PL4074367T3 - Szyki do dostarczania zmiennych pól elektrycznych do leczenia nowotworów (ttfields) z indywidualnie dostępnymi elementami elektrody i czujnikami temperatury - Google Patents
Szyki do dostarczania zmiennych pól elektrycznych do leczenia nowotworów (ttfields) z indywidualnie dostępnymi elementami elektrody i czujnikami temperaturyInfo
- Publication number
- PL4074367T3 PL4074367T3 PL22177344.3T PL22177344T PL4074367T3 PL 4074367 T3 PL4074367 T3 PL 4074367T3 PL 22177344 T PL22177344 T PL 22177344T PL 4074367 T3 PL4074367 T3 PL 4074367T3
- Authority
- PL
- Poland
- Prior art keywords
- ttfields
- arrays
- temperature sensors
- electrode elements
- individually accessible
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 238000003491 array Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36002—Cancer treatment, e.g. tumour
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
- A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
- A61N1/36031—Control systems using physiological parameters for adjustment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
- A61N1/403—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00059—Material properties
- A61B2018/00071—Electrical conductivity
- A61B2018/00077—Electrical conductivity high, i.e. electrically conducting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/0016—Energy applicators arranged in a two- or three dimensional array
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00172—Connectors and adapters therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00666—Sensing and controlling the application of energy using a threshold value
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00791—Temperature
- A61B2018/00815—Temperature measured by a thermistor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/0091—Handpieces of the surgical instrument or device
- A61B2018/00916—Handpieces of the surgical instrument or device with means for switching or controlling the main function of the instrument or device
- A61B2018/00922—Handpieces of the surgical instrument or device with means for switching or controlling the main function of the instrument or device by switching or controlling the treatment energy directly within the hand-piece
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
- A61N1/0492—Patch electrodes
- A61N1/0496—Patch electrodes characterised by using specific chemical compositions, e.g. hydrogel compositions, adhesives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Radiology & Medical Imaging (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Physiology (AREA)
- Surgery (AREA)
- Physics & Mathematics (AREA)
- Plasma & Fusion (AREA)
- Otolaryngology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962955664P | 2019-12-31 | 2019-12-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL4074367T3 true PL4074367T3 (pl) | 2023-07-31 |
Family
ID=74004134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL22177344.3T PL4074367T3 (pl) | 2019-12-31 | 2020-12-21 | Szyki do dostarczania zmiennych pól elektrycznych do leczenia nowotworów (ttfields) z indywidualnie dostępnymi elementami elektrody i czujnikami temperatury |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11878163B2 (pl) |
| EP (3) | EP4054701A1 (pl) |
| JP (2) | JP2023508585A (pl) |
| KR (1) | KR20220123079A (pl) |
| CN (1) | CN114901344A (pl) |
