DE69616541T2 - System zum erfühlen von unter-der-haut temperaturen in körpergewebe während ablation - Google Patents

System zum erfühlen von unter-der-haut temperaturen in körpergewebe während ablation

Info

Publication number
DE69616541T2
DE69616541T2 DE69616541T DE69616541T DE69616541T2 DE 69616541 T2 DE69616541 T2 DE 69616541T2 DE 69616541 T DE69616541 T DE 69616541T DE 69616541 T DE69616541 T DE 69616541T DE 69616541 T2 DE69616541 T2 DE 69616541T2
Authority
DE
Germany
Prior art keywords
tissue
electrode
systems
body tissue
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69616541T
Other languages
English (en)
Other versions
DE69616541D1 (de
Inventor
Dorin Panescu
K Swanson
D Fleischman
M Bourne
G Whayne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Ltd Barbados
Original Assignee
Boston Scientific Ltd Barbados
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/432,091 external-priority patent/US5688267A/en
Priority claimed from US08/432,325 external-priority patent/US5800432A/en
Application filed by Boston Scientific Ltd Barbados filed Critical Boston Scientific Ltd Barbados
Publication of DE69616541D1 publication Critical patent/DE69616541D1/de
Application granted granted Critical
Publication of DE69616541T2 publication Critical patent/DE69616541T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/06—Electrodes for high-frequency therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A61N1/403—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206—Generators therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00084—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00238—Type of minimally invasive operation
    • A61B2017/00243—Type of minimally invasive operation cardiac
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
    • A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
    • A61B2018/00023—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids closed, i.e. without wound contact by the fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
    • A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
    • A61B2018/00029—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids open
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00059—Material properties
    • A61B2018/00071—Electrical conductivity
    • A61B2018/00083—Electrical conductivity low, i.e. electrically insulating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00059—Material properties
    • A61B2018/00089—Thermal conductivity
    • A61B2018/00095—Thermal conductivity high, i.e. heat conducting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/0069—Sensing and controlling the application of energy using fuzzy logic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00696—Controlled or regulated parameters
    • A61B2018/00761—Duration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00791—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00791—Temperature
    • A61B2018/00815—Temperature measured by a thermistor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00886—Duration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206—Generators therefor
    • A61B2018/1246—Generators therefor characterised by the output polarity
    • A61B2018/126—Generators therefor characterised by the output polarity bipolar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1405—Electrodes having a specific shape
    • A61B2018/1425—Needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1405—Electrodes having a specific shape
    • A61B2018/1435—Spiral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • A61B2018/1861—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves with an instrument inserted into a body lumen or cavity, e.g. a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/50—Temperature

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Cardiology (AREA)
  • Plasma & Fusion (AREA)
  • Otolaryngology (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgical Instruments (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Treatment Of Fiber Materials (AREA)
DE69616541T 1995-05-01 1996-04-30 System zum erfühlen von unter-der-haut temperaturen in körpergewebe während ablation Expired - Fee Related DE69616541T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US43200195A 1995-05-01 1995-05-01
US43232195A 1995-05-01 1995-05-01
US43190795A 1995-05-01 1995-05-01
US43185795A 1995-05-01 1995-05-01
US08/432,091 US5688267A (en) 1995-05-01 1995-05-01 Systems and methods for sensing multiple temperature conditions during tissue ablation
US08/432,325 US5800432A (en) 1995-05-01 1995-05-01 Systems and methods for actively cooling ablation electrodes using diodes
PCT/US1996/006017 WO1996036860A2 (en) 1995-05-01 1996-04-30 Systems and methods for sensing sub-surface temperatures in body tissue during ablation with actively cooled electrodes

Publications (2)

Publication Number Publication Date
DE69616541D1 DE69616541D1 (de) 2001-12-06
DE69616541T2 true DE69616541T2 (de) 2002-07-18

Family

ID=27559983

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69616541T Expired - Fee Related DE69616541T2 (de) 1995-05-01 1996-04-30 System zum erfühlen von unter-der-haut temperaturen in körpergewebe während ablation

Country Status (7)

Country Link
EP (1) EP0823842B1 (de)
JP (1) JP3835703B2 (de)
AT (1) ATE207726T1 (de)
CA (1) CA2217024A1 (de)
DE (1) DE69616541T2 (de)
ES (1) ES2164886T3 (de)
WO (1) WO1996036860A2 (de)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10306013A1 (de) * 2003-01-17 2004-07-29 Disetronic Licensing Ag Temperatursensible Kanüle
DE10342709A1 (de) * 2003-09-11 2005-04-21 Biotronik Gmbh & Co Kg Katheter
US7513891B2 (en) 2003-01-17 2009-04-07 Disetronic Licensing Ag Temperature-sensitive cannula

