KR20230052995A - 시퀀싱 반응을 위한 중합 효소 - Google Patents
시퀀싱 반응을 위한 중합 효소 Download PDFInfo
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- KR20230052995A KR20230052995A KR1020237012002A KR20237012002A KR20230052995A KR 20230052995 A KR20230052995 A KR 20230052995A KR 1020237012002 A KR1020237012002 A KR 1020237012002A KR 20237012002 A KR20237012002 A KR 20237012002A KR 20230052995 A KR20230052995 A KR 20230052995A
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Abstract
변형된 재조합 중합 효소를 포함하는 조성물이, 이러한 변형된 중합 효소를 코딩하는 핵산 분자와 함께 제공된다. 일부 측면에서, 핵산 분자를 합성하거나 또는 핵산 주형을 시퀀싱하기 위해 이러한 중합 효소를 사용하는 방법이 제공된다.
Description
관련 출원
본 출원은 35 U.S.C. § 119(e) 하에, 2016년 12월 19일에 출원된 미국 가출원 번호 62/436,410을 우선권 주장하며, 이 가출원은 그 전문이 본원에 참조로 포함된다.
본 출원의 분야
본 출원은 일반적으로, 생물학적 및/또는 화학적 샘플의 시퀀싱 분석을 위한 방법 및 조성물에 관한 것이다.
DNA 폴리머라제는 모든 생물체의 게놈 복제에 필수적인 뉴클레오티드 중합 효소이다. DNA 폴리머라제는 복제 및 복구 동안 게놈 무결성을 유지하는 역할 이외에도, DNA 클로닝, 돌연변이 유발, 및 시퀀싱을 포함하여 시험관 내에서의 DNA 조작을 위해 널리 사용되고 있다. 주형 DNA에 따라 상보적 가닥을 합성할 수 있는 DNA 폴리머라제의 기본적인 능력은 보존되지만, 효소 간에는 전진성(processivity), 충실도, 및 기질 뉴클레오티드 선택성을 포함한 특이적 특성이 상이하다.
본원에 개시된 기술의 측면은 시험관내 중합 반응을 시행하기 위해 사용될 수 있는 변형된 중합 효소 (예를 들어, 폴리머라제)에 관한 것이다. 일부 측면에서, 본원에 기재된 폴리머라제는 시퀀싱 반응 (예를 들어, 핵산 시퀀싱)에 사용하기 적합하다. 일부 측면에서, 본 개시내용은 하나 이상의 변형을 갖는 재조합 폴리머라제를 제공한다. 일부 실시양태에서, 본 개시내용의 재조합 폴리머라제는 아미노산 돌연변이 또는 도메인 치환 중 적어도 하나를 포함한다.
일부 측면에서, 본 개시내용은 자연 발생 폴리머라제 (예를 들어, 표 1로부터 선택됨)에 기초하고 하나 이상의 아미노산 돌연변이 및/또는 절편 치환을 포함하는 아미노산 서열을 갖는 변형된 중합 효소 (예를 들어, 핵산 중합 효소, 또는 핵산 폴리머라제)를 제공한다. 일부 실시양태에서, 변형된 중합 효소는 하나 이상의 절편 치환 (예를 들어, 여기서 폴리머라제의 하나 이상의 절편이 상이한 폴리머라제로부터의 하나 이상의 상응하는 절편으로 대체된다), 하나 이상의 아미노산 부가, 결실, 및/또는 치환, 또는 그의 조합을 포함한다. 일부 실시양태에서, 절편은 폴리머라제의 규정된 영역 (예를 들어, 구조적 또는 기능적 도메인 또는 서브 도메인), 또는 그의 부분을 포함하며, 이는 하나 이상의 플랭킹 아미노산 (예를 들어, 표 1의 자연 발생 폴리머라제 내의 특정 영역 또는 그의 부분의 어느 한쪽 상의 아미노산 1 내지 50개, 1 내지 40개, 1 내지 30개, 1 내지 20개, 5 내지 10개, 5 내지 25개, 또는 이들 범위 내의 임의의 정수)을 임의로 포함한다. 일부 실시양태에서, 하나 이상의 아미노산 삽입, 결실, 또는 치환은 하나 이상의 위치에서 2개의 자연 발생 폴리머라제 간의 자연 발생 차이에 상응한다. 일부 실시양태에서, 하나 이상의 아미노산 삽입, 결실, 또는 치환은 새로운 비-자연 발생 변화이다. 일부 실시양태에서, 아미노산 치환은 보존적 아미노산 치환 (예를 들어, 하나의 아미노산을 유사한 특성, 예를 들어 유사한 하전, 극성, 소수성, 친수성, 및/또는 다른 유사한 특성, 예컨대 유사한 크기를 갖는 또 다른 아미노산으로 대체시킨다)이다. 일부 실시양태에서, 아미노산 치환은 비-보존적 아미노산 치환이다. 일부 실시양태에서, 하나 이상의 아미노산 삽입, 결실, 또는 치환은 상이한 폴리머라제로부터의 하나 이상의 교환된 절편 내 및/또는 원래의 폴리머라제의 절편 내를 포함하여, 변형된 폴리머라제 내의 임의의 위치(들)에서 일어날 수 있다.
따라서, 일부 실시양태에서 본 개시내용은 표 1로부터 선택된 아미노산 서열 (또는 표 1로부터 선택된 아미노산 서열에 대해 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80%, 80-90%, 90-95%, 95-99%, 또는 그 초과의 아미노산 서열 동일성을 갖는 아미노산 서열)을 갖고, 표 2, 표 3, 표 4, 또는 표 5로부터의 하나 이상의 아미노산 변형을 포함하는 재조합 중합 효소를 제공한다. 일부 실시양태에서, 하나 이상의 아미노산 변형은 적어도 하나의 아미노산 돌연변이 (예를 들어, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25개, 또는 그 초과의 아미노산 돌연변이)를 포함한다. 일부 실시양태에서, 하나 이상의 아미노산 변형은 적어도 1개 내지 5개 이하의 아미노산 돌연변이, 적어도 1개 내지 10개 이하의 아미노산 돌연변이, 적어도 1개 내지 15개 이하의 아미노산 돌연변이, 적어도 1개 내지 25개 이하의 아미노산 돌연변이, 적어도 1개 내지 50개 이하의 아미노산 돌연변이, 또는 적어도 1개 내지 100개 이하의 아미노산 돌연변이를 포함한다. 일부 실시양태에서, 하나 이상의 아미노산 변형은 적어도 하나의 도메인 치환 (예를 들어, 전체 도메인의 치환, 또는 특정 도메인 또는 특정 도메인의 부분을 포괄하는 절편의 치환)을 포함한다. 일부 실시양태에서, 적어도 하나의 도메인 치환은 엑소뉴클레아제 도메인 치환 및 폴리머라제 도메인 치환 중 적어도 하나를 포함한다. 일부 실시양태에서, 엑소뉴클레아제 도메인 치환은 엑소뉴클레아제 루프 치환을 포함한다. 일부 실시양태에서, 폴리머라제 도메인 치환은 팜(palm) 서브 도메인 치환, TPR1 서브 도메인 치환, 핑거 서브 도메인 치환, TPR2 서브 도메인 치환, 또는 섬(thumb) 서브 도메인 치환 중 어느 하나 (예를 들어, 전체의 폴리머라제, 팜, TPR1, 핑거, TPR2, 또는 섬 도메인 또는 서브 도메인, 또는 하나 이상의 플랭킹 아미노산을 임의로 포함한 그 중 어느 하나의 부분의 치환)를 포함한다. 일부 실시양태에서, 하나 이상의 아미노산 변형은 적어도 하나의 도메인 치환 및 적어도 하나의 아미노산 돌연변이를 포함한다. 일부 실시양태에서, 아미노산 돌연변이는 아미노산 삽입, 결실, 또는 치환일 수 있다.
일부 실시양태에서, 본 개시내용의 재조합 중합 효소는 표 2로부터 선택된 서열을 갖는다. 일부 실시양태에서, 본 개시내용은 표 3으로부터 선택된 서열을 갖는 재조합 중합 효소를 제공한다.
일부 실시양태에서, 재조합 중합 효소는 정제 태그를 추가로 포함한다. 일부 실시양태에서, 정제 태그는 중합 효소 서열 내의 영역과 공유 결합된다. 일부 실시양태에서, 정제 태그는 중합 효소 서열의 말단 단부와 공유 결합된다. 일부 실시양태에서, 정제 태그는 C-말단 태그이다. 일부 실시양태에서, 정제 태그는 N-말단 태그이다. 일부 실시양태에서, 정제 태그는 His 태그 (예를 들어, 반복 히스티딘 잔기의 서열, 예컨대 헥사히스티딘 서열)이다.
일부 실시양태에서, 재조합 중합 효소는 커플링 기를 추가로 포함한다. 일부 실시양태에서, 커플링 기는 중합 효소 서열 내의 영역에 부착된다. 일부 실시양태에서, 커플링 기는 중합 효소의 말단 단부에 부착된다. 일부 실시양태에서, 커플링 기는 재조합 중합 효소의 C-말단 단부에 부착된다. 일부 실시양태에서, 커플링 기는 재조합 중합 효소의 N-말단 단부에 부착된다. 일부 실시양태에서, 커플링 기는 비오티닐화 서열이다. 일부 실시양태에서, 재조합 중합 효소는 펩티드 링커 (예를 들어, 5 내지 15개의 아미노산 또는 그 초과의 길이)와 직접적으로 연결되거나 또는 이러한 링커에 의해 분리된 정제 태그 (예를 들어, His 태그)와 커플링 기 (예를 들어, 비오티닐화 서열)를 포함한다 (예를 들어, 그의 C 말단에 포함한다).
일부 실시양태에서, 재조합 중합 효소는 특정 표면 상에 고정화된다. 일부 실시양태에서, 이러한 표면은 재조합 중합 효소와 결합하도록 설정된 커플링 기를 포함한다. 일부 실시양태에서, 상기 표면은 나노개구를 포함한다. 일부 실시양태에서, 상기 표면은 샘플 웰의 바닥면을 포함한다. 일부 실시양태에서, 샘플 웰은 표면 (예를 들어, 칩 또는 통합 장치의 표면) 상의 복수 개의 샘플 웰 사이에 배치된다. 일부 실시양태에서, 복수 개의 샘플 웰 각각은 재조합 중합 효소를 수용하도록 설정된다. 일부 실시양태에서, 재조합 중합 효소를 포함하는 복수 개의 샘플 웰 각각은 단일 분자 시퀀싱 반응을 시행할 수 있다.
일부 측면에서, 본 개시내용은 본원에 기재된 재조합 중합 효소를 코딩하는 단리된 핵산 분자를 제공한다. 일부 실시양태에서, 이러한 단리된 핵산 분자는 RNA를 포함한다. 일부 실시양태에서, 단리된 핵산 분자는 DNA를 포함한다. 일부 실시양태에서, 단리된 핵산 분자는 바이러스 벡터를 포함한다. 일부 실시양태에서, 단리된 핵산 분자는 발현 벡터를 포함한다. 일부 실시양태에서, 단리된 핵산 분자는 플라스미드를 포함한다. 일부 실시양태에서, 단리된 핵산은 프로모터 (예를 들어, 유도성 프로모터)를 포함한다. 일부 실시양태에서, 단리된 핵산은 재조합 중합 효소를 발현할 수 있는 숙주 세포 내에 있다. 일부 실시양태에서, 재조합 중합 효소는 숙주 세포로부터 (예를 들어, 바이오리액터에서의 성장 및 유도성 프로모터의 유도 후, 예를 들어 숙주 세포 제제로부터) 단리된다.
일부 측면에서, 본 개시내용은 본 출원에 기재된 재조합 중합 효소를 포함하는 조성물을 제공한다. 일부 실시양태에서, 이러한 조성물은 핵산을 시퀀싱하는 방법에 사용된다. 일부 실시양태에서, 상기 조성물은 시퀀싱 반응 혼합물을 추가로 포함한다. 일부 실시양태에서, 시퀀싱 반응 혼합물은 뉴클레오시드 폴리포스페이트 (예를 들어, 2개 이상의 포스페이트 기를 포함하는 뉴클레오시드, 예컨대 뉴클레오티드 또는 뉴클레오시드 헥사포스페이트), 시퀀싱될 주형 핵산, 상보적 가닥 합성을 위한 출발점으로서 제공되는 핵산 프라이머, 2가 금속 이온, 완충제 성분, 및 염 중 하나 이상을 포함할 수 있다. 일부 실시양태에서, 뉴클레오시드 폴리포스페이트는 검출 가능한 모이어티 (예를 들어, 발광 표지)를 포함한다.
일부 측면에서, 본 개시내용은 본 출원에 기재된 재조합 중합 효소를 시퀀싱 반응 혼합물과 접촉시킴으로써 핵산을 시퀀싱하는 방법을 제공한다. 일부 실시양태에서, 시퀀싱 반응 혼합물은 뉴클레오시드 폴리포스페이트 (예를 들어, 2개 이상의 포스페이트 기를 포함하는 뉴클레오시드, 예컨대 뉴클레오티드 또는 뉴클레오시드 헥사포스페이트), 시퀀싱될 주형 핵산, 상보적 가닥 합성을 위한 출발점으로서 제공되는 핵산 프라이머, 2가 금속 이온, 완충제 성분, 및 염 중 하나 이상을 포함할 수 있다. 일부 실시양태에서, 뉴클레오시드 폴리포스페이트는 발광 표지를 포함한다. 일부 실시양태에서, 상기 방법은 주형 핵산에 상보적인 성장 가닥 내의 하나 이상의 뉴클레오시드 폴리포스페이트의 혼입을 검출하는 것을 추가로 포함한다. 일부 실시양태에서, 검출하는 것은 혼입 이벤트에 관여하는 발광성 표지된 뉴클레오시드 폴리포스페이트의 하나 이상의 발광 특성 (예를 들어, 수명, 세기, 광자 도착 시간, 양자 수율)을 측정하는 것을 포함한다.
일부 측면에서, 본 개시내용은 표 1에서의 재조합 중합 효소 중 어느 하나의 엑소뉴클레아제 영역 또는 그의 부분 (및 임의로, 한쪽 또는 양쪽 상의 플랭킹 아미노산)을 포함하는 절편을 포함하는 재조합 중합 효소를 제공한다. 일부 측면에서, 본 개시내용은 표 1에서의 재조합 중합 효소 중 어느 하나의 팜 영역 또는 그의 부분 (및 임의로, 한쪽 또는 양쪽 상의 플랭킹 아미노산)을 포함하는 절편을 포함하는 재조합 중합 효소를 제공한다. 일부 측면에서, 본 개시내용은 표 1에서의 재조합 중합 효소 중 어느 하나의 TPR1 영역 또는 그의 부분 (및 임의로, 한쪽 또는 양쪽 상의 플랭킹 아미노산)을 포함하는 절편을 포함하는 재조합 중합 효소를 제공한다. 일부 측면에서, 본 개시내용은 표 1에서의 재조합 중합 효소 중 어느 하나의 핑거 영역 또는 그의 부분 (및 임의로, 한쪽 또는 양쪽 상의 플랭킹 아미노산)을 포함하는 절편을 포함하는 재조합 중합 효소를 제공한다. 일부 측면에서, 본 개시내용은 표 1에서의 재조합 중합 효소 중 어느 하나의 TPR2 영역 또는 그의 부분 (및 임의로, 한쪽 또는 양쪽 상의 플랭킹 아미노산)을 포함하는 절편을 포함하는 재조합 중합 효소를 제공한다. 일부 측면에서, 본 개시내용은 표 1에서의 재조합 중합 효소 중 어느 하나의 섬 영역 또는 그의 부분 (및 임의로, 한쪽 또는 양쪽 상의 플랭킹 아미노산)을 포함하는 절편을 포함하는 재조합 중합 효소를 제공한다. 일부 측면에서, 본 개시내용은 본원에 기재된 바와 같은 2개 이상의 절편을 포함하는 재조합 중합 효소를 제공한다.
따라서, 일부 실시양태에서, 재조합 중합 효소는 상이한 중합 효소로부터의 (예를 들어, 상이한 종으로부터의) 하나 이상의 아미노산 절편을 포함하는 키메라 효소이다. 일부 실시양태에서, 키메라 폴리머라제는 하나 이상의 절편을 상이한 중합 효소로부터의 절편(들)으로 대체시킨 제1 중합 효소로부터의 아미노산 서열을 포함한다. 일부 실시양태에서, 상이한 중합 효소로부터의 하나 이상의 절편은 M2Y 폴리머라제로부터의 아미노산 1-51을 포함하는 절편, 이. 파에시움(E. faecium) 폴리머라제로부터의 아미노산 271-375를 포함하는 절편, 이. 파에시움 폴리머라제로부터의 아미노산 72-89를 포함하는 절편, 및/또는 이. 파에시움 폴리머라제로부터의 아미노산 445-449를 포함하는 절편일 수 있다. 일부 실시양태에서, M2Y 폴리머라제로부터의 1-51 절편이 상응하는 자연 발생 폴리머라제 절편 (예를 들어, Φ29 폴리머라제의 아미노산 1-54)을 대체한다. 일부 실시양태에서, 이. 파에시움 폴리머라제로부터의 271-375 절편이 상응하는 자연 발생 폴리머라제 절편 (예를 들어, Φ29 폴리머라제의 아미노산 260-359)을 대체한다. 일부 실시양태에서, 이. 파에시움 폴리머라제로부터의 72-89 절편이 상응하는 자연 발생 폴리머라제 절편 (예를 들어, Φ29 폴리머라제의 아미노산 75-91)을 대체한다. 일부 실시양태에서, 이. 파에시움 폴리머라제로부터의 445-449 절편이 상응하는 자연 발생 폴리머라제 절편 (예를 들어, Φ29 폴리머라제의 아미노산 429-433)을 대체한다.
일부 실시양태에서, 재조합 중합 효소는 Φ29 내에서의 하기 치환에 상응하는 하나 이상의 치환을 포함한다: M8R, V51A, N62D, I71V, L107I, K131E, K135Q, L142K, G197D, Y224K, E239G, V250A/I, L253A/H, Y281H, I288L, T301C, R306Q, R308L, D325E, D341E, K354R, T368F, E375Y, A437G, A444T, E466K, D476H, A484E, E508R, D510K/R, K512Y, E515Q, K539E, D570S, 및 T571V.
일부 실시양태에서, 변형된 폴리머라제는 본원에 기재된 절편 치환 및/또는 아미노산 삽입, 결실, 및/또는 치환 중 하나 이상을 포함하고, 또한 하나 이상의 (예를 들어, 1-5, 5-10, 10-25, 25-50, 50-75, 75-100, 100-125, 125-150개의) 부가의 아미노산 삽입, 결실, 및/또는 치환 (예를 들어, 보존적 또는 비-보존적 아미노산 치환)을 포함한다. 따라서, 일부 실시양태에서, 표 2 또는 표 3의 변형된 폴리머라제는 하나 이상의 (예를 들어, 1-5, 5-10, 10-25, 25-50, 50-75, 75-100, 100-125, 125-150개의) 부가의 아미노산 삽입, 결실, 및/또는 치환 (예를 들어, 보존적 또는 비-보존적 아미노산 치환)을 포함할 수 있다.
이들 및 다른 측면은 하기 상세한 설명에 보다 상세하게 기재되고 비-제한적 도면 및 실시예에 의해 예시된다.
통상의 기술자는 본원에 기재된 도면이 단지 예시하기 위한 것임을 이해할 것이다. 일부 경우에, 본 발명의 이해를 용이하게 하기 위하여, 본 발명의 다양한 측면이 과장되거나 또는 확대되어 보여질 수 있음을 이해해야 한다. 본 도면에서, 유사한 참조 문자는 일반적으로, 다양한 도면 전반에 걸쳐 유사한 특색, 기능적으로 유사하고/하거나 구조적으로 유사한 요소를 지칭한다. 본 도면은 반드시 축척된 것은 아니며, 대신 교시의 원리를 예시하는 것에 중점을 둔다. 본 도면은 어떤 방식으로든 본 교시의 범위를 제한하지 않는다.
본 발명의 특색 및 이점은 도면과 연계하여 후술되는 상세한 설명으로부터 더욱 명백해질 것이다.
본 도면과 관련하여 실시양태를 설명할 때, 방향에 대한 언급 ( "위", "아래", "상단", "하단", "좌측", "우측", "수평", "수직" 등)을 이용할 수 있다. 이러한 언급은 단지 정상적인 배향으로 본 도면을 보는 독자를 돕기 위한 것이다. 이들 방향 언급은 구체화된 장치의 선호되거나 또는 유일한 배향을 기재하기 위한 것이 아니다. 장치는 다른 배향으로 구체화될 수 있다.
상세한 설명으로부터 명백한 바와 같이, 본 도면 (예를 들어, 도 1 내지 도 7)에 도시되고 본 출원 전반에 걸쳐 예시의 목적으로 추가로 기재된 예들은 비-제한적 실시양태를 설명하고, 일부 경우에는 특정 프로세스를 단순화하거나 또는 더 명확하게 예시하기 위하여 특색 또는 단계를 생략할 수 있다.
도 1은 단일 분자 프로세스를 모니터링하기 위한 비-제한적 프로세스에서 시그널 판독정보와 관련하여 중합 반응의 진행을 예시하는 개략도이다.
도 2는 Φ29 폴리머라제의 구조 및 이러한 폴리머라제의 도메인 및 서브 도메인을 도시하는 비-제한적 예시이다.
도 3은 폴리펩티드 가닥의 도메인 및 서브 도메인 내에 돌연변이 부위를 수반한 선택된 돌연변이 변이체의 비-제한적 예를 도시한다.
도 4는 폴리펩티드 가닥 내로 치환된 상이한 도메인 및 서브 도메인을 갖는 선택된 키메라 폴리머라제 변이체의 비-제한적 예를 도시한다.
도 5a는 Φ29 폴리머라제의 엑소뉴클레아제 도메인 내의 루프 영역을 도시하는 비-제한적 예시이다.
도 5b는 Φ29 폴리머라제의 엑소뉴클레아제 영역과 다른 폴리머라제의 비-제한적 세트 간의 서열 상동성 정렬을 도시한다.
도 6은 하나 이상의 부위 특이적 돌연변이를 포함하는 키메라 폴리머라제 변이체의 비-제한적 일반적인 예를 도시한다.
도 7은 이. 콜라이(E. coli)에서 발현된 폴리머라제의 순도를 평가하기 위해 시행된 SDS-PAGE의 그림이다.
본 발명의 특색 및 이점은 도면과 연계하여 후술되는 상세한 설명으로부터 더욱 명백해질 것이다.
본 도면과 관련하여 실시양태를 설명할 때, 방향에 대한 언급 ( "위", "아래", "상단", "하단", "좌측", "우측", "수평", "수직" 등)을 이용할 수 있다. 이러한 언급은 단지 정상적인 배향으로 본 도면을 보는 독자를 돕기 위한 것이다. 이들 방향 언급은 구체화된 장치의 선호되거나 또는 유일한 배향을 기재하기 위한 것이 아니다. 장치는 다른 배향으로 구체화될 수 있다.
상세한 설명으로부터 명백한 바와 같이, 본 도면 (예를 들어, 도 1 내지 도 7)에 도시되고 본 출원 전반에 걸쳐 예시의 목적으로 추가로 기재된 예들은 비-제한적 실시양태를 설명하고, 일부 경우에는 특정 프로세스를 단순화하거나 또는 더 명확하게 예시하기 위하여 특색 또는 단계를 생략할 수 있다.
도 1은 단일 분자 프로세스를 모니터링하기 위한 비-제한적 프로세스에서 시그널 판독정보와 관련하여 중합 반응의 진행을 예시하는 개략도이다.
도 2는 Φ29 폴리머라제의 구조 및 이러한 폴리머라제의 도메인 및 서브 도메인을 도시하는 비-제한적 예시이다.
도 3은 폴리펩티드 가닥의 도메인 및 서브 도메인 내에 돌연변이 부위를 수반한 선택된 돌연변이 변이체의 비-제한적 예를 도시한다.
도 4는 폴리펩티드 가닥 내로 치환된 상이한 도메인 및 서브 도메인을 갖는 선택된 키메라 폴리머라제 변이체의 비-제한적 예를 도시한다.
도 5a는 Φ29 폴리머라제의 엑소뉴클레아제 도메인 내의 루프 영역을 도시하는 비-제한적 예시이다.
도 5b는 Φ29 폴리머라제의 엑소뉴클레아제 영역과 다른 폴리머라제의 비-제한적 세트 간의 서열 상동성 정렬을 도시한다.
도 6은 하나 이상의 부위 특이적 돌연변이를 포함하는 키메라 폴리머라제 변이체의 비-제한적 일반적인 예를 도시한다.
도 7은 이. 콜라이(E. coli)에서 발현된 폴리머라제의 순도를 평가하기 위해 시행된 SDS-PAGE의 그림이다.
본 개시내용의 측면은 변형된 중합 효소 및 그의 조성물에 관한 것이다. 일부 측면에서, 본 개시내용은 변형된 재조합 중합 효소를 사용하는 방법 및 이러한 효소를 포함하는 조성물을 제공한다. 일부 실시양태에서, 본 개시내용은 시험관내 중합 반응을 시행하기 위해 사용될 수 있는 변형된 재조합 중합 효소 및 조성물을 제공한다. 일부 측면에서, 본원에 기재된 중합 효소는 변형된 재조합 핵산 폴리머라제, 예를 들어, 변형된 재조합 DNA 폴리머라제이다. 일부 실시양태에서, 본 개시내용에 의해 제공된 변형된 재조합 DNA 폴리머라제는 DNA의 조작 (예를 들어, DNA 시퀀싱)과 관련된 시험관내 반응을 위해 사용될 수 있다.
다른 측면 중에서, 본 개시내용은 시험관내 중합 반응을 시행하기 위해 사용될 수 있는 변형된 중합 효소 (예를 들어, 폴리머라제)를 제공한다. 일부 실시양태에서, 본원에 기재된 폴리머라제는 개별적으로 또는 조합하여, 시퀀싱 반응을 시행하는 데 유용한 하나 이상의 변형을 포함한다. 일부 실시양태에서, 본원에 기재된 변형 중 하나 이상을 활용하여, 시퀀싱 반응을 시행하는 데 유용한 하나 이상의 특성, 예를 들어, 폴리머라제 전진성, 충실도 (예를 들어, 정확도), 기질 (예를 들어, 뉴클레오시드 폴리포스페이트) 결합 친화성, 기질 활용률 (예를 들어, 뉴클레오시드 폴리포스페이트가 주형 가닥에 상보적인 성장 가닥 내로 혼입되는 비율), 변형된 기질 (예를 들어, 표지된 뉴클레오시드 폴리포스페이트)과의 폴리머라제 상호 작용, 또는 그의 일부 조합과 같은 특성을 갖는 폴리머라제를 생산할 수 있다. 일부 실시양태에서, 상기 변형 중 하나 이상은 폴리머라제의 교정 능력을 최소화하거나 또는 없앤다. 예를 들어, 일부 실시양태에서, 하나 이상의 변형은 폴리머라제의 엑소뉴클레아제 활성 상의 손실을 초래하는 폴리머라제의 엑소뉴클레아제 도메인에 대해 이루어질 수 있다.
일부 측면에서, 본 출원은 단일 분자 핵산 시퀀싱 기술에 유리한 변경된 생화학적 특성을 갖는 변형된 폴리머라제에 관한 것이다. 일부 실시양태에서, 본원에 기재된 변이체 폴리머라제는 단일 분자 시퀀싱 반응에서 개선된 시그널 판독정보를 제공하도록 변형되었다. 도 1은 실시간 시그널 판독정보와 관련하여 시퀀싱 반응의 진행을 예시하는 예를 제공한다. 이론에 얽매이고자 한 것은 아니지만, 일부 단일 분자 핵산 시퀀싱 반응은 계획 (100)에 따라서 진행되는 것으로 여겨진다.
반응의 시작에서 (패널 I), 폴리머라제 (파선)는 관찰 영역에 한정되고 주형 가닥 및 프라이머 가닥과 결합된다. 도시된 바와 같이, 상이한 유형의 검출 가능한 표지를 각각 갖는 상이한 유형의 뉴클레오티드 (예를 들어, A, G, T, C, U)가 동일한 반응 혼합물에 존재한다. 폴리머라제가 발광성 표지된 뉴클레오티드와 연합되면 (패널 II), 이러한 표지는 일정 기간 동안 관찰 영역에 한정된다. 혼입 이벤트 동안에는, 예를 들어, 이러한 기간이 상기 표지가 관찰 영역에서의 그의 존재를 검출하고 확인하기에 충분한 양의 에너지를 수용 및/또는 방출하기에 충분할 수 있다. 시그널 판독정보 (102)와 관련하여 계획 (100)의 패널 I 및 II에 의해 예시된 바와 같이, 혼입 이벤트는 펄스 폭 (pw)에 상응하는 일정 기간 동안 시그널 펄스와 연관될 수 있다.
일부 실시양태에서, 혼입 이벤트와 연관된 개별 시그널 펄스는 혼입되는 뉴클레오티드의 유형 또는 특이적 시점에서의 폴리머라제의 활성과 같은 각종 조건에 의해 영향을 받을 수 있다는 것을 인지해야 한다. 일부 실시양태에서, 개별 시그널 펄스는 약 10밀리초 내지 약 10초의 개별 펄스 폭을 가질 수 있다. 따라서, 일부 실시양태에서, 개별 펄스 폭은 비교 목적을 위한 파라미터를 제공하기 위해 평균될 수 있다. 본원에 사용된 바와 같이, 일부 실시양태에서, "펄스 폭"은 각각의 개별 시그널 펄스가 개별 펄스 폭을 갖는 복수 개의 개별 시그널 펄스의 평균에 상응하는 값을 지칭한다.
일부 실시양태에서, 본 출원의 변형된 중합 효소는 약 10밀리초 내지 약 10초의 펄스 폭을 생산한다. 일부 실시양태에서, 펄스 폭은 적어도 10밀리초 내지 10초 이하, 적어도 10밀리초 내지 5초 이하, 적어도 10밀리초 내지 1초 이하, 또는 약 10밀리초 내지 약 1초이다. 일부 실시양태에서, 펄스 폭은 약 10 내지 약 500밀리초, 약 10 내지 약 200밀리초, 약 10 내지 약 100밀리초, 약 10 내지 약 50밀리초, 약 50밀리초 내지 약 1초, 약 50 내지 약 500밀리초, 약 50 내지 약 200밀리초, 약 50 내지 약 100밀리초, 약 100밀리초 내지 약 1초, 약 100 내지 약 500밀리초, 약 100 내지 약 200밀리초, 약 200밀리초 내지 약 1초, 약 200 내지 약 500밀리초, 또는 약 500밀리초 내지 약 1초이다.
뉴클레오티드가 성장 가닥 내로 혼입되고 발광 표지가 절단된 후, 이러한 표지는 조명 용적으로부터 확산되어 관찰 영역에서 더 이상 검출 가능하지 않다 (패널 III). 또한, 패널 III에 예시된 바와 같이, 혼입 이벤트 후, 폴리머라제는 주형 가닥을 따라 진행하여 후속의 발광성 표지된 뉴클레오티드와 연합될 수 있다. 패널 I에서 패널 II로의 진행과 유사하게, 시그널 트레이스 (102)에서 패널 III에서 패널 IV로의 진행에 상응하는 시그널은 비교적 낮은 세기 수준에서부터 연합 이벤트를 표시하는 시그널 펄스로 그 세기가 증가한다. 시그널 트레이스 (102)의 관점에서, 혼입 이벤트와 후속 연합 이벤트 사이의 기간은 인터펄스 거리 (ipd)와 연관될 수 있다.
펄스 폭과 관련하여 전술한 바와 같이, 일부 실시양태에서, 제1 시그널 펄스와 제2 시그널 펄스 사이의 기간과 연관된 개별 인터펄스 거리는 특이적 시점에서의 폴리머라제의 활성 또는 전진성과 같은 각종 조건에 의해 영향을 받을 수 있다. 일부 실시양태에서, 개별 인터펄스 거리는 약 10밀리초 내지 약 1분 이상 (예를 들어, 약 1 내지 약 60초, 약 1 내지 약 30초, 약 1 내지 약 20초, 약 1 내지 약 10초, 또는 약 1초 미만)의 기간에 상응한다. 따라서, 일부 실시양태에서, 개별 인터펄스 거리는 비교 목적을 위한 파라미터를 제공하기 위해 평균될 수 있다. 본원에 사용된 바와 같이, 일부 실시양태에서, "인터펄스 거리"는 복수 개의 개별 인터펄스 거리의 평균에 상응하는 값을 지칭한다.
일부 실시양태에서, 본 출원의 변형된 중합 효소는 약 10밀리초 내지 약 10초의 인터펄스 거리를 초래한다. 일부 실시양태에서, 인터펄스 거리는 적어도 10밀리초 내지 10초 이하, 적어도 10밀리초 내지 5초 이하, 적어도 10밀리초 내지 1초 이하, 또는 약 10밀리초 내지 약 1초이다. 일부 실시양태에서, 인터펄스 거리는 약 10 내지 약 500밀리초, 약 10 내지 약 200밀리초, 약 10 내지 약 100밀리초, 약 10 내지 약 50밀리초, 약 50밀리초 내지 약 1초, 약 50 내지 약 500밀리초, 약 50 내지 약 200밀리초, 약 50 내지 약 100밀리초, 약 100밀리초 내지 약 1초, 약 100 내지 약 500밀리초, 약 100 내지 약 200밀리초, 약 200밀리초 내지 약 1초, 약 200 내지 약 500밀리초, 또는 약 500밀리초 내지 약 1초이다.
펄스 폭 및/또는 인터펄스 거리의 특징은, 일부 실시양태에서, 특이적 발광 표지를 확인하기 위해 사용될 수 있다. 일부 실시양태에서, 본 개시내용의 변형된 폴리머라제는 주형 가닥의 뉴클레오티드 서열을 결정하기 위해 발광성 표지된 뉴클레오티드의 연합을 표시하는 일련의 펄스 폭을 관찰함으로써 시퀀싱 반응에 사용될 수 있다. 일부 실시양태에서, 이러한 프로세스에서의 인공물은 부정확한 시퀀싱 정보를 야기할 수 있다. 예를 들어, 패널 V는 발광성 표지된 뉴클레오티드가 시그널 펄스를 발생시키기에 충분한 기간 동안 관찰 영역에 한정되지만 혼입 이벤트가 없는 결합 및 방출 이벤트를 예시한다.
패널 V에 제시된 바와 같이, 패널 IV에서 검출된 혼입 후에, 절단된 발광 표지는 관찰 가능한 영역 밖으로 확산한다 (i). 추가로 발광성 표지된 뉴클레오티드는 관찰 가능한 영역에서 폴리머라제와 연합하여 검출 가능한 시그널을 발생시킨다 (ii). 성장 가닥 내로 혼입되기 보다는, 발광성 표지된 뉴클레오티드가 폴리머라제로부터 해리되어 다시 반응 혼합물 내로 확산된다 (iii). 따라서, 동일한 유형의 뉴클레오티드의 후속적으로 성공적인 혼입 후 (도시되지 않음), 패널 V에 상응하는 시그널 펄스는 시퀀싱 정보 판독에 명백한 삽입을 초래할 것이다. 따라서, 일부 실시양태에서, 본 출원의 변형된 폴리머라제는 이들 및 다른 인공물 이벤트로부터의 진실한 혼입 이벤트를 판별하기에 충분한 길이의 펄스 폭을 갖는다. 일부 실시양태에서, 본 출원의 변형된 폴리머라제는 폴리머라제 활성 부위로부터의 조기 기질 방출 가능성을 감소시키는 하나 이상의 변형을 갖는다. 일부 실시양태에서, 본 출원의 변형된 폴리머라제는 일단 기질이 폴리머라제 활성 부위와 연합되면 기질 혼입의 가능성을 증가시키는 하나 이상의 변형을 갖는다.
일부 실시양태에서, 본 개시내용에 의해 제공된 변형된 폴리머라제는 하나 이상의 변형을 수반한 표 1에 제시된 야생형 폴리머라제 서열 [서열식별번호 (SEQ ID NO): 1-19]에 따르는 폴리머라제 서열을 포함한다 (예를 들어, 표 2-5에 예시된 바와 같거나, 또는 그의 2개 이상의 조합).
<표 1>
야생형 폴리머라제 아미노산 서열
일부 실시양태에서, 야생형 폴리머라제 서열 (예를 들어, 표 1에 제시된 바와 같음)은 하나 이상의 변형이 재조합 변이체 폴리머라제를 생성하기 위해 만들어질 수 있는 대다수의 폴리머라제 서열을 제공한다. 본원에 사용된 바와 같이, 변형된 폴리머라제의 "대다수의 폴리머라제 서열" 또는 "대다수의 서열"은 변형된 폴리머라제 서열 내에서 우세한 야생형 폴리머라제 서열을 지칭한다 (예를 들어, 변형된 폴리머라제 내의 아미노산의 적어도 50%가 대다수의 서열 내의 아미노산에 상응한다). 일부 실시양태에서, 변형된 폴리머라제 서열은 하나 이상의 아미노산 돌연변이를 추가로 포함하는 대다수의 서열을 포함한다. 일부 실시양태에서, 하나 이상의 아미노산 돌연변이는 상동 단백질 내의 위치에 상응하는 위치에 아미노산을 포함한다. 예를 들어, 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 (서열식별번호: 1) 내의 A484에 상응하는 위치에 돌연변이를 포함한다. 다른 폴리머라제 내의 A484에 상응하는 아미노산은 상동성 정렬을 포함하여 관련 기술분야에 공지된 임의의 방법에 의해 결정될 수 있다. 이러한 분석의 비-제한적 예로서, 상동성 정렬은 표 1에 보고된 수많은 폴리머라제를 사용하여 시행되었으며, Φ29 폴리머라제 내의 A484가 M2Y 내의 A481, 바실루스(Bacillus) 파지 VMY22 내의 A492, 엔테로코쿠스 파에시움(Enterococcus faecium) 내의 K500, 및 루실리아 쿠프리나(Lucilia cuprina) 내의 K827에 상응하는 것으로 결정되었다. 따라서, 상동성 정렬 및 관련 기술분야에 공지된 유사한 방법을 사용하여, 본원에 기재된 변형된 잔기의 위치에 상응하는 다른 폴리머라제 내의 아미노산을 확인할 수 있다. 따라서, 본 개시내용의 변형이 본원에 기재된 폴리머라제 (예를 들어, 표 1에 열거된 것)로 제한하려는 것이 아니고, 공지된 기술을 사용하여 임의의 중합 효소로 연장될 수 있다는 것을 인지해야 한다.
일부 실시양태에서, 변형된 폴리머라제는 표 1에 열거된 폴리머라제 중 하나 이상 (예를 들어, 서열식별번호: 1, 서열식별번호: 5, 또는 표 1에 열거된 다른 서열)에 대해 적어도 25% 아미노산 서열 동일성을 갖는다. 일부 실시양태에서, 변형된 폴리머라제는 표 1에 열거된 폴리머라제 중 하나 이상 (예를 들어, 서열식별번호: 1, 서열식별번호: 5, 또는 표 1에 열거된 다른 서열)에 대해 25-50%, 50-60%, 60-70%, 70-80%, 80-90%, 90-95%, 또는 95-99%, 또는 그 초과의 아미노산 서열 동일성을 갖는다. 일부 실시양태에서, 이러한 변형된 폴리머라제는 본 출원에 제공된 상이한 변형된 폴리머라제 입체 배치 및/또는 예의 문맥에서 기재된 아미노산 돌연변이 및/또는 도메인 치환 중 하나 이상을 포함한다.
일부 실시양태에서, 상이한 폴리머라제로부터의 하나 이상의 절편 또는 영역은 본 출원에 기재된 특이적 서열에 대해 적어도 80% 아미노산 서열 동일성을 갖는 것으로 기재된다. 이러한 영역은, 예를 들어, 명시된 서열 (예를 들어, 표 1의 자연 발생 폴리머라제 내의 상응하는 절편 또는 영역)에 대해 80-90%, 90-95%, 95-99%, 또는 100% 서열 동일성을 가질 수 있다. 또한, 대체 실시양태에서, 이러한 절편 영역은 명시된 서열 (예를 들어, 표 1의 자연 발생 폴리머라제 내의 상응하는 절편 또는 영역)에 대해 더 낮은 서열 동일성 (예를 들어, 50-60%, 60-70%, 또는 70-80%)의 아미노산 서열 동일성을 가질 수 있다.