| AU (1) | AU2020416669A1 (pl) |
| BR (1) | BR112022012409A2 (pl) |
| CA (1) | CA3163316A1 (pl) |
| DK (1) | DK4074367T3 (pl) |
| ES (1) | ES2950234T3 (pl) |
| FI (1) | FI4074367T3 (pl) |
| HU (1) | HUE061733T2 (pl) |
| IL (1) | IL294386B1 (pl) |
| MX (1) | MX2022006136A (pl) |
| PL (1) | PL4074367T3 (pl) |
| TW (2) | TWI888461B (pl) |
| WO (1) | WO2021137094A1 (pl) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017289870B2 (en) | 2016-06-30 | 2021-12-23 | Novocure Gmbh | Arrays for longitudinal delivery of TTFields to a body |
| US11986647B2 (en) | 2018-09-07 | 2024-05-21 | Novocure Gmbh | Treating autoinflammatory and mitochondrial diseases using an alternating electric field |
| EP3878505B1 (en) | 2018-10-15 | 2023-05-24 | Novocure GmbH | Generating tumor treating fields (ttfields) with high uniformity throughout the brain |
| JP7148722B2 (ja) | 2018-10-25 | 2022-10-05 | ゼーヴ・ボンゾン | 被験者の脊椎構造体に対する交番電界(例えばTTField)の送達 |
| CN118079235A (zh) | 2018-11-29 | 2024-05-28 | 诺沃库勒有限责任公司 | 用于递送TTField(肿瘤治疗场)的增强灵活性换能器阵列 |
| US11276171B2 (en) | 2019-01-08 | 2022-03-15 | Novocure Gmbh | Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (TTFields) |
| CN113966243A (zh) | 2019-04-17 | 2022-01-21 | 诺沃库勒有限责任公司 | 在不损害隔离的情况下从隔离的系统上传数据 |
| WO2022064339A1 (en) | 2020-09-25 | 2022-03-31 | Novocure Gmbh | Varying the metallization area on individual electrode elements in a tumor treating fields (ttfields) system to maximize current without overheating |
| US11759628B2 (en) * | 2020-12-09 | 2023-09-19 | Lifebridge Innovations, Pbc | Insulated electrode for delivering tumor treating electromagnetic fields |
| CN117083103A (zh) | 2021-02-17 | 2023-11-17 | 诺沃库勒有限责任公司 | 具有具备单独可调整的有源面积的电极元件集合的用于输送肿瘤治疗场(TTFields)的阵列 |
| EP4304704A1 (en) | 2021-03-12 | 2024-01-17 | Novocure GmbH | Methods of treating disease by skewing macrophage phenotype with alternating electric fields |
| EP4284489B1 (en) | 2021-03-31 | 2025-07-16 | Novocure Gmbh | Impedance tomography using electrodes of a tumor treating fields (ttfields) system |
| MX2023014225A (es) * | 2021-06-30 | 2024-01-24 | Novocure Gmbh | Uso de condensadores para regular la corriente en matrices de transductores para aplicar campos de tratamiento de tumores (ttfields). |
| EP4376939A1 (en) * | 2021-09-14 | 2024-06-05 | Novocure GmbH | Temperature independent method and system for applying ttfields |
| US20250177764A1 (en) * | 2021-12-22 | 2025-06-05 | Jiangsu Healthy Life Innovation Medical Technology Co., Ltd | Tumor treating field system and method for applying alternating current signals thereof |
| US12377280B2 (en) | 2021-12-30 | 2025-08-05 | Novocure Gmbh | Selecting values of parameters for treatment using tumor treating fields (TTFields) |
| CN114534091B (zh) * | 2022-02-17 | 2022-09-09 | 湖南安泰康成生物科技有限公司 | 利用电场抑制肿瘤增殖的设备及其控制装置 |
| IL314392A (en) | 2022-03-30 | 2024-09-01 | Novocure Gmbh | Reducing electrosensation whilst treating a subject using alternating electric fields by pairing transducer arrays together |
| JP2025511071A (ja) | 2022-03-30 | 2025-04-15 | ノボキュア ゲーエムベーハー | インターリーブ冷却期間による腫瘍治療場のピーク強度強化 |
| CN119968220A (zh) * | 2022-09-30 | 2025-05-09 | 诺沃库勒有限责任公司 | 用于TTField施加系统的单导线温度测量解决方案及其生产和使用方法 |
| WO2024090939A1 (ko) * | 2022-10-25 | 2024-05-02 | 주식회사 필드큐어 | 전기장 전달 시스템 및 방법 |
| CN115845260B (zh) * | 2022-12-30 | 2024-07-05 | 江苏海莱新创医疗科技有限公司 | 肿瘤电场治疗系统及其电极片、温度检测方法 |
