PL3746564T3 - Sposób amplifikacji kwasów nukleinowych - Google Patents

Sposób amplifikacji kwasów nukleinowych

Info

Publication number
PL3746564T3
PL3746564T3 PL19743724.7T PL19743724T PL3746564T3 PL 3746564 T3 PL3746564 T3 PL 3746564T3 PL 19743724 T PL19743724 T PL 19743724T PL 3746564 T3 PL3746564 T3 PL 3746564T3
Authority
PL
Poland
Prior art keywords
nucleic acid
acid amplification
amplification
nucleic
acid
Prior art date
Application number
PL19743724.7T
Other languages
English (en)
Inventor
Charles GAWAD
John Easton
Veronica GONZALEZ-PENA
Original Assignee
St. Jude Children's Research Hospital, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by St. Jude Children's Research Hospital, Inc. filed Critical St. Jude Children's Research Hospital, Inc.
Publication of PL3746564T3 publication Critical patent/PL3746564T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/186—Modifications characterised by incorporating a non-extendable or blocking moiety
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2531/00—Reactions of nucleic acids characterised by
    • C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
    • C12Q2531/119—Strand displacement amplification [SDA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/122—Massive parallel sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
PL19743724.7T 2018-01-29 2019-01-28 Sposób amplifikacji kwasów nukleinowych PL3746564T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862623471P 2018-01-29 2018-01-29
PCT/US2019/015452 WO2019148119A1 (en) 2018-01-29 2019-01-28 Method for nucleic acid amplification

Publications (1)

Publication Number Publication Date
PL3746564T3 true PL3746564T3 (pl) 2023-05-22

Family

ID=67396233

Family Applications (1)

Application Number Title Priority Date Filing Date
PL19743724.7T PL3746564T3 (pl) 2018-01-29 2019-01-28 Sposób amplifikacji kwasów nukleinowych

Country Status (14)

Country Link
US (3) US11905553B2 (pl)
EP (2) EP4183886B1 (pl)
JP (1) JP7457434B2 (pl)
KR (1) KR102653725B1 (pl)
CN (1) CN112041459A (pl)
AU (2) AU2019212953B2 (pl)
CA (1) CA3089756A1 (pl)
DK (2) DK4183886T3 (pl)
EA (1) EA202091673A1 (pl)
ES (1) ES2937927T3 (pl)
IL (2) IL276343B1 (pl)
PL (1) PL3746564T3 (pl)
SG (1) SG11202007225TA (pl)
WO (1) WO2019148119A1 (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA202091673A1 (ru) 2018-01-29 2021-02-03 Ст. Джуд Чилдрен'С Рисерч Хоспитал, Инк. Способ амплификации нуклеиновых кислот
CA3149201A1 (en) * 2019-07-31 2021-02-04 BioSkryb Genomics, Inc. Genetic mutational analysis
US11795450B2 (en) * 2019-09-06 2023-10-24 Microsoft Technology Licensing, Llc Array-based enzymatic oligonucleotide synthesis
CN112831543B (zh) * 2019-11-25 2023-08-29 中国科学院青岛生物能源与过程研究所 单细胞全基因组扩增试剂盒及其应用
AU2021219665A1 (en) * 2020-02-10 2022-09-01 BioSkryb Genomics, Inc. Phi29 mutants and use thereof
US20230129100A1 (en) * 2020-05-07 2023-04-27 BioSkryb Genomics, Inc. Detection of low abundance nucleic acids
US11702683B2 (en) 2020-05-28 2023-07-18 Microsoft Technology Licensing, Llc De novo polynucleotide synthesis with substrate-bound polymerase
GB202111194D0 (en) 2021-08-03 2021-09-15 Cergentis B V Method
WO2023107453A1 (en) * 2021-12-06 2023-06-15 Chan Zuckerberg Biohub, Inc. Method for combined genome methylation and variation analyses
WO2023215524A2 (en) * 2022-05-05 2023-11-09 BioSkryb Genomics, Inc. Primary template-directed amplification and methods thereof
WO2024049276A1 (ko) * 2022-09-01 2024-03-07 주식회사 키오믹스 다중 표적 dna의 선택적 증폭용 조성물 및 이를 이용한 증폭 방법
CN117343999B (zh) * 2023-12-05 2024-03-01 上海锐赛循益生物技术有限公司 基于左侧探针退火和右侧探针退火延伸的核酸扩增方法