2개 이상의 아미노산 서열을 비교할 목적으로, 제1 아미노산 서열과 제2 아미노산 서열 간의 "서열 동일성" (본원에서 "아미노산 동일성"으로서 지칭되기도 함)의 백분율은 [제2 아미노산 서열 내의 상응하는 위치에서의 아미노산 잔기와 동일한 제1 아미노산 서열 내의 아미노산 잔기의 수]를 [제1 아미노산 서열 내의 아미노산 잔기의 총 수]로 나누고 이에 [100%]를 곱합으로써 계산될 수 있으며, 여기서 제1 아미노산 서열과 비교해서 제2 아미노산 서열 내의 아미노산 잔기의 각각의 결실, 삽입, 치환 또는 부가는 단일 아미노산 잔기 (위치)에서의 차이로서 간주되는데, 즉 본원에 정의된 바와 같은 "아미노산 차이"로서 간주된다. 또 다른 한편으로, 두 아미노산 서열 간의 서열 동일성의 정도는 공지된 컴퓨터 알고리즘을 이용하여, 예를 들어, 문헌 [Smith and Waterman (1970) Adv. Appl. Math. 2:482c]의 국소 상동성 알고리즘에 의해, 문헌 [Needleman and Wunsch, J. Mol. Biol. (1970) 48:443]의 상동성 정렬 알고리즘에 의해, 문헌 [Pearson and Lipman. Proc. Natl. Acad. Sci. USA (1998) 85:2444]의 유사성 검색 방법에 의해, 또는 블라스트(Blast), 클러스털 오메가(Clustal Omega), 또는 다른 서열 정렬 알고리즘으로서 이용 가능한 알고리즘의 컴퓨터화된 구현에 의해, 및 예를 들어, 표준 설정을 이용하여 계산될 수 있다. 통상적으로, 상기 그 개요가 서술된 계산 방법에 따라 두 아미노산 서열 간의 "서열 동일성"의 백분율을 결정할 목적으로, 가장 많은 수의 아미노산 잔기를 갖는 아미노산 서열이 "제1" 아미노산 서열로서 간주될 것이고, 다른 아미노산 서열이 "제2" 아미노산 서열로서 간주될 것이다.
부가적으로, 또는 또 다른 한편으로, 2개 이상의 서열은 서열 간의 동일성에 관하여 평가될 수 있다. 2개 이상의 핵산 또는 아미노산 서열의 문맥에서 용어 "동일한" 또는 퍼센트 "동일성"은 동일한 2개 이상의 서열 또는 하위 서열을 지칭한다. 2개의 서열이 하기 서열 비교 알고리즘 중 하나를 이용하거나 또는 수동 정렬 및 육안 검사에 의해 측정된 바와 같이 비교 창 또는 지명된 영역에 걸쳐 최대 상응도를 위해 비교 및 정렬되는 경우, 명시된 영역에 걸쳐 또는 전체의 서열에 걸쳐 동일한 아미노산 잔기 또는 뉴클레오티드의 명시된 백분율 (예를 들어, 적어도 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5%, 99.6%, 99.7%, 99.8% 또는 99.9% 동일함)을 갖는 경우에 이러한 2개의 서열은 "실질적으로 동일하다". 임의로, 동일성은 적어도 약 25, 50, 75, 또는 100개 아미노산의 길이인 영역에 걸쳐, 또는 보다 바람직하게 100 내지 150, 200개 또는 그 초과의 아미노산의 길이인 영역에 걸쳐 존재한다.
부가적으로, 또는 또 다른 한편으로, 2개 이상의 서열은 서열 간의 정렬에 관하여 평가될 수 있다. 2개 이상의 핵산 또는 아미노산 서열의 문맥에서 용어 "정렬" 또는 퍼센트 "정렬"은 동일한 2개 이상의 서열 또는 하위 서열을 지칭한다. 2개의 서열이 하기 서열 비교 알고리즘 중 하나를 이용하거나 또는 수동 정렬 및 육안 검사에 의해 측정된 바와 같이 비교 창 또는 지명된 영역에 걸쳐 최대 상응도를 위해 비교 및 정렬되는 경우, 명시된 영역에 걸쳐 또는 전체의 서열에 걸쳐 동일한 아미노산 잔기 또는 뉴클레오티드의 명시된 백분율 (예를 들어, 적어도 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5%, 99.6%, 99.7%, 99.8% 또는 99.9% 동일함)을 갖는 경우에 이러한 2개의 서열은 "실질적으로 정렬된다". 임의로, 정렬은 적어도 약 25, 50, 75, 또는 100개 아미노산의 길이인 영역에 걸쳐, 또는 보다 바람직하게 100 내지 150, 200개 또는 그 초과의 아미노산의 길이인 영역에 걸쳐 존재한다.
일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 K131, K135, L142, Y148, Y224, E239, V250, L253, R306, R308, E375, A437, E466, D476, A484, E508, D510, K512, E515, K539, D570, 및 T571에 상응하는 위치에 하나 이상 (예를 들어, 2개 이상, 5개 이상, 10개 이상, 15개 이상, 20개 이상, 예를 들어 모두)의 아미노산 돌연변이를 포함한다. 예를 들어, 일부 실시양태에서, 변형된 폴리머라제가 Φ29 폴리머라제 대다수의 서열을 포함하는 경우, 이러한 변형된 폴리머라제는 앞서 열거된 바와 같은 위치에 하나 이상의 돌연변이를 포함한다. 일부 실시양태에서, 변형된 폴리머라제가 Φ29 폴리머라제 대다수의 서열을 포함하지 않는 경우, 이러한 변형된 폴리머라제는, 예를 들어, 상동성 정렬 또는 관련 기술분야에 공지된 다른 방법에 의해 결정된 바와 같이, 상기 열거된 위치에 상응하는 하나 이상의 아미노산을 포함한다.
일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 Y148, Y226, V250, N251, T368, E375, K379, Q380, A437, P477, K478, 및 A484에 상응하는 하나 이상의 위치에 돌연변이를 포함한다. 일부 실시양태에서, 본 개시내용의 변형된 폴리머라제는 Y148, Y226, V250, N251, T368, E375, K379, Q380, A437, P477, K478, 및 A484 중 하나 이상에 돌연변이를 포함하는 변형된 Φ29 폴리머라제이다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484C 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484S 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484T 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484Q 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484N 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484E 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484D 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484K 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484R 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484H 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484Y 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484X 중 하나 이상을 포함하며, 여기서 X는 본원에 기재된 바와 같은 비-자연 아미노산을 나타낸다. 본원에 사용된 바와 같은, 하나 이상은 상기 열거된 아미노산 치환 중 2개 이상, 4개 이상, 6개 이상, 8개 이상, 10개 이상, 12개 이상, 예를 들어 모두일 수 있다.
일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 M8, V51, N62, I71, L107, K131, K135, L142, G197, Y224, E239, V250, L253, Y281, I288, T301, R306, R308, D325, D341, K354, T368, E375, A437, A444, E466, D476, A484, E508, D510, K512, E515, K539, D570, 및 T571에 상응하는 하나 이상의 위치 (예를 들어, 1 내지 35개 위치 또는 그 사이의 임의의 정수, 예를 들어 2개 이상, 5개 이상, 10개 이상, 15개 이상, 20개 이상, 예를 들어 모두)에 돌연변이를 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 M8, V51, N62, I71, L107, K131, K135, L142, G197, Y224, E239, V250, L253, Y281, I288, T301, R306, R308, D325, D341, K354, T368, E375, A437, A444, E466, D476, A484, E508, D510, K512, E515, K539, D570, 및 T571 중 하나 이상에 돌연변이를 포함하는 변형된 Φ29 폴리머라제이다. 일부 실시양태에서, 변형된 폴리머라제는 하기 돌연변이 M8R, V51A, N62D, I71V, L107I, K131E, K135Q, L142K, G197D, Y224K, E239G, V250A, V250I, L253A, L253H, Y281H, I288L, T301C, R306Q, R308L, D325E, D341E, K354R, T368F, E375Y, A437G, A444T, E466K, D476H, A484E, E508R, D510K, D510R, K512Y, E515Q, K539E, D570S, 및 T571V 중 하나 이상 (예를 들어, 1 내지 35개 또는 그 사이의 임의의 정수, 예를 들어 2개 이상, 5개 이상, 10개 이상, 15개 이상, 20개 이상, 예를 들어 모두)을 포함한다.
일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 K135, L142, Y224, E239, V250, L253, E375, A437, E466, D476, A484, E508, D510, K512, E515, K539, D570, 및 T571에 상응하는 하나 이상의 위치 (예를 들어, 1 내지 18개의 위치 또는 그 사이의 임의의 정수, 예를 들어 2개 이상, 5개 이상, 10개 이상, 15개 이상, 예를 들어 모두)에 돌연변이를 포함한다. 일부 실시양태에서, 본 개시내용의 변형된 폴리머라제는 K135, L142, Y224, E239, V250, L253, E375, A437, E466, D476, A484, E508, D510, K512, E515, K539, D570, 및 T571 중 하나 이상에 돌연변이를 포함하는 변형된 Φ29 폴리머라제이다. 일부 실시양태에서, 변형된 폴리머라제는 K135Q, L142K, Y224K, E239G, V250I, L253A, E375Y, A437G, E466K, D476H, A484E, E508R, D510R, K512Y, E515Q, K539E, D570S, 및 T571V 중 하나 이상 (예를 들어, 1 내지 18개 또는 그 사이의 임의의 정수, 예를 들어 2개 이상, 5개 이상, 10개 이상, 15개 이상, 예를 들어 모두)을 포함한다.
일부 실시양태에서, 본 출원의 변형된 폴리머라제는 TPR1 영역 치환을 포함한다. 예를 들어, 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 (서열식별번호: 1) 내의 S260-L359에 상응하는 TPR1 영역 대신 이. 파에시움으로부터의 TPR1 영역 (예를 들어, 서열식별번호: 5 내의 V271-M375)을 포함한다.
일부 실시양태에서, 본 출원의 변형된 폴리머라제는 엑소뉴클레아제 영역 내의 하나 이상의 치환을 포함한다. 예를 들어, 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 (서열식별번호: 1) 내의 M1-V54에 상응하는 아미노산 대신 M2Y로부터의 엑소뉴클레아제 영역의 부분 (예를 들어, 서열식별번호: 2 내의 M1-I51)을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 (서열식별번호: 1) 내의 E75-N91에 상응하는 아미노산 대신 이. 파에시움으로부터의 엑소뉴클레아제 영역의 부분 (예를 들어, 서열식별번호: 5 내의 F72-S89)을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 M1-V54 및 E75-N91에 각각 상응하는 아미노산 대신 M2Y로부터의 엑소뉴클레아제 영역의 부분 및 이. 파에시움으로부터의 엑소뉴클레아제 영역의 부분을 포함한다.
일부 실시양태에서, 본 출원의 변형된 폴리머라제는 변형된 팜 영역을 포함한다. 예를 들어, 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 (서열식별번호: 1) 내의 M429-I433에 상응하는 아미노산 대신 이. 파에시움으로부터의 팜 영역의 부분 (예를 들어, 서열식별번호: 5 내의 L445-V449)을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 A444에 상응하는 위치에 알라닌에서 티민으로의 돌연변이 (예를 들어, A444T)를 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 이. 파에시움으로부터의 팜 영역의 부분 및 Φ29 폴리머라제 내의 A444T에 상응하는 아미노산 돌연변이를 포함한다.
일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 G197, I71, 및 L107에 상응하는 하나 이상의 위치 (예를 들어, 1, 2, 또는 3개)에 돌연변이를 포함한다. 일부 실시양태에서, 본 개시내용의 변형된 폴리머라제는 G197, I71, 및 L107 중 하나 이상 (예를 들어, 1, 2, 또는 3개)에 돌연변이를 포함하는 변형된 Φ29 폴리머라제이다. 일부 실시양태에서, 변형된 폴리머라제는 G197D, I71V, 및 L107I 중 하나 이상 (예를 들어, 1, 2, 또는 3개)을 포함한다.
일부 실시양태에서, 본 출원의 변형된 폴리머라제는 폴리머라제의 하나 이상의 영역 또는 절편 (예를 들어, 플랭킹 아미노산을 임의로 포함한, 도메인 또는 그의 부분) 내의 하나 이상의 아미노산 돌연변이를 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 엑소뉴클레아제 영역, 팜 영역, TPR1 영역, 핑거 영역, TPR2 영역, 및 섬 영역 중 하나 이상 내의 하나 이상의 아미노산 돌연변이를 포함한다.
일부 실시양태에서, 변형된 폴리머라제는 엑소뉴클레아제 영역 내의 하나 이상의 위치 (예를 들어, 엑소뉴클레아제 영역의 엑소뉴클레아제 루프)에 돌연변이를 포함한다. 일부 실시양태에서, Φ29 폴리머라제 대다수의 서열을 갖는 변형된 폴리머라제는 엑소뉴클레아제 영역 내의 하나 이상의 위치에 돌연변이를 포함한다. 예를 들어, 일부 실시양태에서, 본 개시내용의 변형된 폴리머라제는 Φ29 폴리머라제의 엑소뉴클레아제 영역 내의 E75, R76, S82, A83, D84, G85, L86, P87, N88, Y90, 및 N91 중 하나 이상에 돌연변이를 포함하는 변형된 Φ29 폴리머라제이다. 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 E75, R76, S82, A83, D84, G85, L86, P87, N88, Y90, 및 N91에 상응하는 위치에 하나 이상의 아미노산 돌연변이를 포함한다. 따라서, 일부 실시양태에서, 변형된 폴리머라제가 Φ29 폴리머라제 대다수의 서열을 포함하지 않는 경우, 이러한 변형된 폴리머라제는, 예를 들어, 상동성 정렬 또는 관련 기술분야에 공지된 다른 방법에 의해 결정된 바와 같이, 상기 열거된 위치에 상응하는 하나 이상의 아미노산을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 E75F, R76K, S82C, A83K, D84E, G85A, L86K, P87E, N88R, Y90F, 및 N91S 중 하나 이상을 포함한다. 따라서, 일부 실시양태에서, 엑소뉴클레아제 도메인 또는 그의 부분을 포함하는 절편은 상이한 폴리머라제로부터의 상응하는 엑소뉴클레아제 도메인에 대해 교환된다. 예를 들어, 일부 실시양태에서, 하나의 폴리머라제의 엑소뉴클레아제 도메인의 플랭킹 아미노산 및 루프를 포함하는 절편은 또 다른 폴리머라제로부터의 상응하는 절편으로 대체된다. 예를 들어, 일부 실시양태에서, Φ29 E75-N91 절편은 이. 파에시움으로부터의 상응하는 F72-S89 절편으로 대체된다. 일부 실시양태에서, 엑소뉴클레아제 루프를 포함하는 절편을 교환하는 것은 폴리머라제의 인터펄스 거리를 감소시킬 수 있다.
일부 실시양태에서, 변형된 폴리머라제는 TPR1 영역 내의 하나 이상의 위치에 돌연변이를 포함한다. 예를 들어, 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 Y281, I288, T301, D325, D341, 및 K354에 상응하는 하나 이상 (예를 들어, 1, 2, 3, 4, 5, 또는 6개)의 위치에 돌연변이를 포함한다. 일부 실시양태에서, 본 개시내용의 변형된 폴리머라제는 Y281, I288, T301, D325, D341, 및 K354 중 하나 이상 (예를 들어, 1, 2, 3, 4, 5, 또는 6개)에 돌연변이를 포함하는 변형된 Φ29 폴리머라제이다. 일부 실시양태에서, Y281, I288, T301, D325, D341, 및 K354 중 하나 이상 (예를 들어, 1, 2, 3, 4, 5, 또는 6개)에서의 아미노산은 다른 폴리머라제 (예를 들어, M2Y, 루실리아 쿠프리나, 바실루스 균주, 예를 들어 GA-1) 내의 상응하는 위치에서의 아미노산으로 변화된다. 일부 실시양태에서, 변형된 폴리머라제는 Y281H, I288L, T301C, D325E, D341E, 및 K354R 중 하나 이상 (예를 들어, 1, 2, 3, 4, 5, 또는 6개)을 포함한다. 일부 실시양태에서, Φ29 폴리머라제 내의 Y281, I288, T301, D325, D341, 및 K354에 상응하는 하나 이상 (예를 들어, 1, 2, 3, 4, 5, 또는 6개)의 위치에서의 돌연변이는 (예를 들어, 단일 분자 시퀀싱 반응에서의) 혼입 속도를 증가시킨다.
일부 실시양태에서, 변형된 폴리머라제는 팜 영역 내의 하나 이상의 위치에 돌연변이를 포함한다. 예를 들어, 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 M429, G430, V431, I433, 및 A444에 상응하는 하나 이상 (예를 들어, 1, 2, 3, 4, 또는 5개)의 위치에 돌연변이를 포함한다. 일부 실시양태에서, 본 개시내용의 변형된 폴리머라제는 M429, G430, V431, I433, 및 A444 중 하나 이상 (예를 들어, 1, 2, 3, 4, 또는 5개)에 돌연변이를 포함하는 변형된 Φ29 폴리머라제이다. 일부 실시양태에서, M429, G430, V431, I433, 및 A444 중 하나 이상 (예를 들어, 1, 2, 3, 4, 또는 5개)에서의 아미노산은 다른 폴리머라제 (예를 들어, M2Y, 루실리아 쿠프리나, 바실루스 균주, 예를 들어 GA-1) 내의 상응하는 위치에서의 아미노산으로 변화된다. 일부 실시양태에서, 변형된 폴리머라제는 M429L, G430A, V431S, I433V, 및 A444T 중 하나 이상 (예를 들어, 1, 2, 3, 4, 또는 5개)을 포함한다. 일부 실시양태에서, Φ29 폴리머라제 내의 M429, G430, V431, I433, 및 A444에 상응하는 하나 이상 (예를 들어, 1, 2, 3, 4, 또는 5개)의 위치에서의 돌연변이는 (예를 들어, 단일 분자 시퀀싱 반응에서의) 정확도를 증가시킨다.
일부 실시양태에서, 변형된 폴리머라제는 팜 영역 내의 하나 이상의 위치 및 엑소뉴클레아제 영역 내의 하나 이상의 위치에 돌연변이를 포함한다. 예를 들어, 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 G197, M8, 및 V51에 상응하는 하나 이상 (예를 들어, 1, 2, 또는 3개)의 위치에 돌연변이를 포함한다. 일부 실시양태에서, 본 개시내용의 변형된 폴리머라제는 G197, M8, 및 V51 중 하나 이상 (예를 들어, 1, 2, 또는 3개)에 돌연변이를 포함하는 변형된 Φ29 폴리머라제이다. 일부 실시양태에서, 변형된 폴리머라제는 G197D, M8R, 및 V51A 중 하나 이상 (예를 들어, 1, 2, 또는 3개)을 포함한다. 일부 실시양태에서, Φ29 폴리머라제 내의 G197, M8, 및 V51에 상응하는 하나 이상 (예를 들어, 1, 2, 또는 3개)의 위치에서의 돌연변이는 생산 수율, 열 안정성을 개선시키고/시키거나 부하 (예를 들어, 어레이의 샘플 웰 내로의 부하)의 효율을 개선시킬 수 있다.
일부 실시양태에서, 변형된 폴리머라제는 팜 영역 내의 하나 이상의 위치 및 섬 영역 내의 하나 이상의 위치에 돌연변이를 포함한다. 예를 들어, 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 E466, D476, K539, D570, 및 T571에 상응하는 하나 이상 (예를 들어, 1, 2, 3, 4, 또는 5개)의 위치에 돌연변이를 포함한다. 일부 실시양태에서, 본 개시내용의 변형된 폴리머라제는 E466, D476, K539, D570, 및 T571 중 하나 이상 (예를 들어, 1, 2, 3, 4, 또는 5개)에 돌연변이를 포함하는 변형된 Φ29 폴리머라제이다. 일부 실시양태에서, 변형된 폴리머라제는 E466K, D476H, K539E, D570S, 및 T571V 중 하나 이상 (예를 들어, 1, 2, 3, 4, 또는 5개)을 포함한다.
일부 실시양태에서, 변형된 폴리머라제는 M2Y 폴리머라제 내의 N59, Y145, V247, L250, E372, A481, 및 K509에 상응하는 위치에 하나 이상 (예를 들어, 1, 2, 3, 4, 5, 6, 또는 7개)의 아미노산 돌연변이를 포함한다. 예를 들어, 일부 실시양태에서, 변형된 폴리머라제가 M2Y 폴리머라제 대다수의 서열을 포함하는 경우, 이러한 변형된 폴리머라제는 앞에 열거된 바와 같은 위치에 하나 이상의 돌연변이를 포함한다. 일부 실시양태에서, 변형된 폴리머라제가 M2Y 폴리머라제 대다수의 서열을 포함하지 않는 경우, 이러한 변형된 폴리머라제는, 예를 들어, 상동성 정렬 또는 관련 기술분야에 공지된 다른 방법에 의해 결정된 바와 같이, 상기 열거된 위치에 상응하는 하나 이상의 아미노산 돌연변이를 포함한다.
일부 실시양태에서, 변형된 폴리머라제는 야생형 폴리머라제 (예를 들어, 표 1에 제시된 바와 같음)의 하나 이상의 절편 (예를 들어, 플랭킹 아미노산을 임의로 포함한, 도메인 또는 그의 부분)을 포함한다. 일부 실시양태에서, 엔테로코쿠스 파에시움 폴리머라제의 하나 이상의 절편 (예를 들어, 플랭킹 아미노산을 임의로 포함한, 도메인 또는 그의 부분) (예를 들어, 서열식별번호: 5의 하나 이상의 절편)이 서열식별번호: 1-4, 및 6-19 중 임의의 것의 하나 이상의 절편을 대체할 수 있다. 일부 실시양태에서, 엔테로코쿠스 파에시움 폴리머라제의 하나 이상의 절편 (예를 들어, 플랭킹 아미노산을 임의로 포함한, 도메인 또는 그의 부분)이 Φ29 폴리머라제의 하나 이상의 절편을 대체할 수 있다. 일부 실시양태에서, 엔테로코쿠스 파에시움 폴리머라제의 하나 이상의 절편 (예를 들어, 플랭킹 아미노산을 임의로 포함한, 도메인 또는 그의 부분)이 M2Y 폴리머라제의 하나 이상의 절편을 대체할 수 있다. 일부 실시양태에서, 엔테로코쿠스 파에시움 폴리머라제의 하나 이상의 절편 (예를 들어, 플랭킹 아미노산을 임의로 포함한, 도메인 또는 그의 부분)이 Φ29 폴리머라제 및/또는 M2Y 폴리머라제의 하나 이상의 절편을 대체할 수 있다. 일부 실시양태에서, 엔테로코쿠스 파에시움 폴리머라제의 하나 이상의 절편 (예를 들어, 플랭킹 아미노산을 임의로 포함한, 도메인 또는 그의 부분) (예를 들어, 서열식별번호: 5의 도메인 또는 그의 변형된 형태, 예를 들어, 하나 이상의 아미노산 치환을 함유함)이 본원에 기재된 변이체 폴리머라제 (예를 들어, 표 2에 열거된 변이체 폴리머라제, 또는 표 2에 예시되거나 또는 표 3-5에 기재된 하나 이상의 아미노산 치환 또는 다른 도메인 치환을 함유하는 변이체 폴리머라제)의 하나 이상의 절편을 대체할 수 있다.
일부 실시양태에서, 변형된 폴리머라제의 대다수의 서열은 예로서 상기 열거된 폴리머라제 내의 위치에 상응하는 하나 이상의 상동 아미노산을 포함하지 않는다. 이러한 경우, 일부 실시양태에서, 변형된 폴리머라제는 하나 이상의 돌연변이를 포함하지 않는다. 그러나, 일부 실시양태에서, 원하는 아미노산 서열을 본원에 기재된 폴리머라제 서열과 비교할 때 주변 상동 잔기가 확인 가능한 경우, 돌연변이된 아미노산은 상기 주변 상동 잔기에 기초하여 추론되는 폴리머라제 내의 특정 부위에서의 삽입으로서 상기 변형된 폴리머라제에 포함된다. 돌연변이된 폴리머라제 변이체는 본원에 기재된 실시양태에 따라서 조작되었고 표 2에 열거된다 (서열식별번호: 20-96).
<표 2>
상동 폴리머라제 변이체
일부 실시양태에서, 아미노산은 폴리머라제의 구조 및/또는 기능에 기초하여 변형을 위해 선택된다. 예를 들어, 도 2는 Φ29 폴리머라제 (200)의 카툰 예시를 도시한다. 폴딩된 3차원 구조는 오버레이 (202)에 상응하는 별개의 도메인 및 서브 도메인을 포함한다: N-말단 엑소뉴클레아제 도메인 (1); 및 팜 서브 도메인 (2), 말단 단백질 영역 1 서브 도메인 (TPR1) (3), 핑거 서브 도메인 (4), TPR2 서브 도메인 (5), 및 섬 서브 도메인 (6)을 함유하는 C-말단 폴리머라제 도메인. 이들 도메인 및 서브 도메인은 N-말단에서 C-말단 방식으로 배향되는, 폴리펩티드 구축물 (204)에 따르는 폴리펩티드 가닥의 부위에 매핑된다. 도시된 바와 같이, N-말단 엑소뉴클레아제 도메인 (1)은 야생형 Φ29 폴리머라제의 잔기 1-189에 걸쳐 있고, C-말단 폴리머라제 도메인은 잔기 190-575에 걸쳐 있다. C-말단 폴리머라제 도메인 내에서, 팜 서브 도메인 (2)은 야생형 Φ29 폴리머라제의 잔기 190-260 및 427-530에 걸쳐 있고, TPR1 서브 도메인 (3)은 잔기 261-358에 걸쳐 있으며, 핑거 서브 도메인 (4)은 잔기 359-394에 걸쳐 있고, TPR2 서브 도메인 (5)은 잔기 395-426에 걸쳐 있으며, 섬 서브 도메인 (6)은 잔기 531-575에 걸쳐 있다. 본 출원에 기재된 상이한 폴리머라제의 등가 절편 (예를 들어, 플랭킹 아미노산을 임의로 포함한, 도메인 또는 그의 부분)이 서로 대체되어 키메라 폴리머라제를 생산할 수 있다. 예를 들어, 하나의 폴리머라제 (예를 들어, 표 1에 제시된 야생형 서열을 갖거나 또는 표 2에 예시되거나 또는 표 3-5에 기재된 하나 이상의 돌연변이를 갖는다)로부터의 엑소뉴클레아제 도메인, 팜 서브 도메인, TPR1 서브 도메인, 하나 이상의 핑거 서브 도메인, TPR2 서브 도메인, 및/또는 섬 서브 도메인 중 하나 이상이 또 다른 폴리머라제 (예를 들어, 표 1에 제시된 야생형 서열을 갖거나 또는 표 2에 예시되거나 또는 표 3-5에 기재된 하나 이상의 돌연변이를 갖는다) 내의 상응하는 도메인을 대체할 수 있다. 일부 실시양태에서, 하나 이상의 플랭킹 아미노산을 임의로 포함한, 이들 도메인 중 하나 이상의 부분을 포함하는 절편이 대체할 수 있다.
일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 이외의 대다수의 폴리머라제 서열을 포함한다. 이러한 실시양태에서, 대다수의 폴리머라제 서열은 (예를 들어, 상동성 정렬, 계산 모델링, 구조적 분석, 또는 임의의 적합한 방법에 기초하여) Φ29 폴리머라제 (200)로 유추될 수 있는 하나 이상의 영역을 포함한다. 본원에 사용된 바와 같은, 폴리머라제의 "영역"은 폴리머라제 효소의 별개의 도메인 또는 서브 도메인을 지칭한다. 예를 들어, 일부 실시양태에서, 폴리머라제의 영역은 N-말단 엑소뉴클레아제 도메인 또는 C-말단 폴리머라제 도메인을 지칭한다. 일부 실시양태에서, 폴리머라제의 영역은 팜 서브 도메인, TPR1 서브 도메인, 핑거 서브 도메인, TPR2 서브 도메인, 또는 섬 서브 도메인을 지칭한다. 따라서, 일부 실시양태에서, 폴리머라제의 영역은 소정의 도메인 또는 서브 도메인을 포함하는 모든 아미노산을 지칭한다. 일부 실시양태에서, 변형된 폴리머라제는 대다수의 폴리머라제 서열의 하나 이상의 영역에 대한 변형을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 대다수의 폴리머라제 서열의 하나 이상의 부분에 대한 변형을 포함한다. 본원에 사용된 바와 같은, 폴리머라제의 "부분"은 폴리머라제 서열 내의 2개 이상의 연속되는 잔기의 연장물을 지칭한다. 일부 실시양태에서, 폴리머라제 서열의 부분은 단일 폴리머라제 도메인 또는 단일 폴리머라제 서브 도메인 내의 2개 이상의 연속되는 아미노산을 지칭한다. 일부 실시양태에서, 폴리머라제 서열의 부분은 2개 이상의 폴리머라제 도메인 및/또는 서브 도메인 전역에 걸쳐 있는 2개 이상의 연속되는 아미노산을 지칭한다. 따라서, 일부 실시양태에서, 폴리머라제 서열의 부분은 폴리머라제 서열 이내의 연속되는 아미노산의 임의의 연장물이다. 일부 실시양태에서, 부분은 5-10개의 연속되는 아미노산, 10-25개의 연속되는 아미노산, 25-50개의 연속되는 아미노산, 50-75개의 연속되는 아미노산, 75-100개의 연속되는 아미노산 또는, 예를 들어, 폴리머라제 영역 또는 도메인의 부분을 구성하는 다른 수의 연속되는 아미노산을 지칭한다.
일부 실시양태에서, 변형된 폴리머라제는 일반적으로 도 2에 도시된 바와 같은 도메인 및/또는 서브 도메인 중 하나 이상 내에서의 하나 이상의 단일 부위 돌연변이를 포함한다. 예를 들어, 도 3은 각각의 폴리펩티드 가닥 이내의 돌연변이 부위 (화살표로 그 근차치가 제시됨)를 수반한 표 2의 선택된 돌연변이 변이체를 도시한다. M2Y 및 M2Y 돌연변이 변이체 H016 (열린 채움), 루실리아 쿠프리나 및 루실리아 쿠프리나 돌연변이 변이체 H018 (점자 채움), 엔테로코쿠스 파에시움 및 엔테로코쿠스 파에시움 돌연변이 변이체 H020 (파선 채움), 및 바실루스 파지 VMY22 및 바실루스 파지 VMY22 돌연변이 변이체 H022 (대각선 채움)에 대한 폴리펩티드 가닥이 도시된다. 그러나, 본원에 기재된 바와 같은 다른 절편 교환 및/또는 아미노산 돌연변이를 포함하는 키메라가 사용될 수도 있다.
일부 실시양태에서, 본원에 기재된 하나 이상의 단일 부위 돌연변이 변형 이외에 또는 그에 대한 대안으로, 대다수의 폴리머라제 서열 내의 아미노산의 연장물 (예를 들어, 2개 이상의 연속되는 아미노산)이 변형된다. 일부 실시양태에서, 아미노산의 연장물은 상이한 폴리머라제 서열의 부분에 상응하는 아미노산의 연장물이다. 예를 들어, 일부 실시양태에서, 대다수의 폴리머라제 서열의 도메인/서브 도메인 (또는 그 내에서의 부분)은 상이한 폴리머라제 서열의 상응하는 도메인/서브 도메인 (또는 그 내에서의 부분)으로 교환된다. 이러한 실시양태에서, 폴리머라제는 키메라 폴리머라제, 키메라 폴리머라제 변이체, 또는 키메라로서 지칭된다. 키메라 폴리머라제는 본원에 기재된 실시양태에 따라서 조작되었고, 표 3에 열거된다 (서열식별번호: 97-516).
<표 3>
키메라 폴리머라제 변이체
일부 실시양태에서, 본 개시내용의 변형된 재조합 폴리머라제 효소는 표 3으로부터 선택된다. 일부 실시양태에서, 키메라 폴리머라제 변이체 (예를 들어, 표 3에 열거된 바와 같음)는 상이한 폴리머라제 서열의 영역 또는 부분으로 치환된 대다수의 서열의 영역 또는 부분을 갖는 대다수의 폴리머라제 서열을 포함한다. 일부 실시양태에서, 대다수의 폴리머라제 서열 내의 영역 (예를 들어, 도메인 및/또는 서브 도메인)을 포함하는 잔기 모두는 상이한 폴리머라제 서열 내의 상응하는 영역을 포함하는 잔기 모두로 치환된다. 일부 실시양태에서, 대다수의 폴리머라제 서열 내의 영역을 포함하는 잔기의 적어도 특정 부분은 상이한 폴리머라제 서열 내의 상응하는 영역을 포함하는 잔기의 적어도 특정 부분으로 치환된다.
일부 실시양태에서, 대다수의 서열 내의 단일 서브 도메인 만이 상이한 서열의 상응하는 서브 도메인으로 치환된다. 예를 들어, 도 4는 표 3으로부터 선택된 키메라 폴리머라제 변이체를 도시한다. 6개의 선택된 변이체가, 아미노 말단에서 카르복시 말단 배향으로 폴리펩티드 이내에 일반적으로 발생하는 바와 같이 서브 도메인을 갖는 폴리펩티드 가닥으로서 제시된다. 도 4의 폴리펩티드 가닥 각각은 Q001의 폴리머라제 대다수의 서열 (흑색 채움)을 포함하며, 하나 이상의 도메인 및/또는 서브 도메인이 M2Y 폴리머라제 (서열식별번호: 2, 열린 채움)의 하나 이상의 상응하는 도메인 및/또는 서브 도메인 또는 루실리아 쿠프리나 (서열식별번호: 3, 점자 채움)의 하나 이상의 상응하는 도메인 및/또는 서브 도메인 및/또는 하나 이상의 플랭킹 아미노산으로 치환된다.
일부 실시양태에서, 키메라 폴리머라제 변이체는 상이한 폴리머라제 서열로부터 치환된 엑소뉴클레아제 도메인을 갖는 대다수의 폴리머라제 서열을 포함한다. 도 4에 도시된 바와 같이, C017은 M2Y 폴리머라제 서열 (예를 들어, 서열식별번호: 2에 제시된 바와 같음)로부터 치환된 엑소뉴클레아제 도메인을 포함하는 키메라 폴리머라제 변이체이다. 유사하게, C020은 루실리아 쿠프리나 폴리머라제 서열 (예를 들어, 서열식별번호: 3에 제시된 바와 같음)로부터 치환된 엑소뉴클레아제 도메인을 포함한다. 일부 실시양태에서, 변형된 폴리머라제 변이체 내의 엑소뉴클레아제 도메인의 변형 또는 대체는 폴리머라제의 교정 능력이 바람직하지 않은 경우 (예를 들어, 시퀀싱 반응에서)에 유용할 수 있다. 그러나, 부가의 및 대안 도메인 및/또는 서브 도메인 치환이 본 개시내용의 변형된 재조합 폴리머라제를 위해 고려된다는 것을 인지해야 한다.
일부 실시양태에서, 키메라 폴리머라제 변이체는 상이한 폴리머라제 서열로부터 치환된 엑소뉴클레아제 루프를 갖는 대다수의 폴리머라제 서열을 포함한다. 본원에 사용된 바와 같은, 일부 실시양태에서, "엑소뉴클레아제 루프"는 엑소뉴클레아제 도메인 내에 루프 영역을 형성하는 연속되는 아미노산의 연장물을 지칭한다. 예를 들어, 도 5a는 전체 투시도 (500) 및 확대 투시도 (502)에서의 Φ29 폴리머라제의 카툰 예시를 도시한다. 전체 투시도 (500)로 도시된 박스 내에 있는 영역의 확대도인 확대 투시도 (502)는 Φ29 폴리머라제의 엑소뉴클레아제 도메인 내의 루프 영역을 나타낸다. 선택된 루프 잔기는 잔기 N77 내지 N88에 걸쳐 있는 엑소뉴클레아제 루프를 형성하는 연속되는 아미노산의 연장물과 함께 확대 투시도 (502)의 스틱 형태로 도시된다. 이러한 엑소뉴클레아제 도메인의 영역에 대한 진화 보존 분석 결과, 루프 및 몇 개의 플랭킹 잔기가 비교적 잘 보존되지 않은 것으로 밝혀졌다. 도 5b는 Φ29 폴리머라제의 엑소뉴클레아제 영역과 표 1로부터 선택된 다른 폴리머라제의 비-제한적 세트 간의 상동성 정렬 (504)을 도시한다. 또한, Φ29 폴리머라제의 엑소뉴클레아제 루프 N77-N88 및 다른 폴리머라제 내의 상응하는 엑소뉴클레아제 루프를 보여주는 루프 상동성 정렬 (506)이 도시된다.
Φ29 폴리머라제의 엑소뉴클레아제 루프 N77-N88에 상응하는 영역 내에서 비교적 낮은 보존성을 보여주는 상동성 분석에 기초하여, 이는 폴리머라제 변이체에서 바람직한 생화학적 특성 (예를 들어, 시퀀싱 반응에서 사용하기에 바람직하다)에 대한 검색에서 변이 공급원을 제공하였다. 따라서, 일부 실시양태에서, 키메라 폴리머라제 변이체는 상이한 폴리머라제 서열로부터 치환된 엑소뉴클레아제 루프를 갖는 대다수의 폴리머라제 서열을 포함하며, 여기서 "엑소뉴클레아제 루프"는 Φ29 폴리머라제의 엑소뉴클레아제 루프 N77-N88과 상동이다 (예를 들어, 도 5b 내의 루프 상동성 정렬 (506)에 의해 도시된 바와 같음).
도 5b 내의 예시적인 정렬에 의해 도시된 바와 같이, 서열 상동성 분석은 Φ29 폴리머라제의 N77-N88과 상동인 엑소뉴클레아제 루프 서열을 확인하기 위해 사용될 수 있다. 한 예로서 제한 없이, 루프 상동성 정렬 (506)은 M2Y (H74-N85), 루실리아 쿠프리나 (N64-G76), 이. 파에시움 (N74-R86), 바실루스 GA-1 (N74-K88), 바실루스 VMY22 (K80-K91), 악티노마이세스(Actinomyces) AV-1 (H93-K105), 감자 낭 선충류 (L86-K99), 이베리아 스라소니 내장(Iberian lynx gut) (D73-R87), 칸디다투스(Candidatus) (N85-N98), 및 에게르텔라 종(Eggerthella sp.) (V73-K88)에 대한 상동 엑소뉴클레아제 루프 서열을 나타낸다. 따라서, 일부 실시양태에서, 치환된 엑소뉴클레아제 루프는 Φ29 폴리머라제의 N77-N88과의 상동성 영역 내의 약 12개 내지 약 16개의 아미노산을 포함할 수 있다. 일부 실시양태에서, 치환된 엑소뉴클레아제 루프는 Φ29 폴리머라제의 N77-N88과의 상동성 영역 내의 약 10개 아미노산 내지 20개 이하의 아미노산, 약 5개 아미노산 내지 15개 이하의 아미노산, 약 5개 아미노산 내지 20개 이하의 아미노산, 또는 약 5개 아미노산 내지 25개 이상의 아미노산을 포함한다.
일부 실시양태에서, 본 출원의 변형된 폴리머라제는 Φ29 폴리머라제의 N77-N88과의 상동성의 엑소뉴클레아제 루프를 포함하는 엑소뉴클레아제 도메인의 영역 내의 하나 이상의 아미노산 돌연변이를 포함한다. 예를 들어, 일부 실시양태에서, 본 개시내용의 변형된 폴리머라제는 Φ29 폴리머라제 내의 E75, R76, S82, A83, D84, G85, L86, P87, N88, Y90, 및 N91 중 하나 이상에서의 돌연변이를 포함하는 변형된 Φ29 폴리머라제이다. 일부 실시양태에서, 변형된 폴리머라제는 E75F, R76K, S82C, A83K, D84E, G85A, L86K, P87E, N88R, Y90F, 및 N91S 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 E75, R76, S82, A83, D84, G85, L86, P87, N88, Y90, 및 N91에 상응하는 위치에 하나 이상의 아미노산 돌연변이를 포함한다. 예를 들어, 일부 실시양태에서, 변형된 폴리머라제가 Φ29 폴리머라제 대다수의 서열을 포함하지 않는 경우, 이러한 변형된 폴리머라제는, 예를 들어, 상동성 정렬 또는 관련 기술분야에 공지된 다른 방법에 의해 결정된 바와 같이, 상기 열거된 위치에 상응하는 하나 이상의 아미노산을 포함한다.