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US5431168A (en) * 1993-08-23 1995-07-11 Cordis-Webster, Inc. Steerable open-lumen catheter
US6056747A (en) * 1997-08-04 2000-05-02 Gynecare, Inc. Apparatus and method for treatment of body tissues
FR2768539B1 (fr) * 1997-09-17 1999-10-22 Adrtp Systemes de mesure du comportement thermique d'un nouveau-ne dans un incubateur
US7006866B1 (en) 1997-11-07 2006-02-28 Siemens Aktiengesellschaft Arrangement for predicting an abnormality of a system and for carrying out an action which counteracts the abnormality
US6358245B1 (en) 1998-02-19 2002-03-19 Curon Medical, Inc. Graphical user interface for association with an electrode structure deployed in contact with a tissue region
US8906010B2 (en) 1998-02-19 2014-12-09 Mederi Therapeutics, Inc. Graphical user interface for association with an electrode structure deployed in contact with a tissue region
US6273886B1 (en) * 1998-02-19 2001-08-14 Curon Medical, Inc. Integrated tissue heating and cooling apparatus
AUPR090300A0 (en) 2000-10-20 2000-11-16 AMC Technologies Pty Limited An electrical lead
AUPS226502A0 (en) 2002-05-13 2002-06-13 Advanced Metal Coatings Pty Limited A multi-electrode lead
AUPS226402A0 (en) 2002-05-13 2002-06-13 Advanced Metal Coatings Pty Limited An ablation catheter
AU2002952318A0 (en) 2002-10-29 2002-11-14 Advanced Metal Coatings Pty Limited Production of lesions in a body
NL1024658C2 (nl) * 2003-10-29 2005-05-02 Univ Medisch Centrum Utrecht Katheter en werkwijze, in het bijzonder voor ablatie en dergelijke techniek.
CA2545419A1 (en) 2003-11-25 2005-06-09 Cathrx Ltd A modular catheter
CA2553793A1 (en) 2004-01-26 2005-08-04 Cathrx Ltd A catheter assembly with an adjustable loop
EP1761187B1 (de) * 2004-05-17 2011-11-30 C.R. Bard, Inc. Irrigierter katheter
EP2198912A1 (de) 2004-08-05 2010-06-23 Cathrx Ltd Steuerbarer Katheter
EP1778339B1 (de) 2004-08-05 2014-08-13 Cathrx Ltd Verfahren zur herstellung einer elektrischen leitung
US20060089637A1 (en) 2004-10-14 2006-04-27 Werneth Randell L Ablation catheter
US7429261B2 (en) 2004-11-24 2008-09-30 Ablation Frontiers, Inc. Atrial ablation catheter and method of use
US7468062B2 (en) 2004-11-24 2008-12-23 Ablation Frontiers, Inc. Atrial ablation catheter adapted for treatment of septal wall arrhythmogenic foci and method of use
US8128621B2 (en) 2005-05-16 2012-03-06 St. Jude Medical, Atrial Fibrillation Division, Inc. Irrigated ablation electrode assembly and method for control of temperature
US20080091193A1 (en) 2005-05-16 2008-04-17 James Kauphusman Irrigated ablation catheter having magnetic tip for magnetic field control and guidance
US7857810B2 (en) * 2006-05-16 2010-12-28 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation electrode assembly and methods for improved control of temperature and minimization of coagulation and tissue damage
EP1895927A4 (de) 2005-06-20 2011-03-09 Medtronic Ablation Frontiers Ablationskatheter
WO2007008954A2 (en) 2005-07-11 2007-01-18 Ablation Frontiers Low power tissue ablation system
KR100807984B1 (ko) * 2006-05-11 2008-02-27 국립암센터 고온 종양치료기
US8641704B2 (en) 2007-05-11 2014-02-04 Medtronic Ablation Frontiers Llc Ablation therapy system and method for treating continuous atrial fibrillation
WO2009048943A1 (en) 2007-10-09 2009-04-16 Boston Scientific Scimed, Inc. Cooled ablation catheter devices and methods of use
WO2009048824A1 (en) * 2007-10-09 2009-04-16 Boston Scientific Scimed, Inc. Electrophysiology electrodes and apparatus including the same
US8052684B2 (en) 2007-11-30 2011-11-08 St. Jude Medical, Atrial Fibrillation Division, Inc. Irrigated ablation catheter having parallel external flow and proximally tapered electrode
JP5169551B2 (ja) * 2008-07-07 2013-03-27 日本ゼオン株式会社 電極カテーテル
US8882761B2 (en) * 2008-07-15 2014-11-11 Catheffects, Inc. Catheter and method for improved ablation
JP2010032324A (ja) * 2008-07-28 2010-02-12 Omron Healthcare Co Ltd 電子体温計
US9474565B2 (en) 2009-09-22 2016-10-25 Mederi Therapeutics, Inc. Systems and methods for treating tissue with radiofrequency energy
EP2480152B1 (de) 2009-09-22 2018-08-29 Mederi Therapeutics Inc. System zur steuerung der verwendung und des betriebs einer familie an verschiedenen behandlungsvorrichtungen
US9750563B2 (en) 2009-09-22 2017-09-05 Mederi Therapeutics, Inc. Systems and methods for treating tissue with radiofrequency energy
US10386990B2 (en) 2009-09-22 2019-08-20 Mederi Rf, Llc Systems and methods for treating tissue with radiofrequency energy
US9775664B2 (en) 2009-09-22 2017-10-03 Mederi Therapeutics, Inc. Systems and methods for treating tissue with radiofrequency energy
US10201385B2 (en) * 2011-09-01 2019-02-12 Biosense Webster (Israel) Ltd. Catheter adapted for direct tissue contact
US8900228B2 (en) * 2011-09-01 2014-12-02 Biosense Webster (Israel) Ltd. Catheter adapted for direct tissue contact and pressure sensing
US8961550B2 (en) 2012-04-17 2015-02-24 Indian Wells Medical, Inc. Steerable endoluminal punch
US9144460B2 (en) * 2012-12-31 2015-09-29 Biosense Webster (Israel) Ltd. Catheter with direct cooling on nonablating element
JP5969635B2 (ja) * 2015-01-15 2016-08-17 日本ライフライン株式会社 カテーテル
US10213253B2 (en) * 2015-12-24 2019-02-26 Biosense Webster (Israel) Ltd. Estimating a temperature during ablation
US11284939B2 (en) * 2017-07-06 2022-03-29 Biosense Webster (Israel) Ltd. Irrigated catheter with improved ablation tip electrode fluid distribution
WO2019060833A1 (en) 2017-09-25 2019-03-28 Sirona Medical Technologies, Inc. CATHETER AND METHOD FOR ENHANCED IRRIGATION
JP6950947B2 (ja) * 2017-11-10 2021-10-13 国立研究開発法人産業技術総合研究所 冷却機能を備えた医療用高周波デバイス
JP6871194B2 (ja) * 2018-03-27 2021-05-12 日本ライフライン株式会社 アブレーションデバイス
US11779391B2 (en) * 2019-02-28 2023-10-10 Biosense Webster (Israel) Ltd. Forming a lesion based on pre-determined amount of abaltive energy vs lesion size curve