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198543A (en) 1989-03-24 1993-03-30 Consejo Superior Investigaciones Cientificas PHI29 DNA polymerase
US5001050A (en) 1989-03-24 1991-03-19 Consejo Superior Investigaciones Cientificas PHφ29 DNA polymerase
ATE496288T1 (de) 1995-10-11 2011-02-15 Luminex Corp Gleichzeitige mehrfachanalyse klinischer proben
JP2001519538A (ja) 1997-10-10 2001-10-23 プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ 核酸アレイのレプリカ増幅
US6511803B1 (en) 1997-10-10 2003-01-28 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6485944B1 (en) 1997-10-10 2002-11-26 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
WO1999026067A1 (en) 1997-11-18 1999-05-27 Bio-Rad Laboratories, Inc. Multiplex flow immunoassays with magnetic particles as solid phase
US20020064837A1 (en) * 1998-05-08 2002-05-30 Thuan Quoc Trinh Method for synthesizing a nucleic acid molecule using a ribonuclease
US6565727B1 (en) 1999-01-25 2003-05-20 Nanolytics, Inc. Actuators for microfluidics without moving parts
US6294063B1 (en) 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
AU6779200A (en) 1999-08-17 2001-03-13 Luminex Corporation Encapsulation of fluorescent particles
US6649414B1 (en) 1999-08-17 2003-11-18 Luminex Corporation Microparticles with multiple fluorescent signals and methods of using same
JP3929775B2 (ja) * 1999-09-13 2007-06-13 ニューゲン テクノロジーズ， インコーポレイテッド ポリヌクレオチド配列の線形等温増幅のための方法および組成物
WO2002007503A1 (en) 2000-07-25 2002-01-31 The Regents Of The University Of California Electrowetting-driven micropumping
US6773566B2 (en) 2000-08-31 2004-08-10 Nanolytics, Inc. Electrostatic actuators for microfluidics and methods for using same
GB0102568D0 (en) * 2001-02-01 2001-03-21 Magnetic Biosolutions Sweden A Method
JP3967319B2 (ja) 2001-06-27 2007-08-29 エフ．ホフマン−ラ ロシュ アーゲー ポリヌクレオチド配列のインビトロ組換えのためのウォークスルー技術
US6977148B2 (en) 2001-10-15 2005-12-20 Qiagen Gmbh Multiple displacement amplification
EP1450956A2 (en) 2001-11-26 2004-09-01 Keck Graduate Institute Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like
AU2003298512A1 (en) * 2002-05-06 2004-05-04 Colorado State University Research Foundation Genotoxicity analysis
FR2841063B1 (fr) 2002-06-18 2004-09-17 Commissariat Energie Atomique Dispositif de deplacement de petits volumes de liquide le long d'un micro-catenaire par des forces electrostatiques
US6911132B2 (en) 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
US7547380B2 (en) 2003-01-13 2009-06-16 North Carolina State University Droplet transportation devices and methods having a fluid surface
JP4773360B2 (ja) 2003-11-17 2011-09-14 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 流体を操作するためのシステム
GB0400584D0 (en) 2004-01-12 2004-02-11 Solexa Ltd Nucleic acid chacterisation
KR20060127132A (ko) 2004-01-14 2006-12-11 루미넥스 코포레이션 동작범위 확장 방법 및 시스템
US20060141487A1 (en) 2004-01-26 2006-06-29 Applera Corporation Methods, compositions, and kits for amplifying and sequencing polynucleotides
FR2866493B1 (fr) 2004-02-16 2010-08-20 Commissariat Energie Atomique Dispositif de controle du deplacement d'une goutte entre deux ou plusieurs substrats solides
JP2007526772A (ja) 2004-02-27 2007-09-20 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ インサイチュー配列決定用ポロニー蛍光ビーズ
FR2872715B1 (fr) 2004-07-08 2006-11-17 Commissariat Energie Atomique Microreacteur goutte
FR2872809B1 (fr) 2004-07-09 2006-09-15 Commissariat Energie Atomique Methode d'adressage d'electrodes
WO2006073504A2 (en) 2004-08-04 2006-07-13 President And Fellows Of Harvard College Wobble sequencing
JP2006058031A (ja) 2004-08-17 2006-03-02 Hitachi High-Technologies Corp 化学分析装置
CN100541677C (zh) 2005-01-20 2009-09-16 卢米尼克斯股份有限公司 用于基于荧光应用的磁性微球
US7458661B2 (en) 2005-01-25 2008-12-02 The Regents Of The University Of California Method and apparatus for promoting the complete transfer of liquid drops from a nozzle
DK1859330T3 (da) 2005-01-28 2012-10-15 Univ Duke Apparater og fremgangsmåder til håndtering af små dråber på et trykt kredsløbskort
US9040237B2 (en) * 2005-03-04 2015-05-26 Intel Corporation Sensor arrays and nucleic acid sequencing applications
US20070023292A1 (en) 2005-07-26 2007-02-01 The Regents Of The University Of California Small object moving on printed circuit board
EP1929046B1 (en) 2005-09-07 2012-07-11 Nugen Technologies, Inc. Improved nucleic acid amplification procedure
CA2984777C (en) 2005-09-21 2018-04-03 Luminex Corporation Methods and systems for image data processing