일부 실시양태에서, 키메라 폴리머라제 변이체는 상이한 폴리머라제 서열로부터 치환된 TPR1 서브 도메인을 갖는 대다수의 폴리머라제 서열을 포함한다. 예를 들어, C018은 M2Y 폴리머라제 서열로부터 치환된 TPR1 서브 도메인을 포함하는 키메라 폴리머라제이다. 유사하게, C021은 루실리아 쿠프리나 폴리머라제로부터 치환된 TPR1 서브 도메인을 포함한다. 일부 실시양태에서, 키메라 폴리머라제 변이체는 상이한 폴리머라제 서열로부터 치환된 팜 서브 도메인을 갖는 대다수의 폴리머라제 서열을 포함한다. 일부 실시양태에서, 키메라 폴리머라제 변이체는 상이한 폴리머라제 서열로부터 치환된 핑거 서브 도메인을 갖는 대다수의 폴리머라제 서열을 포함한다. 일부 실시양태에서, 키메라 폴리머라제 변이체는 상이한 폴리머라제 서열로부터 치환된 TPR2 서브 도메인을 갖는 대다수의 폴리머라제 서열을 포함한다. 일부 실시양태에서, 키메라 폴리머라제 변이체는 상이한 폴리머라제 서열로부터 치환된 섬 서브 도메인을 갖는 대다수의 폴리머라제 서열을 포함한다. 본원에 기재된 바와 같은, 변형된 재조합 폴리머라제는 2개 이상의 도메인 및/또는 서브 도메인 치환을 포함하는 키메라 폴리머라제 변이체를 포함한다.
일부 실시양태에서, 대다수의 서열 내의 2개의 영역 (예를 들어, 도메인/서브 도메인)이 상이한 서열의 2개의 상응하는 영역 (예를 들어, 상응하는 도메인/서브 도메인)으로 치환된다. 예를 들어, 도 4에 도시된 바와 같이, C019는 M2Y 폴리머라제 서열의 상응하는 엑소뉴클레아제 도메인 및 TPR1 서브 도메인으로 치환된 엑소뉴클레아제 도메인 및 TPR1 서브 도메인을 포함하는 키메라 폴리머라제이다. 유사하게, C022는 루실리아 쿠프리나 폴리머라제의 상응하는 엑소뉴클레아제 도메인 및 TPR1 서브 도메인으로 치환된 엑소뉴클레아제 도메인 및 TPR1 서브 도메인을 포함한다. 일부 실시양태에서, 부가의 도메인 및/또는 서브 도메인 치환이 본원에 기재된 변형된 폴리머라제와 함께 고려된다. 예를 들어, 일부 실시양태에서, 대다수의 서열 내의 3개 이상 (예를 들어, 3개, 4개, 5개, 또는 6개)의 영역 (예를 들어, 도메인/서브 도메인)이 상이한 서열의 3개 이상 (예를 들어, 3개, 4개, 5개, 또는 6개)의 상응하는 영역으로 치환된다.
일부 실시양태에서, 키메라 폴리머라제 변이체의 대다수의 폴리머라제 서열은 표 1-3 내의 서열로부터 선택된다. 일부 실시양태에서, 이러한 대다수의 폴리머라제 서열은 표 1-3으로부터 선택된 상이한 폴리머라제 서열로부터 치환된 하나 이상의 영역 및/또는 부분을 포함한다. 예를 들어, 표 4는 표 3으로부터 선택된 키메라 폴리머라제 변이체의 개요를 제공하고, 치환된 영역(들)/부분(들) 및 그 치환이 기초하는 서열에 관한 설명과 함께 각각에 대한 대다수의 폴리머라제 서열을 열거한다.
<표 4>
키메라 폴리머라제 - 치환된 부분
그러나, 예를 들어 본원의 표 중 하나 이상에 기재되고 예시된 바와 같은 다른 키메라가 사용될 수 있고/있거나 추가로 변형될 수 있다.
일부 실시양태에서, 키메라 폴리머라제 변이체는 하나 이상의 부위 특이적 돌연변이를 추가로 포함할 수 있다. 따라서, 일부 실시양태에서, 본원에 기재된 하나 이상의 돌연변이 중 임의의 것 (예를 들어, 표 2 내의 각각의 서열에 포함된 하나 이상의 돌연변이 중 임의의 것)이 본 개시내용에 고려된 키메라 폴리머라제 (예를 들어, 상기에 언급되고 표 3에 열거된 바와 같음) 중 임의의 것에 적용될 수 있다. 도 6은 일반적으로, 하나 이상의 돌연변이를 포함하는 키메라 폴리머라제 변이체를 도시한다. 예를 들어, 돌연변이체 키메라 폴리머라제 (602)는 치환된 M2Y 엑소뉴클레아제 도메인 및 이러한 치환된 도메인 이내에서의 돌연변이를 갖는 Φ29 폴리머라제 대다수의 서열을 포함한다. 일부 실시양태에서, 돌연변이체 키메라 폴리머라제는 2개 이상의 상이한 폴리머라제 서열에 상응하는 영역으로 치환된 2개 이상의 영역을 수반한 대다수의 서열을 포함한다. 예를 들어, 돌연변이체 키메라 폴리머라제 (604)는 치환된 엔테로코쿠스 파에시움 폴리머라제 TPR1 서브 도메인 및 치환된 M2Y 폴리머라제 TPR2 서브 도메인을 갖는 Φ29 폴리머라제 대다수의 서열을 포함하며, 폴리머라제 서열 내의 다양한 위치에서 이루어진 부위 특이적 돌연변이를 수반한다. 일부 실시양태에서, 돌연변이체 키메라 폴리머라제는 상이한 폴리머라제에 상응하는 영역으로 치환된 2개 이상의 영역을 수반한 대다수의 서열을 포함한다. 예를 들어, 돌연변이체 키메라 폴리머라제 (606)는 치환된 엔테로코쿠스 파에시움 폴리머라제 TPR1, TPR2, 및 섬 서브 도메인을 갖는 Φ29 폴리머라제 대다수의 서열을 포함하며, 폴리머라제 서열 내의 다양한 위치에서 이루어진 부위 특이적 돌연변이를 수반한다.
표 5는 표 3으로부터 선택된 키메라 폴리머라제 변이체의 개요를 제공하고, 특별한 변이체가 되도록 이루어진 아미노산 돌연변이에 관한 설명과 함께 각각에 대한 대다수의 폴리머라제 서열을 제공한다.
<표 5>
키메라 폴리머라제 - 부위 특이적 돌연변이체
그러나, 다른 아미노산 돌연변이가 본원에 기재된 하나 이상의 키메라 폴리머라제 내로 혼입될 수 있다. 예를 들어, 하나 이상의 아미노산 변화가 Φ29 폴리머라제 서열과 관련하여 위치 M8, V51, N62, I71, L107, 및/또는 K131 중 하나 이상, 및/또는 위치 K135, L142, G197, Y224, E239, V250, L253, Y281, I288, T301, R306, R308, D325, D341, K354, T368, E375, A437, A444, E466, D476, A484, E508, D510, K512, E515, K539, D570, 및 T571 중 하나 이상에 혼입될 수 있다. 예를 들어, 일부 실시양태에서, 키메라 폴리머라제는 또한, 하기 아미노산 치환: M8R, V51A, N62D, I71V, L107I, 및/또는 K131E 중 하나 이상, 및/또는 하기 아미노산 치환: K135Q, L142K, G197D, Y224K, E239G, V250A, V250I, L253A, L253H, Y281H, I288L, T301C, R306Q, R308L, D325E, D341E, K354R, T368F, E375Y, A437G, A444T, E466K, D476H, A484E, E508R, D510K, D510R, K512Y, E515Q, K539E, D570S, 및/또는 T571V 중 하나 이상을 포함할 수 있다.
본원에 사용된 바와 같은 용어 "폴리머라제" 및 "중합 효소"는 일반적으로, 중합 반응을 촉매할 수 있는 임의의 효소를 지칭한다. 폴리머라제의 예는 DNA 폴리머라제, RNA 폴리머라제, 열 안정성 폴리머라제, 야생형 폴리머라제, 변형된 폴리머라제, 이. 콜라이 DNA 폴리머라제 I, T7 DNA 폴리머라제, 박테리오파지 T4 DNA 폴리머라제 φ29 (파이29) DNA 폴리머라제, Taq 폴리머라제, Tth 폴리머라제, Tli 폴리머라제, Pfu 폴리머라제, Pwo 폴리머라제, VENT® 폴리머라제, Deep VENT™ 폴리머라제, Ex TAQ™ 폴리머라제, LA TAQ™ 폴리머라제, Sso 폴리머라제, Poc 폴리머라제, Pab 폴리머라제, Mth 폴리머라제, ES4 폴리머라제, Tru 폴리머라제, Tac 폴리머라제, Tne 폴리머라제, Tma 폴리머라제, Tca 폴리머라제, Tih 폴리머라제, Tfi 폴리머라제, PLATINUM® Taq 폴리머라제, Tbr 폴리머라제, Tfl 폴리머라제, Tth 폴리머라제, PFUTURBO® 폴리머라제, PYROBEST™ 폴리머라제, Pwo 폴리머라제, KOD 폴리머라제, Bst 폴리머라제, Sac 폴리머라제, 클레노우 단편, 3'에서 5'로의 엑소뉴클레아제 활성을 지닌 폴리머라제, 및 그의 변이체, 변형된 산물 및 유도체를 포함하나, 이에 제한되지는 않는다. 일부 실시양태에서, 폴리머라제는 단일 서브유닛 폴리머라제이다. 폴리머라제의 부가의 예는 M2Y 폴리머라제, 루실리아 쿠프리나 폴리머라제, 엔테로코쿠스 파에시움 폴리머라제, 바실루스 파지 VMY22 폴리머라제, 바실루스 파지 GA-1 폴리머라제, 악티노마이세스 파지 AV-1 폴리머라제, 칸디다투스 모란박테리아(Moranbacteria) 폴리머라제, 바실루스 파지 MG-B1 폴리머라제, 에게르텔라 종 폴리머라제, 스트렙토코쿠스(Streptococcus) 파지 CP-7 폴리머라제, 박테로이데스 종(Bacteroides sp.) 폴리머라제, 클라미디아 트라코마티스(Chlamydia trachomatis) 폴리머라제, 및 글로보데라 팔리다(Globodera pallida) 폴리머라제를 포함한다. DNA 폴리머라제의 비-제한적 예 및 그의 특성은 특히, 문헌 [DNA Replication 2nd edition, Kornberg and Baker, W. H. Freeman, New York, N.Y. (1991)]에 상세히 기재되어 있다. 이러한 서열의 비-제한적 예는 표 1에서 찾을 수 있다 (서열식별번호: 1-19).
표적 핵산의 핵 염기와 상보적인 dNTP 간의 염기쌍을 형성할 때, 폴리머라제는 새로이 합성된 가닥의 3' 히드록실 말단과 dNTP의 알파 포스페이트 간에 포스포디에스테르 결합을 형성함으로써 dNTP를 새로이 합성된 핵산 가닥 내로 혼입시킨다. 일부 실시양태에서, 폴리머라제는 높은 전진성을 지닌 폴리머라제이다. 그러나, 일부 실시양태에서, 폴리머라제는 감소된 전진성을 지닌 폴리머라제이다. 폴리머라제 전진성은 일반적으로, 핵산 주형을 방출하지 않고서도 dNTP를 핵산 주형 내로 연속적으로 혼입할 수 있는 폴리머라제의 능력을 지칭한다.
일부 실시양태에서, 폴리머라제는 낮은 5'-3' 엑소뉴클레아제 활성 및/또는 3'-5' 엑소뉴클레아제를 수반한 폴리머라제이다. 일부 실시양태에서, 폴리머라제는 상응하는 야생형 폴리머라제와 비교하여 감소된 5'-3' 엑소뉴클레아제 활성 및/또는 3'-5' 활성을 갖는 것으로 변형된다 (예를 들어, 아미노산 치환에 의함). DNA 폴리머라제의 추가의 비-제한적 예는 9°NM™ DNA 폴리머라제 [뉴 잉글랜드 바이오랩스(New England Biolabs)], 및 클레노우 엑소-폴리머라제의 P680G 돌연변이체를 포함한다 (Tuske et al. (2000) JBC 275(31):23759-23768). 일부 실시양태에서, 감소된 전진성을 갖는 폴리머라제는 뉴클레오티드 반복 서열의 하나 이상의 연장물 (예를 들어, 동일한 유형의 2개 이상의 순차적 염기)을 함유하는 주형을 시퀀싱하기 위한 증가된 정확도를 제공한다.
핵산 폴리머라제의 전진성, 엑소뉴클레아제 활성, 상이한 유형의 핵산에 대한 상대적 친화성, 또는 다른 특성은 상응하는 야생형 폴리머라제와 비교하여 돌연변이 또는 다른 변형에 의해 관련 기술분야의 통상의 기술자에 의해 증가되거나 또는 감소될 수 있다.
일부 실시양태에서, 변형된 폴리머라제는 하나 이상의 비-자연 아미노산 치환을 포함한다. 본원에 사용된 바와 같은, "비-자연 아미노산"은 하기 20개의 유전적으로 코딩된 알파-아미노산 이외의 임의의 아미노산, 변형된 아미노산, 또는 아미노산 유사체를 지칭한다: 알라닌, 아르기닌, 아스파라긴, 아스파르트산, 시스테인, 글루타민, 글루탐산, 글리신, 히스티딘, 이소류신, 류신, 리신, 메티오닌, 페닐알라닌, 프롤린, 세린, 트레오닌, 트립토판, 티로신, 발린. 일부 실시양태에서, 비-자연 아미노산은 상기 20개의 알파-아미노산 이외의 자연 발생 화합물을 포함할 수 있다. 비-자연 아미노산 및 비-자연 아미노산을 단백질 서열 내로 혼입하는 방법은, 예를 들어, 미국 특허 번호 7,045,337 (그의 내용이 본원에 참조로 포함된다)에 기재된 바와 같이, 관련 기술분야에 공지되어 있다.
본원에 기재된 바와 같은, 폴리머라제 및/또는 폴리머라제 서열은 이들이 공통 조상의 단백질 또는 단백질 서열로부터 자연적으로 또는 인공적으로 유래될 때 "상동"이다. 유사하게, 핵산 및/또는 핵산 서열은 이들이 공통 조상의 핵산 또는 핵산 서열로부터 자연적으로 또는 인공적으로 유래될 때 상동이다. 예를 들어, 임의의 자연 발생 핵산은 폴리펩티드 내의 소정의 위치에서 자연 발생하지 않는 아미노산을 코딩하는 적어도 하나의 특이적 코돈을 포함하도록 임의의 이용 가능한 돌연변이 유발 방법에 의해 변형될 수 있다. 발현될 때, 이와 같이 돌연변이 유발된 핵산은 하나 이상의 돌연변이된 아미노산을 포함하는 폴리펩티드를 코딩한다. 일부 실시양태에서, 상동성은 일반적으로, 2개 이상의 핵산 또는 단백질 (또는 그의 서열) 간의 서열 유사성으로부터 추론된다. 상동성 확립에 유용한 서열 간의 유사성의 정확한 백분율은 문제가 되는 핵산 및 단백질에 따라 다양하지만, 25% 정도의 서열 유사성이 상동성을 확립하는 데 일상적으로 사용된다. 더 높은 수준의 서열 유사성, 예를 들어, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95% 또는 99% 또는 그 초과가 또한, 상동성을 확립하는 데 사용될 수 있다. 서열 유사성 백분율을 결정하는 방법은 관련 기술분야에 널리 공지되어 있다. 일부 실시양태에서, 유사성은, 예를 들어, 디폴트 파라미터를 사용하여, 예를 들어 BLASTP 및 BLASTN 알고리즘을 포함한, 상기 기재된 것과 같은 알고리즘을 사용하여 결정될 수 있다.
일부 실시양태에서, 본 개시내용의 폴리머라제를 발현하기 위해, 이러한 폴리머라제를 코딩하는 DNA를 하나 이상의 발현 벡터 내로 삽입하여, 이와 같이 코딩된 폴리머라제가 전사 및 번역 제어 서열과 작동적으로 연결되도록 한다 [예를 들어, 미국 특허 번호 6,914,128 (그의 내용이 본원에 참조로 포함된다) 참조]. 이와 관련하여, 용어 "작동적으로 연결된"이란 폴리머라제를 코딩하는 서열이 벡터 내로 라이게이션되어 이러한 벡터 내에서의 전사 및 번역 제어 서열이 폴리머라제의 전사 및 번역을 조절하는 의도된 기능을 수행하도록 하는 것을 의미한다. 발현 벡터 및 발현 제어 서열은 사용된 발현 숙주 세포와 화합성이 되도록 선택된다. 폴리머라제-코딩 서열이 표준 방법 (예를 들어, 폴리머라제-코딩 서열 및 벡터 상의 상보적 제한 부위의 라이게이션, 및 제한 부위가 존재하지 않는 경우 평활 말단 라이게이션)에 의해 발현 벡터 내로 삽입된다.
변형된 폴리머라제의 발현을 위하여, 변형된 폴리머라제를 코딩하는 발현 벡터를 표준 기술에 의해 숙주 세포 내로 형질감염시킬 수 있다. 용어 "형질감염"의 다양한 형태는 외인성 DNA를 원핵 또는 진핵 숙주 세포 내로 도입하는 데 흔히 사용되는 광범위한 기술, 예를 들어, 전기천공, 인산칼슘 침전, DEAE-덱스트란 형질감염 등을 포괄하는 것으로 의도된다. 본 개시내용의 폴리머라제를 발현하는 데 적합한 숙주 세포는 원핵 생물, 효모, 또는 고등 진핵 세포를 포함한다.
이러한 목적에 적합한 원핵 생물은 유박테리아, 예컨대 그램 음성 또는 그램 양성 유기체, 예를 들어, 엔테로박테리아세아에(Enterobacteriaceae), 예컨대 에스케리키아(Escherichia), 예를 들어, 이. 콜라이, 엔테로박터(Enterobacter), 에르위니아(Erwinia), 클렙시엘라(Klebsiella), 프로테우스(Proteus), 살모넬라(Salmonella), 예를 들어, 살모넬라 티피무륨(Salmonella typhimurium), 세라티아(Serratia), 예를 들어, 세라티아 마르세스칸스(Serratia marcescans), 및 시겔라(Shigella) 뿐만 아니라 바실루스, 예컨대 비. 서브틸리스(B. subtilis) 및 비. 리케니포르미스(B. licheniformis), 슈도모나스(Pseudomonas), 예컨대 피. 아에루기노사(P. aeruginosa), 및 스트렙토마이세스(Streptomyces)를 포함한다. 원핵 생물 이외에도, 진핵 미생물, 예컨대 섬유상 진균 또는 효모가 폴리펩티드 코딩 벡터에 적합한 클로닝 또는 발현 숙주이다. 사카로마이세스 세레비시아에(Saccharomyces cerevisiae), 또는 일반 빵 효모가 하등 진핵 숙주 미생물 중에서 가장 흔히 사용되고 있다. 그러나, 수많은 다른 속, 종, 및 균주, 예컨대 시조사카로마이세스 폼베(Schizosaccharomyces pombe); 클루이베로마이세스(Kluyveromyces) 숙주, 예컨대, 예를 들어, 케이. 락티스(K. lactis), 케이. 프라길리스(K. fragilis), 케이. 불가리쿠스(K. bulgaricus), 케이. 위케라미이(K. wickeramii), 케이. 왈티이(K. waltii), 케이. 드로소필라룸(K. drosophilarum), 케이. 써모톨레란스(K. thermotolerans), 및 케이. 마륵시아누스(K. marxianus); 피치아 파스토리스(Pichia pastoris); 칸디다(Candida); 트리코데르마 레에시아(Trichoderma reesia); 뉴로스포라 크라사(Neurospora crassa); 쉬반니오마이세스(Schwanniomyces), 예컨대 쉬반니오마이세스 옥시덴탈리스(Schwanniomyces occidentalis); 및 섬유상 진균, 예컨대, 예를 들어, 뉴로스포라(Neurospora), 페니실륨(Penicillium), 톨리포클라디움(Tolypocladium), 및 아스페르길루스(Aspergillus) 숙주, 예컨대 에이. 니둘란스(A. nidulans) 및 에이. 니제르(A. niger)가 통상적으로 이용 가능하고 본원에 유용하다.
일부 실시양태에서, 숙주 세포는 폴리머라제 생산을 위하여 상기 언급된 발현 또는 클로닝 벡터로 형질전환시키고, 프로모터를 유도하거나, 형질전환체를 선택하거나 또는 원하는 서열을 코딩하는 유전자를 증폭시키기 위해 적절하게 변형시킨 통상적인 영양 배지에서 배양한다. 폴리머라제를 생산하기 위해 사용되는 숙주 세포는 각종 배지에서 배양될 수 있다. 상업적으로 이용 가능한 배지, 예컨대 햄스(Ham's) F10™ [시그마(Sigma)], 최소 필수 배지™ (MEM) (시그마), RPMI-1640 (시그마), 및 둘벡코 변형된 이글 배지™ (DMEM) (시그마)가 숙주 세포를 배양하는 데 적합하다. 배양 조건, 예컨대 온도, pH 등은 발현을 위해 선택된 숙주 세포를 이용하여 앞서 사용된 것이고, 관련 기술분야의 통상의 기술자에게 명백할 것이다.
일부 실시양태에서, 폴리머라제 변이체는 세포 내에서, 세포질 주위 공간에서 생산되거나 또는 세포의 배지로 직접 분비될 수 있다. 폴리머라제 변이체가 세포 내에서 생산되는 실시양태에서, 숙주 세포 또는 용해된 세포 (예를 들어, 균질화로부터 생성됨)의 미립자 부스러기는 원심 분리 또는 한외 여과를 포함하지만 이에 제한되지는 않는 다양한 수단에 의해 제거될 수 있다. 폴리머라제가 배지 내로 분비되는 경우, 이러한 발현 시스템으로부터의 상등액은 상업적으로 이용 가능한 단백질 농축 필터를 사용하여 먼저 농축될 수 있으며, 그 후 하나 이상의 부가의 정제 기술을 수행할 수 있으며, 이는 단백질 친화성 크로마토그래피를 포함한 친화성 크로마토그래피, 이온 교환 크로마토그래피, 예컨대 음이온 또는 양이온 교환 크로마토그래피, 및 소수성 상호 작용 크로마토그래피를 포함하지만, 이에 제한되지는 않는다.
일부 실시양태에서, 본 출원의 측면은 생물학적 샘플의 검정과 관계된 방법에 사용될 수 있다. 예시적인 실시양태에서, 본원에 제공된 방법은 샘플 내의 하나 이상의 핵산 또는 폴리펩티드의 서열을 결정하고/하거나 샘플 내의 하나 이상의 핵산 또는 폴리펩티드 변이체 (예를 들어, 관심 유전자 내의 하나 이상의 돌연변이)의 존재 또는 부재를 결정하기 위해 사용되는 기술에 유용하다. 일부 실시양태에서, 시험은 핵산 서열 정보를 제공하거나 또는 진단, 예후, 및/또는 치료 목적으로 하나 이상의 관심 핵산의 존재 또는 부재를 결정하기 위해 환자 샘플 (예를 들어, 인간 환자 샘플) 상에서 수행될 수 있다. 일부 예에서, 진단 시험은, 예를 들어 대상체의 생물학적 샘플 내의 무세포 DNA 분자 및/또는 발현 산물 (예를 들어, RNA)을 시퀀싱함으로써, 대상체의 생물학적 샘플 내의 핵산 분자를 시퀀싱하는 것을 포함할 수 있다. 예를 들어, 본 개시내용은 공동 계류중인 미국 특허 출원 번호: 14/543,865, 14/543,867, 14/543,888, 14/821,656, 14/821,686, 14/821,688, 15/161,067, 15/161,088, 15/161,125, 15/255,245, 15/255,303, 15/255,624, 15/261,697, 15/261,724, 62/289,019, 62/296,546, 62/310,398, 62/339,790, 62/343,997, 62/344,123, 및 62/426,144 (각각의 내용이 본원에 참조로 포함된다)에 기재된 기술에 유리하게 활용될 수 있는 방법 및 조성물을 제공한다.
본 출원의 일부 측면은 생물학적 중합체, 예컨대 핵산 및 단백질을 시퀀싱할 수 있는 기술에 유용하다. 일부 실시양태에서, 본 출원에 기재된 방법 및 조성물은 (예를 들어, 일련의 표지된 뉴클레오티드 또는 아미노산 단량체의 시간 과정에 따른 혼입을 검출함으로써) 핵산 또는 단백질 내로 혼입되는 일련의 뉴클레오티드 또는 아미노산 단량체를 확인해 주는 기술에 사용될 수 있다. 일부 실시양태에서, 본 출원에 기재된 방법 및 조성물은 중합 효소에 의해 합성된 주형 의존성 핵산 시퀀싱 반응 산물 내로 혼입되는 일련의 뉴클레오티드를 확인해 주는 기술 내로 혼입될 수 있다.
시퀀싱 동안, 중합 효소는 표적 핵산 분자 (예를 들어, 시퀀싱 주형의 핵산 분자)의 프라이밍 위치에 커플링 (예를 들어, 부착)될 수 있다. 프라이밍 위치는 표적 핵산 분자의 부분에 상보적인 프라이머를 포함할 수 있다. 대안으로서 프라이밍 위치는 표적 핵산 분자의 이중 가닥 절편 내에 제공되는 갭 또는 닉(nick)이다. 갭 또는 닉은 0 내지 적어도 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 20, 30, 또는 40개의 뉴클레오티드 길이일 수 있다. 닉은 이중 가닥 서열의 한 가닥에서 브레이크를 제공할 수 있으며, 이는 중합 효소, 예컨대, 예를 들어 가닥 치환 폴리머라제 효소를 위한 프라이밍 위치를 제공할 수 있다.
일부 경우에, 시퀀싱 프라이머는 고체 지지체에 고정화될 수 있거나 또는 고정화되지 않을 수 있는 표적 핵산 분자에 어닐링될 수 있다. 고체 지지체는, 예를 들어, 핵산 시퀀싱에 사용되는 통합 장치 상의 샘플 웰을 포함할 수 있다. 일부 실시양태에서, 시퀀싱 프라이머는 고체 지지체에 고정화될 수 있고, 표적 핵산 분자의 혼성화는 또한, 표적 핵산 분자를 고체 지지체에 고정화시킨다. 일부 실시양태에서, 폴리머라제는 고체 지지체에 고정화되고 가용성 프라이머 및 표적 핵산은 폴리머라제에 접촉된다. 그러나, 일부 실시양태에서, 폴리머라제, 표적 핵산 및 프라이머를 포함하는 복합체가 용액 중에 형성되고, 이러한 복합체는 (예를 들어, 폴리머라제, 프라이머, 및/또는 표적 핵산의 고정화를 통해) 고체 지지체에 고정화된다. 일부 실시양태에서, 샘플 웰 내의 어떠한 성분도 고체 지지체에 고정화되지 않는다. 예를 들어, 일부 실시양태에서, 폴리머라제, 표적 핵산, 및 프라이머를 포함하는 복합체가 용액 중에 형성되고, 이러한 복합체는 고체 지지체에 고정화되지 않는다.
적절한 조건 하에, 어닐링된 프라이머/표적 핵산에 접촉되는 폴리머라제 효소는 하나 이상의 뉴클레오티드를 프라이머 상에 부가하거나 혼입시킬 수 있으며, 뉴클레오티드는 프라이머에 5'에서 3'로의 주형 의존성 방식으로 부가될 수 있다. 이와 같이 뉴클레오티드를 (예를 들어, 폴리머라제의 작용을 통해) 프라이머 상으로 혼입하는 것은 일반적으로, 프라이머 연장 반응으로서 지칭될 수 있다. 각각의 뉴클레오티드는 핵산 연장 반응 동안 검출 및 확인될 수 있고 (예를 들어, 그의 발광 수명 및/또는 다른 특징에 기초한다), 연장된 프라이머 내로 혼입된 각각의 뉴클레오티드를 결정하고, 이에 따라 새로이 합성된 핵산 분자의 서열을 결정하는데 사용될 수 있는 검출 가능한 태그와 연합될 수 있다. 새로이 합성된 핵산 분자의 서열 상보성을 통해, 표적 핵산 분자의 서열을 결정할 수도 있다. 일부 경우에, 시퀀싱 프라이머를 표적 핵산 분자에 어닐링시키고 뉴클레오타이드를 시퀀싱 프라이머에 혼입시키는 것은 유사한 반응 조건 (예를 들어, 동일하거나 또는 유사한 반응 온도) 또는 상이한 반응 조건 (예를 들어, 상이한 반응 온도)에서 발생할 수 있다. 일부 실시양태에서, 합성 방법에 의한 시퀀싱은 표적 핵산 분자의 집단 (예를 들어, 표적 핵산의 카피)의 존재 및/또는 표적 핵산의 집단을 달성하기 위한 표적 핵산의 증폭 단계를 포함할 수 있다. 그러나, 일부 실시양태에서, 합성에 의한 시퀀싱은 평가되는 각각의 반응에서 단일 분자의 서열을 결정하는데 사용된다 (그리고 핵산 증폭은 시퀀싱을 위한 표적 주형을 제조하는데 필요하지 않다). 일부 실시양태에서, 복수 개의 단일 분자 시퀀싱 반응은 본 출원의 측면에 따라서 병렬식으로 (예를 들어, 단일 통합 장치 상에서) 수행된다. 예를 들어, 일부 실시양태에서, 복수 개의 단일 분자 시퀀싱 반응은 통합 장치 상의 별도의 반응 챔버에서 각각 수행된다.
일부 실시양태에서, 본 개시내용의 중합 효소는 상당히 작은 용적의 샘플 웰에서 시행되는 단일 분자 시퀀싱 반응에 유용하다. 예를 들어, 샘플 웰의 용적은 일부 구현에서 약 10-21 리터 내지 약 10-15 리터일 수 있다. 샘플 웰이 작은 용적을 갖기 때문에, 단일 샘플 이벤트 (예를 들어, 단일 분자 이벤트)의 검출이 달성 가능하다. 일부 실시양태에서, 표면 (예를 들어, 샘플 웰의 표면)은 본원에 기재된 폴리머라제를 수용하도록 설정된다. 일부 실시양태에서, 샘플 웰은 바닥면과 같은 샘플 웰의 표면 상에 배치될 수 있는 폴리머라제를 수용한다. 일부 실시양태에서, 샘플 웰은 통합 장치 내에 형성되며, 여기서 샘플 웰의 바닥면은 그것이 형성되는 통합 장치의 표면에 대해 원위이다.
특정 실시양태에서, 본원에 기재된 기술은 샘플 웰에 부가될 수 있는 중합 효소, 및 그의 복합체에 관한 것이다. 일부 실시양태에서, 본원에 기재된 중합 효소는 샘플 웰의 표적 용적 (예를 들어, 반응 용적)에 한정될 수 있다. 일부 실시양태에서, 표적 용적은 샘플 웰 내의 영역이다. 하나 이상의 중합 효소가 바닥면 위에 고정화되어야 하는 실시양태에서, 하나 이상의 중합 효소 (예를 들어, 중합 효소 및 그의 복합체)의 부착을 허용하도록 바닥면을 기능화하는 것이 바람직할 수 있다. 일부 실시양태에서, 바닥면은 커플링 기를 포함하는 물질로 기능화된다. 예를 들어, 커플링 기는 화학적 모이어티, 예컨대 아민 기, 카르복실 기, 히드록실 기, 술프히드릴 기, 금속, 킬레이트제 등을 포함할 수 있다. 또 다른 한편으로, 이들은 특이적 결합 요소, 예컨대 비오틴, 아비딘, 스트렙타비딘, 뉴트라비딘, 렉틴, SNAP-태그™ 또는 그에 대한 기질, 연합 또는 결합 펩티드 또는 단백질, 항체 또는 항체 단편, 핵산 또는 핵산 유사체 등을 포함할 수 있다. 부가적으로, 또는 또 다른 한편으로, 커플링 기는 일부 경우에 화학적 작용기와 특이적 결합 요소 둘 다를 포함할 수 있는 관심 분자 (예를 들어, 중합 효소 또는 그의 복합체)와 커플링 또는 결합하는데 사용되는 부가의 기와 커플링하기 위해 사용될 수 있다. 한 예로서, 커플링 기, 예를 들어, 비오틴은 기질 표면 상에 증착될 수 있고 소정의 영역에서 선택적으로 활성화될 수 있다. 이어서, 중간 결합제, 예를 들어, 스트렙타비딘이 제1 커플링 기와 커플링될 수 있다. 이러한 특별한 예에서 비오티닐화될 것인 관심 분자 (예를 들어, 중합 효소 또는 그의 복합체)는 스트렙타비딘과 커플링된다. 일부 실시양태에서, 본원에 기재된 중합 효소는 폴리머라제를 표면 (예를 들어, 샘플 웰의 표면)에 고정화시키는 커플링 기와의 상호 작용을 형성할 수 있는 커플링 모이어티를 추가로 포함할 수 있다. 예를 들어, 일부 실시양태에서, 중합 효소는 아비딘 단백질과 결합할 수 있는 N-말단 또는 C-말단 비오티닐화 서열을 포함한다. 일부 실시양태에서, 비오티닐화 서열은 링커 서열을 추가로 포함한다. 예를 들어, 일부 실시양태에서, C-말단 링커/비오티닐화 서열은 아미노산 서열 GGGSGGGSGGGSGLNDFFEAQKIEWHE (서열식별번호: 517)을 포함한다.
실시예
실시예 1. 변형된 폴리머라제의 발현 및 평가
재조합 폴리머라제 변이체는 이. 콜라이에서 발현되었고, 이를 His-스핀 컬럼을 사용하여 150 mL 규모의 배양물로부터 정제하였다. 단백질 순도는 SDS-PAGE에 이어 쿠마시 블루(Coomassie Blue) 염색함으로써 분석되었다 (도 7). 완충액 교환 및 단백질 농축 후, 30℃에서 30분 동안 트랩 체이스(trap chase)를 이용하여 dNTP의 존재하에 재조합 변이체를 활성 및 전진성에 관하여 평가하였다. 키메라 폴리머라제 변이체 C017 및 C020은 트랩의 존재하에 활성, 전진성, 및 합성 길이를 나타내었다. 변이체 폴리머라제에 의한 dNTP 유사체의 활용률을 측정하여 시퀀싱 반응에서의 폴리머라제의 적합성을 평가하였다. 상동 돌연변이체 변이체와 키메라 폴리머라제 변이체 둘 다는 dN6P의 활용률을 표시하였다. 단일 분자 시퀀싱으로부터의 결과가 하기 표 6에 제시된다.
<표 6>
변형된 폴리머라제를 이용한 시퀀싱 결과
등가물 및 범위
몇 가지 발명적 실시양태가 본원에 기재되고 예시되었지만, 관련 기술분야의 통상의 기술자는 기능을 수행하고/하거나 그 결과 및/또는 본원에 기재된 이점 중 하나 이상을 수득하기 위한 각종 다른 수단 및/또는 구조를 용이하게 구상할 것이며, 이러한 변이 및/또는 변형 각각은 본원에 기재된 발명적 실시양태의 범위 내에 있는 것으로 간주된다. 보다 일반적으로, 관련 기술분야의 통상의 기술자는 본원에 기재된 모든 파라미터, 치수, 물질, 및 입체 배치가 예시적인 것으로 의도되고 실제 파라미터, 치수, 물질, 및/또는 입체 배치가, 본 발명의 교시가 사용하는 특이적 적용(들)에 의존한다는 것을 용이하게 인지할 것이다. 관련 기술분야의 통상의 기술자는 단지 일상적인 실험을 사용하여, 본원에 기재된 특이적 발명적 실시양태에 대한 많은 등가물을 인식하거나 또는 확인할 수 있을 것이다. 따라서, 전술한 실시양태는 단지 한 예로서 제시되고, 첨부된 청구범위 및 그에 대한 등가물의 범위 내에서, 발명적 실시양태는 구체적으로 기재되고 청구된 것과 다르게 실시될 수 있다는 것을 이해해야 한다. 본 개시내용의 발명적 실시양태는 본원에 기재된 각각의 개별적인 특색, 시스템, 물품, 물질, 키트 및/또는 방법에 관한 것이다. 또한, 이러한 특색, 시스템, 물품, 물질, 키트 및/또는 방법이 서로 불일치하지 않는 경우, 이러한 특색, 시스템, 물품, 물질, 키트 및/또는 방법 중 2개 이상의 임의의 조합이 본 개시내용의 발명적 범위 내에 포함된다.
본원에 정의되고 사용된 바와 같은 모든 정의가, 사전적 정의, 참조로 포함된 문헌에서의 정의, 및/또는 정의된 용어의 통상적인 의미에 비해 우선하는 것으로 이해되어야 한다.
본원에 개시된 모든 참고 문헌, 특허 및 특허 출원은 각각이 인용되는 주제에 관해서 참조로 포함되며, 일부 경우에는 그 문서의 전체를 포괄할 수 있다.
본 명세서 및 청구범위에 사용된 바와 같은 단수 형태는 달리 명백하게 표시되지 않는 한, "적어도 하나"를 의미하는 것으로 이해되어야 한다.
본 명세서 및 청구범위에 사용된 바와 같은 문구 "및/또는"은, 이와 같이 결합된 요소 중 "어느 하나 또는 양쪽", 즉 일부 경우에는 결합적으로 존재하고 다른 경우에는 분리적으로 존재하는 요소를 의미하는 것으로 이해되어야 한다. "및/또는"으로 열거된 다수의 요소는 동일한 방식으로, 즉 결합된 요소 중 "하나 이상"으로 해석되어야 한다. 구체적으로 확인된 요소와 관련이 있거나 관련이 없든지 간에, "및/또는" 구절에 의해 구체적으로 확인된 요소 이외에 다른 요소가 임의로 존재할 수 있다. 따라서, 비-제한적 예로서, "포함하는" 것과 같이 제한을 두지 않은 언어와 연계해서 사용될 때, "A 및/또는 B"에 대한 언급은 한 실시양태에서 A 만을 지칭할 수 있고 (B 이외의 요소를 임의로 포함함); 또 다른 실시 양태에서, B 만을 지칭할 수 있으며 (A 이외의 요소를 임의로 포함함); 또한 또 다른 실시양태에서, A와 B 둘 다를 지칭할 수 있다 (다른 요소를 임의로 포함함).
본 명세서 및 청구범위에 사용된 바와 같은 "또는"은 상기 정의된 바와 같은 "및/또는"과 동일한 의미를 갖는 것으로 이해되어야 한다. 예를 들어, 목록에서 항목을 분리할 때, "또는" 또는 "및/또는"은 포괄적인 것으로 해석되어야 하는데, 즉 수많은 요소 또는 요소 목록, 및 임의로 부가의 목록에 없는 항목 중 적어도 하나뿐만 아니라 2개 이상을 포함한다. 그 반대로 명백하게 표시된 용어, 예컨대 "오직 하나" 또는 "정확히 하나", 또는 청구범위에서 사용되는 경우 "~로 이루어진"이란 용어만이 수많은 요소 또는 요소 목록 중 정확히 하나의 요소를 포함하는 것을 지칭할 것이다. 일반적으로, 본원에 사용된 바와 같은 용어 "또는"은 "어느 하나", "하나", "오직 하나" 또는 "정확히 하나"와 같이 배타적인 용어가 선행될 때, 배타적인 대안 (즉, "하나 또는 다른 것이지만, 둘 다가 아닌")을 표시하는 것으로 해석되어야 한다. 청구범위에서 사용될 때 "본질적으로 이루어지는"은 특허법 분야에서 사용된 바와 같은 그의 통상적인 의미를 지닐 것이다.