| CN115980490B (zh) * | 2022-12-30 | 2024-04-19 | 江苏海莱新创医疗科技有限公司 | 电极片的质量检测系统及方法、转接器、电场发生器 |
| CN117839070B (zh) * | 2022-12-30 | 2025-08-19 | 江苏海莱新创医疗科技有限公司 | 肿瘤电场治疗系统、肿瘤治疗设备及电极片温度检测方法 |
| US12268863B2 (en) | 2023-02-06 | 2025-04-08 | Novocure Gmbh | Shiftable transducer array with anisotropic material layer |
| KR20240129583A (ko) | 2023-02-20 | 2024-08-27 | 주식회사 필드큐어 | 대상체에 전기장을 전달하는 임베디드 전극 |
| US20250073462A1 (en) * | 2023-08-30 | 2025-03-06 | Mayo Foundation For Medical Education And Research | Implantable medical systems for cancer treatment with activation energy based therapy modulation |
| CN120501498B (zh) * | 2025-07-22 | 2025-09-16 | 苏州元科医疗器械有限公司 | 对消化道进行电场治疗的装置及电极阵列膜 |
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| US10953209B2 (en) | 2018-03-28 | 2021-03-23 | Board Of Regents Of The University Of Texas System | Treating tumors using TTFields combined with a PARP inhibitor |
| EP3773726B1 (en) | 2018-04-09 | 2024-06-05 | Novocure GmbH | Treating tumors with ttfields and an aurora kinase inhibitor |
| KR102687814B1 (ko) | 2018-04-10 | 2024-07-24 | 지브 봄존 | 서로 다른 반복 시간을 가지는 두 개의 MRI 이미지들로부터 얻어진 1MHz 미만 저주파 교류 전도도 추산치 |
| DK3838333T3 (da) | 2018-07-03 | 2023-03-27 | Univ Leland Stanford Junior | Anvendelse af elektriske vekselfelter til forøgelse af cellmembranpermeabilitet |
| EP3820562A1 (en) | 2018-07-10 | 2021-05-19 | Novocure GmbH | Inhibiting viral infection using alternating electric fields |
| US11179322B2 (en) | 2018-07-10 | 2021-11-23 | Novocure Gmbh | Methods and compositions for treating tumors with TTFields and sorafenib |
| MX2020013431A (es) | 2018-07-18 | 2021-05-27 | Novocure Gmbh | Uso de densidad de perdida de potencia y mediciones relacionadas para cuantificar la dosis de campos de tratamiento de tumores (ttfield). |
| CN112618956B (zh) | 2018-08-23 | 2025-06-27 | 诺沃库勒有限责任公司 | 使用交变电场来提高血脑屏障的通透性 |
| US11160977B2 (en) | 2018-09-04 | 2021-11-02 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the infratentorial brain |
| CN112770806B (zh) | 2018-09-07 | 2025-12-05 | 诺沃库勒有限责任公司 | 使用交变电场治疗自身免疫性疾病以减少t细胞的增殖 |
| US20200108031A1 (en) | 2018-10-05 | 2020-04-09 | Novocure Gmbh | Treating Tumors Using TTFields Combined with ABT-751 |
| EP3878505B1 (en) | 2018-10-15 | 2023-05-24 | Novocure GmbH | Generating tumor treating fields (ttfields) with high uniformity throughout the brain |
| JP7282411B2 (ja) | 2018-10-23 | 2023-05-29 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 交流電場を使用する、幹細胞に基づく療法におけるテラトーマ形成の予防及び処置 |
| JP7148722B2 (ja) | 2018-10-25 | 2022-10-05 | ゼーヴ・ボンゾン | 被験者の脊椎構造体に対する交番電界(例えばTTField)の送達 |
| US20200146586A1 (en) | 2018-11-14 | 2020-05-14 | Novocure Gmbh | Creating Accurate Computational Head Models of Patients Using Datasets Combining MRI and CT Images |
| CN109529192A (zh) * | 2018-11-15 | 2019-03-29 | 郭良 | 一种通过施加交流电场激活erk活性的设备和方法 |
| US11040195B2 (en) * | 2018-11-16 | 2021-06-22 | Pacesetter, Inc. | Systems and methods for reducing RF heating in implantable leads |
| EP4019080B1 (en) | 2018-11-19 | 2025-06-25 | Novocure GmbH | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
| CN118079235A (zh) | 2018-11-29 | 2024-05-28 | 诺沃库勒有限责任公司 | 用于递送TTField(肿瘤治疗场)的增强灵活性换能器阵列 |
| US11276171B2 (en) | 2019-01-08 | 2022-03-15 | Novocure Gmbh | Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (TTFields) |