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JPH01139081A (ja) * 1987-11-27 1989-05-31 Olympus Optical Co Ltd レーザ光照射装置
MX9300607A (es) * 1992-02-06 1993-10-01 American Med Syst Aparato y metodo para tratamiento intersticial.
WO1994010922A1 (en) * 1992-11-13 1994-05-26 Ep Technologies, Inc. Cardial ablation systems using temperature monitoring
US5348554A (en) * 1992-12-01 1994-09-20 Cardiac Pathways Corporation Catheter for RF ablation with cooled electrode

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10306013A1 (de) * 2003-01-17 2004-07-29 Disetronic Licensing Ag Temperatursensible Kanüle
US7513891B2 (en) 2003-01-17 2009-04-07 Disetronic Licensing Ag Temperature-sensitive cannula
DE10342709A1 (de) * 2003-09-11 2005-04-21 Biotronik Gmbh & Co Kg Katheter
US7507237B2 (en) 2003-09-11 2009-03-24 Biotronik Gmbh & Co. Kg Catheter

Also Published As

Publication number Publication date
JPH11506947A (ja) 1999-06-22
CA2217024A1 (en) 1996-11-21
EP0823842B1 (de) 2001-10-31
WO1996036860A2 (en) 1996-11-21
WO1996036860A3 (en) 1997-01-16
JP3835703B2 (ja) 2006-10-18
ES2164886T3 (es) 2002-03-01
EP0823842A2 (de) 1998-02-18
ATE207726T1 (de) 2001-11-15
EP0823842A4 (de) 1999-02-24
DE69616541D1 (de) 2001-12-06

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