본 명세서 및 청구범위에 사용된 바와 같이, 하나 이상의 요소의 목록과 관련하여 "적어도 하나"라는 문구는 상기 요소의 목록 내의 임의의 하나 이상의 요소로부터 선택된 적어도 하나의 요소를 의미하는 것으로 이해되어야 하지만, 요소의 목록 내에 구체적으로 열거된 각각의 및 모든 요소 중 적어로 하나를 반드시 포함하지 않고, 요소의 목록 내의 요소의 임의의 조합을 배제하지 않는다. 이러한 정의는 또한, 구체적으로 확인된 요소와 관련이 있는지의 여부와 상관없이, "적어도 하나"라는 문구가 지칭된 요소 목록 내에서 구체적으로 확인된 요소 이외에 요소가 임의로 존재할 수 있게 해준다. 따라서, 비-제한적 예로서, "A와 B 중 적어도 하나" (또는 동등하게, "A 또는 B 중 적어도 하나" 또는 동등하게는 "A 및/또는 B 중 적어도 하나")는 한 실시양태에서, 적어도 하나, 임의로 2개 이상의 A를 포함하고, B가 존재하지 않은 것 (및 임의로 B 이외의 요소를 포함함)을 지칭할 수 있고; 또 다른 실시 양태에서, 적어도 하나, 임의로 2개 이상의 B를 포함하고, A가 존재하지 않은 것 (및 임의로 A 이외의 요소를 포함함)을 지칭할 수 있으며; 또한 또 다른 실시양태에서, 적어도 하나, 임의로 2개 이상의 A를 포함하고, 적어도 하나, 임의로 2개 이상의 B를 포함하는 것 (및 임의로 다른 원소를 포함함)을 지칭할 수 있다.
반대로 명확하게 표시되지 않는 한, 둘 이상의 단계 또는 동작을 포함하는 본원에 청구된 임의의 방법에서는, 그러한 방법의 단계 또는 동작의 순서가 반드시, 그 방법의 단계 또는 동작이 나열되는 순서로 제한되지 않는다는 것을 이해해야 한다.
청구범위뿐만 아니라 상기 명세서에서, "포함하는", "포함하는", "수반하는", "갖는", "함유하는", "포함하는", "보유하다", "구성된" 등과 같은 모든 이행 어구는 제한을 두지 않는 것으로, 즉 포함하나 이에 제한되지는 않는 것을 의미하는 것으로 이해되어야 한다. 이행 어구 "~로 이루어지는" 및 "본질적으로 ~로 이루어지는" 것 만이 미국 특허청 특허 심사 절차 매뉴얼, 섹션 2111.03에 명시된 바와 같이, 각각 폐쇄 또는 반-폐쇄 이행 어구일 것이다. 제한을 두지 않은 이행 어구 (예를 들어, "포함하는")를 사용하여 본 명세서에 기재된 실시양태는 또한, 대안 실시양태에서 제한을 두지 않은 이행 어구에 의해 기재된 특색으로 "이루어진" 및 "본질적으로 이루어진" 것으로 고려된다. 예를 들어, 본 개시내용이 "A 및 B를 포함하는 조성물"을 기재하는 경우, 본 개시내용은 또한, 대안 실시양태에서 "A 및 B로 이루어진 조성물" 및 "본질적으로 A 및 B로 이루어진 조성물"을 고려한다.
SEQUENCE LISTING
<110> Quantum-Si Incorporated
<120> POLYMERIZING ENZYMES FOR SEQUENCING REACTIONS
<130> R0708.70022WO00
<140> Not Yet Assigned
<141> Concurrently Herewith
<150> US 62/436,410
<151> 2016-12-19
<160> 539
<170> PatentIn version 3.5
<210> 1
<211> 575
<212> PRT
<213> Bacillus phage phi29
<400> 1
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Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
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Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
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Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
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Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
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Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
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Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly
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Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
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Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
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Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
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Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
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Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
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Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
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Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
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Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu
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His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
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Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr
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Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu
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Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro
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Thr His Glu Glu Gly Ala Lys Lys Gln Leu Ala Lys Leu Met Leu Asn
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Pro Phe Pro Val Arg Lys Ile Gly Lys Asp Phe Lys Leu Asn Val Leu
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Ser Ser Asn Gly Glu Arg Ile Thr Ile Ser Val Ser Ser Val Asp Trp
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Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Thr Asn Pro
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Asp Ile Thr Gly Lys Arg Pro Tyr Leu Arg Glu Asp Gly Ser Asn Gly
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Gly Ile Phe Ile Thr Ser Trp Ala Arg Tyr Thr Thr Ile Thr Ser Ala
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Phe Ile Arg Gln Lys Thr Tyr Met Glu Glu Tyr Tyr Ala Lys Tyr Val
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Cys Ala Gly Met Pro Asp Asn Ile Lys Lys His Val Thr Phe Asp Asn
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Phe Asp Ile Gly Phe Thr Met Glu Gly Lys Leu Lys Pro Lys Gln Val
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Thr Asp Val Asn Asp Cys Arg Val Trp Ala Tyr Gly Trp Met Glu Ile
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Leu Lys Asn Ser Arg Phe Gly Phe Lys Gly Asn Glu Tyr Leu Ser Ser
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Ser Asn Gly Glu Arg Ile Thr Ile Ser Val Ser Ser Val Asp Trp Glu
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Leu Ile Arg Glu His Tyr His Val Tyr Asp Val Glu Phe Glu Lys Gly
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Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Thr Asn Pro Asp
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Ile Thr Gly Lys Arg Pro Tyr Leu Arg Glu Asp Gly Ser Asn Gly Phe
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Glu Leu Met Glu Glu Glu Phe Arg Asp Pro Val Tyr Thr Pro Val Gly
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Ile Phe Ile Thr Ser Trp Ala Arg Tyr Thr Thr Ile Thr Ser Ala Gln
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Lys Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Met His Leu
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Val Leu Gly Tyr Trp Lys Lys Glu Gly Gln Phe Lys Gln Gly Lys Phe
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Ile Arg Gln Lys Thr Tyr Met Glu Glu Tyr Tyr Ala Lys Tyr Val Arg
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Ile Cys Asp Lys Glu Glu Ser Asp Thr Thr Ile Ile Glu Ile Lys Cys
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Ala Gly Met Pro Asp Asn Ile Lys Lys His Val Thr Phe Asp Asn Phe
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Asp Ile Gly Phe Thr Met Glu Gly Lys Leu Lys Pro Lys Gln Val Tyr
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Gly Gly Val Val Leu Val Glu Glu Thr Tyr Thr Met Lys
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Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
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Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asp Glu Lys Phe Asp Gly
50 55 60
Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly
85 90 95
Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr
100 105 110
Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp
115 120 125
Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe
130 135 140
Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Tyr Thr Lys Glu Arg Pro
145 150 155 160
Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp
165 170 175
Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu
180 185 190
Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp
195 200 205
Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val
210 215 220
Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly
225 230 235 240
Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly
245 250 255
Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg
260 265 270
Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu
275 280 285
Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg
290 295 300
Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu
305 310 315 320
Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val
325 330 335
Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe
340 345 350
Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met
355 360 365
Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile
370 375 380
Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly
385 390 395 400
Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr
405 410 415
Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu
420 425 430
Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe
435 440 445
Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys
450 455 460
Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
465 470 475 480
Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu
485 490 495
Gly Tyr Trp Lys His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg
500 505 510
Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys
515 520 525
Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe
530 535 540
Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln
545 550 555 560
Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys
565 570
<210> 6
<211> 592
<212> PRT
<213> Bacillus phage VMY22
<400> 6
Met Ala Thr Lys Lys Arg Lys Ala Tyr Ser Cys Asp Phe Glu Ala Thr
1 5 10 15
Thr Ser Thr Tyr Ser Glu Thr Glu Thr Arg Val Trp Ala Tyr Gly Trp
20 25 30
Met Glu Ile Gly Asn Thr Ser His Phe Asn Ile Gly Asp Asn Leu Asp
35 40 45
Glu Phe Met Leu Trp Thr Ser Lys Glu Cys Ala Asp Leu Tyr Phe His
50 55 60
Asp Leu Arg Tyr Asp Gly Glu Phe Ile Val Asn Trp Leu Leu His Lys
65 70 75 80
Gly Tyr Glu Cys Asn Glu Ser Gly Arg Pro Lys Thr Phe Asp Thr Val
85 90 95
Ile Ser Lys Gly Gly Gln Trp Tyr Lys Ile Ala Ile His His Glu Gly
100 105 110
Lys Gly Thr Thr Gln Ile Phe Asp Ser Leu Lys Lys Leu Pro Phe Pro
115 120 125
Val Lys Thr Ile Ala Lys Ala Phe Lys Leu Pro Val Leu Lys Gly Asp
130 135 140
Ile Asp Tyr Asn Leu His Arg Asp Glu Asn His Val Ile Thr Ser Glu
145 150 155 160
Glu Phe Thr Tyr Ile Lys His Asp Ile Glu Ile Val Ala Arg Ala Leu
165 170 175
Asp Ile Gln Ile Asn Gln Gln Gly Leu Val Lys Met Thr Asn Gly Ala
180 185 190
Asp Ser Met Asp His Phe Ile Lys Ser Leu Asp Lys Lys Lys Lys Val
195 200 205
Ala Glu Arg Ile Tyr Asn Gln Tyr Phe Pro Lys Met Ser Ile Ala Met
210 215 220
Asp Ser Ile Phe Arg Lys Ala Tyr Arg Gly Gly Phe Thr Trp Val Asn
225 230 235 240
Pro Lys Phe Lys Gly Gln Glu Val Gly Glu Gly Met Val Phe Asp Val
245 250 255
Asn Ser Leu Tyr Pro Ser Val Met Tyr Tyr Lys Pro Leu Pro Trp Gly
260 265 270
Lys Pro Val Pro Phe Val Gly Lys Tyr Glu Glu Asp Pro Asp Phe Pro
275 280 285
Leu Tyr Ile Cys His Ile Lys Thr Gly Phe Val Leu Lys Glu Gly His
290 295 300
Ile Pro Thr Ile Gln Ile Lys Lys Asn Pro Ile Phe Gln Glu Asn Glu
305 310 315 320
Tyr Leu Glu Thr Ser Gly Gly Ala Pro Val Asp Leu His Val Thr Asn
325 330 335
Val Asp Leu Glu Leu Ile Lys Glu His Tyr Glu Leu Tyr Asp Thr Glu
340 345 350
Tyr Val Gly Gly Trp Lys Phe Arg Gln Gln Thr Gly Ile Phe Asn Asn
355 360 365
Phe Ile Asp Tyr Trp Met Lys Ile Lys Thr Asp Pro Lys Ser Thr Pro
370 375 380
Ala Ile Val Thr Leu Ala Lys Leu Gln Leu Asn Ser Leu Tyr Gly Lys
385 390 395 400
Phe Ala Ser His Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp
405 410 415
Asp Gly Ser Thr Ala Phe Lys Lys Gly Leu Pro Lys Ser Lys Asp Pro
420 425 430
Val Tyr Thr Pro Ala Gly Ala Phe Ile Thr Ala Trp Ala Arg His Met
435 440 445
Thr Ile Thr Thr Ala Gln Lys Val Tyr Asp Arg Ile Leu Tyr Cys Asp
450 455 460
Thr Asp Ser Ile His Ile Leu Gly Ile Asp Ile Pro Glu Ala Ile Lys
465 470 475 480
Asn Asp Ile His Gln Lys Glu Leu Gly Lys Trp Ala Phe Glu Cys Met
485 490 495
Phe Lys Arg Ala Lys Phe Val Arg Gln Lys Thr Tyr Val Glu Asp Met
500 505 510
Tyr Ala Lys Phe Met Ser Tyr Trp Glu Asp Gly Glu Leu Asn Tyr Met
515 520 525
Leu Lys Glu Cys Val Lys Glu Glu Ala Thr Ala Arg Leu Leu Asn Val
530 535 540
Lys Cys Ala Gly Met Pro Gln Ala Val Lys Lys Phe Val Thr Phe Arg
545 550 555 560
Thr Phe Ala Val Gly Phe Thr Ser Asp Thr Gly Lys Leu Lys Pro Lys
565 570 575
His Val Lys Gly Gly Gln Ile Leu Val Asp Val Pro Phe Thr Ile Lys
580 585 590
<210> 7
<211> 578
<212> PRT
<213> Bacillus phage GA-1
<400> 7
Met Ala Arg Ser Val Tyr Val Cys Asp Phe Glu Thr Thr Thr Asp Pro
1 5 10 15
Glu Asp Cys Arg Leu Trp Ala Trp Gly Trp Met Asp Ile Tyr Asn Thr
20 25 30
Asp Lys Trp Ser Tyr Gly Glu Asp Ile Asp Ser Phe Met Glu Trp Ala
35 40 45
Leu Asn Ser Asn Ser Asp Ile Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ser Phe Ile Leu Pro Trp Trp Leu Arg Asn Gly Tyr Val His Thr Glu
65 70 75 80
Glu Asp Arg Thr Asn Thr Pro Lys Glu Phe Thr Thr Thr Ile Ser Gly
85 90 95
Met Gly Gln Trp Tyr Ala Val Asp Val Cys Ile Asn Thr Arg Gly Lys
100 105 110
Asn Lys Asn His Val Val Phe Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Lys Val Glu Gln Ile Ala Lys Gly Phe Gly Leu Pro Val Leu Lys Gly
130 135 140
Asp Ile Asp Tyr Lys Lys Tyr Arg Pro Val Gly Tyr Val Met Asp Asp
145 150 155 160
Asn Glu Ile Glu Tyr Leu Lys His Asp Leu Leu Ile Val Ala Leu Ala
165 170 175
Leu Arg Ser Met Phe Asp Asn Asp Phe Thr Ser Met Thr Val Gly Ser
180 185 190
Asp Ala Leu Asn Thr Tyr Lys Glu Met Leu Gly Val Lys Gln Trp Glu
195 200 205
Lys Tyr Phe Pro Val Leu Ser Leu Lys Val Asn Ser Glu Ile Arg Lys
210 215 220
Ala Tyr Lys Gly Gly Phe Thr Trp Val Asn Pro Lys Tyr Gln Gly Glu
225 230 235 240
Thr Val Tyr Gly Gly Met Val Phe Asp Val Asn Ser Met Tyr Pro Ala
245 250 255
Met Met Lys Asn Lys Leu Leu Pro Tyr Gly Glu Pro Val Met Phe Lys
260 265 270
Gly Glu Tyr Lys Lys Asn Val Glu Tyr Pro Leu Tyr Ile Gln Gln Val
275 280 285
Arg Cys Phe Phe Glu Leu Lys Lys Asp Lys Ile Pro Cys Ile Gln Ile
290 295 300
Lys Gly Asn Ala Arg Phe Gly Gln Asn Glu Tyr Leu Ser Thr Ser Gly
305 310 315 320
Asp Glu Tyr Val Asp Leu Tyr Val Thr Asn Val Asp Trp Glu Leu Ile
325 330 335
Lys Lys His Tyr Asp Ile Phe Glu Glu Glu Phe Ile Gly Gly Phe Met
340 345 350
Phe Lys Gly Phe Ile Gly Phe Phe Asp Glu Tyr Ile Asp Arg Phe Met
355 360 365
Glu Ile Lys Asn Ser Pro Asp Ser Ser Ala Glu Gln Ser Leu Gln Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Thr Asn Pro Asp
385 390 395 400
Ile Thr Gly Lys Val Pro Tyr Leu Asp Glu Asn Gly Val Leu Lys Phe
405 410 415
Arg Lys Gly Glu Leu Lys Glu Arg Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Cys Phe Ile Thr Ala Tyr Ala Arg Glu Asn Ile Leu Ser Asn Ala Gln
435 440 445
Lys Leu Tyr Pro Arg Phe Ile Tyr Ala Asp Thr Asp Ser Ile His Val
450 455 460
Glu Gly Leu Gly Glu Val Asp Ala Ile Lys Asp Val Ile Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Asp His Glu Ala Thr Phe Gln Arg Ala Arg Tyr
485 490 495
Val Arg Gln Lys Thr Tyr Phe Ile Glu Thr Thr Trp Lys Glu Asn Asp
500 505 510
Lys Gly Lys Leu Val Val Cys Glu Pro Gln Asp Ala Thr Lys Val Lys
515 520 525
Pro Lys Ile Ala Cys Ala Gly Met Ser Asp Ala Ile Lys Glu Arg Ile
530 535 540
Arg Phe Asn Glu Phe Lys Ile Gly Tyr Ser Thr His Gly Ser Leu Lys
545 550 555 560
Pro Lys Asn Val Leu Gly Gly Val Val Leu Met Asp Tyr Pro Phe Ala
565 570 575
Ile Lys
<210> 8
<211> 566
<212> PRT
<213> Actinomyces phage AV-1
<400> 8
Met Val Arg Gln Ser Thr Ile Ala Ser Pro Ala Arg Gly Gly Val Arg
1 5 10 15
Arg Ser His Lys Lys Val Pro Ser Phe Cys Ala Asp Phe Glu Thr Thr
20 25 30
Thr Asp Glu Asp Asp Cys Arg Val Trp Ser Trp Gly Ile Ile Gln Val
35 40 45
Gly Lys Leu Gln Asn Tyr Val Asp Gly Ile Ser Leu Asp Gly Phe Met
50 55 60
Ser His Ile Ser Glu Arg Ala Ser His Ile Tyr Phe His Asn Leu Ala
65 70 75 80
Phe Asp Gly Thr Phe Ile Leu Asp Trp Leu Leu Lys His Gly Tyr Arg
85 90 95
Trp Thr Lys Glu Asn Pro Gly Val Lys Glu Phe Thr Ser Leu Ile Ser
100 105 110
Arg Met Gly Lys Tyr Tyr Ser Ile Thr Val Val Phe Glu Thr Gly Phe
115 120 125
Arg Val Glu Phe Arg Asp Ser Phe Lys Lys Leu Pro Met Ser Val Ser
130 135 140
Ala Ile Ala Lys Ala Phe Asn Leu His Asp Gln Lys Leu Glu Ile Asp
145 150 155 160
Tyr Glu Lys Pro Arg Pro Ile Gly Tyr Ile Pro Thr Glu Gln Glu Lys
165 170 175
Arg Tyr Gln Arg Asn Asp Val Ala Ile Val Ala Gln Ala Leu Glu Val
180 185 190
Gln Phe Ala Glu Lys Met Thr Lys Leu Thr Ala Gly Ser Asp Ser Leu
195 200 205
Ala Thr Tyr Lys Lys Met Thr Gly Lys Leu Phe Ile Arg Arg Phe Pro
210 215 220
Ile Leu Ser Pro Glu Ile Asp Thr Glu Ile Arg Lys Ala Tyr Arg Gly
225 230 235 240
Gly Phe Thr Tyr Ala Asp Pro Arg Tyr Ala Lys Lys Leu Asn Gly Lys
245 250 255
Gly Ser Val Tyr Asp Val Asn Ser Leu Tyr Pro Ser Val Met Arg Thr
260 265 270
Ala Leu Leu Pro Tyr Gly Glu Pro Ile Tyr Ser Glu Gly Ala Pro Arg
275 280 285
Thr Asn Arg Pro Leu Tyr Ile Ala Ser Ile Thr Phe Thr Ala Lys Leu
290 295 300
Lys Pro Asn His Ile Pro Cys Ile Gln Ile Lys Lys Asn Leu Ser Phe
305 310 315 320
Asn Pro Thr Gln Tyr Leu Glu Glu Val Lys Glu Pro Thr Thr Val Val
325 330 335
Ala Thr Asn Ile Asp Ile Glu Leu Trp Lys Lys His Tyr Asp Phe Lys
340 345 350
Ile Tyr Ser Trp Asn Gly Thr Phe Glu Phe Arg Gly Ser His Gly Phe
355 360 365
Phe Asp Thr Tyr Val Asp His Phe Met Glu Ile Lys Lys Asn Ser Thr
370 375 380
Gly Gly Leu Arg Gln Ile Ala Lys Leu His Leu Asn Ser Leu Tyr Gly
385 390 395 400
Lys Phe Ala Thr Asn Pro Asp Ile Thr Gly Lys His Pro Thr Leu Lys
405 410 415
Asp Asn Arg Val Ser Leu Val Met Asn Glu Pro Glu Thr Arg Asp Pro
420 425 430
Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala Tyr Ala Arg Lys Lys
435 440 445
Thr Ile Ser Ala Ala Gln Asp Asn Tyr Glu Thr Phe Ala Tyr Ala Asp
450 455 460
Thr Asp Ser Leu His Leu Ile Gly Pro Thr Thr Pro Pro Asp Ser Leu
465 470 475 480
Trp Val Asp Pro Val Glu Leu Gly Ala Trp Lys His Glu Ser Ser Phe
485 490 495
Thr Lys Ser Val Tyr Ile Arg Ala Lys Gln Tyr Ala Glu Glu Ile Gly
500 505 510
Gly Lys Leu Asp Val His Ile Ala Gly Met Pro Arg Asn Val Ala Ala
515 520 525
Thr Leu Thr Leu Glu Asp Met Leu His Gly Gly Thr Trp Asn Gly Lys
530 535 540
Leu Ile Pro Val Arg Val Pro Gly Gly Thr Val Leu Lys Asp Thr Thr
545 550 555 560
Phe Thr Leu Lys Ile Asp
565
<210> 9
<211> 593
<212> PRT
<213> Candidatus Moranbacteria
<400> 9
Met Lys Leu Lys Ser Lys Tyr Val Ala Asp Phe Glu Ala Thr Gly Glu
1 5 10 15
Glu Gln Tyr Lys Ile Asp Gly Ser Thr His Val Trp Ala Val Gly Val
20 25 30
Ile Asp Ile Glu Thr Glu Glu Thr Val Leu Ile Ser Asn Asp Ile Ala
35 40 45
Asp Phe Met Asn Trp Leu Ser Lys Asp Asn His Asn His Lys Asn Lys
50 55 60
Glu Val Phe Phe His Asn Leu Lys Tyr Asp Gly Asp Phe Ile Val Lys
65 70 75 80
Phe Leu Leu Glu Asn Gly Phe Lys His Ser Arg Glu Arg Ala Leu Tyr
85 90 95
Ser Asn Glu Phe Ser Thr Leu Ile Ser Asp Thr Gly Thr Trp Tyr Glu
100 105 110
Ile Lys Ile Cys Phe His Ala Leu Lys Thr Arg Lys Val Glu Val Lys
115 120 125
Ile His Asp Ser Tyr Lys Leu Leu Pro Phe Ser Glu Glu Lys Ile Ala
130 135 140
Lys Ala Phe Lys Leu Thr Val Ser Lys Gly Glu Ile Asp Tyr Asp Arg
145 150 155 160
Tyr Arg Pro Val Gly Tyr Gln Leu Gln Glu Tyr Glu Val Asp Tyr Leu
165 170 175
Lys Thr Asp Leu Leu Ile Met Ala Gln Ala Leu Lys Val Gln Met Asn
180 185 190
Lys Gly Leu Thr Lys Met Thr Ile Gly Ser Asn Ala Leu Ala Asp Tyr
195 200 205
Lys Gln Arg Ile Ser Lys Asp Lys Phe Lys Tyr Leu Phe Pro Val Leu
210 215 220
Asp Asn Ile Ile Asp Ala Asp Leu Arg His Ala Tyr Arg Gly Gly His
225 230 235 240
Thr Tyr Leu Gln Pro Phe Tyr Ala Asn Lys Ile Leu Glu Asn Val His
245 250 255
Ser Tyr Asp Lys Asn Ser Met His Pro Ser Gln Met Lys Asn Met Pro
260 265 270
Met Pro Tyr Gly Ile Pro Val Tyr Tyr Glu Gly Glu Tyr Lys Asn Asp
275 280 285
Pro Asp Tyr Pro Leu Phe Ile Gln Ser Ile Glu Ile Asp Cys Lys Val
290 295 300
Lys Lys Gly Tyr Leu Pro Thr Ile Gln Pro Arg Asn Ala Phe Arg Phe
305 310 315 320
Ala Thr Thr Glu Phe Leu Glu Asp Thr Lys Gly Glu Pro Ile Gln Leu
325 330 335
Phe Val Thr Ser Ile Asp Leu Met Leu Ile Leu Glu His Tyr Asp Ile
340 345 350
His Tyr Ile Gln Tyr Leu Glu Gly Phe Lys Phe Arg Ser His Ile Gly
355 360 365
Leu Phe Asp Glu Tyr Ile Asp Tyr Trp Tyr His Ile Lys Glu Thr Asn
370 375 380
Thr Gly Pro Leu Arg Glu Ile Ala Lys Leu Met Leu Asn Asn Leu Tyr
385 390 395 400
Gly Lys Phe Gly Thr Asn Pro Ile Arg Ala Arg Lys Glu Pro Ile Tyr
405 410 415
Asp Lys Thr Lys Gly Ala Val Tyr Val Asn Leu Pro Ala Glu Glu Gly
420 425 430
Asp Ala Val Tyr Ile Pro Met Ala Cys Phe Ile Thr Ala Tyr Ser Arg
435 440 445
Tyr Asp Leu Ile Ser Thr Ala Gln Lys Phe Tyr Lys Asn Val Val Tyr
450 455 460
Met Asp Thr Asp Ser Ile Lys Phe Tyr Gly Ile Ser Arg Glu Val Ile
465 470 475 480
Glu Ala Gln Ile Glu Val His Asp Thr Lys Ile Gly Ala Trp Lys Tyr
485 490 495
Glu Gly Thr Ala Lys Met Phe Lys Ala Leu Arg Pro Lys Thr Tyr Ala
500 505 510
Tyr Ile Asp Glu Asn Asp Glu Leu Asp Val Lys Cys Ala Gly Leu Pro
515 520 525
Lys Lys Ala Lys Lys Asp Ile Thr Phe Asp Thr Phe Gln Tyr Gly Phe
530 535 540
Val Ser Lys Glu Lys Leu Glu Ile Lys Arg Val Lys Gly Gly Thr Ile
545 550 555 560
Leu Leu Lys Thr Lys Phe Glu Ile Lys Lys Gln Val Asp Asn Lys His
565 570 575
Ile Asp Thr Glu Tyr Phe Glu Asp Glu Asp Ile Asp Ile Phe Asn Gln
580 585 590
Leu
<210> 10
<211> 669
<212> PRT
<213> Bacillus phage MG-B1
<400> 10
Met Lys Lys Lys Arg Thr Lys Thr Lys Ile Lys Thr Tyr Ala Cys Asp
1 5 10 15
Phe Glu Thr Asn Thr Glu Ala Trp Leu His Glu Asp Lys Leu Arg Asp
20 25 30
Glu Leu Lys Thr Lys Glu Glu Asn Pro Glu Leu Trp Arg Lys Arg Glu
35 40 45
Ala Trp Lys Leu His Thr Gly Gly Asp Lys Ala Phe Val Trp Ser Trp
50 55 60
Gly Gly Thr Glu Ile Arg Glu Asp Met Ser Phe Lys Gly Glu Leu Asp
65 70 75 80
Asn Phe Val Val Gly Lys Gly Ile Ser Glu Tyr Val Asp Trp Met Leu
85 90 95
Asp Gly Ser Lys Asn Val Trp Phe His Asn Leu Lys Phe Asp Gly Ser
100 105 110
Phe Ile Ala Val Glu Leu Leu Arg Arg Gly Phe Lys Phe Thr Phe Asp
115 120 125
Arg Asn Pro Ala Ile Gly Glu Phe Thr Gly Leu Ile Asp Gly Lys Lys
130 135 140
Met Trp Phe Glu Leu Ile Ile Cys Lys Glu Gly Lys Arg Gly Gly Arg
145 150 155 160
Gln Phe Ile Thr Ile Lys Asp Ser Leu Lys Lys Val Pro Phe Gly Leu
165 170 175
Arg Val Ala Ala Met Ala Phe Gly Leu Asp Val Phe Lys Asp Asp Met
180 185 190
Asp Tyr Asp Val Ile Arg Glu Pro Phe Glu Pro Ile Gly Glu Ala Asp
195 200 205
Tyr Lys Tyr Leu Lys Lys Asp Val Glu Ile Thr Ala Lys Ile Ile His
210 215 220
Tyr Gln Val Phe Gln Ser Gly Leu Lys Lys Thr Thr Ile Gly Ser Asp
225 230 235 240
Ala Leu Asn Glu Phe Lys Ser Thr Val Gly Gly Asp Lys Gly Phe Lys
245 250 255
Glu Ile Phe Pro Val Met Asp Phe Asp Thr Asp Ser Phe Ile Arg Lys
260 265 270
Ser Tyr Phe Gly Gly Val Thr Gln Val Lys Pro Gly Met Glu Gly Lys
275 280 285
Leu Ile Gly Glu Gly Ser Val Phe Asp Ile Val Ser Met Tyr Pro Trp
290 295 300
Val Gln Tyr Thr Lys Leu Leu Pro Tyr Gly Leu Pro Ile Glu Tyr Asn
305 310 315 320
Gly Glu Tyr Thr Tyr Asp Glu Glu Tyr Pro Leu Tyr Val Gln Gln Val
325 330 335
Ser Phe Ser Phe Val Val Lys Asp Asn Met Leu Pro Thr Ile Gln Leu
340 345 350
Lys Lys Gln Asn Val Glu Phe Asn Tyr Asn Glu Ala Asp Asp Val Arg
355 360 365
Lys Phe Asn Gly Arg Glu Phe Gln Lys Thr Ser Tyr Gly Glu Ile Val
370 375 380
Thr Met Tyr Val Thr Asn Val Gln Trp Glu Gln Ile Gln Lys His Tyr
385 390 395 400
Trp Leu Asp Asp Leu His Phe His Lys Gly Met Met Phe Lys Gly Lys
405 410 415
Ile Gly Leu Phe Lys Glu His Ile Asp Lys Trp Leu Lys Val Lys Lys
420 425 430
Gln Ala Asn Asp Asp Gly Asn Asp Ala Leu Lys Ser Leu Ala Lys Leu
435 440 445
Met Leu Asn Ser Pro Tyr Gly Lys Phe Gly Thr Asn Thr Ile Arg Leu
450 455 460
Asn Val Glu Pro Phe Leu Trp Glu Asp Asp Glu Ser Leu Gly Phe Arg
465 470 475 480
Val Glu Asp Asp Asp Pro Pro Pro Ala Asp Pro Ile Tyr Thr Ala Tyr
485 490 495
Ala Ser Phe Val Thr Ala Tyr Ala Arg Glu Glu Leu Val Ser Thr Ile
500 505 510
Met Met Cys Tyr Asp Arg Phe Val Tyr Cys Asp Thr Asp Ser Ile His
515 520 525
Leu Ile Gly Thr Glu Ile Pro Glu Gly Ile Lys His Lys Ile Gly Gly
530 535 540
Asp Leu Gly Asp Trp Glu Pro Glu Ser Glu Phe Lys Leu Ala Lys Phe
545 550 555 560
His Arg Ala Lys Thr Tyr Cys Glu Met Val Tyr Ala Lys Lys Val Met
565 570 575
Lys Lys Asp Arg Trp Gly Asp Val Val Glu Ser Leu Lys His Cys Ser
580 585 590
Lys Glu Glu Trp Gly Thr Leu Pro Gln Asp Gln Lys Thr Leu Asp Lys
595 600 605
Asn Leu Lys Cys Ala Gly Leu Gln Gly His Leu Lys Asp Tyr Val Ser
610 615 620
Phe Glu Glu Phe Glu Ile Gly Leu Lys Ile Asn Pro Glu Val Asn Lys
625 630 635 640
Asp Ile Met Gly Lys Pro Leu Gly Lys Leu Met Pro Cys Gln Val Lys
645 650 655
Gly Gly Thr Leu Leu Lys Val Arg Lys Phe Ser Leu Asn
660 665
<210> 11
<211> 572
<212> PRT
<213> Eggerthella sp.
<400> 11
Met Asn Glu Tyr Ile Ser Asp Phe Glu Thr Gln Lys Asp Pro Asp Thr
1 5 10 15
Gly Val Met Ser Val Trp Ala Trp Ser Ile Val Asp Val Asn Asp Leu
20 25 30
Ser Asn Ile Gln Tyr Gly Asn Asn Ile Glu Ser Trp Leu Ser Ala Ile
35 40 45
Gln Gly Leu Pro Asn Gly Ser Leu Ile Gly Phe His Asn Leu Lys Phe
50 55 60
Asp Gly Ser Tyr Ile Leu Ser Tyr Leu Leu Gly Val Ala Lys Trp Glu
65 70 75 80
Tyr Asn Asp Lys Pro Lys Ala Arg Lys Ala Lys Thr Val Glu Cys Leu
85 90 95
Ile Ser Ser Ile Gly Val His Tyr Asn Tyr Arg Ile Asn Phe Thr Lys
100 105 110
Arg Lys Tyr Val Lys Ile Tyr Asp Thr Leu Lys Ile Phe Asn Met Ser
115 120 125
Val Ser Gln Ile Ala Lys Ser Phe Gly Ile Lys Glu Gln Lys Gly Ser
130 135 140
Ile Asp Tyr Ala Ile Phe Arg Gly Tyr Asn Tyr Thr Met Thr Pro Lys
145 150 155 160
Glu Val Glu Tyr Ile Thr Asn Asp Val Lys Ile Val Ala Lys Ala Ile
165 170 175
Lys Gln Phe Arg Asn Glu Gly His Glu Arg Asn Thr Ile Ala Ser Asn
180 185 190
Ala Met Arg Tyr Tyr Lys Lys Asn Ser Tyr Tyr Ser Asn Tyr Glu Phe
195 200 205
Leu Thr Tyr Phe Pro His Leu Asp Asp Asp Leu Tyr His Leu Leu Lys
210 215 220
Arg Ala Tyr Lys Gly Gly Tyr Cys Tyr Val Asn Pro Lys Phe Lys Gly
225 230 235 240
Lys Pro Val Gly His Gly Arg Val Tyr Asp Val Asn Ser Leu Tyr Pro
245 250 255
Ser Val Met Ser Asp Pro Gln Asn Lys Tyr Pro Ile Gly Thr Pro Val
260 265 270
Phe Phe Glu Gly Lys Tyr Lys Asp Asp Pro Ile Tyr Pro Leu Tyr Ile
275 280 285
Gln Phe Ile Thr Ala Gln Phe Glu Leu Lys Lys Gly Lys Ile Pro Thr
290 295 300
Ile Gln Ile Lys Asn Asp Lys Arg Phe Asn Pro Arg Glu Tyr Val Thr
305 310 315 320
Ser Thr Gly Cys Leu Met Val Asn Leu Tyr Leu Thr Asn Val Asp Leu
325 330 335
Glu Met Phe Tyr Glu Cys Tyr Asn Ile Lys Glu Ile Gln Tyr Ile Gly
340 345 350
Gly Tyr Lys Phe Ile Gly Arg Ser Gly Ile Phe Ile Asp Tyr Val Asn
355 360 365
His Phe Lys Glu Met Lys Met Gln Ala Thr Ile Glu Lys Asn Ala Gly
370 375 380
Lys Arg Ser Ile Ala Lys Leu Phe Leu Asn Ser Leu Tyr Gly Lys Phe
385 390 395 400
Gly Ala Ser Asn Asp Lys Phe Val Lys Arg Pro Tyr Ile Asn Asp Lys
405 410 415
Gly Ile Leu Ala Tyr Gln Thr Val Glu Thr Pro Arg Pro Ala Lys Thr
420 425 430
Val Tyr Val Pro Val Ala Ala Phe Val Thr Ala Tyr Ala Arg Arg Phe
435 440 445
Ile Gln Thr Leu Phe Ile Lys Asn Val Asp Arg Cys Cys Tyr Cys Asp
450 455 460
Thr Asp Ser Leu His Leu Ile Gly Asp Asp Pro Pro Glu Gly Val Lys
465 470 475 480
Ile Ser Asp Thr Glu Phe Asn Cys Met Ala His Glu Ser Ser Phe Ser
485 490 495
Arg Ala Lys Phe Leu Gly Ala Lys Leu Tyr Ile Glu Glu Asp Glu Gln
500 505 510
Gly Asn Leu Asp Val Lys Ala Ala Gly Leu Gly Gln Asn Glu Val Val
515 520 525
Lys Asn Gln Ile Thr Phe Asp Asn Phe Asn Thr Glu Gln Glu Tyr Phe
530 535 540
Gly Ile Leu Lys Ser Lys Thr Val Gln Gly Gly Val Glu Leu Ser Glu
545 550 555 560
Ser Thr Phe Lys Ile Arg Glu Arg Gly Thr Arg Phe
565 570
<210> 12
<211> 568
<212> PRT
<213> Streptococcus phage CP-7
<400> 12
Met Thr Cys Tyr Tyr Ala Gly Asp Phe Glu Thr Thr Thr Asn Glu Glu
1 5 10 15
Glu Thr Glu Val Trp Leu Ser Cys Phe Ala Lys Val Ile Asp Tyr Asp
20 25 30
Lys Leu Asp Thr Phe Lys Val Asn Thr Ser Leu Glu Asp Phe Leu Lys
35 40 45
Ser Leu Tyr Leu Asp Leu Asp Lys Thr Tyr Thr Glu Thr Gly Glu Asp
50 55 60
Glu Phe Ile Ile Phe Phe His Asn Leu Lys Phe Asp Gly Ser Phe Leu
65 70 75 80
Leu Ser Phe Phe Leu Asn Asn Asp Ile Glu Cys Thr Tyr Phe Ile Asn
85 90 95
Asp Met Gly Val Trp Tyr Ser Ile Thr Leu Glu Phe Pro Asp Phe Thr
100 105 110
Leu Thr Phe Arg Asp Ser Leu Lys Ile Leu Asn Phe Ser Ile Ala Thr
115 120 125
Met Ala Gly Leu Phe Lys Met Pro Ile Ala Lys Gly Thr Thr Pro Leu
130 135 140
Leu Lys His Lys Pro Asp Glu Ile Lys Pro Glu Trp Ile Asp Tyr Ile
145 150 155 160
His Val Asp Val Ala Ile Leu Ala Arg Gly Ile Phe Ala Met Tyr Tyr
165 170 175
Glu Glu Asn Phe Ser Lys Tyr Thr Ser Ala Ser Glu Ala Leu Thr Glu
180 185 190
Phe Lys Arg Ile Phe Arg Lys Ser Lys Arg Lys Phe Arg Asp Phe Phe
195 200 205
Pro Ile Leu Asp Glu Lys Val Asp Asp Phe Cys Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Trp Thr Phe Ala Asn Pro Lys Thr Gln Gly Arg Thr Leu Lys
225 230 235 240
Gln Leu Ile Asp Ile Tyr Asp Ile Asn Ser Met Tyr Pro Ala Thr Met
245 250 255
Leu Gln Asn Ala Leu Pro Ile Gly Ile Pro Lys Arg Tyr Lys Gly Lys
260 265 270
Pro Lys Glu Ile Lys Glu Asp His Tyr Tyr Ile Tyr His Ile Lys Ala
275 280 285
Asp Phe Asp Leu Lys Arg Gly Tyr Leu Pro Thr Ile Gln Ile Lys Lys
290 295 300
Lys Leu Asp Ala Leu Arg Ile Gly Val Arg Thr Ser Asp Tyr Val Thr
305 310 315 320
Thr Ser Lys Asn Glu Val Ile Asp Leu Tyr Leu Thr Asn Phe Asp Leu
325 330 335
Asp Leu Phe Leu Lys His Tyr Asp Ala Thr Ile Met Tyr Val Glu Thr
340 345 350
Leu Glu Phe Gln Thr Glu Ser Gly Leu Phe Asp Asp Tyr Ile Thr Thr
355 360 365
Tyr Arg Tyr Lys Lys Glu Asn Ala Gln Ser Pro Ala Glu Lys Gln Lys
370 375 380
Ala Lys Ile Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Ala Lys Ile
385 390 395 400
Ile Ser Val Lys Lys Leu Ala Tyr Leu Asp Asp Lys Gly Ile Leu Arg
405 410 415
Phe Lys Asn Asp Asp Glu Glu Glu Val Gln Pro Val Tyr Ala Pro Val
420 425 430
Ala Leu Phe Val Thr Ser Ile Ala Arg His Phe Ile Ile Ser Asn Ala
435 440 445
Gln Glu Asn Tyr Asp Asn Phe Leu Tyr Ala Asp Thr Asp Ser Leu His
450 455 460
Leu Phe His Ser Asp Ser Leu Val Leu Asp Ile Asp Pro Ser Glu Phe
465 470 475 480
Gly Lys Trp Ala His Glu Gly Arg Ala Val Lys Ala Lys Tyr Leu Arg
485 490 495
Ser Lys Leu Tyr Ile Glu Glu Leu Ile Gln Glu Asp Gly Thr Thr His
500 505 510
Leu Asp Val Lys Gly Ala Gly Met Thr Pro Glu Ile Lys Glu Lys Ile
515 520 525
Thr Phe Glu Asn Phe Val Ile Gly Ala Thr Phe Glu Gly Lys Arg Ala
530 535 540
Ser Lys Gln Ile Lys Gly Gly Thr Leu Ile Tyr Glu Thr Thr Phe Lys
545 550 555 560
Ile Arg Glu Thr Asp Tyr Leu Val
565
<210> 13
<211> 616
<212> PRT
<213> Bacteroides sp.
