/IL294386B2/en unknown
- 2020-12-21 CA CA3163316A patent/CA3163316A1/en active Pending
- 2020-12-21 FI FIEP22177344.3T patent/FI4074367T3/fi active
- 2020-12-25 TW TW109146226A patent/TWI888461B/zh active
- 2020-12-25 TW TW113131110A patent/TWI896294B/zh active
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2023
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2025
- 2025-07-29 JP JP2025126396A patent/JP2025161824A/ja active Pending
- 2025-09-09 US US19/323,314 patent/US20260007881A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HUE061733T2 (hu) | 2023-08-28 |
| US20210196348A1 (en) | 2021-07-01 |
| IL294386B2 (en) | 2026-01-01 |
| MX2022006136A (es) | 2022-06-17 |
| EP4212203A1 (en) | 2023-07-19 |
| NZ788868A (en) | 2024-07-05 |
| IL294386B1 (en) | 2025-09-01 |
| WO2021137094A1 (en) | 2021-07-08 |
| AU2020416669A1 (en) | 2022-06-16 |
| ES2950234T3 (es) | 2023-10-06 |
| IL294386A (en) | 2022-08-01 |
| BR112022012409A2 (pt) | 2022-08-30 |
| KR20220123079A (ko) | 2022-09-05 |
| US20260007881A1 (en) | 2026-01-08 |
| TWI888461B (zh) | 2025-07-01 |
| US20240139505A1 (en) | 2024-05-02 |
| CN114901344B (zh) | 2026-01-23 |
| CN121695416A (zh) | 2026-03-20 |
| CA3163316A1 (en) | 2021-07-08 |
| JP2025161824A (ja) | 2025-10-24 |
| EP4074367B1 (en) | 2023-04-19 |
| EP4054701A1 (en) | 2022-09-14 |
| CN114901344A (zh) | 2022-08-12 |
| TW202138023A (zh) | 2021-10-16 |
| JP2023508585A (ja) | 2023-03-02 |
| US11878163B2 (en) | 2024-01-23 |
| TW202446439A (zh) | 2024-12-01 |
| US12434053B2 (en) | 2025-10-07 |
| TWI896294B (zh) | 2025-09-01 |
| PL4074367T3 (pl) | 2023-07-31 |
| EP4074367A1 (en) | 2022-10-19 |
| FI4074367T3 (fi) | 2023-06-21 |
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