CA2624634A1 (en) * 2005-10-03 2007-04-12 Applera Corporation Compositions, methods, and kits for amplifying nucleic acids
WO2007120208A2 (en) 2005-11-14 2007-10-25 President And Fellows Of Harvard College Nanogrid rolling circle dna sequencing
US20070207513A1 (en) 2006-03-03 2007-09-06 Luminex Corporation Methods, Products, and Kits for Identifying an Analyte in a Sample
CA2680061C (en) 2006-04-18 2015-10-13 Duke University Droplet-based biochemistry
US7901947B2 (en) 2006-04-18 2011-03-08 Advanced Liquid Logic, Inc. Droplet-based particle sorting
EP2040082A4 (en) 2006-07-10 2014-04-23 Hitachi High Tech Corp LIQUID TRANSFER DEVICE
WO2008055256A2 (en) 2006-11-02 2008-05-08 The Regents Of The University Of California Method and apparatus for real-time feedback control of electrical manipulation of droplets on chip
US20080242560A1 (en) * 2006-11-21 2008-10-02 Gunderson Kevin L Methods for generating amplified nucleic acid arrays
US7897737B2 (en) * 2006-12-05 2011-03-01 Lasergen, Inc. 3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing
US7893227B2 (en) * 2006-12-05 2011-02-22 Lasergen, Inc. 3′-OH unblocked nucleotides and nucleosides base modified with non-cleavable, terminating groups and methods for their use in DNA sequencing
AU2007333040B2 (en) 2006-12-13 2013-02-07 Luminex Corporation Systems and methods for multiplex analysis of PCR in real time
WO2008093098A2 (en) 2007-02-02 2008-08-07 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
US20080269068A1 (en) 2007-02-06 2008-10-30 President And Fellows Of Harvard College Multiplex decoding of sequence tags in barcodes
CA2856143C (en) 2007-02-09 2016-11-01 Advanced Liquid Logic, Inc. Droplet actuator devices and methods employing magnetic beads
US20100048410A1 (en) 2007-03-22 2010-02-25 Advanced Liquid Logic, Inc. Bead Sorting on a Droplet Actuator
US20100130369A1 (en) 2007-04-23 2010-05-27 Advanced Liquid Logic, Inc. Bead-Based Multiplexed Analytical Methods and Instrumentation
WO2009003184A1 (en) 2007-06-27 2008-12-31 Digital Biosystems Digital microfluidics based apparatus for heat-exchanging chemical processes
US8093064B2 (en) 2008-05-15 2012-01-10 The Regents Of The University Of California Method for using magnetic particles in droplet microfluidics
US20110319298A1 (en) * 2009-04-21 2011-12-29 Benner Steven A Differential detection of single nucleotide polymorphisms
US20100330556A1 (en) * 2009-06-30 2010-12-30 Brian Jon Peter Genome analysis using a nicking endonuclease
US20130053252A1 (en) * 2009-09-25 2013-02-28 President & Fellows Of Harvard College Nucleic acid amplification and sequencing by synthesis with fluorogenic nucleotides
US8895242B2 (en) * 2009-10-20 2014-11-25 The Regents Of The University Of California Single molecule nucleic acid nanoparticles
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
WO2012048341A1 (en) 2010-10-08 2012-04-12 President And Fellows Of Harvard College High-throughput single cell barcoding
GB201106254D0 (en) * 2011-04-13 2011-05-25 Frisen Jonas Method and product
CN103748236B (zh) 2011-04-15 2018-12-25 约翰·霍普金斯大学 安全测序系统
CN103917661A (zh) * 2011-05-12 2014-07-09 网络百奥有限公司 用于快速多重扩增str基因座的方法和组合物
CN104080958A (zh) * 2011-10-19 2014-10-01 纽亘技术公司 用于定向核酸扩增和测序的组合物和方法
US20130309676A1 (en) 2012-05-18 2013-11-21 Alfred E. Mann Foundation For Scientific Research Biased n-mers identification methods, probes and systems for target amplification and detection
EP4148142A1 (en) 2012-05-21 2023-03-15 The Scripps Research Institute Methods of sample preparation
US8895249B2 (en) * 2012-06-15 2014-11-25 Illumina, Inc. Kinetic exclusion amplification of nucleic acid libraries
EP3626866B1 (en) * 2013-08-19 2021-03-24 Abbott Molecular Inc. Next-generation sequencing libraries
JP6996844B2 (ja) 2014-02-27 2022-02-03 ジャンプコード ゲノミクス，インク． 体細胞可動要素の分析のための方法、およびその使用
US20150353989A1 (en) 2014-06-09 2015-12-10 Illumina Cambridge Limited Sample preparation for nucleic acid amplification
AU2015315103B2 (en) 2014-09-09 2022-01-27 Igenomx International Genomics Corporation Methods and compositions for rapid nucleic acid library preparation
CA2967447A1 (en) 2014-12-05 2016-06-09 Foundation Medicine, Inc. Multigene analysis of tumor samples
EP4407625A2 (en) 2016-05-26 2024-07-31 Becton, Dickinson and Company Molecular label counting adjustment methods
EA202091673A1 (ru) 2018-01-29 2021-02-03 Ст. Джуд Чилдрен'С Рисерч Хоспитал, Инк. Способ амплификации нуклеиновых кислот