<400> 13
Met Ser Lys Lys Ser Ala Lys Lys Pro Val Ile Ile Ala Ala Asp Phe
1 5 10 15
Glu Thr Thr Val Tyr Pro Gly Gln Thr Ser Thr Glu Val Trp Ser Ala
20 25 30
Ala Trp Ile Glu Leu Phe Thr Glu Arg Pro His Val Arg Gly Asn Ile
35 40 45
Glu Asp Phe Leu Asn Asp Ile Phe Asn Leu Asn Lys Asn Val Leu Cys
50 55 60
Tyr Phe His Asn Leu Arg Phe Asp Gly Ala Phe Ile Val Tyr Trp Leu
65 70 75 80
Leu Lys Asn Gly Tyr Thr Trp Asn Asn Ala Arg Asn Lys Gly Met Asn
85 90 95
Ala Lys Glu Phe Lys Ala Leu Ile Ser Asp Thr Asn Lys Trp Tyr Thr
100 105 110
Val Thr Val Lys Pro Lys Phe Asp Thr Val Ile Glu Phe Arg Asp Ser
115 120 125
Val Lys Leu Met Pro Met Thr Leu Asp Gln Ile Gly Ser Ala Phe Asn
130 135 140
Thr Lys His Arg Lys Leu Glu Met Glu Tyr Ile Gly Met Arg His Ala
145 150 155 160
Asn Cys Glu Ile Thr Pro Glu Glu Tyr Ala Tyr Ile Ile Asn Asp Ile
165 170 175
Tyr Val Leu Lys Glu Ala Leu Glu Val Met Ile Lys Ser Gly His Asp
180 185 190
Lys Leu Thr Ile Gly Ser Cys Cys Met Asp Glu Phe Lys Asn Lys Phe
195 200 205
Asp Ala Met Asp Phe Lys Ala Ala Phe Pro Asn Leu Lys Glu Ile Ala
210 215 220
Leu Ile Lys Tyr Glu Leu Gly Ser Asp Asn Val Asp Gln Tyr Ile Arg
225 230 235 240
Lys Ala Tyr Lys Gly Gly Tyr Cys Tyr Tyr Lys Tyr Lys Gln Arg Lys
245 250 255
His Ile Thr Gln Asn Gly Met Thr Phe Asp Val Asn Ser Leu Tyr Pro
260 265 270
Ser Val Met His Ser Lys Ser Gly Asn Tyr Tyr Pro Thr Gly Lys Pro
275 280 285
Ile Phe Phe Glu Lys Ala Ile Pro Tyr Lys Cys Leu Glu Ala Arg Val
290 295 300
Tyr Pro Phe Tyr Val Arg Leu Arg Cys Arg Phe Lys Leu Lys Asp Gly
305 310 315 320
Phe Leu Pro Thr Val Gln Ile Lys Gly Asp Tyr Lys Tyr Asn Ser Thr
325 330 335
Gln Trp Leu Glu Thr Ser Asp Ile Tyr Tyr Arg Gly Lys Tyr Tyr Arg
340 345 350
Tyr Phe Thr Asn Lys Glu Gly Gln Lys Glu Glu Ala Arg Pro Glu Leu
355 360 365
Thr Leu Phe Met Thr Asp Tyr Leu Leu Leu Leu Glu His Tyr Asp Val
370 375 380
Tyr Asp Leu Glu Ile Leu Asp Gly Cys Tyr Phe His Gly Ala Ile Gly
385 390 395 400
Leu Phe Asp Thr Tyr Ile Asp His Tyr Met Lys Ile Lys Met Thr Thr
405 410 415
Lys Asp Lys Gly Glu Arg Thr Glu Ala Lys Leu Phe Leu Asn Asn Leu
420 425 430
Tyr Gly Arg Leu Ala Ile Asn Asp Asn Ser Ser Tyr Arg Glu Pro Phe
435 440 445
Ile Asp Pro Glu Thr Asp Ser Ile Gly Phe Glu Leu His Pro Glu His
450 455 460
Glu Lys Asp Thr Leu Tyr Ile Ala Ala Gly Ala Ala Val Thr Ala Tyr
465 470 475 480
Ala Arg Tyr Phe Thr Ile Thr His Ala Gln Ala Asn Tyr Gln Asn Phe
485 490 495
Val Tyr Ser Asp Thr Asp Ser Ile His Met Leu Asp Asp Gly Gln Pro
500 505 510
Val Lys Met Ile Lys Glu His Ala Thr Glu Leu Leu His Trp Lys Arg
515 520 525
Glu Ser Asp Trp Ser Ser Ala Ile Phe Ile Arg Gln Lys Thr Tyr Ala
530 535 540
Glu Phe Val Gln Lys Glu Asp Gly Lys Lys Val Thr Gly His Trp Glu
545 550 555 560
Ile Lys Cys Ala Gly Met Pro Glu Lys Ser Lys Lys Leu Phe Leu Ala
565 570 575
Ser His Pro Ile Thr Asp Phe Lys Ile Gly Leu Lys Val Gly Gly Lys
580 585 590
Leu Lys Pro Lys Tyr Ile Ser Gly Gly Met Val Leu Val Glu Asp Phe
595 600 605
Tyr Thr Leu Arg Ala Lys Arg Cys
610 615
<210> 14
<211> 641
<212> PRT
<213> Chlamydia trachomatis
<400> 14
Met Lys Ala Arg Lys Phe Lys Ile Tyr Ala Ala Asp Phe Glu Thr Thr
1 5 10 15
Val Phe Lys Gly Gln Thr Phe Thr Glu Val Trp Ser Ala Cys Phe Cys
20 25 30
Glu Leu Tyr Lys Lys Asp Ala Lys Ile Met His Ser Ile Gln Asp Phe
35 40 45
Phe Asn Tyr Phe Phe Ser Leu Asn Glu Asn Ile Lys Met Tyr Phe His
50 55 60
Asn Leu Lys Phe Asp Gly Ser Phe Ile Leu Ser Tyr Leu Leu Lys Asp
65 70 75 80
Leu Lys Tyr Glu Gln Ala Tyr Glu Lys Met Asn Ala Asp Gly Ser Leu
85 90 95
Val Arg Trp Leu Glu Thr Lys Asp Met Lys Asn Asn Ser Ile Lys Tyr
100 105 110
Ser Ile Ser Glu Met Gly Gln Trp Tyr Tyr Ile Ile Ile Lys Lys Asn
115 120 125
Asn Lys Ile Ile Glu Ile Arg Asp Ser Leu Lys Leu Leu Pro Phe Ser
130 135 140
Leu Glu Ala Ile Gly Lys Ser Phe Asp Thr Glu His Lys Lys Leu Lys
145 150 155 160
Met Lys Tyr Glu Gly Tyr Arg Tyr Ala Gly Cys Glu Ile Thr Pro Glu
165 170 175
Glu Gln Ala Tyr Ile Lys Asn Asp Val Leu Val Leu Lys Glu Ala Leu
180 185 190
Glu Ile Met Phe Asn Glu Lys His Glu Ser Leu Thr Ile Gly Ser Cys
195 200 205
Cys Leu Asn Glu Tyr Lys Thr Ile Met Thr Lys Phe Leu Ile Glu Arg
210 215 220
Leu Tyr Pro Asn Ile Ala Glu Tyr Thr Val Asn Val Pro Leu Glu Phe
225 230 235 240
Lys Asn Ala Asp Glu Tyr Val Arg Lys Ser Tyr Lys Gly Gly Trp Cys
245 250 255
Tyr Leu Lys Lys Gly Cys Glu Asn Lys Ile Tyr Asn Asn Gly Thr Thr
260 265 270
Ala Asp Val Asn Ser Leu Tyr Ser Ser Val Met His Ser Glu Ser Gly
275 280 285
Asn Tyr Tyr Pro Val Gly Leu Pro Thr Phe Trp Ser Gly Asn Tyr Ile
290 295 300
Pro Glu Ile Ala Lys Glu Lys Tyr Tyr Phe Ile Arg Ile Lys Thr Arg
305 310 315 320
Phe Tyr Leu Lys Lys Arg Phe Leu Pro Cys Ile Gln Val Lys Asn Thr
325 330 335
Tyr Arg Tyr Lys Ser Thr Glu Trp Leu Glu Thr Ser Asp Phe Tyr Asp
340 345 350
Lys Lys Thr Asn Lys Tyr Tyr Lys Lys Tyr Leu Asp Ile Asn Gly Asn
355 360 365
Glu Gln Asn Thr Gln Val Ile Leu Thr Leu Thr Met Thr Asp Phe Glu
370 375 380
Leu Ile Lys Glu His Tyr Asn Leu Val Asp Phe Glu Ile Leu Asp Gly
385 390 395 400
Cys Tyr Phe Asp Lys Glu Ile Gly Leu Phe Asp Glu Tyr Ile Asn Lys
405 410 415
Tyr Lys Lys Ile Lys Leu Asn Ser Lys Gly Ala Lys Lys Thr Leu Ala
420 425 430
Lys Leu Tyr Leu Asn Asn Leu Tyr Gly Lys Thr Ala Thr Asn Thr Asp
435 440 445
Ser Ser Phe Lys Val Ala Tyr Ile Lys Asp Asp Leu Ser Leu Gly Phe
450 455 460
Tyr Gly Val Tyr Ala Cys Asp Lys Lys Pro Phe Tyr Ile Pro Val Gly
465 470 475 480
Ser Ala Ile Thr Ser Tyr Ala Arg Asn Phe Thr Ile Arg Ala Ala Gln
485 490 495
Lys Asn Tyr Lys Asn Phe Ile Tyr Ala Asp Thr Asp Ser Ile His Cys
500 505 510
Lys Cys Asn Pro Ala Glu Ile Lys Gly Ile Thr Ile Asp Asp Lys Lys
515 520 525
Phe Leu Cys Trp Lys Leu Glu Ser Cys Trp Asp Lys Gly Leu Phe Val
530 535 540
Arg Gln Lys Thr Tyr Ile Glu His Ile Thr Ala Glu Asn Leu Lys Pro
545 550 555 560
Ile Asp Lys Pro Phe Tyr Asn Val Lys Cys Ala Gly Met Pro Glu Gln
565 570 575
Cys Lys Thr Leu Phe Leu Lys Ser Ile Gly Glu Asp Val Asp Ile Ser
580 585 590
Asp Leu Asn Ile Asn Asp Asp Ala Lys Glu Phe Leu Lys Lys Lys Arg
595 600 605
Thr Ile Lys Asp Phe Lys Ala Gly Leu Ser Val Pro Leu Lys Leu Arg
610 615 620
Pro Val Gln Ile Asn Gly Gly Val Leu Leu Thr Glu Thr Phe Tyr Thr
625 630 635 640
Met
<210> 15
<211> 574
<212> PRT
<213> Globodera pallida
<400> 15
Met Pro Leu Pro Arg Lys Lys Ala Ser Ser Asn Gly Leu Ser Lys Arg
1 5 10 15
Ile Tyr Leu Ala Asp Phe Glu Thr Thr Thr Gln Ala Glu Asp Cys Arg
20 25 30
Val Trp Ser Trp Gly Leu Cys Ser Val Glu Asn Thr Glu Asn Val Glu
35 40 45
Phe Gly Gly Asp Leu Asp Ser Phe Ile Glu Arg Ile Ser Glu Glu Asn
50 55 60
Ser Ile Thr Phe Phe His Asn Leu Lys Phe Asp Gly Ala Phe Ile Leu
65 70 75 80
Asp Arg Leu Phe Arg Leu Gly Tyr Glu Phe Thr Asp Glu Lys Ala Pro
85 90 95
Gln Val Lys Glu Phe Ser Thr Leu Ile Ser Lys Met Gly Gln Phe Tyr
100 105 110
Ser Ile Lys Val Arg Trp Glu Asn Gly Met Phe Thr Glu Phe Arg Asp
115 120 125
Ser Leu Lys Lys Leu Pro Met Ser Val Lys Gln Val Ala Lys Thr Phe
130 135 140
Lys Leu Asp Gln Ala Lys Gly Glu Ile Asp Tyr His Tyr Leu Arg Pro
145 150 155 160
Val Gly Trp Val Met Thr Pro Glu Glu Arg Glu Tyr Val Lys Asn Asp
165 170 175
Val Gln Ile Val Ala Arg Ala Leu Lys Val Gln Leu Gln Glu Gly Met
180 185 190
Thr Arg Leu Thr Val Gly Ala Asp Ser Leu Ala Gln Tyr Lys Ser Met
195 200 205
Met Gly Lys Asp Phe Glu Arg His Phe Pro Val Leu Thr Arg Thr Ile
210 215 220
Asp Ala Glu Ile Arg Arg Ala Tyr Arg Gly Gly Trp Ala Tyr Ala Asp
225 230 235 240
Glu Arg His Arg Gly Lys Val Val Gly Ala Gly Gln Thr Phe Asp Val
245 250 255
Asn Ser Leu Tyr Pro Ser Val Met Tyr Ser Lys Val Leu Pro Tyr Gly
260 265 270
Glu Pro Val Phe Tyr Pro Asn Gly Leu Pro Glu Val Thr Glu Asp His
275 280 285
Pro Leu Phe Ile Thr Cys Ile Thr Phe Thr Ala Lys Ile Arg Asp Gly
290 295 300
His Leu Pro Cys Ile Gln Ile Lys Asn Ser Ser Leu Phe Thr Pro Thr
305 310 315 320
Glu Tyr Val Lys Glu Val Leu Asp Pro Ile Thr Met Tyr Cys Thr Asn
325 330 335
Val Asp Leu Glu Leu Trp Gln Glu His Tyr Asp Met Asp Ile Leu Ala
340 345 350
Tyr Asn Gly Ala Trp Leu Phe Arg Gly Ile Arg Gly Phe Phe Asn Asp
355 360 365
Tyr Ile Asp His Trp Met Arg Ile Lys Glu Glu Ser Glu Gly Gly Arg
370 375 380
Lys Leu Ile Ala Lys Leu His Leu Asn Ser Leu Tyr Gly Lys Phe Ala
385 390 395 400
Thr Asn Pro Asp Val Thr Pro Lys Ile Pro Ile Phe Asp Glu Glu Lys
405 410 415
Asp Ile Val Arg Leu Ile Glu Gly Pro Pro Asp Glu Arg Asn Pro Val
420 425 430
Tyr Thr Ala Met Gly Val Phe Ile Thr Ser Tyr Ala Arg Asp Leu Thr
435 440 445
Ile Arg Thr Ala Gln Asp His Tyr Asp Arg Phe Leu Tyr Ala Asp Thr
450 455 460
Asp Ser Leu His Leu Leu Thr Ser Asp Gly Thr Asn Asn Gly Arg Lys
465 470 475 480
Ser Lys Ala Leu Glu Val His Pro Ser Lys Leu Gly Tyr Trp Lys His
485 490 495
Glu Tyr Asp Phe Asp Ala Gly Leu Phe Val Arg Ala Lys Ala Tyr Thr
500 505 510
Glu Leu Met Thr Gly Glu Phe His Val Lys Ser Lys Cys Glu Cys Asp
515 520 525
Thr Pro Asn Asp Leu His Tyr Gln Thr His Ile Ala Gly Met Pro Glu
530 535 540
Ala Ile Ala Gln His Ile Thr Phe Glu Ser Tyr Arg Asp Gly Ala Thr
545 550 555 560
Phe Glu Gly Lys Leu Ala Pro Gln Arg Val Pro Gly Gly Ile
565 570
<210> 16
<211> 584
<212> PRT
<213> Globodera sp.
<400> 16
Met Pro Leu Pro Arg Lys Lys Ala Ser Ser Asn Gly Leu Ser Lys Arg
1 5 10 15
Ile Tyr Leu Ala Asp Phe Glu Thr Thr Thr Gln Ala Glu Asp Cys Arg
20 25 30
Val Trp Ser Trp Gly Leu Cys Ser Val Glu Asn Thr Glu Asn Val Glu
35 40 45
Phe Gly Gly Asp Leu Asp Ser Phe Ile Glu Arg Ile Ser Glu Glu Asn
50 55 60
Ser Ile Thr Phe Phe His Asn Leu Lys Phe Asp Gly Ala Phe Ile Leu
65 70 75 80
Asp Arg Leu Phe Arg Leu Gly Tyr Glu Phe Thr Asp Glu Lys Ala Pro
85 90 95
Gln Val Lys Glu Phe Ser Thr Leu Ile Ser Lys Met Gly Gln Phe Tyr
100 105 110
Ser Ile Lys Val Arg Trp Glu Asn Gly Met Phe Thr Glu Phe Arg Asp
115 120 125
Ser Leu Lys Lys Leu Pro Met Ser Val Lys Gln Val Ala Lys Thr Phe
130 135 140
Lys Leu Asp Gln Ala Lys Gly Glu Ile Asp Tyr His Tyr Leu Arg Pro
145 150 155 160
Val Gly Trp Val Met Thr Pro Glu Glu Arg Glu Tyr Val Lys Asn Asp
165 170 175
Val Gln Ile Val Ala Arg Ala Leu Lys Val Gln Leu Gln Glu Gly Met
180 185 190
Thr Arg Leu Thr Val Gly Ala Asp Ser Leu Ala Gln Tyr Lys Ser Met
195 200 205
Met Gly Lys Asp Phe Glu Arg His Phe Pro Val Leu Thr Arg Thr Ile
210 215 220
Asp Ala Glu Ile Arg Arg Ala Tyr Arg Gly Gly Trp Ala Tyr Ala Asp
225 230 235 240
Glu Arg His Arg Gly Lys Val Val Gly Ala Gly Gln Thr Phe Asp Val
245 250 255
Asn Ser Leu Tyr Pro Ser Val Met Tyr Ser Lys Val Leu Pro Tyr Gly
260 265 270
Glu Pro Val Phe Tyr Pro Asn Gly Leu Pro Glu Val Thr Glu Asp His
275 280 285
Pro Leu Phe Ile Thr Cys Ile Thr Phe Thr Ala Lys Ile Arg Asp Gly
290 295 300
His Leu Pro Cys Ile Gln Ile Lys Asn Ser Ser Leu Phe Thr Pro Thr
305 310 315 320
Glu Tyr Val Lys Glu Val Leu Asp Pro Ile Thr Met Tyr Cys Thr Asn
325 330 335
Val Asp Leu Glu Leu Trp Gln Glu His Tyr Asp Met Asp Ile Leu Ala
340 345 350
Tyr Asn Gly Ala Trp Leu Phe Arg Gly Ile Arg Gly Phe Phe Asn Asp
355 360 365
Tyr Ile Asp His Trp Met Arg Ile Lys Glu Glu Ser Glu Gly Gly Arg
370 375 380
Lys Leu Ile Ala Lys Leu His Leu Asn Ser Leu Tyr Gly Lys Phe Ala
385 390 395 400
Thr Asn Pro Asp Val Thr Pro Lys Ile Pro Ile Phe Asp Glu Glu Lys
405 410 415
Asp Ile Val Arg Leu Ile Glu Gly Pro Pro Asp Glu Arg Asn Pro Val
420 425 430
Tyr Thr Ala Met Gly Val Phe Ile Thr Ser Tyr Ala Arg Asp Leu Thr
435 440 445
Ile Arg Thr Ala Gln Asp His Tyr Asp Arg Phe Leu Tyr Ala Asp Thr
450 455 460
Asp Ser Leu His Leu Leu Thr Ser Asp Gly Thr Asn Asn Gly Arg Lys
465 470 475 480
Ser Lys Ala Leu Glu Val His Pro Ser Lys Leu Gly Tyr Trp Lys His
485 490 495
Glu Tyr Asp Phe Asp Ala Gly Leu Phe Val Arg Ala Lys Ala Tyr Thr
500 505 510
Glu Leu Met Thr Gly Glu Phe His Val Lys Ser Lys Cys Glu Cys Asp
515 520 525
Thr Pro Asn Asp Leu His Tyr Gln Thr His Ile Ala Gly Met Pro Glu
530 535 540
Ala Ile Ala Gln His Ile Thr Phe Glu Ser Tyr Arg Asp Gly Ala Thr
545 550 555 560
Phe Glu Gly Lys Leu Ala Pro Gln Arg Val Pro Gly Gly Ile Val Leu
565 570 575
Val Asp Asp Thr Phe Thr Ile Lys
580
<210> 17
<211> 548
<212> PRT
<213> Lynx pardinus
<220>
<221> misc_feature
<222> (339)..(374)
<223> Xaa can be any naturally occurring amino acid
<400> 17
Met Pro Ser Tyr Thr Ala Asp Phe Glu Thr Thr Thr Val Ala Asp Asp
1 5 10 15
Cys Arg Val Trp Ala Trp Ala Thr Ser Arg Ile Gly Asn Pro Asp Asp
20 25 30
Val Gln Leu Gly Asn Ser Ile Asp Thr Phe Leu Glu Trp Cys Arg Val
35 40 45
His Ser Gly Ser Arg Val Tyr Phe His Asn Leu Lys Phe Asp Gly Lys
50 55 60
Phe Ile Leu His Lys Ile Leu Thr Asp Gly Trp Lys Trp Ile Pro Asp
65 70 75 80
Lys Asn Asp Cys Ala Asn Arg Thr Phe Thr Thr Leu Ile Ser Asp Met
85 90 95
Ser Gln Phe Tyr Ser Ile Lys Leu Trp Phe Asp Glu Ser Lys Ser Ile
100 105 110
Glu Phe Leu Asp Ser Leu Lys Val Ile Pro Leu Pro Ile Ala Ala Ile
115 120 125
Pro Lys Ala Phe Gly Leu Glu Ile Glu Lys Leu Asp Leu Asp Tyr Gln
130 135 140
Ala Ser Arg Glu Val Gly His Glu Leu Thr Glu Asp Glu Lys Glu Tyr
145 150 155 160
Ile Ala His Asp Val Lys Ile Ala Ala Met Ala Met Asp Thr Met Phe
165 170 175
Ser Gln Gly Met Lys Lys Ile Thr Ala Gly Ser Asn Ala Phe Ala Asp
180 185 190
Tyr Lys Lys Thr Ile Gly Gly Lys Lys Arg Phe Arg Asp Trp Phe Pro
195 200 205
Glu Pro Glu Tyr Asp Glu Asp Leu Arg Lys Gly Gly Cys Tyr Lys Gly
210 215 220
Gly Phe Thr Ala Val Asn Pro Lys Ile Ala Gly Lys Lys Leu Gly Lys
225 230 235 240
Gly Val Ser Phe Asp Val Asn Ser Leu Tyr Pro Ser Val Met Ala Ser
245 250 255
Ser His Gly Glu Val Leu Pro Tyr Gly Glu Pro Ile Pro Tyr Asp Gly
260 265 270
Gly Tyr Glu Gln Asp Glu Asp His Pro Leu Tyr Ile Gln Phe Ile Glu
275 280 285
Ala Asp Phe Ala Val Lys Glu Asn Arg Ile Pro Cys Leu Gln Leu Lys
290 295 300
Gly Asn Val Met Phe Gly Glu Thr Glu Tyr Ile Arg Asp Ser Lys Gly
305 310 315 320
Met Gln Thr Leu Cys Leu Thr Ser Val Asp Met Glu Met Leu Phe Glu
325 330 335
His Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
340 345 350
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
355 360 365
Xaa Xaa Xaa Xaa Xaa Xaa Arg Thr Ile Ala Lys Leu Gln Leu Asn Ser
370 375 380
Leu Phe Ala Ala Asn Pro Val Lys Gln Ser Arg Met Pro Tyr Leu Asp
385 390 395 400
Glu Gly Ile Val Lys Tyr Ala Leu Leu Glu Pro Glu His Ala Glu Ala
405 410 415
Gln Tyr Leu Pro Ala Gly Ala Phe Ile Thr Ser Tyr Ala Arg Gln Phe
420 425 430
Thr Ile Arg Ala Ala Gln Ala Asn Tyr Glu Arg Trp Leu Tyr Cys Asp
435 440 445
Thr Asp Ser Val Tyr Leu Arg Gly Thr Glu Pro Pro Val Asp Met Arg
450 455 460
Val Asp Ala Tyr Glu Leu Gly Ala Trp Lys Lys Glu His Glu Phe Asp
465 470 475 480
Cys Phe Lys Ala Ile Arg Ala Lys Thr Tyr Cys Phe Glu Glu Asp Gly
485 490 495
Glu Leu Thr Val His Cys Ala Gly Met Pro Ala Arg Cys His Glu His
500 505 510
Val Thr Met Asp Asn Phe Glu Val Gly Ala Ser Phe Pro Gly Lys Leu
515 520 525
Lys Pro Lys Asp Val Asn Gly Gly Thr Ile Leu Val Glu Asp Val Phe
530 535 540
Thr Ile Arg Pro
545
<210> 18
<211> 611
<212> PRT
<213> Enterococcus faecium (SK)
<400> 18
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Asp Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly
50 55 60
Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Ser Lys
65 70 75 80
Glu Thr Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly
85 90 95
Gln Trp Tyr Ala Leu Glu Ile Cys Trp Glu Val Asn Tyr Thr Thr Thr
100 105 110
Lys Ser Gly Lys Thr Lys Lys Glu Lys Val Arg Thr Ile Ile Tyr Asp
115 120 125
Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Gln Ile Ala Glu Ala Phe
130 135 140
Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Tyr Thr Lys Glu Arg Pro
145 150 155 160
Val Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp
165 170 175
Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu
180 185 190
Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Lys Asp Trp
195 200 205
Leu Lys Ala Thr His Gly Lys Ser Thr Phe Lys Gln Trp Phe Pro Ile
210 215 220
Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly
225 230 235 240
Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Asp Gly
245 250 255
Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg
260 265 270
Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Pro
275 280 285
Asn Asn Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg
290 295 300
Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu
305 310 315 320
Phe Ile Gln Asn Glu Tyr Leu Asp Ser Ser Val Asn Lys Leu Gly Val
325 330 335
Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Glu Leu Phe
340 345 350
Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met
355 360 365
Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile
370 375 380
Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly
385 390 395 400
Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr
405 410 415
Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu
420 425 430
Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe
435 440 445
Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys
450 455 460
Phe Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Val Gly
465 470 475 480
Thr Asp Val Pro Glu Ala Ile Glu His Leu Val Asp Pro Lys Lys Leu
485 490 495
Gly Tyr Trp Gly His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg
500 505 510
Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys
515 520 525
Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe
530 535 540
Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln
545 550 555 560
Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys Gly His His
565 570 575
His His His His His His His His Gly Gly Gly Ser Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala Gln Lys Ile Glu
595 600 605
Trp His Glu
610
<210> 19
<211> 646
<212> PRT
<213> Bacillus phage Harambe
<400> 19
Met Gly Asn Lys Lys Arg Lys Ile Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Asp Val Asn Asp Cys Arg Val Trp Ala Tyr Gly Leu Met Glu Ile
20 25 30
Asp Gly Lys Phe Glu Asn Tyr Lys Glu Gly Asn Asn Ile Asp Glu Phe
35 40 45
Met Glu Trp Thr Glu Gln Glu Gln Gly Asp Leu Tyr Phe His Asn Leu
50 55 60
Arg Phe Asp Gly Glu Phe Ile Val Asn Trp Leu Leu His Lys Gly Tyr
65 70 75 80
Arg Phe Asn Asn Thr Arg Lys Ala Gly Thr Phe Asn Ala Val Ile Ser
85 90 95
Ser Met Gly Gln Trp Tyr Lys Ile Asp Ile Tyr Tyr Gly Arg Glu Gly
100 105 110
Lys Lys Val Phe Lys Thr Ser Ile Tyr Asp Ser Leu Lys Lys Leu Pro
115 120 125
Phe Pro Val Lys Thr Ile Ala Lys Ala Phe Lys Leu Pro Ile Glu Lys
130 135 140
Gly Asp Ile Asp Tyr Asp Ala Pro Arg Pro Val Gly His Gln Ile Thr
145 150 155 160
Pro Asp Glu Ser Lys Tyr Ile Lys Asn Asp Val Glu Ile Ile Ala Arg
165 170 175
Ala Leu His Ser Gln Leu Asn Thr Ala Lys Leu Thr Lys Met Thr Ile
180 185 190
Gly Ser Asp Ala Leu Asp Gly Phe Lys His Ser Leu His Lys Ser Pro
195 200 205
Lys Val Ser Lys Arg Met Tyr Asp His His Phe Pro Val Ile Ser Asn
210 215 220
Ala Ile His Glu Glu Phe Lys Lys Ala Tyr Arg Gly Gly Phe Thr Trp
225 230 235 240
Ala Asn Pro Lys Tyr Ala Gly Lys Val Ile Gly Asn Gly Leu Val Phe
245 250 255
Asp Val Asn Ser Leu Tyr Pro Ser Val Met Tyr Asp Lys Pro Leu Pro
260 265 270
Tyr Gly Leu Pro Val Pro Phe Ser Gly Glu Tyr Glu Tyr Asp Glu Thr
275 280 285
His Pro Leu Phe Ile Gln His Ile Lys Cys Gly Phe Glu Leu Lys Asp
290 295 300
Gly His Ile Pro Thr Ile Gln Ile Lys Lys Asn Phe Arg Phe Ala Asp
305 310 315 320
Asn Glu Tyr Leu His Ser Ser Glu Gly Asn Ile Leu Asp Leu His Val
325 330 335
Thr Asn Val Asp Leu Ala Leu Ile Lys Glu His Tyr Thr Leu Tyr Glu
340 345 350
Glu Glu Tyr Leu Gln Gly Tyr Lys Phe Lys Gln Val Thr Gly Leu Phe
355 360 365
Lys Asn Tyr Ile Asp Tyr Trp Ser Asp Lys Lys Ile Asn Ala Glu Asp
370 375 380
Pro Ala Ile Arg Gln Met Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly
385 390 395 400
Lys Phe Gly Thr Ser Ile Asp Val Thr Gly Lys Glu Val Phe Leu Lys
405 410 415
Glu Asp Gly Ser Thr Gly Phe Arg Lys Gly Gln Lys Glu Glu Arg Asp
420 425 430
Pro Val Tyr Met Pro Met Gly Ala Phe Ile Thr Ala Tyr Ala Arg Asp
435 440 445
Val Thr Ile Arg Thr Ala Gln Lys Cys Tyr Asp Arg Ile Leu Tyr Cys
450 455 460
Asp Thr Asp Ser Ile His Leu Val Gly Thr Glu Ile Pro Glu Ala Ile
465 470 475 480
Lys Asp Arg Ile His Asp Lys Lys Leu Gly Tyr Trp Ala His Glu Ser
485 490 495
Thr Phe Trp Arg Ala Lys Phe Ile Arg Gln Lys Thr Tyr Ile Glu Asp
500 505 510
Leu Cys Met Arg Phe Glu Gly Glu Lys Val Asn Gly Glu Trp Lys Phe
515 520 525
Lys Met Val Glu Glu Lys Asp Ile Thr Lys Ala Thr Ala Arg Glu Leu
530 535 540
Ser Val Lys Cys Ala Gly Met Pro Ala Gln Val Lys Gln Tyr Val Thr
545 550 555 560
Phe Asp Asn Phe Gly Val Asp Phe Lys His Asp Pro Asn Asp Tyr Thr
565 570 575
Asp Glu Glu Ile Lys Arg Lys Asn Ile Lys Phe Lys Leu Lys Pro Thr
580 585 590
His Arg Lys Gly Gly Gln Val Leu Val Pro Thr Pro Phe Thr Ile Lys
595 600 605
Gly His His His His His His His His His His Gly Gly Gly Ser Gly
610 615 620
Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala Gln
625 630 635 640
Lys Ile Glu Trp His Glu
645
<210> 20
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 20
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Ile His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Leu Ser Thr Lys Lys Phe Asn Lys Val Phe
195 200 205
Pro Lys Leu Ser Leu Pro Met Asp Lys Glu Ile Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Lys Tyr Lys Glu Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr
245 250 255
Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys Tyr
260 265 270
Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu
275 280 285
Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn
290 295 300
Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro
305 310 315 320
Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His
325 330 335
Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu
340 345 350
Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Val Lys
355 360 365
Thr His Glu Glu Gly Ala Lys Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly Phe Arg Val Gly Asp Glu
405 410 415
Glu Tyr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Ala Arg Phe Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val
450 455 460
Pro Glu Ile Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp Gly Lys Leu Lys Glu
500 505 510
Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Thr Ile Lys Lys Lys Val Thr Phe Asp Asn Phe Ala
530 535 540
Val Gly Phe Ser Ser Met Gly Lys Pro Lys Pro Val Gln Val Asn Gly
545 550 555 560
Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 21
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 21
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Ile His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Leu Ser Thr Lys Lys Phe Asn Lys Val Phe
195 200 205
Pro Lys Leu Ser Leu Pro Met Asp Lys Glu Ile Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Lys Tyr Lys Glu Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ser Gln Met Tyr
245 250 255
Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys Tyr
260 265 270
Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu
275 280 285
Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn
290 295 300
Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro
305 310 315 320
Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His
325 330 335
Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu
340 345 350
Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Val Lys
355 360 365
Thr His Glu Glu Gly Ala Lys Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly Phe Arg Val Gly Asp Glu
405 410 415
Glu Tyr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Ala Arg Phe Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val
450 455 460
Pro Glu Ile Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp Gly Lys Leu Lys Glu
500 505 510
Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Thr Ile Lys Lys Lys Val Thr Phe Asp Asn Phe Ala
530 535 540
Val Gly Phe Ser Ser Met Gly Lys Pro Lys Pro Val Gln Val Asn Gly
545 550 555 560
Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 22
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 22
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Ile His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Leu Ser Thr Lys Lys Phe Asn Lys Val Phe
195 200 205
Pro Lys Leu Ser Leu Pro Met Asp Lys Glu Ile Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Lys Tyr Lys Glu Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ser Gln Met Tyr
245 250 255
Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys Tyr
260 265 270
Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu
275 280 285
Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn
290 295 300
Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro
305 310 315 320
Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His
325 330 335
Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu
340 345 350
Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Val Lys
355 360 365
Thr His Glu Tyr Gly Ala Lys Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly Phe Arg Val Gly Asp Glu
405 410 415
Glu Tyr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Ala Arg Phe Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val
450 455 460
Pro Glu Ile Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp Gly Tyr Leu Lys Glu
500 505 510
Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Thr Ile Lys Lys Lys Val Thr Phe Asp Asn Phe Ala
530 535 540
Val Gly Phe Ser Ser Met Gly Lys Pro Lys Pro Val Gln Val Asn Gly
545 550 555 560
Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 23
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 23
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Leu Ser Thr Lys Lys Phe Asn Lys Val Phe
195 200 205
Pro Lys Leu Ser Leu Pro Met Asp Lys Glu Ile Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Lys Tyr Lys Glu Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ser Gln Met Tyr
245 250 255
Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys Tyr
260 265 270
Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu
275 280 285
Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn
290 295 300
Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro
305 310 315 320
Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His
325 330 335
Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu
340 345 350
Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Val Lys
355 360 365
Thr His Glu Tyr Gly Ala Lys Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly Phe Arg Val Gly Asp Glu
405 410 415
Glu Tyr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Ala Arg Phe Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val
450 455 460
Pro Glu Ile Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp Gly Tyr Leu Lys Glu
500 505 510
Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Thr Ile Lys Lys Lys Val Thr Phe Asp Asn Phe Ala
530 535 540
Val Gly Phe Ser Ser Met Gly Lys Pro Lys Pro Val Gln Val Asn Gly
545 550 555 560
Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 24
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 24
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly
50 55 60
Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly
85 90 95
Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr
100 105 110
Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp
115 120 125
Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe
130 135 140
Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro
145 150 155 160
Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp
165 170 175
Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu
180 185 190
Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp
195 200 205
Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val
210 215 220
Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly
225 230 235 240
Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly
245 250 255
Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg
260 265 270
Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu
275 280 285
Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg
290 295 300
Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu
305 310 315 320
Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val
325 330 335
Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe
340 345 350
Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met
355 360 365
Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile
370 375 380
Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly
385 390 395 400
Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr
405 410 415
Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu
420 425 430
Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe
435 440 445
Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys
450 455 460
Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
465 470 475 480
Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu
485 490 495
Gly Tyr Trp Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg
500 505 510
Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys
515 520 525
Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe
530 535 540
Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln
545 550 555 560
Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys
565 570
<210> 25
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 25
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly
50 55 60
Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly
85 90 95
Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr
100 105 110
Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp
115 120 125
Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe
130 135 140
Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro
145 150 155 160
Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp
165 170 175
Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu
180 185 190
Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp
195 200 205
Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val
210 215 220
Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly
225 230 235 240
Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly
245 250 255
Ile Val Phe Asp Ala Asn Ser Ala Tyr Pro Ser Gln Met Tyr Val Arg
260 265 270
Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu
275 280 285
Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg
290 295 300
Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu
305 310 315 320
Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val
325 330 335
Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe
340 345 350
Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met
355 360 365
Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile
370 375 380
Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly
385 390 395 400
Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr
405 410 415
Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu
420 425 430
Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe
435 440 445
Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys
450 455 460
Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
465 470 475 480
Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu
485 490 495
Gly Tyr Trp Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg
500 505 510
Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys
515 520 525
Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe
530 535 540
Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln
545 550 555 560
Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys
565 570
<210> 26
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 26
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly
50 55 60
Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly
85 90 95
Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr
100 105 110
Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp
115 120 125
Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe
130 135 140
Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro
145 150 155 160
Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp
165 170 175
Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu
180 185 190
Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp
195 200 205
Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val
210 215 220
Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly
225 230 235 240
Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly
245 250 255
Ile Val Phe Asp Ala Asn Ser Ala Tyr Pro Ser Gln Met Tyr Val Arg
260 265 270
Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu
275 280 285
Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg
290 295 300
Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu
305 310 315 320
Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val
325 330 335
Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe
340 345 350
Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met
355 360 365
Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile
370 375 380
Glu Val Lys Asn Thr Thr Tyr Gly Ala Arg Lys Ala Asn Ala Lys Gly
385 390 395 400
Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr
405 410 415
Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu
420 425 430
Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe
435 440 445
Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys
450 455 460
Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
465 470 475 480
Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu
485 490 495
Gly Tyr Trp Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg
500 505 510
Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys
515 520 525
Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe
530 535 540
Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln
545 550 555 560
Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys
565 570
<210> 27
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 27
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Ile His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Leu Ser Thr Lys Lys Phe Asn Lys Val Phe
195 200 205
Pro Lys Leu Ser Leu Pro Met Asp Lys Glu Ile Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Lys Tyr Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ser Gln Met Tyr
245 250 255
Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys Tyr
260 265 270
Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu
275 280 285
Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn
290 295 300
Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro
305 310 315 320
Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His
325 330 335
Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu
340 345 350
Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Val Lys
355 360 365
Thr His Glu Tyr Gly Ala Lys Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly Phe Arg Val Gly Asp Glu
405 410 415
Glu Tyr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Phe Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val
450 455 460
Pro Glu Ile Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Lys Gly Tyr Leu Lys Gln
500 505 510
Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Thr Ile Lys Lys Lys Val Thr Phe Asp Asn Phe Ala
530 535 540
Val Gly Phe Ser Ser Met Gly Lys Pro Lys Pro Val Gln Val Asn Gly
545 550 555 560
Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 28
<211> 589
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 28
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Asp Val Asn Asp Cys Arg Val Trp Ala Tyr Gly Trp Met Glu Ile
20 25 30
Gly Lys Thr Ser Asn Tyr Lys Ile Gly Thr Asp Phe Asn Glu Phe Met
35 40 45
Glu Trp Met Ile His Ser Ser Ser Arg Leu Tyr Phe His Asp Leu Lys
50 55 60
Phe Asp Gly Ser Phe Ile Val Asn Trp Leu Leu His Asn Gly Tyr Thr
65 70 75 80
Trp Thr Lys Arg Pro Ser Lys Glu Gly Gln Phe Ser Thr Leu Ile Ser
85 90 95
Lys Met Gly Gln Trp Tyr Gly Ile Thr Ile Cys Ser Gly Arg Asp Gly
100 105 110
Arg Lys Lys Lys Leu Thr Thr Ile His Asp Ser Leu Lys Lys Leu Pro
115 120 125
Phe Pro Val Arg Lys Ile Gly Lys Asp Phe Lys Leu Asn Val Leu Lys
130 135 140
Gly Asp Ile Asp Ile His Lys Pro Arg Pro Ile Gly Tyr Glu Ile Asp
145 150 155 160
Asp Glu Glu Tyr Gln Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu
165 170 175
Ala Leu Glu Val Gln Thr Val Gln Gly Leu Thr Gly Met Thr Asn Gly
180 185 190
Lys Asp Ala Leu Asp Glu Phe Val Asn Met Ser Gly Lys Leu Tyr Glu
195 200 205
Lys Leu Phe Pro Val Phe Ser Leu Glu Leu Asn Glu Glu Ile Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Pro Val Tyr Gly Gly Lys
225 230 235 240
Lys Tyr Val Lys Asp Gly Ile Val Phe Asp Ala Asn Ser Ala Tyr Pro
245 250 255
Ser Gln Met Tyr Asp Arg Asp Leu Pro Cys Gly Val Pro Ile Pro Phe
260 265 270
Glu Gly Glu Tyr Val Tyr Asp Lys Ser His Pro Leu Tyr Ile Gln Lys
275 280 285
Leu Thr Phe Glu Phe Glu Leu Lys Glu Asn Tyr Ile Pro Thr Ile Gln
290 295 300
Leu Lys Asn Ser Arg Phe Gly Phe Lys Gly Asn Glu Tyr Leu Ser Ser
305 310 315 320
Ser Asn Gly Glu Arg Ile Thr Ile Ser Val Ser Ser Val Asp Trp Glu
325 330 335
Leu Ile Arg Glu His Tyr His Val Tyr Asp Val Glu Phe Glu Lys Gly
340 345 350
Trp Lys Phe Arg Ser Thr Lys Gln Ala Phe Arg Gln Tyr Ile Asp Lys
355 360 365
Trp Met Leu Val Lys Asn Met Ser Tyr Gly Ala Lys Lys Ala Ile Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Thr Asn Pro Asp
385 390 395 400
Ile Thr Gly Lys Arg Pro Tyr Leu Arg Glu Asp Gly Ser Asn Gly Phe
405 410 415
Glu Leu Met Glu Glu Glu Phe Arg Asp Pro Val Tyr Thr Pro Val Gly
420 425 430
Ile Phe Ile Thr Ser Trp Ala Arg Tyr Thr Thr Ile Thr Ser Ala Gln
435 440 445
Lys Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Met His Leu
450 455 460
Glu Gly Leu Asp Val Pro Glu Ser Ile Lys Asp Ile Val Ala Asp Asp
465 470 475 480
Val Leu Gly Tyr Trp Glu Lys Glu Gly Gln Phe Lys Gln Gly Lys Phe
485 490 495
Ile Arg Gln Lys Thr Tyr Met Glu Glu Tyr Tyr Ala Lys Tyr Val Arg
500 505 510
Asp Glu Asn Gly Glu Ile Lys Tyr Asp Asp Glu Lys Pro Tyr Lys Thr
515 520 525
Ile Cys Asp Lys Glu Glu Ser Asp Thr Thr Ile Ile Glu Ile Lys Cys
530 535 540
Ala Gly Met Pro Asp Asn Ile Lys Lys His Val Thr Phe Asp Asn Phe
545 550 555 560
Asp Ile Gly Phe Thr Met Glu Gly Lys Leu Lys Pro Lys Gln Val Tyr
565 570 575
Gly Gly Val Val Leu Val Glu Glu Thr Tyr Thr Met Lys
580 585
<210> 29
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 29
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asp Glu Lys Phe Asp Gly
50 55 60
Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly
85 90 95
Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr
100 105 110
Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp
115 120 125
Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe
130 135 140
Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro
145 150 155 160
Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp
165 170 175
Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu
180 185 190
Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp
195 200 205
Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val
210 215 220
Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly
225 230 235 240
Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly
245 250 255
Ile Val Phe Asp Ala Asn Ser Ala Tyr Pro Ser Gln Met Tyr Val Arg
260 265 270
Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu
275 280 285
Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg
290 295 300
Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu
305 310 315 320
Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val
325 330 335
Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe
340 345 350
Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met
355 360 365
Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile
370 375 380
Glu Val Lys Asn Thr Thr Tyr Gly Ala Arg Lys Ala Asn Ala Lys Gly
385 390 395 400
Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr
405 410 415
Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu
420 425 430
Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe
435 440 445
Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys
450 455 460
Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
465 470 475 480
Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu
485 490 495
Gly Tyr Trp Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg
500 505 510
Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys
515 520 525
Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe
530 535 540
Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln
545 550 555 560
Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys
565 570
<210> 30
<211> 592
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 30
Met Ala Thr Lys Lys Arg Lys Ala Tyr Ser Cys Asp Phe Glu Ala Thr
1 5 10 15
Thr Ser Thr Tyr Ser Glu Thr Glu Thr Arg Val Trp Ala Tyr Gly Trp
20 25 30
Met Glu Ile Gly Asn Thr Ser His Phe Asn Ile Gly Asp Asn Leu Asp
35 40 45
Glu Phe Met Leu Trp Thr Ser Lys Glu Cys Ala Asp Leu Tyr Phe His
50 55 60
Asp Leu Arg Tyr Asp Gly Glu Phe Ile Val Asn Trp Leu Leu His Lys
65 70 75 80
Gly Tyr Glu Cys Asn Glu Ser Gly Arg Pro Lys Thr Phe Asp Thr Val
85 90 95
Ile Ser Lys Gly Gly Gln Trp Tyr Lys Ile Ala Ile His His Glu Gly
100 105 110
Lys Gly Thr Thr Gln Ile Phe Asp Ser Leu Lys Lys Leu Pro Phe Pro
115 120 125
Val Lys Thr Ile Ala Lys Ala Phe Lys Leu Pro Val Leu Lys Gly Asp
130 135 140
Ile Asp Ile Asn Leu His Arg Asp Glu Asn His Val Ile Thr Ser Glu
145 150 155 160
Glu Phe Thr Tyr Ile Lys His Asp Ile Glu Ile Val Ala Arg Ala Leu
165 170 175
Asp Ile Gln Ile Asn Gln Gln Gly Leu Val Lys Met Thr Asn Gly Ala
180 185 190
Asp Ser Met Asp His Phe Ile Lys Ser Leu Asp Lys Lys Lys Lys Val
195 200 205
Ala Glu Arg Ile Tyr Asn Gln Tyr Phe Pro Lys Met Ser Ile Ala Met
210 215 220
Asp Ser Ile Phe Arg Lys Ala Tyr Arg Gly Gly Phe Thr Trp Val Asn
225 230 235 240
Pro Lys Phe Lys Gly Gln Glu Val Gly Glu Gly Met Val Phe Asp Ala
245 250 255
Asn Ser Ala Tyr Pro Ser Val Met Tyr Tyr Lys Pro Leu Pro Trp Gly
260 265 270
Lys Pro Val Pro Phe Val Gly Lys Tyr Glu Glu Asp Pro Asp Phe Pro
275 280 285
Leu Tyr Ile Cys His Ile Lys Thr Gly Phe Val Leu Lys Glu Gly His
290 295 300
Ile Pro Thr Ile Gln Ile Lys Lys Asn Pro Ile Phe Gln Glu Asn Glu
305 310 315 320
Tyr Leu Glu Thr Ser Gly Gly Ala Pro Val Asp Leu His Val Thr Asn
325 330 335
Val Asp Leu Glu Leu Ile Lys Glu His Tyr Glu Leu Tyr Asp Thr Glu
340 345 350
Tyr Val Gly Gly Trp Lys Phe Arg Gln Gln Thr Gly Ile Phe Asn Asn
355 360 365
Phe Ile Asp Tyr Trp Met Lys Ile Lys Thr Asp Pro Lys Ser Thr Pro
370 375 380
Ala Ile Val Thr Leu Ala Lys Leu Gln Leu Asn Ser Leu Tyr Gly Lys
385 390 395 400
Phe Ala Ser His Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp
405 410 415
Asp Gly Ser Thr Ala Phe Lys Lys Gly Leu Pro Lys Ser Lys Asp Pro
420 425 430
Val Tyr Thr Pro Ala Gly Ala Phe Ile Thr Ala Trp Ala Arg His Met
435 440 445
Thr Ile Thr Thr Ala Gln Lys Val Tyr Asp Arg Ile Leu Tyr Cys Asp
450 455 460
Thr Asp Ser Ile His Ile Leu Gly Ile Asp Ile Pro Glu Ala Ile Lys
465 470 475 480
Asn Asp Ile His Gln Lys Glu Leu Gly Lys Trp Glu Phe Glu Cys Met
485 490 495
Phe Lys Arg Ala Lys Phe Val Arg Gln Lys Thr Tyr Val Glu Asp Met
500 505 510
Tyr Ala Lys Phe Met Lys Tyr Trp Glu Asp Gly Glu Leu Asn Tyr Tyr
515 520 525
Leu Lys Glu Cys Val Lys Glu Glu Ala Thr Ala Arg Leu Leu Asn Val
530 535 540
Lys Cys Ala Gly Met Pro Gln Ala Val Lys Lys Phe Val Thr Phe Arg
545 550 555 560
Thr Phe Ala Val Gly Phe Thr Ser Asp Thr Gly Lys Leu Lys Pro Lys
565 570 575
His Val Lys Gly Gly Gln Ile Leu Val Asp Val Pro Phe Thr Ile Lys
580 585 590
<210> 31
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 31
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly
50 55 60
Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly
85 90 95
Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr
100 105 110
Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp
115 120 125
Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe
130 135 140
Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Tyr Thr Lys Glu Arg Pro
145 150 155 160
Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp
165 170 175
Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu
180 185 190
Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp
195 200 205
Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val
210 215 220
Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly
225 230 235 240
Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly
245 250 255
Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg
260 265 270
Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu
275 280 285
Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg
290 295 300
Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu
305 310 315 320
Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val
325 330 335
Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe
340 345 350
Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met
355 360 365
Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile
370 375 380
Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly
385 390 395 400
Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr
405 410 415
Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu
420 425 430
Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe
435 440 445
Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys
450 455 460
Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
465 470 475 480
Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu
485 490 495
Gly Tyr Trp Lys His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg
500 505 510
Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys
515 520 525
Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe
530 535 540
Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln
545 550 555 560
Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys
565 570
<210> 32
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 32
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly
50 55 60
Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly
85 90 95
Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr
100 105 110
Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp
115 120 125
Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe
130 135 140
Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro
145 150 155 160
Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp
165 170 175
Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu
180 185 190
Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp
195 200 205
Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val
210 215 220
Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly
225 230 235 240
Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly
245 250 255
Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg
260 265 270
Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu
275 280 285
Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg
290 295 300
Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu
305 310 315 320
Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val
325 330 335
Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe
340 345 350
Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met
355 360 365
Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile
370 375 380
Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly
385 390 395 400
Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr
405 410 415
Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu
420 425 430
Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe
435 440 445
Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys
450 455 460
Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
465 470 475 480
Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu
485 490 495
Gly Tyr Trp Lys His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg
500 505 510
Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys
515 520 525
Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe
530 535 540
Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln
545 550 555 560
Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys
565 570
<210> 33
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 33
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly
50 55 60
Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly
85 90 95
Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr
100 105 110
Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp
115 120 125
Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe
130 135 140
Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro
145 150 155 160
Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp
165 170 175
Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu
180 185 190
Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp
195 200 205
Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val
210 215 220
Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly
225 230 235 240
Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly
245 250 255
Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg
260 265 270
Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu
275 280 285
Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg
290 295 300
Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu
305 310 315 320
Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val
325 330 335
Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe
340 345 350
Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met
355 360 365
Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile
370 375 380
Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly
385 390 395 400
Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr
405 410 415
Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu
420 425 430
Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe
435 440 445
Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys
450 455 460
Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
465 470 475 480
Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu
485 490 495
Gly Tyr Trp Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg
500 505 510
Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys
515 520 525
Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe
530 535 540
Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln
545 550 555 560
Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys
565 570
<210> 34
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 34
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly
50 55 60
Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly
85 90 95
Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr
100 105 110
Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp
115 120 125
Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe
130 135 140
Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro
145 150 155 160
Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp
165 170 175
Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu
180 185 190
Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp
195 200 205
Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val
210 215 220
Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly
225 230 235 240
Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly
245 250 255
Ile Val Phe Asp Ala Asn Ser His Tyr Pro Ser Gln Met Tyr Val Arg
260 265 270
Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu
275 280 285
Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg
290 295 300
Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu
305 310 315 320
Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val
325 330 335
Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe
340 345 350
Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met
355 360 365
Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile
370 375 380
Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly
385 390 395 400
Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr
405 410 415
Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu
420 425 430
Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe
435 440 445
Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys
450 455 460
Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
465 470 475 480
Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu
485 490 495
Gly Tyr Trp Lys His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg
500 505 510
Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys
515 520 525
Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe
530 535 540
Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln
545 550 555 560
Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys
565 570
<210> 35
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 35
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly
50 55 60
Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly
85 90 95
Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr
100 105 110
Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp
115 120 125
Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe
130 135 140
Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro
145 150 155 160
Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp
165 170 175
Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu
180 185 190
Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp
195 200 205
Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val
210 215 220
Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly
225 230 235 240
Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly
245 250 255
Ile Val Phe Asp Ala Asn Ser Ala Tyr Pro Ser Gln Met Tyr Val Arg
260 265 270
Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu
275 280 285
Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg
290 295 300
Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu
305 310 315 320
Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val
325 330 335
Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe
340 345 350
Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met
355 360 365
Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile
370 375 380
Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly
385 390 395 400
Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr
405 410 415
Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu
420 425 430
Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe
435 440 445
Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys
450 455 460
Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
465 470 475 480
Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu
485 490 495
Gly Tyr Trp Lys His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg
500 505 510
Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys
515 520 525
Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe
530 535 540
Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln
545 550 555 560
Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys
565 570
<210> 36
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 36
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly
50 55 60
Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly
85 90 95
Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr
100 105 110
Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp
115 120 125
Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe
130 135 140
Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro
145 150 155 160
Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp
165 170 175
Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu
180 185 190
Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp
195 200 205
Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val
210 215 220
Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly
225 230 235 240
Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly
245 250 255
Ile Val Phe Asp Ala Asn Ser His Tyr Pro Ser Gln Met Tyr Val Arg
260 265 270
Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu
275 280 285
Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg
290 295 300
Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu
305 310 315 320
Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val
325 330 335
Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe
340 345 350
Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met
355 360 365
Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile
370 375 380
Glu Val Lys Asn Thr Thr Tyr Gly Ala Arg Lys Ala Asn Ala Lys Gly
385 390 395 400
Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr
405 410 415
Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu
420 425 430
Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe
435 440 445
Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys
450 455 460
Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
465 470 475 480
Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu
485 490 495
Gly Tyr Trp Lys His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg
500 505 510
Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys
515 520 525
Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe
530 535 540
Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln
545 550 555 560
Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys
565 570
<210> 37
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 37
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly
50 55 60
Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly
85 90 95
Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr
100 105 110
Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp
115 120 125
Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe
130 135 140
Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro
145 150 155 160
Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp
165 170 175
Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu
180 185 190
Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp
195 200 205
Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val
210 215 220
Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly
225 230 235 240
Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly
245 250 255
Ile Val Phe Asp Ala Asn Ser His Tyr Pro Ser Gln Met Tyr Val Arg
260 265 270
Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu
275 280 285
Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg
290 295 300
Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu
305 310 315 320
Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val
325 330 335
Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe
340 345 350
Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met
355 360 365
Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile
370 375 380
Glu Val Lys Asn Thr Thr Tyr Gly Ala Arg Lys Ala Asn Ala Lys Gly
385 390 395 400
Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr
405 410 415
Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu
420 425 430
Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe
435 440 445
Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys
450 455 460
Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
465 470 475 480
Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu
485 490 495
Gly Tyr Trp Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg
500 505 510
Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys
515 520 525
Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe
530 535 540
Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln
545 550 555 560
Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys
565 570
<210> 38
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 38
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly
50 55 60
Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly
85 90 95
Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr
100 105 110
Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp
115 120 125
Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe
130 135 140
Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro
145 150 155 160
Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp
165 170 175
Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu
180 185 190
Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp
195 200 205
Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val
210 215 220
Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly
225 230 235 240
Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly
245 250 255
Ile Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr Val Arg
260 265 270
Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu
275 280 285
Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg
290 295 300
Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu
305 310 315 320
Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val
325 330 335
Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe
340 345 350
Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met
355 360 365
Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Thr
370 375 380
Glu Val Lys Thr Thr Thr Tyr Gly Ala Arg Lys Gln Leu Ala Lys Leu
385 390 395 400
Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr
405 410 415
Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu
420 425 430
Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe
435 440 445
Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys
450 455 460
Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
465 470 475 480
Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Pro Lys Lys Leu
485 490 495
Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Phe Ile Arg
500 505 510
Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys
515 520 525
Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe
530 535 540
Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln
545 550 555 560
Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys
565 570
<210> 39
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 39
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly
50 55 60
Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly
85 90 95
Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr
100 105 110
Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp
115 120 125
Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe
130 135 140
Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro
145 150 155 160
Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp
165 170 175
Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu
180 185 190
Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp
195 200 205
Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val
210 215 220
Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly
225 230 235 240
Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly
245 250 255
Ile Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr Val Arg
260 265 270
Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu
275 280 285
Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg
290 295 300
Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu
305 310 315 320
Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val
325 330 335
Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe
340 345 350
Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met
355 360 365
Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile
370 375 380
Glu Val Lys Asn Thr Thr Tyr Gly Ala Arg Lys Gln Asn Ala Lys Leu
385 390 395 400
Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr
405 410 415
Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu
420 425 430
Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe
435 440 445
Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys
450 455 460
Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
465 470 475 480
Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu
485 490 495
Gly Tyr Trp Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg
500 505 510
Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys
515 520 525
Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe
530 535 540
Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln
545 550 555 560
Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys
565 570
<210> 40
<211> 591
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 40
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly
50 55 60
Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly
85 90 95
Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr
100 105 110
Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp
115 120 125
Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe
130 135 140
Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro
145 150 155 160
Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp
165 170 175
Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu
180 185 190
Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp
195 200 205
Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val
210 215 220
Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly
225 230 235 240
Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly
245 250 255
Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg
260 265 270
Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu
275 280 285
Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg
290 295 300
Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu
305 310 315 320
Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val
325 330 335
Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe
340 345 350
Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met
355 360 365
Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile
370 375 380
Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly
385 390 395 400
Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr
405 410 415
Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu
420 425 430
Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe
435 440 445
Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys
450 455 460
Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
465 470 475 480
Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu
485 490 495
Gly Tyr Trp Lys His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg
500 505 510
Gln Lys Thr Tyr Val Glu Glu Ile Tyr Met Lys Arg Val Lys Gly Tyr
515 520 525
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Gly Glu Leu Asn Val
530 535 540
Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp
545 550 555 560
Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg
565 570 575
Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys
580 585 590
<210> 41
<211> 611
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 41
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Asp Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly
50 55 60
Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Ser Lys
65 70 75 80
Glu Thr Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly
85 90 95
Gln Trp Tyr Ala Leu Glu Ile Cys Trp Glu Val Asn Tyr Thr Thr Thr
100 105 110
Lys Ser Gly Lys Thr Lys Lys Glu Lys Val Arg Thr Ile Ile Tyr Asp
115 120 125
Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Gln Ile Ala Glu Ala Phe
130 135 140
Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro
145 150 155 160
Val Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp
165 170 175
Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu
180 185 190
Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Lys Asp Trp
195 200 205
Leu Lys Ala Thr His Gly Lys Ser Thr Phe Lys Gln Trp Phe Pro Ile
210 215 220
Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly
225 230 235 240
Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Asp Gly
245 250 255
Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg
260 265 270
Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Pro
275 280 285
Asn Asn Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg
290 295 300
Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu
305 310 315 320
Phe Ile Gln Asn Glu Tyr Leu Asp Ser Ser Val Asn Lys Leu Gly Val
325 330 335
Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Glu Leu Phe
340 345 350
Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met
355 360 365
Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile
370 375 380
Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly
385 390 395 400
Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr
405 410 415
Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu
420 425 430
Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe
435 440 445
Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys
450 455 460
Phe Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Val Gly
465 470 475 480
Thr Asp Val Pro Glu Ala Ile Glu His Leu Val Asp Pro Lys Lys Leu
485 490 495
Gly Tyr Trp Gly His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg
500 505 510
Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys
515 520 525
Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe
530 535 540
Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln
545 550 555 560
Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys Gly His His
565 570 575
His His His His His His His His Gly Gly Gly Ser Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala Gln Lys Ile Glu
595 600 605
Trp His Glu
610
<210> 42
<211> 613
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 42
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys Gly
565 570 575
His His His His His His His His His His Gly Gly Gly Ser Gly Gly
580 585 590
Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala Gln Lys
595 600 605
Ile Glu Trp His Glu
610
<210> 43
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 43
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 44
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 44
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Lys Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 45
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 45
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Lys
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 46
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 46
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Cys His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 47
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 47
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Arg Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 48
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 48
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Arg Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 49
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 49
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Arg Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 50
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 50
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Asp Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 51
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 51
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 52
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 52
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Asp Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 53
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 53
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Phe Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 54
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 54
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys
500 505 510
Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys
565 570 575
<210> 55
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 55
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Cys His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys
500 505 510
Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys
565 570 575
<210> 56
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 56
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ser His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys
500 505 510
Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys
565 570 575
<210> 57
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 57
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Thr His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys
500 505 510
Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys
565 570 575
<210> 58
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 58
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Asn His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys
500 505 510
Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys
565 570 575
<210> 59
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 59
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Gln His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys
500 505 510
Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys
565 570 575
<210> 60
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 60
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys
500 505 510
Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys
565 570 575
<210> 61
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 61
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Lys
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 62
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 62
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Asn His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 63
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 63
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Gln His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 64
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 64
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Phe
465 470 475 480
Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 65
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 65
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Lys Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 66
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 66
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ser
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 67
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 67
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Asp Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 68
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 68
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Trp Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 69
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 69
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Trp Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 70
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 70
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Phe Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 71
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 71
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Ala Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 72
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 72
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Arg Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 73
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 73
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Asp
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Lys
465 470 475 480
Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 74
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 74
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Glu
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Lys
465 470 475 480
Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 75
<211> 613
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 75
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys Gly
565 570 575
His His His His His His His His His His Gly Gly Gly Ser Gly Gly
580 585 590
Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala Gln Lys
595 600 605
Ile Glu Trp His Glu
610
<210> 76
<211> 613
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 76
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys Gly
565 570 575
His His His His His His His His His His Gly Gly Gly Ser Gly Gly
580 585 590
Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala Gln Lys
595 600 605
Ile Glu Trp His Glu
610
<210> 77
<211> 613
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 77
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys Gly
565 570 575
His His His His His His His His His His Gly Gly Gly Ser Gly Gly
580 585 590
Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala Gln Lys
595 600 605
Ile Glu Trp His Glu
610
<210> 78
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 78
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Lys
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 79
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 79
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Lys
500 505 510
Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 80
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 80
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 81
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 81
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys
500 505 510
Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 82
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 82
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys
500 505 510
Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 83
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 83
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys
500 505 510
Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys
565 570 575
<210> 84
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 84
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val Asp Gly Lys
500 505 510
Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys
565 570 575
<210> 85
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 85
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val His Gly Lys
500 505 510
Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys
565 570 575
<210> 86
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 86
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys
500 505 510
Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Leu Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys
565 570 575
<210> 87
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 87
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val Asp Gly Lys
500 505 510
Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys
565 570 575
<210> 88
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 88
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val His Gly Lys
500 505 510
Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys
565 570 575
<210> 89
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 89
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Asn Val Asn Gly Lys
500 505 510
Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys
565 570 575
<210> 90
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 90
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val His Gly Lys
500 505 510
Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys
565 570 575
<210> 91
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 91
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Asn Val Asn Gly Lys
500 505 510
Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys
565 570 575
<210> 92
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 92
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val Asp Gly Lys
500 505 510
Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys
565 570 575
<210> 93
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 93
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val His Gly Lys
500 505 510
Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys
565 570 575
<210> 94
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 94
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val Asp Gly Lys
500 505 510
Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys
565 570 575
<210> 95
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 95
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val His Gly Lys
500 505 510
Leu Val Asn Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys
565 570 575
<210> 96
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 96
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val Asp Gly Lys
500 505 510
Leu Val Asn Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys
565 570 575
<210> 97
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 97
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr
260 265 270
Val Trp Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu
275 280 285
Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn
290 295 300
Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro
305 310 315 320
Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His
325 330 335
Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu
340 345 350
Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile
450 455 460
Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln
500 505 510
Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570
<210> 98
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 98
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr
260 265 270
Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu
275 280 285
Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn
290 295 300
Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro
305 310 315 320
Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His
325 330 335
Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala
340 345 350
Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile
450 455 460
Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln
500 505 510
Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570
<210> 99
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 99
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr
260 265 270
Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu
275 280 285
Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn
290 295 300
Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Ile
305 310 315 320
Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His
325 330 335
Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala
340 345 350
Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile
450 455 460
Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln
500 505 510
Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570
<210> 100
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 100
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Ser Arg Ile Leu Pro Tyr Gly Asp Pro Ile Val Phe Asp Gly Lys Tyr
260 265 270
Val Trp Asp Asp Glu Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu
275 280 285
Phe Glu Leu Lys Asp Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser
290 295 300
Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile
305 310 315 320
Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His
325 330 335
Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala
340 345 350
Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile
450 455 460
Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln
500 505 510
Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570
<210> 101
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 101
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Ser Arg Ile Leu Pro Tyr Gly Asp Pro Ile Val Phe Asp Gly Lys Tyr
260 265 270
Val Trp Asp Asp Glu Tyr Pro Leu His Ile Gln His Ile Arg Cys Asp
275 280 285
Phe Glu Leu Lys Asp Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser
290 295 300
Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Asp Leu
305 310 315 320
Val Glu Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His
325 330 335
Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala
340 345 350
Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile
450 455 460
Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln
500 505 510
Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570
<210> 102
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 102
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Ser Arg Ile Leu Pro Tyr Gly Asp Pro Ile Val Phe Asp Gly Lys Tyr
260 265 270
Val Trp Asp Asp Glu Tyr Pro Leu His Ile Gln His Ile Arg Cys Asp
275 280 285
Phe Glu Leu Lys Asp Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser
290 295 300
Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Asp Leu
305 310 315 320
Val Glu Leu Trp Ile Ser Gln Val Asp Ile Asp Leu Met Lys Glu His
325 330 335
Tyr Glu Leu Tyr Asn Val Glu Tyr Leu Ser Gly Ile Lys Phe Arg Ala
340 345 350
Thr Thr Gly Ile Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile
450 455 460
Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln
500 505 510
Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570
<210> 103
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 103
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Arg Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Leu Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Asn Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Leu Val Asn Trp Leu Glu Gln His Gly Phe Arg Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr
260 265 270
Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu
275 280 285
Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser
290 295 300
Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile
305 310 315 320
Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His
325 330 335
Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala
340 345 350
Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile
450 455 460
Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln
500 505 510
Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570
<210> 104
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 104
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Arg Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Leu Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Asn Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Leu Val Asn Trp Leu Glu Gln His Gly Phe Arg Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Ser Arg Ile Leu Pro Tyr Gly Asp Pro Ile Val Phe Asp Gly Lys Tyr
260 265 270
Val Trp Asp Asp Glu Tyr Pro Leu His Ile Gln His Ile Arg Cys Asp
275 280 285
Phe Glu Leu Lys Asp Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser
290 295 300
Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Asp Leu
305 310 315 320
Val Glu Leu Trp Ile Ser Gln Val Asp Ile Asp Leu Met Lys Glu His
325 330 335
Tyr Glu Leu Tyr Asn Val Glu Tyr Leu Ser Gly Ile Lys Phe Arg Ala
340 345 350
Thr Thr Gly Ile Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile
450 455 460
Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln
500 505 510
Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570
<210> 105
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 105
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Ser Arg Ile Leu Pro Tyr Gly Asp Pro Ile Val Phe Asp Gly Lys Tyr
260 265 270
Val Trp Asp Asp Glu Tyr Pro Leu His Ile Gln His Ile Arg Cys Asp
275 280 285
Phe Glu Leu Lys Asp Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser
290 295 300
Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Leu
305 310 315 320
Val Glu Leu Tyr Val Thr Asn Ile Asp Leu Asp Leu Ile Lys Glu His
325 330 335
Tyr Glu Leu Tyr Asn Val Glu Tyr Leu Ser Gly Leu Lys Phe Arg Ala
340 345 350
Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile
450 455 460
Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln
500 505 510
Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570
<210> 106
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 106
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly
50 55 60
Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr
260 265 270
Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu
275 280 285
Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser
290 295 300
Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile
305 310 315 320
Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His
325 330 335
Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala
340 345 350
Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile
450 455 460
Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln
500 505 510
Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570
<210> 107
<211> 582
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 107
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly
50 55 60
Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly
85 90 95
Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr
100 105 110
Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp
115 120 125
Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe
130 135 140
Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Tyr Thr Lys Glu Arg Pro
145 150 155 160
Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp
165 170 175
Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu
180 185 190
Asp Arg Met Thr Ala Gly Ser Asp Ser Leu Lys Gly Phe Lys Asp Ile
195 200 205
Ile Thr Thr Lys Lys Phe Lys Lys Val Phe Pro Thr Leu Ser Leu Gly
210 215 220
Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu
225 230 235 240
Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly Glu Gly Met Val Phe Asp
245 250 255
Ala Asn Ser His Tyr Pro Ala Gln Met Tyr Ser Arg Leu Leu Pro Tyr
260 265 270
Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr Val Trp Asp Glu Asp Tyr
275 280 285
Pro Leu His Ile Gln His Ile Arg Cys Glu Phe Glu Leu Lys Glu Gly
290 295 300
Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser Arg Phe Tyr Lys Gly Asn
305 310 315 320
Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile Ala Asp Leu Trp Leu Ser
325 330 335
Asn Val Asp Leu Glu Leu Met Lys Glu His Tyr Asp Leu Tyr Asn Val
340 345 350
Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala Thr Thr Gly Leu Phe Lys
355 360 365
Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala
370 375 380
Ile Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe
385 390 395 400
Ala Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn
405 410 415
Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val
420 425 430
Tyr Thr Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr
435 440 445
Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr
450 455 460
Asp Ser Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp
465 470 475 480
Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe
485 490 495
Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr
500 505 510
Met Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr
515 520 525
Thr Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile
530 535 540
Lys Lys Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys
545 550 555 560
Met Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp
565 570 575
Glu Thr Phe Thr Ile Lys
580
<210> 108
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 108
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 109
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 109
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr
565 570 575
Phe Thr Ile Lys
580
<210> 110
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 110
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly
50 55 60
Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Ile Lys Arg Ser
290 295 300
Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile
305 310 315 320
Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His
325 330 335
Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala
340 345 350
Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile
450 455 460
Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln
500 505 510
Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570
<210> 111
<211> 587
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 111
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly
50 55 60
Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly
85 90 95
Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr
100 105 110
Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp
115 120 125
Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe
130 135 140
Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Tyr Thr Lys Glu Arg Pro
145 150 155 160
Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp
165 170 175
Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu
180 185 190
Asp Arg Met Thr Ala Gly Ser Asp Ser Leu Lys Gly Phe Lys Asp Ile
195 200 205
Ile Thr Thr Lys Lys Phe Lys Lys Val Phe Pro Thr Leu Ser Leu Gly
210 215 220
Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu
225 230 235 240
Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly Glu Gly Met Val Phe Asp
245 250 255
Ala Asn Ser His Tyr Pro Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr
260 265 270
Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr
275 280 285
Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg Leu Lys Glu Arg
290 295 300
His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu Phe Ile Gln Asn
305 310 315 320
Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val Asp Glu Leu Ile
325 330 335
Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu His Tyr
340 345 350
Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser
355 360 365
Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr
370 375 380
Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn Ser
385 390 395 400
Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val Pro
405 410 415
Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu
420 425 430
Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala Trp
435 440 445
Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile
450 455 460
Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile Pro
465 470 475 480
Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp Glu
485 490 495
His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr
500 505 510
Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln Gly
515 520 525
Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala Gly
530 535 540
Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys Val
545 550 555 560
Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly Gly
565 570 575
Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
580 585
<210> 112
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 112
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr
260 265 270
Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu
275 280 285
Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser
290 295 300
Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile
305 310 315 320
Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His
325 330 335
Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala
340 345 350
Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile
450 455 460
Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln
500 505 510
Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570
<210> 113
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 113
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr
260 265 270
Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu
275 280 285
Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser
290 295 300
Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile
305 310 315 320
Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His
325 330 335
Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala
340 345 350
Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile
450 455 460
Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln
500 505 510
Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570
<210> 114
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 114
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asp Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln
260 265 270
Gly Lys Tyr Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile
275 280 285
Arg Phe Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Lys Asn Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly
305 310 315 320
Val Glu Pro Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile
325 330 335
Gln Glu His Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys
340 345 350
Phe Arg Glu Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 115
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 115
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys Tyr
260 265 270
Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu
275 280 285
Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn
290 295 300
Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro
305 310 315 320
Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His
325 330 335
Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu
340 345 350
Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile
450 455 460
Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln
500 505 510
Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570
<210> 116
<211> 576
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 116
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Asp Val Asn Asp Cys Arg Val Trp Ala Tyr Gly Trp Met Glu Ile
20 25 30
Gly Lys Thr Ser Asn Tyr Lys Ile Gly Thr Asp Phe Asn Glu Phe Met
35 40 45
Glu Trp Met Ile His Ser Ser Ser Arg Leu Tyr Phe His Asp Leu Lys
50 55 60
Phe Asp Gly Ser Phe Ile Val Asn Trp Leu Leu His Asn Gly Tyr Thr
65 70 75 80
Trp Thr Lys Arg Pro Ser Lys Glu Gly Gln Phe Ser Thr Leu Ile Ser
85 90 95
Lys Met Gly Gln Trp Tyr Gly Ile Thr Ile Cys Ser Gly Arg Asp Gly
100 105 110
Arg Lys Lys Lys Leu Thr Thr Ile His Asp Ser Leu Lys Lys Leu Pro
115 120 125
Phe Pro Val Arg Lys Ile Gly Lys Asp Phe Lys Leu Asn Val Leu Lys
130 135 140
Gly Asp Ile Asp Tyr His Lys Pro Arg Pro Ile Gly Tyr Glu Ile Asp
145 150 155 160
Asp Glu Glu Tyr Gln Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu
165 170 175
Ala Leu Glu Val Gln Thr Val Gln Gly Leu Thr Gly Met Thr Asn Gly
180 185 190
Ser Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe
195 200 205
Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg
210 215 220
Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly
225 230 235 240
Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro
245 250 255
Ala Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe
260 265 270
Glu Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His
275 280 285
Ile Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln
290 295 300
Ile Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser
305 310 315 320
Gly Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu
325 330 335
Met Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu
340 345 350
Lys Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp
355 360 365
Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys
370 375 380
Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val
385 390 395 400
Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg
405 410 415
Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val
420 425 430
Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala
435 440 445
Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr
450 455 460
Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys
465 470 475 480
Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu
485 490 495
Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly
500 505 510
Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser
515 520 525
Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe
530 535 540
Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val
545 550 555 560
Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 117
<211> 576
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 117
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asp Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Asp Arg Asp Leu Pro Cys Gly Val Pro Ile Pro Phe Glu
260 265 270
Gly Glu Tyr Val Tyr Asp Lys Ser His Pro Leu Tyr Ile Gln Lys Leu
275 280 285
Thr Phe Glu Phe Glu Leu Lys Glu Asn Tyr Ile Pro Thr Ile Gln Leu
290 295 300
Lys Asn Ser Arg Phe Gly Phe Lys Gly Asn Glu Tyr Leu Ser Ser Ser
305 310 315 320
Asn Gly Glu Arg Ile Thr Ile Ser Val Ser Ser Val Asp Trp Glu Leu
325 330 335
Ile Arg Glu His Tyr His Val Tyr Asp Val Glu Phe Glu Lys Gly Trp
340 345 350
Lys Phe Arg Ser Thr Lys Gln Ala Phe Lys Asp Phe Ile Asp Lys Trp
355 360 365
Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys
370 375 380
Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val
385 390 395 400
Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg
405 410 415
Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val
420 425 430
Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala
435 440 445
Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr
450 455 460
Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys
465 470 475 480
Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu
485 490 495
Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly
500 505 510
Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser
515 520 525
Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe
530 535 540
Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val
545 550 555 560
Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 118
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 118
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Asp Val Asn Asp Cys Arg Val Trp Ala Tyr Gly Trp Met Glu Ile
20 25 30
Gly Lys Thr Ser Asn Tyr Lys Ile Gly Thr Asp Phe Asn Glu Phe Met
35 40 45
Glu Trp Met Ile His Ser Ser Ser Arg Leu Tyr Phe His Asp Leu Lys
50 55 60
Phe Asp Gly Ser Phe Ile Val Asn Trp Leu Leu His Asn Gly Tyr Thr
65 70 75 80
Trp Thr Lys Arg Pro Ser Lys Glu Gly Gln Phe Ser Thr Leu Ile Ser
85 90 95
Lys Met Gly Gln Trp Tyr Gly Ile Thr Ile Cys Ser Gly Arg Asp Gly
100 105 110
Arg Lys Lys Lys Leu Thr Thr Ile His Asp Ser Leu Lys Lys Leu Pro
115 120 125
Phe Pro Val Arg Lys Ile Gly Lys Asp Phe Lys Leu Asn Val Leu Lys
130 135 140
Gly Asp Ile Asp Tyr His Lys Pro Arg Pro Ile Gly Tyr Glu Ile Asp
145 150 155 160
Asp Glu Glu Tyr Gln Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu
165 170 175
Ala Leu Glu Val Gln Thr Val Gln Gly Leu Thr Gly Met Thr Asn Gly
180 185 190
Ser Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe
195 200 205
Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg
210 215 220
Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly
225 230 235 240
Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro
245 250 255
Ala Gln Met Tyr Asp Arg Asp Leu Pro Cys Gly Val Pro Ile Pro Phe
260 265 270
Glu Gly Glu Tyr Val Tyr Asp Lys Ser His Pro Leu Tyr Ile Gln Lys
275 280 285
Leu Thr Phe Glu Phe Glu Leu Lys Glu Asn Tyr Ile Pro Thr Ile Gln
290 295 300
Leu Lys Asn Ser Arg Phe Gly Phe Lys Gly Asn Glu Tyr Leu Ser Ser
305 310 315 320
Ser Asn Gly Glu Arg Ile Thr Ile Ser Val Ser Ser Val Asp Trp Glu
325 330 335
Leu Ile Arg Glu His Tyr His Val Tyr Asp Val Glu Phe Glu Lys Gly
340 345 350
Trp Lys Phe Arg Ser Thr Lys Gln Ala Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 119
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 119
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Phe Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 120
<211> 582
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 120
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly
50 55 60
Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly
85 90 95
Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr
100 105 110
Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp
115 120 125
Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe
130 135 140
Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Tyr Thr Lys Glu Arg Pro
145 150 155 160
Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp
165 170 175
Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu
180 185 190
Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Phe Lys Asp Ile
195 200 205
Ile Thr Thr Lys Lys Phe Lys Lys Val Phe Pro Thr Leu Ser Leu Gly
210 215 220
Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu
225 230 235 240
Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly Glu Gly Met Val Phe Asp
245 250 255
Ala Asn Ser His Tyr Pro Ala Gln Met Tyr Ser Arg Leu Leu Pro Tyr
260 265 270
Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr Val Trp Asp Glu Asp Tyr
275 280 285
Pro Leu His Ile Gln His Ile Arg Cys Glu Phe Glu Leu Lys Glu Gly
290 295 300
Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser Arg Phe Tyr Lys Gly Asn
305 310 315 320
Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile Ala Asp Leu Trp Leu Ser
325 330 335
Asn Val Asp Leu Glu Leu Met Lys Glu His Tyr Asp Leu Tyr Asn Val
340 345 350
Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala Thr Thr Gly Leu Phe Lys
355 360 365
Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala
370 375 380
Ile Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe
385 390 395 400
Ala Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn
405 410 415
Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val
420 425 430
Tyr Thr Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr
435 440 445
Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr
450 455 460
Asp Ser Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp
465 470 475 480
Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe
485 490 495
Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr
500 505 510
Met Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr
515 520 525
Thr Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile
530 535 540
Lys Lys Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys
545 550 555 560
Met Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp
565 570 575
Glu Thr Phe Thr Ile Lys
580
<210> 121
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 121
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr
260 265 270
Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu
275 280 285
Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser
290 295 300
Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile
305 310 315 320
Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His
325 330 335
Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala
340 345 350
Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val
450 455 460
Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln
500 505 510
Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570
<210> 122
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 122
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr
260 265 270
Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu
275 280 285
Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser
290 295 300
Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile
305 310 315 320
Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His
325 330 335
Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala
340 345 350
Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val
450 455 460
Pro Glu Ala Ile Glu His Leu Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln
500 505 510
Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570
<210> 123
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 123
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr
260 265 270
Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu
275 280 285
Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser
290 295 300
Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile
305 310 315 320
Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His
325 330 335
Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala
340 345 350
Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile
450 455 460
Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Val Lys Lys Val Arg Gly Tyr Leu Val Gln
500 505 510
Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570
<210> 124
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 124
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr
260 265 270
Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu
275 280 285
Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser
290 295 300
Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile
305 310 315 320
Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His
325 330 335
Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala
340 345 350
Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val
450 455 460
Pro Glu Ala Ile Glu His Leu Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Val Lys Lys Val Arg Gly Tyr Leu Val Gln
500 505 510
Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570
<210> 125
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 125
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr
260 265 270
Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu
275 280 285
Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser
290 295 300
Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile
305 310 315 320
Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His
325 330 335
Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala
340 345 350
Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile
450 455 460
Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln
500 505 510
Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570
<210> 126
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 126
Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn
1 5 10 15
Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp
20 25 30
Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu
35 40 45
Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 127
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 127
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 128
<211> 596
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 128
Met Val Arg Gln Ser Thr Ile Ala Ser Pro Ala Arg Gly Gly Val Arg
1 5 10 15
Arg Ser His Lys Lys Val Pro Ser Phe Cys Ala Asp Phe Glu Thr Thr
20 25 30
Thr Asp Glu Asp Asp Cys Arg Val Trp Ser Trp Gly Ile Ile Gln Val
35 40 45
Gly Lys Leu Gln Asn Tyr Val Asp Gly Ile Ser Leu Asp Gly Phe Met
50 55 60
Ser His Ile Ser Glu Arg Ala Ser His Ile Tyr Phe His Asp Leu Lys
65 70 75 80
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
85 90 95
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
100 105 110
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
115 120 125
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
130 135 140
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
145 150 155 160
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
165 170 175
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
180 185 190
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
195 200 205
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
210 215 220
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
225 230 235 240
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
245 250 255
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
260 265 270
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
275 280 285
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
290 295 300
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
305 310 315 320
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
325 330 335
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
340 345 350
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
355 360 365
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
370 375 380
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
385 390 395 400
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
405 410 415
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
420 425 430
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
435 440 445
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
450 455 460
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
465 470 475 480
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
485 490 495
Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
500 505 510
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
515 520 525
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
530 535 540
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys
545 550 555 560
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
565 570 575
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr
580 585 590
Phe Thr Ile Lys
595
<210> 129
<211> 579
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 129
Met Asn Glu Tyr Ile Ser Asp Phe Glu Thr Gln Lys Asp Pro Asp Thr
1 5 10 15
Gly Val Met Ser Val Trp Ala Trp Ser Ile Val Asp Val Asn Asp Leu
20 25 30
Ser Asn Ile Gln Tyr Gly Asn Asn Ile Glu Ser Trp Leu Ser Ala Ile
35 40 45
Gln Gly Leu Pro Asn Gly Ser Leu Ile Gly Phe His Asp Leu Lys Phe
50 55 60
Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp
65 70 75 80
Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met
85 90 95
Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg
100 105 110
Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro
115 120 125
Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp
130 135 140
Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu
145 150 155 160
Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu
165 170 175
Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp
180 185 190
Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys
195 200 205
Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala
210 215 220
Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu
225 230 235 240
Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln
245 250 255
Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly
260 265 270
Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys
275 280 285
Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys
290 295 300
Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn
305 310 315 320
Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp
325 330 335
Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr
340 345 350
Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile
355 360 365
Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln
370 375 380
Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn
385 390 395 400
Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu
405 410 415
Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro
420 425 430
Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala
435 440 445
Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile
450 455 460
His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp
465 470 475 480
Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala
485 490 495
Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg
500 505 510
Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile
515 520 525
Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu
530 535 540
Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro
545 550 555 560
Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe
565 570 575
Thr Ile Lys
<210> 130
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 130
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 131
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 131
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp
355 360 365
Ile Asp Lys Trp Ile Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys
370 375 380
Ala Asn Ala Lys Gly Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu
530 535 540
Leu Val Thr Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys
545 550 555 560
Leu Leu Pro Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met
565 570 575
Phe Thr Ile Lys
580
<210> 132
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 132
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr
385 390 395 400
Asn Pro Asp Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile
405 410 415
Val Arg Leu Thr Leu Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu
530 535 540
Leu Val Thr Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys
545 550 555 560
Leu Leu Pro Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met
565 570 575
Phe Thr Ile Lys
580
<210> 133
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 133
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Tyr Ser Glu
260 265 270
Gly Ala Pro Arg Thr Asn Arg Pro Leu Tyr Ile Ala Ser Ile Thr Phe
275 280 285
Thr Ala Lys Leu Lys Pro Asn His Ile Pro Cys Ile Gln Ile Lys Lys
290 295 300
Asn Leu Ser Phe Asn Pro Thr Gln Tyr Leu Glu Glu Val Lys Glu Pro
305 310 315 320
Thr Thr Val Val Ala Thr Asn Ile Asp Ile Glu Leu Trp Lys Lys His
325 330 335
Tyr Asp Phe Lys Ile Tyr Ser Trp Asn Gly Thr Phe Glu Phe Arg Gly
340 345 350
Ser His Gly Phe Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile
450 455 460
Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln
500 505 510
Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570
<210> 134
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 134
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Ile Gly Thr Pro Val Phe Phe Glu
260 265 270
Gly Lys Tyr Lys Asp Asp Pro Ile Tyr Pro Leu Tyr Ile Gln Phe Ile
275 280 285
Thr Ala Gln Phe Glu Leu Lys Lys Gly Lys Ile Pro Thr Ile Gln Ile
290 295 300
Lys Asn Asp Lys Arg Phe Asn Pro Arg Glu Tyr Val Thr Ser Thr Gly
305 310 315 320
Cys Leu Met Val Asn Leu Tyr Leu Thr Asn Val Asp Leu Glu Met Phe
325 330 335
Tyr Glu Cys Tyr Asn Ile Lys Glu Ile Gln Tyr Ile Gly Gly Tyr Lys
340 345 350
Phe Ile Gly Arg Ser Gly Ile Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys
565 570 575
<210> 135
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 135
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 136
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 136
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 137
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 137
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 138
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 138
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Thr Leu Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 139
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 139
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp
500 505 510
Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 140
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 140
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp
500 505 510
Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 141
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 141
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 142
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 142
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 143
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 143
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp
500 505 510
Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 144
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 144
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp
500 505 510
Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 145
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 145
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp
500 505 510
Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 146
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 146
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp
500 505 510
Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 147
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 147
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp
500 505 510
Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 148
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 148
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp
500 505 510
Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 149
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 149
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 150
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 150
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 151
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 151
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp
500 505 510
Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 152
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 152
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp
500 505 510
Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 153
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 153
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp
500 505 510
Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 154
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 154
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp
500 505 510
Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 155
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 155
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp
385 390 395 400
Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu
405 410 415
Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp
500 505 510
Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr
530 535 540
Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro
545 550 555 560
Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile
565 570 575
Lys
<210> 156
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 156
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp
385 390 395 400
Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu
405 410 415
Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp
500 505 510
Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 157
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 157
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp
500 505 510
Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr
530 535 540
Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro
545 550 555 560
Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile
565 570 575
Lys
<210> 158
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 158
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp
385 390 395 400
Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu
405 410 415
Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp
500 505 510
Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr
530 535 540
Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro
545 550 555 560
Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile
565 570 575
Lys
<210> 159
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 159
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp
385 390 395 400
Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu
405 410 415
Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp
500 505 510
Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 160
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 160
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp
500 505 510
Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr
530 535 540
Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro
545 550 555 560
Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile
565 570 575
Lys
<210> 161
<211> 618
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 161
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe
340 345 350
Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr
565 570 575
Phe Thr Ile Lys Gly His His His His His His His His His His Gly
580 585 590
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe
595 600 605
Phe Glu Ala Gln Lys Ile Glu Trp His Glu
610 615
<210> 162
<211> 618
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 162
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe
340 345 350
Thr Tyr Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr
565 570 575
Phe Thr Ile Lys Gly His His His His His His His His His His Gly
580 585 590
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe
595 600 605
Phe Glu Ala Gln Lys Ile Glu Trp His Glu
610 615
<210> 163
<211> 618
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 163
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr
565 570 575
Phe Thr Ile Lys Gly His His His His His His His His His His Gly
580 585 590
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe
595 600 605
Phe Glu Ala Gln Lys Ile Glu Trp His Glu
610 615
<210> 164
<211> 618
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 164
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr
565 570 575
Phe Thr Ile Lys Gly His His His His His His His His His His Gly
580 585 590
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe
595 600 605
Phe Glu Ala Gln Lys Ile Glu Trp His Glu
610 615
<210> 165
<211> 618
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 165
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Asn Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Asn Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Val Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Phe
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr
565 570 575
Phe Thr Ile Lys Gly His His His His His His His His His His Gly
580 585 590
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe
595 600 605
Phe Glu Ala Gln Lys Ile Glu Trp His Glu
610 615
<210> 166
<211> 618
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 166
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Val Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Phe
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr
565 570 575
Phe Thr Ile Lys Gly His His His His His His His His His His Gly
580 585 590
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe
595 600 605
Phe Glu Ala Gln Lys Ile Glu Trp His Glu
610 615
<210> 167
<211> 618
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 167
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val
290 295 300
Lys Gln Asn Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Asn Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe
340 345 350
Thr Tyr Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr
565 570 575
Phe Thr Ile Lys Gly His His His His His His His His His His Gly
580 585 590
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe
595 600 605
Phe Glu Ala Gln Lys Ile Glu Trp His Glu
610 615
<210> 168
<211> 618
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 168
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Asn Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Asn Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe
340 345 350
Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr
565 570 575
Phe Thr Ile Lys Gly His His His His His His His His His His Gly
580 585 590
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe
595 600 605
Phe Glu Ala Gln Lys Ile Glu Trp His Glu
610 615
<210> 169
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 169
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 170
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 170
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Val Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 171
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 171
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 172
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 172
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 173
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 173
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Val Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Phe Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 174
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 174
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 175
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 175
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 176
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 176
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Asn
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 177
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 177
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 178
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 178
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Asn
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 179
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 179
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Asn
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 180
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 180
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Asn
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 181
<211> 618
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 181
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val
290 295 300
Lys Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr
565 570 575
Phe Thr Ile Lys Gly His His His His His His His His His His Gly
580 585 590
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe
595 600 605
Phe Glu Ala Gln Lys Ile Glu Trp His Glu
610 615
<210> 182
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 182
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val
290 295 300
Lys Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr
565 570 575
Phe Thr Ile Lys
580
<210> 183
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 183
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 184
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 184
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp
500 505 510
Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 185
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 185
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp
500 505 510
Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 186
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 186
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp
130 135 140
Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr
145 150 155 160
Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp
500 505 510
Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 187
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 187
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 188
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 188
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 189
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 189
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 190
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 190
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 191
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 191
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn
290 295 300
Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Val Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Phe Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 192
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 192
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Val Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Phe Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 193
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 193
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Asn
290 295 300
Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 194
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 194
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn
290 295 300
Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 195
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 195
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 196
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 196
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 197
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 197
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Ile Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Leu Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Ile Gly Tyr Lys Ile Thr Pro Asp Glu Tyr
145 150 155 160
Ala Tyr Leu Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 198
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 198
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Ile Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Leu Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Ile Gly Tyr Lys Ile Thr Pro Asp Glu Tyr
145 150 155 160
Ala Tyr Leu Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 199
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 199
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Glu Gly Ile Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu
100 105 110
His Thr Ile Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Leu Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Ile Gly Tyr Lys Ile Thr Pro Asp Glu Tyr
145 150 155 160
Ala Tyr Leu Lys Asn Asp Ile Gln Ile Leu Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 200
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 200
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 201
<211> 616
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 201
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr
565 570 575
Ile Lys Gly His His His His His His His His His His Gly Gly Gly
580 585 590
Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu
595 600 605
Ala Gln Lys Ile Glu Trp His Glu
610 615
<210> 202
<211> 616
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 202
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Leu His Asn Gly Tyr Thr Trp Thr Lys
65 70 75 80
Arg Pro Ser Lys Glu Gly Gln Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr
565 570 575
Ile Lys Gly His His His His His His His His His His Gly Gly Gly
580 585 590
Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu
595 600 605
Ala Gln Lys Ile Glu Trp His Glu
610 615
<210> 203
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 203
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Leu His Lys Gly Tyr Glu Cys Asn Glu
65 70 75 80
Ser Gly Arg Pro Lys Thr Phe Asp Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 204
<211> 616
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 204
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Leu Lys His Gly Tyr Arg Trp Thr Lys
65 70 75 80
Glu Asn Pro Gly Val Lys Glu Phe Thr Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr
565 570 575
Ile Lys Gly His His His His His His His His His His Gly Gly Gly
580 585 590
Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu
595 600 605
Ala Gln Lys Ile Glu Trp His Glu
610 615
<210> 205
<211> 616
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 205
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr
565 570 575
Ile Lys Gly His His His His His His His His His His Gly Gly Gly
580 585 590
Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu
595 600 605
Ala Gln Lys Ile Glu Trp His Glu
610 615
<210> 206
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 206
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Thr Ala
65 70 75 80
Glu Gly Glu Pro Asn Thr Tyr Ser Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 207
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 207
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Leu Lys Asn Gly Phe Lys Trp Thr Ala
65 70 75 80
Glu Gly Leu Pro Arg Thr Tyr Ser Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 208
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 208
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Tyr Lys Trp Thr Ala
65 70 75 80
Glu Gly Leu Pro Asn Thr Phe Ser Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 209
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 209
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Lys Asn Gly Tyr Lys Trp Thr Ala
65 70 75 80
Glu Gly Leu Pro Lys Thr Phe Ser Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 210
<211> 618
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 210
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Leu Arg Asn Gly Tyr Val His Thr Glu
65 70 75 80
Glu Asp Arg Thr Asn Thr Pro Lys Glu Phe Thr Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr
565 570 575
Phe Thr Ile Lys Gly His His His His His His His His His His Gly
580 585 590
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe
595 600 605
Phe Glu Ala Gln Lys Ile Glu Trp His Glu
610 615
<210> 211
<211> 579
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 211
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Arg Leu Gly Tyr Glu Phe Thr Asp
65 70 75 80
Glu Lys Ala Pro Gln Val Lys Glu Phe Ser Thr Ile Ile Ser Arg Met
85 90 95
Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg
100 105 110
Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro
115 120 125
Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp
130 135 140
Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu
145 150 155 160
Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu
165 170 175
Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp
180 185 190
Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys
195 200 205
Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala
210 215 220
Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu
225 230 235 240
Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln
245 250 255
Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly
260 265 270
Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys
275 280 285
Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys
290 295 300
Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn
305 310 315 320
Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp
325 330 335
Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr
340 345 350
Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile
355 360 365
Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln
370 375 380
Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn
385 390 395 400
Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu
405 410 415
Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro
420 425 430
Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala
435 440 445
Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile
450 455 460
His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp
465 470 475 480
Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala
485 490 495
Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg
500 505 510
Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile
515 520 525
Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu
530 535 540
Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro
545 550 555 560
Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe
565 570 575
Thr Ile Lys
<210> 212
<211> 618
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 212
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Leu Thr Asp Gly Trp Lys Trp Ile Pro
65 70 75 80
Asp Lys Asn Asp Cys Ala Asn Arg Thr Phe Thr Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr
565 570 575
Phe Thr Ile Lys Gly His His His His His His His His His His Gly
580 585 590
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe
595 600 605
Phe Glu Ala Gln Lys Ile Glu Trp His Glu
610 615
<210> 213
<211> 617
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 213
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Leu Glu Asn Gly Phe Lys His Ser Arg
65 70 75 80
Glu Arg Ala Leu Tyr Ser Asn Glu Phe Ser Thr Ile Ile Ser Arg Met
85 90 95
Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg
100 105 110
Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro
115 120 125
Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp
130 135 140
Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu
145 150 155 160
Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu
165 170 175
Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp
180 185 190
Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys
195 200 205
Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala
210 215 220
Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu
225 230 235 240
Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln
245 250 255
Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly
260 265 270
Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys
275 280 285
Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys
290 295 300
Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn
305 310 315 320
Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp
325 330 335
Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr
340 345 350
Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile
355 360 365
Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln
370 375 380
Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn
385 390 395 400
Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu
405 410 415
Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro
420 425 430
Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala
435 440 445
Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile
450 455 460
His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp
465 470 475 480
Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala
485 490 495
Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg
500 505 510
Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile
515 520 525
Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu
530 535 540
Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro
545 550 555 560
Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe
565 570 575
Thr Ile Lys Gly His His His His His His His His His His Gly Gly
580 585 590
Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe
595 600 605
Glu Ala Gln Lys Ile Glu Trp His Glu
610 615
<210> 214
<211> 619
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 214
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Leu Gly Val Ala Lys Trp Glu Tyr Asn
65 70 75 80
Asp Lys Pro Lys Ala Arg Lys Ala Lys Thr Val Glu Thr Ile Ile Ser
85 90 95
Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly
100 105 110
Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro
115 120 125
Phe Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys
130 135 140
Gly Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr
145 150 155 160
Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu
165 170 175
Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly
180 185 190
Ser Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe
195 200 205
Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg
210 215 220
Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly
225 230 235 240
Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro
245 250 255
Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr
260 265 270
Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn
275 280 285
Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln
290 295 300
Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser
305 310 315 320
Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn
325 330 335
Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His
340 345 350
Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp
355 360 365
Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile
370 375 380
Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala
385 390 395 400
Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly
405 410 415
Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr
420 425 430
Thr Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile
435 440 445
Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp
450 455 460
Ser Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile
465 470 475 480
Val Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys
485 490 495
Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met
500 505 510
Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr
515 520 525
Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys
530 535 540
Lys Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met
545 550 555 560
Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu
565 570 575
Thr Phe Thr Ile Lys Gly His His His His His His His His His His
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp
595 600 605
Phe Phe Glu Ala Gln Lys Ile Glu Trp His Glu
610 615
<210> 215
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 215
Met Ser Arg Lys Met Tyr Ser Ala Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ser Tyr Gly Trp Met Glu Val Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Asp Ile Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ser Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 216
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 216