| EP3911299A1 (en) | 2019-02-22 | 2021-11-24 | Novocure GmbH | Treating gastric cancer using ttfields combined with xelox or folfox |
| EP3974022B1 (en) | 2019-02-26 | 2024-04-17 | Novocure GmbH | Determining a frequency for ttfields treatment based on a physical parameter of targeted cancer cells |
| PL3917423T3 (pl) | 2019-02-27 | 2025-03-31 | Novocure Gmbh | Dostarczanie pól leczących guzy (pól elektrycznych do leczenia nowotworów ttfields) za pomocą wszczepialnych szyków przetworników |
| US11911610B2 (en) | 2019-03-29 | 2024-02-27 | Novocure Gmbh | Methods for restoring sensitivity to TTFields in TTFields-resistant cancer cells with PTGER3 inhibitors |
| CN113966243A (zh) | 2019-04-17 | 2022-01-21 | 诺沃库勒有限责任公司 | 在不损害隔离的情况下从隔离的系统上传数据 |
| WO2021019403A1 (en) | 2019-07-31 | 2021-02-04 | Yoram Wasserman | Applying tumor treating fields (ttfields) via electrodes embedded into skull implants |
| US12343336B2 (en) | 2019-08-05 | 2025-07-01 | Novocure Gmbh | Increasing cancer cells' sensitivity to tumor treating fields (TTFields) by inhibiting IL11 activity |
| US11890467B2 (en) | 2019-08-30 | 2024-02-06 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the neck |
| CA3152250A1 (en) | 2019-09-10 | 2021-03-18 | Novocure Gmbh | A method of reducing viability of cancer cells by applying alternating electric fields and administering checkpoint inhibitors to the cancer cells |
-
2020
- 2020-12-21 PL PL22177344.3T patent/PL4074367T3/pl unknown
- 2020-12-21 CA CA3163316A patent/CA3163316A1/en active Pending
- 2020-12-21 DK DK22177344.3T patent/DK4074367T3/da active
- 2020-12-21 IL IL294386A patent/IL294386B1/en unknown
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- 2020-12-21 HU HUE22177344A patent/HUE061733T2/hu unknown
- 2020-12-21 KR KR1020227026417A patent/KR20220123079A/ko active Pending
- 2020-12-21 EP EP20829225.0A patent/EP4054701A1/en active Pending
- 2020-12-21 WO PCT/IB2020/062309 patent/WO2021137094A1/en not_active Ceased
- 2020-12-21 BR BR112022012409A patent/BR112022012409A2/pt unknown
- 2020-12-21 CN CN202080091024.6A patent/CN114901344A/zh active Pending
- 2020-12-21 FI FIEP22177344.3T patent/FI4074367T3/fi active
- 2020-12-21 JP JP2022540519A patent/JP2023508585A/ja active Pending
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- 2020-12-21 MX MX2022006136A patent/MX2022006136A/es unknown
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| TWI888461B (zh) | 2025-07-01 |
| US20210196348A1 (en) | 2021-07-01 |
| DK4074367T3 (da) | 2023-05-22 |
| NZ788868A (en) | 2024-07-05 |
| TWI896294B (zh) | 2025-09-01 |
| BR112022012409A2 (pt) | 2022-08-30 |
| US12434053B2 (en) | 2025-10-07 |
| EP4074367A1 (en) | 2022-10-19 |
| MX2022006136A (es) | 2022-06-17 |
| IL294386B1 (en) | 2025-09-01 |
| US11878163B2 (en) | 2024-01-23 |
| TW202138023A (zh) | 2021-10-16 |
| CN114901344A (zh) | 2022-08-12 |
| US20240139505A1 (en) | 2024-05-02 |
| EP4212203A1 (en) | 2023-07-19 |
| TW202446439A (zh) | 2024-12-01 |
| EP4074367B1 (en) | 2023-04-19 |
| AU2020416669A1 (en) | 2022-06-16 |
| EP4054701A1 (en) | 2022-09-14 |
| JP2025161824A (ja) | 2025-10-24 |
| ES2950234T3 (es) | 2023-10-06 |
| HUE061733T2 (hu) | 2023-08-28 |
| WO2021137094A1 (en) | 2021-07-08 |
| FI4074367T3 (fi) | 2023-06-21 |
| KR20220123079A (ko) | 2022-09-05 |
| JP2023508585A (ja) | 2023-03-02 |
| IL294386A (en) | 2022-08-01 |
| CA3163316A1 (en) | 2021-07-08 |
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