Also Published As

Publication number Publication date
IL276343A (en) 2020-09-30
AU2023202656A1 (en) 2023-05-18
WO2019148119A1 (en) 2019-08-01
AU2019212953B2 (en) 2023-02-02
ES2937927T3 (es) 2023-04-03
DK3746564T3 (da) 2023-01-30
US20240035080A1 (en) 2024-02-01
AU2019212953A1 (en) 2020-08-27
IL276343B1 (en) 2024-06-01
EP3746564A4 (en) 2021-10-27
EP4183886B1 (en) 2024-04-17
EP3746564B1 (en) 2023-01-04
EP3746564A1 (en) 2020-12-09
JP7457434B2 (ja) 2024-03-28
JP2021511794A (ja) 2021-05-13
CA3089756A1 (en) 2019-08-01
CN112041459A (zh) 2020-12-04
DK4183886T3 (da) 2024-06-03
US20200362394A1 (en) 2020-11-19
KR102653725B1 (ko) 2024-04-01
EP4183886A1 (en) 2023-05-24
US11643682B2 (en) 2023-05-09
US20230022451A1 (en) 2023-01-26
SG11202007225TA (en) 2020-08-28
IL312691A (en) 2024-07-01
US11905553B2 (en) 2024-02-20
KR20200138183A (ko) 2020-12-09
EA202091673A1 (ru) 2021-02-03

Similar Documents

Publication Publication Date Title
IL276343A (en) A method for increasing nucleic acid
HK1248284A1 (zh) 多重乳液核酸擴增
IL271205A (en) Methods for assembling contiguous nucleic acids
EP3450569A4 (en) DNA AMPLIFICATION METHOD
EP3789503C0 (en) METHOD FOR AMPLIFYING NUCLEIC ACIDS
EP3734294A4 (en) METHOD OF EXTRACTION OF NUCLEIC ACID USING A CARTRIDGE
ZA202007778B (en) Nucleic acid detection method
EP3488016A4 (en) METHOD FOR AMPLIFICATING NUCLEIC ACID SEQUENCES
GB201701262D0 (en) Nucleic acid detection method
GB201621271D0 (en) Method for nucleic acid depletion
EP3347714A4 (en) METHOD AND SYSTEMS FOR QUANTITATIVE MULTIPLEX NUCLEIC ACID AMPLIFICATION
EP3460072A4 (en) NUCLEIC ACID EXTRACTION METHOD USING A SOLID SUBJECT
EP3346006A4 (en) DNA AMPLIFICATION METHOD
HK1250682A1 (zh) 核酸擴增
EP3431598A4 (en) PROCESS FOR COLLECTING NUCLEIC ACID
EP3460058A4 (en) METHOD FOR AMPLIFICATING CYCLIC DNA
EP3202901A4 (en) Method for nucleic acid amplification
IL275910A (en) Methods for viral nucleic acid analysis
EP3272866A4 (en) Method for collecting nucleic acid
EP3467835C0 (en) IMPROVED ALIGNMENT METHOD FOR NUCLEIC ACID SEQUENCES
EP3307907C0 (en) AUTOMATIC METHOD FOR THE ISOLATION OF NUCLEIC ACIDS.
EP3733846A4 (en) METHOD FOR RECOVERY OF NUCLEIC ACID
GB201903391D0 (en) Nucleic acid amplification methods
SG11202108563QA (en) Methods for nucleic acid analysis
EP3658685A4 (en) AMPLIFICATION OF NUCLEIC ACIDS