Met Ser Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Val Met Glu Val Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Asp Ile Asp Glu Phe Met Gln Trp Ile
35 40 45
Met Glu Ile Gln Ser Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 217
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 217
Met Ser Arg Lys Val Phe Thr Ala Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Trp Met Glu Val Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Ile Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 218
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 218
Met Ser Arg Lys Val Tyr Thr Ala Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Trp Met Glu Val Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Ile Asp Glu Phe Met Gln Trp Ile
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 219
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 219
Met Ser Arg Lys Met Tyr Thr Ala Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Asp Ile Asp Glu Phe Met Gln Trp Ile
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 220
<211> 615
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 220
Met Ser Arg Lys Met Tyr Ser Ala Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Ile Asp Glu Phe Met Gln Trp Ile
35 40 45
Met Glu Ile Gln Ser Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys Gly His His His His His His His His His His Gly Gly Gly Ser
580 585 590
Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala
595 600 605
Gln Lys Ile Glu Trp His Glu
610 615
<210> 221
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 221
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Phe Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
Asp Pro Lys Lys Leu Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr
565 570 575
Phe Thr Ile Lys
580
<210> 222
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 222
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Phe Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
Asp Pro Lys Lys Leu Gly Tyr Trp Asn His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr
565 570 575
Phe Thr Ile Lys
580
<210> 223
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 223
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Phe Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
Asp Pro Lys Lys Leu Gly Tyr Trp Gln His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr
565 570 575
Phe Thr Ile Lys
580
<210> 224
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 224
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Phe Tyr Ile Lys Thr Arg Ser Glu Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
Asp Pro Lys Lys Leu Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr
565 570 575
Phe Thr Ile Lys
580
<210> 225
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 225
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 226
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 226
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 227
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 227
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 228
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 228
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 229
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 229
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 230
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 230
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 231
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 231
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 232
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 232
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 233
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 233
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 234
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 234
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 235
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 235
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 236
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 236
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 237
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 237
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr
565 570 575
Ile Lys
<210> 238
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 238
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr
565 570 575
Ile Lys
<210> 239
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 239
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 240
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 240
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr
565 570 575
Ile Lys
<210> 241
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 241
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 242
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 242
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 243
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 243
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 244
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 244
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 245
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 245
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 246
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 246
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Ile Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 247
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 247
Met His Lys Met Ser Lys Lys Met Phe Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val
20 25 30
Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met
35 40 45
Gln Trp Ile Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr
565 570 575
Phe Thr Ile Lys
580
<210> 248
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 248
Met His Lys Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val
20 25 30
Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Ser Ile Asp Glu Phe Met
35 40 45
Gln Trp Val Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr
565 570 575
Phe Thr Ile Lys
580
<210> 249
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 249
Met Ser Lys Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met Gln Trp Ile
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 250
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 250
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met Gln Trp Ile
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 251
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 251
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Leu Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met Gln Trp Ile
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 252
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 252
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Leu Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Thr Ile Asp Glu Phe Met Gln Trp Ile
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 253
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 253
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Thr Ile Asp Glu Phe Met Gln Trp Ile
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 254
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 254
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met Gln Trp Ile
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 255
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 255
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Thr Ile Asp Glu Phe Met Gln Trp Ile
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 256
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 256
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Thr Leu Asp Glu Phe Met Gln Trp Ile
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 257
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 257
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Ile Asp Glu Phe Met Gln Trp Ile
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 258
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 258
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Leu Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Ile Asp Glu Phe Met Gln Trp Ile
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 259
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 259
Met His Lys Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val
20 25 30
Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met
35 40 45
Gln Trp Ala Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr
565 570 575
Phe Thr Ile Lys
580
<210> 260
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 260
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 261
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 261
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met Gln Trp Ile
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 262
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 262
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Thr Ile Asp Glu Phe Met Gln Trp Ile
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 263
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 263
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 264
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 264
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 265
<211> 581
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 265
Met His Lys Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val
20 25 30
Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met
35 40 45
Gln Trp Ala Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys
65 70 75 80
Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser
85 90 95
Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly
100 105 110
Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro
115 120 125
Phe Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys
130 135 140
Gly Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr
145 150 155 160
Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu
165 170 175
Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly
180 185 190
Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe
195 200 205
Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg
210 215 220
Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly
225 230 235 240
Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro
245 250 255
Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr
260 265 270
Glu Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn
275 280 285
Leu Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln
290 295 300
Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser
305 310 315 320
Val Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn
325 330 335
Val Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His
340 345 350
Tyr Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp
355 360 365
Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile
370 375 380
Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala
385 390 395 400
Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly
405 410 415
Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr
420 425 430
Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile
435 440 445
Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp
450 455 460
Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile
465 470 475 480
Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys
485 490 495
Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met
500 505 510
Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr
515 520 525
Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys
530 535 540
Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met
545 550 555 560
Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser
565 570 575
Val Phe Thr Ile Lys
580
<210> 266
<211> 581
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 266
Met His Lys Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val
20 25 30
Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met
35 40 45
Gln Trp Ala Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys
65 70 75 80
Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser
85 90 95
Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly
100 105 110
Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro
115 120 125
Phe Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys
130 135 140
Gly Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr
145 150 155 160
Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu
165 170 175
Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly
180 185 190
Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe
195 200 205
Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg
210 215 220
Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly
225 230 235 240
Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro
245 250 255
Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr
260 265 270
Glu Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn
275 280 285
Leu Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln
290 295 300
Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser
305 310 315 320
Val Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn
325 330 335
Val Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His
340 345 350
Tyr Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp
355 360 365
Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile
370 375 380
Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala
385 390 395 400
Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly
405 410 415
Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr
420 425 430
Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile
435 440 445
Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp
450 455 460
Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile
465 470 475 480
Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys
485 490 495
Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met
500 505 510
Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr
515 520 525
Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys
530 535 540
Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met
545 550 555 560
Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser
565 570 575
Val Phe Thr Ile Lys
580
<210> 267
<211> 581
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 267
Met His Lys Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val
20 25 30
Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met
35 40 45
Gln Trp Ala Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys
65 70 75 80
Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser
85 90 95
Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly
100 105 110
Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro
115 120 125
Phe Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys
130 135 140
Gly Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr
145 150 155 160
Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu
165 170 175
Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly
180 185 190
Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe
195 200 205
Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg
210 215 220
Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly
225 230 235 240
Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro
245 250 255
Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr
260 265 270
Gln Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn
275 280 285
Leu Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln
290 295 300
Val Lys Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser
305 310 315 320
Val Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn
325 330 335
Val Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His
340 345 350
Tyr Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp
355 360 365
Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile
370 375 380
Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala
385 390 395 400
Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly
405 410 415
Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr
420 425 430
Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile
435 440 445
Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp
450 455 460
Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile
465 470 475 480
Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys
485 490 495
Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met
500 505 510
Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr
515 520 525
Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys
530 535 540
Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met
545 550 555 560
Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser
565 570 575
Val Phe Thr Ile Lys
580
<210> 268
<211> 581
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 268
Met His Lys Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val
20 25 30
Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met
35 40 45
Gln Trp Ala Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys
65 70 75 80
Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser
85 90 95
Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly
100 105 110
Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro
115 120 125
Phe Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys
130 135 140
Gly Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr
145 150 155 160
Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu
165 170 175
Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly
180 185 190
Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe
195 200 205
Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg
210 215 220
Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly
225 230 235 240
Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro
245 250 255
Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr
260 265 270
Gln Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn
275 280 285
Leu Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln
290 295 300
Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser
305 310 315 320
Val Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn
325 330 335
Val Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His
340 345 350
Tyr Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp
355 360 365
Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile
370 375 380
Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala
385 390 395 400
Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly
405 410 415
Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr
420 425 430
Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile
435 440 445
Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp
450 455 460
Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile
465 470 475 480
Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys
485 490 495
Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met
500 505 510
Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr
515 520 525
Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys
530 535 540
Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met
545 550 555 560
Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser
565 570 575
Val Phe Thr Ile Lys
580
<210> 269
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 269
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 270
<211> 581
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 270
Met His Lys Met Ser Lys Lys Met Phe Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val
20 25 30
Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met
35 40 45
Gln Trp Ile Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys
65 70 75 80
Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser
85 90 95
Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly
100 105 110
Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro
115 120 125
Phe Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys
130 135 140
Gly Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr
145 150 155 160
Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu
165 170 175
Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly
180 185 190
Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe
195 200 205
Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg
210 215 220
Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly
225 230 235 240
Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro
245 250 255
Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr
260 265 270
Glu Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn
275 280 285
Leu Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln
290 295 300
Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser
305 310 315 320
Val Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn
325 330 335
Val Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His
340 345 350
Tyr Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp
355 360 365
Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile
370 375 380
Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala
385 390 395 400
Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly
405 410 415
Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr
420 425 430
Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile
435 440 445
Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp
450 455 460
Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile
465 470 475 480
Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys
485 490 495
Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met
500 505 510
Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr
515 520 525
Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys
530 535 540
Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met
545 550 555 560
Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser
565 570 575
Val Phe Thr Ile Lys
580
<210> 271
<211> 579
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 271
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp
50 55 60
Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys
65 70 75 80
Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met
85 90 95
Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg
100 105 110
Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro
115 120 125
Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp
130 135 140
Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu
145 150 155 160
Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu
165 170 175
Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp
180 185 190
Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys
195 200 205
Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala
210 215 220
Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu
225 230 235 240
Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln
245 250 255
Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly
260 265 270
Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys
275 280 285
Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys
290 295 300
Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn
305 310 315 320
Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp
325 330 335
Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr
340 345 350
Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile
355 360 365
Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln
370 375 380
Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn
385 390 395 400
Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu
405 410 415
Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro
420 425 430
Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr
435 440 445
Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile
450 455 460
His Leu Thr Gly Thr Lys Val Pro Asp Ile Ile Lys Asp Leu Val His
465 470 475 480
Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala
485 490 495
Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg
500 505 510
Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile
515 520 525
Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu
530 535 540
Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro
545 550 555 560
Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe
565 570 575
Thr Ile Lys
<210> 272
<211> 579
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 272
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp
50 55 60
Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys
65 70 75 80
Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met
85 90 95
Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg
100 105 110
Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro
115 120 125
Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp
130 135 140
Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu
145 150 155 160
Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu
165 170 175
Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp
180 185 190
Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys
195 200 205
Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala
210 215 220
Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu
225 230 235 240
Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln
245 250 255
Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly
260 265 270
Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys
275 280 285
Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys
290 295 300
Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn
305 310 315 320
Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp
325 330 335
Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr
340 345 350
Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile
355 360 365
Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln
370 375 380
Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn
385 390 395 400
Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu
405 410 415
Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro
420 425 430
Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr
435 440 445
Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile
450 455 460
His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His
465 470 475 480
Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala
485 490 495
Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg
500 505 510
Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile
515 520 525
Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu
530 535 540
Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro
545 550 555 560
Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe
565 570 575
Thr Ile Lys
<210> 273
<211> 579
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 273
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp
50 55 60
Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys
65 70 75 80
Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met
85 90 95
Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg
100 105 110
Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro
115 120 125
Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp
130 135 140
Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu
145 150 155 160
Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu
165 170 175
Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp
180 185 190
Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys
195 200 205
Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala
210 215 220
Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu
225 230 235 240
Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln
245 250 255
Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly
260 265 270
Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys
275 280 285
Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys
290 295 300
Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn
305 310 315 320
Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp
325 330 335
Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr
340 345 350
Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile
355 360 365
Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln
370 375 380
Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn
385 390 395 400
Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu
405 410 415
Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro
420 425 430
Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr
435 440 445
Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile
450 455 460
His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His
465 470 475 480
Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala
485 490 495
Lys Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg
500 505 510
Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile
515 520 525
Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu
530 535 540
Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro
545 550 555 560
Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe
565 570 575
Thr Ile Lys
<210> 274
<211> 579
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 274
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp
50 55 60
Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys
65 70 75 80
Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met
85 90 95
Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg
100 105 110
Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro
115 120 125
Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp
130 135 140
Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu
145 150 155 160
Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu
165 170 175
Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp
180 185 190
Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys
195 200 205
Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala
210 215 220
Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu
225 230 235 240
Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln
245 250 255
Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly
260 265 270
Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys
275 280 285
Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys
290 295 300
Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn
305 310 315 320
Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp
325 330 335
Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr
340 345 350
Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile
355 360 365
Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln
370 375 380
Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn
385 390 395 400
Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu
405 410 415
Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro
420 425 430
Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr
435 440 445
Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile
450 455 460
His Leu Thr Gly Thr Lys Val Pro Asp Ile Ile Lys Asp Ile Val His
465 470 475 480
Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala
485 490 495
Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg
500 505 510
Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Thr
515 520 525
Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu
530 535 540
Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro
545 550 555 560
Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe
565 570 575
Thr Ile Lys
<210> 275
<211> 579
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 275
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp
50 55 60
Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys
65 70 75 80
Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met
85 90 95
Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg
100 105 110
Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro
115 120 125
Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp
130 135 140
Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu
145 150 155 160
Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu
165 170 175
Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp
180 185 190
Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys
195 200 205
Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala
210 215 220
Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu
225 230 235 240
Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln
245 250 255
Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly
260 265 270
Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys
275 280 285
Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys
290 295 300
Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn
305 310 315 320
Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp
325 330 335
Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr
340 345 350
Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile
355 360 365
Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln
370 375 380
Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn
385 390 395 400
Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu
405 410 415
Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro
420 425 430
Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr
435 440 445
Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile
450 455 460
His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Ile Val His
465 470 475 480
Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala
485 490 495
Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg
500 505 510
Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Gly
515 520 525
Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu
530 535 540
Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro
545 550 555 560
Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe
565 570 575
Thr Ile Lys
<210> 276
<211> 579
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 276
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp
50 55 60
Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys
65 70 75 80
Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met
85 90 95
Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg
100 105 110
Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro
115 120 125
Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp
130 135 140
Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu
145 150 155 160
Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu
165 170 175
Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp
180 185 190
Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys
195 200 205
Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala
210 215 220
Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu
225 230 235 240
Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln
245 250 255
Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly
260 265 270
Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys
275 280 285
Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys
290 295 300
Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn
305 310 315 320
Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp
325 330 335
Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr
340 345 350
Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile
355 360 365
Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln
370 375 380
Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn
385 390 395 400
Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu
405 410 415
Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro
420 425 430
Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr
435 440 445
Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile
450 455 460
His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His
465 470 475 480
Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala
485 490 495
Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg
500 505 510
Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Gly
515 520 525
Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu
530 535 540
Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro
545 550 555 560
Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe
565 570 575
Thr Ile Lys
<210> 277
<211> 579
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 277
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp
50 55 60
Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys
65 70 75 80
Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met
85 90 95
Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg
100 105 110
Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro
115 120 125
Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp
130 135 140
Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu
145 150 155 160
Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu
165 170 175
Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp
180 185 190
Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys
195 200 205
Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala
210 215 220
Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu
225 230 235 240
Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln
245 250 255
Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly
260 265 270
Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys
275 280 285
Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys
290 295 300
Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn
305 310 315 320
Lys Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp
325 330 335
Val Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr
340 345 350
Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile
355 360 365
Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln
370 375 380
Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn
385 390 395 400
Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu
405 410 415
Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro
420 425 430
Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr
435 440 445
Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile
450 455 460
His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His
465 470 475 480
Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala
485 490 495
Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg
500 505 510
Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile
515 520 525
Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu
530 535 540
Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro
545 550 555 560
Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe
565 570 575
Thr Ile Lys
<210> 278
<211> 579
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 278
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp
50 55 60
Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys
65 70 75 80
Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met
85 90 95
Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg
100 105 110
Lys Leu His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro
115 120 125
Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp
130 135 140
Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu
145 150 155 160
Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu
165 170 175
Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp
180 185 190
Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys
195 200 205
Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala
210 215 220
Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu
225 230 235 240
Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln
245 250 255
Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly
260 265 270
Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys
275 280 285
Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys
290 295 300
Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn
305 310 315 320
Lys Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp
325 330 335
Val Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr
340 345 350
Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile
355 360 365
Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln
370 375 380
Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn
385 390 395 400
Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu
405 410 415
Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro
420 425 430
Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr
435 440 445
Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile
450 455 460
His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His
465 470 475 480
Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala
485 490 495
Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg
500 505 510
Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile
515 520 525
Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu
530 535 540
Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro
545 550 555 560
Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe
565 570 575
Thr Ile Lys
<210> 279
<211> 579
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 279
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp
50 55 60
Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys
65 70 75 80
Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met
85 90 95
Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg
100 105 110
Lys Gln His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro
115 120 125
Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp
130 135 140
Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu
145 150 155 160
Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu
165 170 175
Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp
180 185 190
Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys
195 200 205
Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala
210 215 220
Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu
225 230 235 240
Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln
245 250 255
Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly
260 265 270
Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys
275 280 285
Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys
290 295 300
Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn
305 310 315 320
Lys Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp
325 330 335
Val Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr
340 345 350
Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile
355 360 365
Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln
370 375 380
Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn
385 390 395 400
Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu
405 410 415
Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro
420 425 430
Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr
435 440 445
Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile
450 455 460
His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His
465 470 475 480
Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala
485 490 495
Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg
500 505 510
Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile
515 520 525
Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu
530 535 540
Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro
545 550 555 560
Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe
565 570 575
Thr Ile Lys
<210> 280
<211> 579
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 280
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp
50 55 60
Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys
65 70 75 80
Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met
85 90 95
Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg
100 105 110
Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro
115 120 125
Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp
130 135 140
Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu
145 150 155 160
Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu
165 170 175
Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp
180 185 190
Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys
195 200 205
Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala
210 215 220
Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu
225 230 235 240
Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln
245 250 255
Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly
260 265 270
Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys
275 280 285
Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys
290 295 300
Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn
305 310 315 320
Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp
325 330 335
Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr
340 345 350
Tyr Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile
355 360 365
Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln
370 375 380
Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn
385 390 395 400
Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu
405 410 415
Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro
420 425 430
Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr
435 440 445
Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile
450 455 460
His Leu Thr Gly Thr Lys Val Pro Asp Val Ile Lys Asp Ile Val His
465 470 475 480
Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala
485 490 495
Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg
500 505 510
Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile
515 520 525
Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu
530 535 540
Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro
545 550 555 560
Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe
565 570 575
Thr Ile Lys
<210> 281
<211> 579
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 281
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp
50 55 60
Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys
65 70 75 80
Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met
85 90 95
Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg
100 105 110
Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro
115 120 125
Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp
130 135 140
Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu
145 150 155 160
Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu
165 170 175
Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp
180 185 190
Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys
195 200 205
Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala
210 215 220
Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu
225 230 235 240
Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln
245 250 255
Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly
260 265 270
Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys
275 280 285
Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys
290 295 300
Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn
305 310 315 320
Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp
325 330 335
Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr
340 345 350
Tyr Gly Tyr Met Phe Arg Ser Ser Cys Asp Met Phe Lys Asp Phe Ile
355 360 365
Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln
370 375 380
Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn
385 390 395 400
Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu
405 410 415
Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro
420 425 430
Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr
435 440 445
Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile
450 455 460
His Leu Thr Gly Thr Lys Val Pro Asp Val Ile Lys Asp Ile Val His
465 470 475 480
Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala
485 490 495
Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg
500 505 510
Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile
515 520 525
Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu
530 535 540
Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro
545 550 555 560
Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe
565 570 575
Thr Ile Lys
<210> 282
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 282
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 283
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 283
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 284
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 284
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 285
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 285
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 286
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 286
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 287
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 287
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Val Pro Asp Ile Ile Lys Asp Leu Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 288
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 288
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 289
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 289
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 290
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 290
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Val Pro Asp Ile Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Thr Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 291
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 291
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Gly Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 292
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 292
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Gly Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 293
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 293
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp Val
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 294
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 294
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Leu His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp Val
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 295
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 295
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Gln His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp Val
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 296
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 296
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Val Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 297
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 297
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ser Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Val Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 298
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 298
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Val Pro Asp Ile Ile Lys Asp Leu Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 299
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 299
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 300
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 300
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys
260 265 270
Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys
275 280 285
Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg
290 295 300
Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu
305 310 315 320
Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu
325 330 335
His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys
340 345 350
Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 301
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 301
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Val Asn Ser Met Tyr Pro Ala Met Met
245 250 255
Lys Asn Lys Leu Leu Pro Tyr Gly Glu Pro Val Met Phe Lys Gly Glu
260 265 270
Tyr Lys Lys Asn Val Glu Tyr Pro Leu Tyr Ile Gln Gln Val Arg Cys
275 280 285
Phe Phe Glu Leu Lys Lys Asp Lys Ile Pro Cys Ile Gln Ile Lys Gly
290 295 300
Asn Ala Arg Phe Gly Gln Asn Glu Tyr Leu Ser Thr Ser Gly Asp Glu
305 310 315 320
Tyr Val Asp Leu Tyr Val Thr Asn Val Asp Trp Glu Leu Ile Lys Lys
325 330 335
His Tyr Asp Ile Phe Glu Glu Glu Phe Ile Gly Gly Phe Met Phe Lys
340 345 350
Gly Phe Ile Gly Phe Phe Asp Glu Tyr Ile Asp Arg Phe Met Glu Ile
355 360 365
Lys Asn Ser Pro Asp Ser Ser Ala Glu Gln Ser Leu Gln Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe
420 425 430
Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570 575
<210> 302
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 302
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Lys Asn Val Glu Tyr Pro Leu Tyr Ile Gln Gln Val Arg Cys
275 280 285
Phe Phe Glu Leu Lys Lys Asp Lys Ile Pro Cys Ile Gln Ile Lys Gly
290 295 300
Asn Ala Arg Phe Gly Gln Asn Glu Tyr Leu Ser Thr Ser Gly Asp Glu
305 310 315 320
Tyr Val Asp Leu Tyr Val Thr Asn Val Asp Trp Glu Leu Ile Lys Lys
325 330 335
His Tyr Asp Ile Phe Glu Glu Glu Phe Ile Gly Gly Phe Met Phe Lys
340 345 350
Gly Phe Ile Gly Phe Phe Asp Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 303
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 303
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys
260 265 270
Tyr Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe
275 280 285
Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys
290 295 300
Asn Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu
305 310 315 320
Pro Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu
325 330 335
His Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg
340 345 350
Glu Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 304
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 304
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 305
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 305
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Pro Asn Asn Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Asp Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Glu Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 306
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 306
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg
290 295 300
Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 307
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 307
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg
290 295 300
Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu
305 310 315 320
Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu
325 330 335
His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg
340 345 350
Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 308
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 308
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg
290 295 300
Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu
305 310 315 320
Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Glu Leu Met Lys Glu
325 330 335
His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg
340 345 350
Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 309
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 309
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Leu Leu Pro Tyr Gly Glu Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg
290 295 300
Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu
305 310 315 320
Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Glu Leu Met Lys Glu
325 330 335
His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Lys
340 345 350
Ala Thr Thr Gly Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 310
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 310
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Leu Leu Pro Tyr Gly Glu Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Thr Thr Gly Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 311
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 311
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Leu Leu Pro Tyr Gly Glu Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg
290 295 300
Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu
305 310 315 320
Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu
325 330 335
His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Lys
340 345 350
Ala Thr Thr Gly Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 312
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 312
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg
290 295 300
Ser Arg Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu
305 310 315 320
Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu
325 330 335
His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg
340 345 350
Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 313
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 313
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg
290 295 300
Ser Arg Leu Phe Lys Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu
305 310 315 320
Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu
325 330 335
His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg
340 345 350
Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 314
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 314
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg
290 295 300
Ser Arg Leu Tyr Lys Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu
305 310 315 320
Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu
325 330 335
His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg
340 345 350
Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 315
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 315
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg
290 295 300
Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu
305 310 315 320
Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu
325 330 335
His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg
340 345 350
Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 316
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 316
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg
290 295 300
Ser Arg Leu Phe Lys Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu
305 310 315 320
Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu
325 330 335
His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg
340 345 350
Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 317
<211> 574
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 317
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Leu Pro Val Pro Phe Ser Gly Glu
260 265 270
Tyr Glu Tyr Asp Glu Thr His Pro Leu Phe Ile Gln His Ile Lys Cys
275 280 285
Gly Phe Glu Leu Lys Asp Gly His Ile Pro Thr Ile Gln Ile Lys Lys
290 295 300
Asn Phe Arg Phe Ala Asp Asn Glu Tyr Leu His Ser Ser Glu Gly Asn
305 310 315 320
Ile Leu Asp Leu His Val Thr Asn Val Asp Leu Ala Leu Ile Lys Glu
325 330 335
His Tyr Thr Leu Tyr Glu Glu Glu Tyr Leu Gln Gly Tyr Lys Phe Lys
340 345 350
Gln Val Thr Gly Leu Phe Lys Asn Tyr Ile Asp Tyr Trp Ser Asp Lys
355 360 365
Lys Ile Asn Ala Glu Asp Pro Ala Ile Arg Gln Met Ala Lys Leu Met
370 375 380
Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly
385 390 395 400
Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly
405 410 415
Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val
420 425 430
Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr
435 440 445
Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr
450 455 460
Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly
465 470 475 480
Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln
485 490 495
Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu
500 505 510
Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys
515 520 525
Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn
530 535 540
Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val
545 550 555 560
Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 318
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 318
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 319
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 319
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 320
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 320
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu
305 310 315 320
Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu
325 330 335
His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg
340 345 350
Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 321
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 321
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 322
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 322
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 323
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 323
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Val Asn Ser Met Tyr Pro Ala Met Met
245 250 255
Lys Asn Lys Leu Leu Pro Tyr Gly Glu Pro Val Met Phe Lys Gly Glu
260 265 270
Tyr Lys Lys Asn Val Glu Tyr Pro Leu Tyr Ile Gln Gln Val Arg Cys
275 280 285
Phe Phe Glu Leu Lys Lys Asp Lys Ile Pro Cys Ile Gln Ile Lys Gly
290 295 300
Asn Ala Arg Phe Gly Gln Asn Glu Tyr Leu Ser Thr Ser Gly Asp Glu
305 310 315 320
Tyr Val Asp Leu Tyr Val Thr Asn Val Asp Trp Glu Leu Ile Lys Lys
325 330 335
His Tyr Asp Ile Phe Glu Glu Glu Phe Ile Gly Gly Phe Met Phe Lys
340 345 350
Gly Phe Ile Gly Phe Phe Asp Glu Tyr Ile Asp Arg Phe Met Glu Ile
355 360 365
Lys Asn Ser Pro Asp Ser Ser Ala Glu Gln Ser Leu Gln Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe
420 425 430
Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570 575
<210> 324
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 324
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg
290 295 300
Ser Arg Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu
305 310 315 320
Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu
325 330 335
His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg
340 345 350
Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 325
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 325
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg
290 295 300
Ser Arg Leu Phe Lys Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu
305 310 315 320
Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu
325 330 335
His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg
340 345 350
Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 326
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 326
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg
290 295 300
Ser Arg Leu Tyr Lys Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu
305 310 315 320
Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu
325 330 335
His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg
340 345 350
Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 327
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 327
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg
290 295 300
Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu
305 310 315 320
Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu
325 330 335
His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg
340 345 350
Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 328
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 328
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg
290 295 300
Ser Arg Leu Phe Lys Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 329
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 329
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg
290 295 300
Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 330
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 330
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg
290 295 300
Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu
305 310 315 320
Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu
325 330 335
His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg
340 345 350
Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 331
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 331
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg
290 295 300
Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu
305 310 315 320
Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Glu Leu Met Lys Glu
325 330 335
His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg
340 345 350
Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 332
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 332
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 333
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 333
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 334
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 334
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 335
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 335
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 336
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 336
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg
290 295 300
Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 337
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 337
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg
290 295 300
Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu
305 310 315 320
Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu
325 330 335
His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg
340 345 350
Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Phe Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 338
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 338
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg
290 295 300
Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu
305 310 315 320
Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Glu Leu Met Lys Glu
325 330 335
His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg
340 345 350
Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Phe Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 339
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 339
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Val Pro Asp Ile Ile Lys Asp Leu Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 340
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 340
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 341
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 341
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 342
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 342
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Val Pro Asp Ile Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Thr Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 343
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 343
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Lys Asn Lys Leu Leu Pro Tyr Gly Glu Pro Val Met Phe Lys
260 265 270
Gly Glu Tyr Lys Lys Asn Val Glu Tyr Pro Leu Tyr Ile Gln Gln Val
275 280 285
Arg Cys Phe Phe Glu Leu Lys Lys Asp Lys Ile Pro Cys Ile Gln Ile
290 295 300
Lys Gly Asn Ala Arg Phe Gly Gln Asn Glu Tyr Leu Ser Thr Ser Gly
305 310 315 320
Asp Glu Tyr Val Asp Leu Tyr Val Thr Asn Val Asp Trp Glu Leu Ile
325 330 335
Lys Lys His Tyr Asp Ile Phe Glu Glu Glu Phe Ile Gly Gly Phe Met
340 345 350
Phe Lys Gly Met Phe Lys Asp Phe Ile Asp Lys Trp Phe Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys Ile
450 455 460
Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln
500 505 510
Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 344
<211> 576
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 344
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys
65 70 75 80
Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser
85 90 95
Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly
100 105 110
Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro
115 120 125
Phe Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys
130 135 140
Gly Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr
145 150 155 160
Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu
165 170 175
Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly
180 185 190
Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe
195 200 205
Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg
210 215 220
Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly
225 230 235 240
Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro
245 250 255
Ala Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe
260 265 270
Glu Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His
275 280 285
Ile Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln
290 295 300
Ile Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser
305 310 315 320
Gly Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu
325 330 335
Met Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu
340 345 350
Lys Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp
355 360 365
Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys
370 375 380
Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val
385 390 395 400
Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg
405 410 415
Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser
420 425 430
Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala
435 440 445
Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr
450 455 460
Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys
465 470 475 480
Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu
485 490 495
Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly
500 505 510
Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser
515 520 525
Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe
530 535 540
Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val
545 550 555 560
Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570 575
<210> 345
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 345
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val
565 570 575
Phe Thr Ile Lys
580
<210> 346
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 346
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp His Pro Leu His Ile Gln His Leu
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Cys Ile Gln Ile
290 295 300
Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Glu Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Arg Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570 575
<210> 347
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 347
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val
565 570 575
Phe Thr Ile Lys
580
<210> 348
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 348
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr
245 250 255
Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr
260 265 270
Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu
275 280 285
Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Gln Ser
290 295 300
Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile
305 310 315 320
Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His
325 330 335
Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala
340 345 350
Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys Ile
450 455 460
Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr Leu Val Gln
500 505 510
Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 349
<211> 576
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 349
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys
65 70 75 80
Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser
85 90 95
Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly
100 105 110
Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro
115 120 125
Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys
130 135 140
Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr
145 150 155 160
Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu
165 170 175
Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly
180 185 190
Ser Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe
195 200 205
Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg
210 215 220
Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly
225 230 235 240
Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro
245 250 255
Ala Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe
260 265 270
Glu Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His
275 280 285
Ile Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln
290 295 300
Ile Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser
305 310 315 320
Gly Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu
325 330 335
Met Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu
340 345 350
Lys Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp
355 360 365
Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys
370 375 380
Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val
385 390 395 400
Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg
405 410 415
Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val
420 425 430
Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala
435 440 445
Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr
450 455 460
Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys
465 470 475 480
Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu
485 490 495
Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly
500 505 510
Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser
515 520 525
Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe
530 535 540
Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val
545 550 555 560
Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570 575
<210> 350
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 350
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570 575
<210> 351
<211> 572
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 351
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr
245 250 255
Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr
260 265 270
Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu
275 280 285
Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Gln Ser
290 295 300
Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile
305 310 315 320
Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His
325 330 335
Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala
340 345 350
Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys
355 360 365
Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn
370 375 380
Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val
385 390 395 400
Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu
405 410 415
Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala
420 425 430
Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg
435 440 445
Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys Ile
450 455 460
Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr Trp
465 470 475 480
Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr
485 490 495
Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr Leu Val Gln
500 505 510
Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala
515 520 525
Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe Lys
530 535 540
Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly
545 550 555 560
Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 352
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 352
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys
260 265 270
Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys
275 280 285
Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Gln
290 295 300
Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu
305 310 315 320
Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu
325 330 335
His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys
340 345 350
Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 353
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 353
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe
420 425 430
Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570 575
<210> 354
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 354
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570 575
<210> 355
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 355
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe
420 425 430
Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570 575
<210> 356
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 356
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile
290 295 300
Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570 575
<210> 357
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 357
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 358
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 358
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val
565 570 575
Phe Thr Ile Lys
580
<210> 359
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 359
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 360
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 360
Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp His Pro Leu His Ile Gln His Leu
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Cys Ile Gln Ile
290 295 300
Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Glu Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Arg Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570 575
<210> 361
<211> 575
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 361
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu
260 265 270
Gly Lys Tyr Val Trp Asp Glu Asp His Pro Leu His Ile Gln His Leu
275 280 285
Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Cys Ile Gln Ile
290 295 300
Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly
305 310 315 320
Gly Glu Ile Ala Glu Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met
325 330 335
Lys Glu His Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys
340 345 350
Phe Arg Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr
355 360 365
Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu
370 375 380
Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr
385 390 395 400
Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu
405 410 415
Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe
420 425 430
Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys
435 440 445
Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly
450 455 460
Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro Lys Lys Leu
465 470 475 480
Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg
485 490 495
Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr
500 505 510
Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val
515 520 525
Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu
530 535 540
Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln
545 550 555 560
Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570 575
<210> 362
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 362
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val
565 570 575
Phe Thr Ile Lys
580
<210> 363
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 363
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 364
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 364
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val
465 470 475 480
His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val
565 570 575
Phe Thr Ile Lys
580
<210> 365
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 365
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 366
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 366
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 367
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 367
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 368
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 368
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 369
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 369
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 370
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 370
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 371
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 371
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Val Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 372
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 372
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 373
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 373
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Gln His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 374
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 374
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp Val
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 375
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 375
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 376
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 376
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Gln His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Val
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 377
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 377
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 378
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 378
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Val Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 379
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 379
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Val Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 380
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 380
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Val Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 381
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 381
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Asp Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 382
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 382
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Leu Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 383
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 383
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp Val
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 384
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 384
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 385
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 385
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 386
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 386
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 387
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 387
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 388
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 388
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 389
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 389
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 390
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 390
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 391
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 391
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 392
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 392
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 393
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 393
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 394
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 394
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 395
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 395
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr
565 570 575
Ile Lys
<210> 396
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 396
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 397
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 397
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 398
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 398
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 399
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 399
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 400
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 400
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr
565 570 575
Ile Lys
<210> 401
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 401
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 402
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 402
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Arg Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Asp Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 403
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 403
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 404
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 404
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu
115 120 125
Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile
565 570 575
Lys
<210> 405
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 405
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 406
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 406
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 407
<211> 581
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 407
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys
65 70 75 80
Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser
85 90 95
Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly
100 105 110
Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro
115 120 125
Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys
130 135 140
Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr
145 150 155 160
Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu
165 170 175
Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly
180 185 190
Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe
195 200 205
Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg
210 215 220
Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly
225 230 235 240
Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro
245 250 255
Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr
260 265 270
Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn
275 280 285
Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln
290 295 300
Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser
305 310 315 320
Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn
325 330 335
Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His
340 345 350
Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp
355 360 365
Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile
370 375 380
Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala
385 390 395 400
Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly
405 410 415
Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr
420 425 430
Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile
435 440 445
Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp
450 455 460
Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile
465 470 475 480
Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys
485 490 495
Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met
500 505 510
Lys Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr
515 520 525
Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys
530 535 540
Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met
545 550 555 560
Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser
565 570 575
Val Phe Thr Ile Lys
580
<210> 408
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 408
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val
565 570 575
Phe Thr Ile Lys
580
<210> 409
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 409
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val
465 470 475 480
His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val
565 570 575
Phe Thr Ile Lys
580
<210> 410
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 410
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val Arg
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 411
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 411
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val Arg
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 412
<211> 581
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 412
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys
65 70 75 80
Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser
85 90 95
Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly
100 105 110
Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro
115 120 125
Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys
130 135 140
Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr
145 150 155 160
Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu
165 170 175
Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly
180 185 190
Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe
195 200 205
Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg
210 215 220
Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly
225 230 235 240
Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro
245 250 255
Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr
260 265 270
Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn
275 280 285
Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln
290 295 300
Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser
305 310 315 320
Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn
325 330 335
Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His
340 345 350
Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp
355 360 365
Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile
370 375 380
Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala
385 390 395 400
Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly
405 410 415
Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr
420 425 430
Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile
435 440 445
Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp
450 455 460
Ser Ile His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu
465 470 475 480
Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys
485 490 495
Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met
500 505 510
Lys Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr
515 520 525
Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys
530 535 540
Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met
545 550 555 560
Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser
565 570 575
Val Phe Thr Ile Lys
580
<210> 413
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 413
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val
465 470 475 480
His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val
565 570 575
Phe Thr Ile Lys
580
<210> 414
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 414
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 415
<211> 581
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 415
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys
65 70 75 80
Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser
85 90 95
Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly
100 105 110
Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro
115 120 125
Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys
130 135 140
Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr
145 150 155 160
Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu
165 170 175
Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly
180 185 190
Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe
195 200 205
Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg
210 215 220
Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly
225 230 235 240
Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro
245 250 255
Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr
260 265 270
Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn
275 280 285
Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln
290 295 300
Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser
305 310 315 320
Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn
325 330 335
Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His
340 345 350
Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp
355 360 365
Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile
370 375 380
Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala
385 390 395 400
Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly
405 410 415
Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr
420 425 430
Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile
435 440 445
Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp
450 455 460
Ser Ile His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu
465 470 475 480
Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys
485 490 495
Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met
500 505 510
Lys Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr
515 520 525
Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys
530 535 540
Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met
545 550 555 560
Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser
565 570 575
Val Phe Thr Ile Lys
580
<210> 416
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 416
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 417
<211> 581
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 417
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys
65 70 75 80
Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser
85 90 95
Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly
100 105 110
Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro
115 120 125
Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys
130 135 140
Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr
145 150 155 160
Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu
165 170 175
Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly
180 185 190
Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe
195 200 205
Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg
210 215 220
Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly
225 230 235 240
Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro
245 250 255
Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr
260 265 270
Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn
275 280 285
Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln
290 295 300
Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser
305 310 315 320
Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn
325 330 335
Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His
340 345 350
Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp
355 360 365
Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile
370 375 380
Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala
385 390 395 400
Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly
405 410 415
Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr
420 425 430
Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile
435 440 445
Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp
450 455 460
Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile
465 470 475 480
Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys
485 490 495
Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met
500 505 510
Lys Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr
515 520 525
Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys
530 535 540
Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met
545 550 555 560
Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser
565 570 575
Val Phe Thr Ile Lys
580
<210> 418
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 418
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 419
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 419
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 420
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 420
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 421
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 421
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 422
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 422
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 423
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 423
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 424
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 424
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 425
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 425
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 426
<211> 581
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 426
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys
65 70 75 80
Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser
85 90 95
Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly
100 105 110
Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro
115 120 125
Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys
130 135 140
Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr
145 150 155 160
Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu
165 170 175
Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly
180 185 190
Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe
195 200 205
Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg
210 215 220
Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly
225 230 235 240
Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro
245 250 255
Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr
260 265 270
Glu Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn
275 280 285
Leu Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln
290 295 300
Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser
305 310 315 320
Val Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn
325 330 335
Val Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His
340 345 350
Tyr Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp
355 360 365
Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile
370 375 380
Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala
385 390 395 400
Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly
405 410 415
Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr
420 425 430
Thr Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile
435 440 445
Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp
450 455 460
Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile
465 470 475 480
Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys
485 490 495
Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met
500 505 510
Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr
515 520 525
Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys
530 535 540
Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met
545 550 555 560
Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser
565 570 575
Val Phe Thr Ile Lys
580
<210> 427
<211> 581
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 427
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys
65 70 75 80
Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser
85 90 95
Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly
100 105 110
Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro
115 120 125
Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys
130 135 140
Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr
145 150 155 160
Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu
165 170 175
Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly
180 185 190
Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe
195 200 205
Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg
210 215 220
Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly
225 230 235 240
Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro
245 250 255
Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr
260 265 270
Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn
275 280 285
Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln
290 295 300
Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser
305 310 315 320
Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn
325 330 335
Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His
340 345 350
Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp
355 360 365
Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile
370 375 380
Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala
385 390 395 400
Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly
405 410 415
Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr
420 425 430
Thr Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile
435 440 445
Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp
450 455 460
Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile
465 470 475 480
Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys
485 490 495
Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met
500 505 510
Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr
515 520 525
Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys
530 535 540
Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met
545 550 555 560
Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser
565 570 575
Val Phe Thr Ile Lys
580
<210> 428
<211> 581
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 428
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys
65 70 75 80
Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser
85 90 95
Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly
100 105 110
Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro
115 120 125
Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys
130 135 140
Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr
145 150 155 160
Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu
165 170 175
Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly
180 185 190
Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe
195 200 205
Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg
210 215 220
Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly
225 230 235 240
Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro
245 250 255
Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr
260 265 270
Glu Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn
275 280 285
Leu Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln
290 295 300
Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser
305 310 315 320
Val Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn
325 330 335
Val Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His
340 345 350
Tyr Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp
355 360 365
Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile
370 375 380
Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala
385 390 395 400
Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly
405 410 415
Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr
420 425 430
Thr Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile
435 440 445
Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp
450 455 460
Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile
465 470 475 480
Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys
485 490 495
Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met
500 505 510
Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr
515 520 525
Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys
530 535 540
Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met
545 550 555 560
Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser
565 570 575
Val Phe Thr Ile Lys
580
<210> 429
<211> 581
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 429
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys
65 70 75 80
Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser
85 90 95
Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly
100 105 110
Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro
115 120 125
Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys
130 135 140
Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr
145 150 155 160
Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu
165 170 175
Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly
180 185 190
Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe
195 200 205
Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg
210 215 220
Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly
225 230 235 240
Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro
245 250 255
Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr
260 265 270
Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn
275 280 285
Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln
290 295 300
Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser
305 310 315 320
Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn
325 330 335
Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His
340 345 350
Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp
355 360 365
Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile
370 375 380
Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala
385 390 395 400
Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly
405 410 415
Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr
420 425 430
Thr Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile
435 440 445
Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp
450 455 460
Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile
465 470 475 480
Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys
485 490 495
Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met
500 505 510
Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr
515 520 525
Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys
530 535 540
Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met
545 550 555 560
Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser
565 570 575
Val Phe Thr Ile Lys
580
<210> 430
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 430
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 431
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 431
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 432
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 432
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile
20 25 30
Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val
565 570 575
Phe Thr Ile Lys
580
<210> 433
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 433
Met Lys His Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile
20 25 30
Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val
565 570 575
Phe Thr Ile Lys
580
<210> 434
<211> 581
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 434
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile
20 25 30
Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys
65 70 75 80
Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser
85 90 95
Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly
100 105 110
Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro
115 120 125
Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys
130 135 140
Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr
145 150 155 160
Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu
165 170 175
Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly
180 185 190
Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe
195 200 205
Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg
210 215 220
Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly
225 230 235 240
Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro
245 250 255
Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr
260 265 270
Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn
275 280 285
Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln
290 295 300
Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser
305 310 315 320
Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn
325 330 335
Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His
340 345 350
Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp
355 360 365
Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile
370 375 380
Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala
385 390 395 400
Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly
405 410 415
Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr
420 425 430
Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile
435 440 445
Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp
450 455 460
Ser Ile His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu
465 470 475 480
Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys
485 490 495
Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met
500 505 510
Lys Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr
515 520 525
Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys
530 535 540
Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met
545 550 555 560
Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser
565 570 575
Val Phe Thr Ile Lys
580
<210> 435
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 435
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val
565 570 575
Phe Thr Ile Lys
580
<210> 436
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 436
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val
565 570 575
Phe Thr Ile Lys
580
<210> 437
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 437
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Leu Ala Val Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val
565 570 575
Phe Thr Ile Lys
580
<210> 438
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 438
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val
565 570 575
Phe Thr Ile Lys
580
<210> 439
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 439
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Leu Ala Val Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val
565 570 575
Phe Thr Ile Lys
580
<210> 440
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 440
Met Lys His Met Ser Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile
20 25 30
Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Gln Trp Ala Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val
565 570 575
Phe Thr Ile Lys
580
<210> 441
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 441
Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr Thr Lys Val
1 5 10 15
Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 442
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 442
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile Glu Asp His
20 25 30
Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 443
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 443
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Ala Trp Ala
35 40 45
Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 444
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 444
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile Glu Asp His
20 25 30
Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Ala Trp Ala
35 40 45
Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 445
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 445
Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr Thr Lys Val
1 5 10 15
Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Ala Trp Ala
35 40 45
Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 446
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 446
Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr Thr Lys Val
1 5 10 15
Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile Glu Asp His
20 25 30
Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp
385 390 395 400
Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe
405 410 415
Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 447
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 447
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile
20 25 30
Gly Asn Leu Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Gln Trp Ala Met Lys Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val
565 570 575
Phe Thr Ile Lys
580
<210> 448
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 448
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile
20 25 30
Gly Asn His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Gln Trp Ala Met Lys Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser
385 390 395 400
Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala
405 410 415
Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu
530 535 540
Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys
545 550 555 560
Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val
565 570 575
Phe Thr Ile Lys
580
<210> 449
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 449
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 450
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 450
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro
385 390 395 400
Asp Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg
405 410 415
Leu Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val
530 535 540
Thr Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu
545 550 555 560
Pro Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr
565 570 575
Ile Lys
<210> 451
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 451
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro
385 390 395 400
Asp Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg
405 410 415
Leu Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 452
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 452
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro
385 390 395 400
Asp Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg
405 410 415
Leu Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val
530 535 540
Thr Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu
545 550 555 560
Pro Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr
565 570 575
Ile Lys
<210> 453
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 453
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp
385 390 395 400
Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu
405 410 415
Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly
420 425 430
Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr
530 535 540
Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro
545 550 555 560
Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile
565 570 575
Lys
<210> 454
<211> 580
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 454
Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr
1 5 10 15
Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile
20 25 30
Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met
35 40 45
Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys
50 55 60
Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys
65 70 75 80
Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg
85 90 95
Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys
100 105 110
Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe
115 120 125
Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly
130 135 140
Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro
145 150 155 160
Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala
165 170 175
Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser
180 185 190
Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys
195 200 205
Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys
210 215 220
Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys
225 230 235 240
Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala
245 250 255
Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu
260 265 270
Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile
275 280 285
Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val
290 295 300
Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val
305 310 315 320
Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val
325 330 335
Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr
340 345 350
Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe
355 360 365
Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys
370 375 380
Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr
385 390 395 400
Asn Pro Asp Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile
405 410 415
Val Arg Leu Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr
420 425 430
Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr
435 440 445
Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser
450 455 460
Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val
465 470 475 480
His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg
485 490 495
Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys
500 505 510
Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp
515 520 525
Ile Lys Phe Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu
530 535 540
Leu Val Thr Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys
545 550 555 560
Leu Leu Pro Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met
565 570 575
Phe Thr Ile Lys
580
<210> 455
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 455
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp
385 390 395 400
Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu
405 410 415
Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr
530 535 540
Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro
545 550 555 560
Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile
565 570 575
Lys
<210> 456
<211> 577
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 456
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala
65 70 75 80
Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln
85 90 95
Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile
100 105 110
His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys
115 120 125
Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp
130 135 140
Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr
145 150 155 160
Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile
165 170 175
Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu
180 185 190
Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe
195 200 205
Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg
210 215 220
Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly
225 230 235 240
Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr
245 250 255
Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr
260 265 270
Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg
275 280 285
Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser
290 295 300
Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu
305 310 315 320
Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp
325 330 335
Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly
340 345 350
Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys
355 360 365
Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala
370 375 380
Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp
385 390 395 400
Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu
405 410 415
Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala
420 425 430
Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln
435 440 445
Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu
450 455 460
Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys
465 470 475 480
Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr
485 490 495
Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg
500 505 510
Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe
515 520 525
Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr
530 535 540
Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro
545 550 555 560
Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile
565 570 575
Lys
<210> 457
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 457
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Gln
290 295 300
Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu
305 310 315 320
Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu
325 330 335
His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Lys
340 345 350
Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 458
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 458
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 459
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 459
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg
290 295 300
Ser Arg Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu
305 310 315 320
Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu
325 330 335
His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg
340 345 350
Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 460
<211> 573
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 460
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg
290 295 300
Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu
305 310 315 320
Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Glu Leu Met Lys Glu
325 330 335
His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg
340 345 350
Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile
355 360 365
Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu
370 375 380
Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys
385 390 395 400
Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu
405 410 415
Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr
420 425 430
Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp
435 440 445
Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys
450 455 460
Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr
465 470 475 480
Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys
485 490 495
Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr Leu Val
500 505 510
Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys
515 520 525
Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe
530 535 540
Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro
545 550 555 560
Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys
565 570
<210> 461
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 461
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 462
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 462
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 463
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 463
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 464
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 464
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Val Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 465
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 465
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Val Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 466
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 466
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 467
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 467
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met
420 425 430
Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 468
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 468
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 469
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 469
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 470
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 470
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 471
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 471
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 472
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 472
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly
405 410 415
Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 473
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 473
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ile Leu Gly
405 410 415
Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 474
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 474
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ala Leu Gly
405 410 415
Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 475
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 475
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asp Gly Ala Leu Gly
405 410 415
Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 476
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 476
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asp Gly Ile Val Arg
405 410 415
Leu Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 477
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 477
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asp Gly Ile Val Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 478
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 478
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ile Val Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 479
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 479
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ile Val Gly
405 410 415
Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 480
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 480
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ala Val Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 481
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 481
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ile Val Gly
405 410 415
Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 482
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 482
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val
530 535 540
Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Lys Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 483
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 483
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val
530 535 540
Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 484
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 484
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val
530 535 540
Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Thr Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 485
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 485
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Thr Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 486
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 486
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Thr Ile Lys Glu Glu Val
530 535 540
Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Lys Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 487
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 487
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Thr Ile Lys Glu Glu Val
530 535 540
Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 488
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 488
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Thr Ile Lys Glu Glu Val
530 535 540
Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Thr Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 489
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 489
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Ile Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Leu Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Ile Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Val Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 490
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 490
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Leu Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Ile Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 491
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 491
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Leu Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Ile Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 492
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 492
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 493
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 493
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ala Leu Gly
405 410 415
Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 494
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 494
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ile Val Gly
405 410 415
Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 495
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 495
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ile Val Gly
405 410 415
Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val
530 535 540
Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Lys Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 496
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 496
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ile Val Gly
405 410 415
Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val
530 535 540
Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Thr Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 497
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 497
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Leu Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Ile Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ile Val Gly
405 410 415
Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val
530 535 540
Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Thr Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 498
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 498
Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Leu Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Ile Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ile Val Gly
405 410 415
Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val
530 535 540
Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Thr Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 499
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 499
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Ile Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Leu Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Ile Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ile Val Gly
405 410 415
Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val
530 535 540
Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Thr Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 500
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 500
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly
405 410 415
Phe Arg Val Gly Asp Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 501
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 501
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly
405 410 415
Phe Arg Val Gly Asp Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Thr Ile Lys Glu Glu Val
530 535 540
Thr Phe Asp Asn Phe Ala Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 502
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 502
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Val Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 503
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 503
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Lys Leu Thr Thr Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 504
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 504
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Gln Arg Thr Ile Phe Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 505
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 505
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Gln Arg Thr Ile Phe Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 506
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 506
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Asn His Val Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 507
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 507
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Asn His Val Val Phe Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 508
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 508
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Gly Thr Thr Gln Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 509
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 509
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Phe Arg Val Glu Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 510
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 510
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Phe Arg Val Glu Phe Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 511
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 511
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Asp Lys Tyr Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 512
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 512
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Pro Lys Tyr Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 513
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 513
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Pro Lys Phe Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 514
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 514
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asn Pro Arg Tyr Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 515
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 515
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asp Pro Lys Tyr Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 516
<211> 578
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 516
Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu
1 5 10 15
Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu
20 25 30
Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val
35 40 45
Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly
50 55 60
Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys
65 70 75 80
Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly
85 90 95
Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys
100 105 110
Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val
115 120 125
Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile
130 135 140
Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu
145 150 155 160
Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu
165 170 175
Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser
180 185 190
Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val
195 200 205
Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr
210 215 220
Arg Gly Gly Phe Thr Trp Leu Asp Pro Arg Tyr Lys Gly Lys Glu Ile
225 230 235 240
Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met
245 250 255
Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu
260 265 270
Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val
275 280 285
Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln
290 295 300
Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys
305 310 315 320
Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu
325 330 335
Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr
340 345 350
Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp
355 360 365
Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu
370 375 380
Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro
385 390 395 400
Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly
405 410 415
Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu
420 425 430
Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala
435 440 445
Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His
450 455 460
Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro
465 470 475 480
Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys
485 490 495
Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val
500 505 510
Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys
515 520 525
Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val
530 535 540
Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys
545 550 555 560
Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr
565 570 575
Ile Lys
<210> 517
<211> 27
<212> PRT
<213> Artificial sequence
<220>
<223> Synthetic polypeptide
<400> 517
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp
1 5 10 15
Phe Phe Glu Ala Gln Lys Ile Glu Trp His Glu
20 25
<210> 518
<211> 53
<212> PRT
<213> Bacillus phage phi29
<400> 518
Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly Ala Phe Ile Ile Asn
1 5 10 15
Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala Asp Gly Leu Pro Asn
20 25 30
Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln Trp Tyr Met Ile Asp
35 40 45
Ile Cys Leu Gly Tyr
50
<210> 519
<211> 53
<212> PRT
<213> Bacteriophage M2Y
<400> 519
Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly Ala Phe Ile Val Asn
1 5 10 15
Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn Glu Gly Leu Pro Asn
20 25 30
Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln Trp Tyr Met Ile Asp
35 40 45
Ile Cys Phe Gly Tyr
50
<210> 520
<211> 54
<212> PRT
<213> Lucilia cuprina
<400> 520
Arg Leu Tyr Phe His Asp Leu Lys Phe Asp Gly Ser Phe Ile Val Asn
1 5 10 15
Trp Leu Leu His Asn Gly Tyr Thr Trp Thr Lys Arg Pro Ser Lys Glu
20 25 30
Gly Gln Phe Ser Thr Leu Ile Ser Lys Met Gly Gln Trp Tyr Gly Ile
35 40 45
Thr Ile Cys Ser Gly Arg
50
<210> 521
<211> 54
<212> PRT
<213> Enterococcus faecium
<400> 521
Asp Ile Tyr Phe His Asp Glu Lys Phe Asp Gly Glu Phe Met Leu Ser
1 5 10 15
Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys Glu Ala Lys Glu Glu
20 25 30
Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly Gln Trp Tyr Ala Leu
35 40 45
Glu Ile Cys Trp Asn Val
50
<210> 522
<211> 56
<212> PRT
<213> Bacillus phage GA-1
<400> 522
Asp Ile Tyr Phe His Asn Leu Lys Phe Asp Gly Ser Phe Ile Leu Pro
1 5 10 15
Trp Trp Leu Arg Asn Gly Tyr Val His Thr Glu Glu Asp Arg Thr Asn
20 25 30
Thr Pro Lys Glu Phe Thr Thr Thr Ile Ser Gly Met Gly Gln Trp Tyr
35 40 45
Ala Val Asp Val Cys Ile Asn Thr
50 55
<210> 523
<211> 53
<212> PRT
<213> Bacillus phage VMY22
<400> 523
Asp Leu Tyr Phe His Asp Leu Arg Tyr Asp Gly Glu Phe Ile Val Asn
1 5 10 15
Trp Leu Leu His Lys Gly Tyr Glu Cys Asn Glu Ser Gly Arg Pro Lys
20 25 30
Thr Phe Asp Thr Val Ile Ser Lys Gly Gly Gln Trp Tyr Lys Ile Ala
35 40 45
Ile His His Glu Gly
50
<210> 524
<211> 54
<212> PRT
<213> Actinomyces phage AV-1
<400> 524
His Ile Tyr Phe His Asn Leu Ala Phe Asp Gly Thr Phe Ile Leu Asp
1 5 10 15
Trp Leu Leu Lys His Gly Tyr Arg Trp Thr Lys Glu Asn Pro Gly Val
20 25 30
Lys Glu Phe Thr Ser Leu Ile Ser Arg Met Gly Lys Tyr Tyr Ser Ile
35 40 45
Thr Val Val Phe Glu Thr
50
<210> 525
<211> 55
<212> PRT
<213> Globodera sp.
<400> 525
Ile Thr Phe Phe His Asn Leu Lys Phe Asp Gly Ala Phe Ile Leu Asp
1 5 10 15
Arg Leu Phe Arg Leu Gly Tyr Glu Phe Thr Asp Glu Lys Ala Pro Gln
20 25 30
Val Lys Glu Phe Ser Thr Leu Ile Ser Lys Met Gly Gln Phe Tyr Ser
35 40 45
Ile Lys Val Arg Trp Glu Asn
50 55
<210> 526
<211> 56
<212> PRT
<213> Lynx pardinus
<400> 526
Arg Val Tyr Phe His Asn Leu Lys Phe Asp Gly Lys Phe Ile Leu His
1 5 10 15
Lys Ile Leu Thr Asp Gly Trp Lys Trp Ile Pro Asp Lys Asn Asp Cys
20 25 30
Ala Asn Arg Thr Phe Thr Thr Leu Ile Ser Asp Met Ser Gln Phe Tyr
35 40 45
Ser Ile Lys Leu Trp Phe Asp Glu
50 55
<210> 527
<211> 55
<212> PRT
<213> Candidatus Moranbacteria
<400> 527
Glu Val Phe Phe His Asn Leu Lys Tyr Asp Gly Asp Phe Ile Val Lys
1 5 10 15
Phe Leu Leu Glu Asn Gly Phe Lys His Ser Arg Glu Arg Ala Leu Tyr
20 25 30
Ser Asn Glu Phe Ser Thr Leu Ile Ser Asp Thr Gly Thr Trp Tyr Glu
35 40 45
Ile Lys Ile Cys Phe His Ala
50 55
<210> 528
<211> 57
<212> PRT
<213> Eggerthella sp.
<400> 528
Leu Ile Gly Phe His Asn Leu Lys Phe Asp Gly Ser Tyr Ile Leu Ser
1 5 10 15
Tyr Leu Leu Gly Val Ala Lys Trp Glu Tyr Asn Asp Lys Pro Lys Ala
20 25 30
Arg Lys Ala Lys Thr Val Glu Cys Leu Ile Ser Ser Ile Gly Val His
35 40 45
Tyr Asn Tyr Arg Ile Asn Phe Thr Lys
50 55
<210> 529
<211> 12
<212> PRT
<213> Bacillus phage phi29
<400> 529
Asn Gly Phe Lys Trp Ser Ala Asp Gly Leu Pro Asn
1 5 10
<210> 530
<211> 12
<212> PRT
<213> Bacteriophage M2Y
<400> 530
His Gly Phe Lys Trp Ser Asn Glu Gly Leu Pro Asn
1 5 10
<210> 531
<211> 13
<212> PRT
<213> Lucilia cuprina
<400> 531
Asn Gly Tyr Thr Trp Thr Lys Arg Pro Ser Lys Glu Gly
1 5 10
<210> 532
<211> 13
<212> PRT
<213> Enterococcus faecium
<400> 532
Asn Gly Phe Lys Trp Cys Lys Glu Ala Lys Glu Glu Arg
1 5 10
<210> 533
<211> 15
<212> PRT
<213> Bacillus phage GA-1
<400> 533
Asn Gly Tyr Val His Thr Glu Glu Asp Arg Thr Asn Thr Pro Lys
1 5 10 15
<210> 534
<211> 12
<212> PRT
<213> Bacillus phage VMY22
<400> 534
Lys Gly Tyr Glu Cys Asn Glu Ser Gly Arg Pro Lys
1 5 10
<210> 535
<211> 13
<212> PRT
<213> Actinomyces phage AV-1
<400> 535
His Gly Tyr Arg Trp Thr Lys Glu Asn Pro Gly Val Lys
1 5 10
<210> 536
<211> 14
<212> PRT
<213> Globodera sp.
<400> 536
Leu Gly Tyr Glu Phe Thr Asp Glu Lys Ala Pro Gln Val Lys
1 5 10
<210> 537
<211> 15
<212> PRT
<213> Lynx pardinus
<400> 537
Asp Gly Trp Lys Trp Ile Pro Asp Lys Asn Asp Cys Ala Asn Arg
1 5 10 15
<210> 538
<211> 14
<212> PRT
<213> Eggerthella sp.
<400> 538
Asn Gly Phe Lys His Ser Arg Glu Arg Ala Leu Tyr Ser Asn
1 5 10
<210> 539
<211> 16
<212> PRT
<213> Eggerthella sp.
<400> 539
Val Ala Lys Trp Glu Tyr Asn Asp Lys Pro Lys Ala Arg Lys Ala Lys
1 5 10 15
Claims (1)
- 표 1로부터 선택된 제1 중합 효소에 기초한 재조합 중합 효소이며, 여기서 제1 중합 효소의 적어도 하나의 아미노산 절편이 표 1로부터 선택된 제2 중합 효소로부터의 상응하는 아미노산 절편으로 대체되었고, 제1 중합 효소와 제2 중합 효소가 상이하고, 임의로 재조합 중합 효소가 표 1의 제1 및/또는 제2 중합 효소의 서열과 비교하여 하나 이상의 아미노산 삽입, 결실, 또는 치환을 추가로 포함하는 것인 재조합 중합 효소.
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US201662436410P | 2016-12-19 | 2016-12-19 | |
US62/436,410 | 2016-12-19 | ||
PCT/US2017/067427 WO2018118997A2 (en) | 2016-12-19 | 2017-12-19 | Polymerizing enzymes for sequencing reactions |
KR1020197020661A KR20190093659A (ko) | 2016-12-19 | 2017-12-19 | 시퀀싱 반응을 위한 중합 효소 |
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KR1020197020661A KR20190093659A (ko) | 2016-12-19 | 2017-12-19 | 시퀀싱 반응을 위한 중합 효소 |
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US (2) | US11312944B2 (ko) |
EP (1) | EP3555272A2 (ko) |
JP (2) | JP2020501573A (ko) |
KR (2) | KR20230052995A (ko) |
CN (1) | CN110268055A (ko) |
AU (1) | AU2017378990B2 (ko) |
BR (1) | BR112019012181A2 (ko) |
CA (1) | CA3047321A1 (ko) |
MX (1) | MX2019007248A (ko) |
TW (1) | TWI788318B (ko) |
WO (1) | WO2018118997A2 (ko) |
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-
2017
- 2017-12-19 KR KR1020237012002A patent/KR20230052995A/ko not_active Application Discontinuation
- 2017-12-19 TW TW106144668A patent/TWI788318B/zh active
- 2017-12-19 CA CA3047321A patent/CA3047321A1/en active Pending
- 2017-12-19 BR BR112019012181-1A patent/BR112019012181A2/pt not_active Application Discontinuation
- 2017-12-19 US US15/846,967 patent/US11312944B2/en active Active
- 2017-12-19 WO PCT/US2017/067427 patent/WO2018118997A2/en active Application Filing
- 2017-12-19 AU AU2017378990A patent/AU2017378990B2/en active Active
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- 2017-12-19 EP EP17838018.4A patent/EP3555272A2/en active Pending
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- 2017-12-19 KR KR1020197020661A patent/KR20190093659A/ko not_active Application Discontinuation
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Also Published As
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KR20190093659A (ko) | 2019-08-09 |
AU2017378990B2 (en) | 2024-05-16 |
WO2018118997A3 (en) | 2018-08-02 |
TW201835328A (zh) | 2018-10-01 |
MX2019007248A (es) | 2019-08-16 |
AU2017378990A1 (en) | 2019-06-20 |
US20230058852A1 (en) | 2023-02-23 |
JP2023026651A (ja) | 2023-02-24 |
US20180208911A1 (en) | 2018-07-26 |
CA3047321A1 (en) | 2018-06-28 |
CN110268055A (zh) | 2019-09-20 |
TWI788318B (zh) | 2023-01-01 |
JP2020501573A (ja) | 2020-01-23 |
WO2018118997A2 (en) | 2018-06-28 |
EP3555272A2 (en) | 2019-10-23 |
US11312944B2 (en) | 2022-04-26 |
BR112019012181A2 (pt) | 2019-11-05 |
US20180362941A9 (en) | 2018-12-20 |
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