PL374218A1 - Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors - Google Patents
Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitorsInfo
- Publication number
- PL374218A1 PL374218A1 PL03374218A PL37421803A PL374218A1 PL 374218 A1 PL374218 A1 PL 374218A1 PL 03374218 A PL03374218 A PL 03374218A PL 37421803 A PL37421803 A PL 37421803A PL 374218 A1 PL374218 A1 PL 374218A1
- Authority
- PL
- Poland
- Prior art keywords
- pyrazolo
- kinase inhibitors
- compounds useful
- aniline compounds
- pyrimidine
- Prior art date
Links
- YKKUNOSQQQYXIQ-UHFFFAOYSA-N NC1=CC=CC=C1.N1=CN=C2C=NNC2=C1 Chemical class NC1=CC=CC=C1.N1=CN=C2C=NNC2=C1 YKKUNOSQQQYXIQ-UHFFFAOYSA-N 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38201402P | 2002-05-20 | 2002-05-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL374218A1 true PL374218A1 (en) | 2005-10-03 |
Family
ID=29584346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL03374218A PL374218A1 (en) | 2002-05-20 | 2003-05-16 | Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6962915B2 (enExample) |
| EP (1) | EP1507780B1 (enExample) |
| JP (1) | JP2005531584A (enExample) |
| AR (1) | AR040031A1 (enExample) |
| AU (1) | AU2003241561A1 (enExample) |
| ES (1) | ES2391948T3 (enExample) |
| IS (1) | IS7534A (enExample) |
| MY (1) | MY135309A (enExample) |
| NO (1) | NO20044866L (enExample) |
| PE (1) | PE20040512A1 (enExample) |
| PL (1) | PL374218A1 (enExample) |
| TW (1) | TW200400034A (enExample) |
| WO (1) | WO2003099820A1 (enExample) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200300350A (en) * | 2001-11-14 | 2003-06-01 | Bristol Myers Squibb Co | C-5 modified indazolylpyrrolotriazines |
| BR0309669A (pt) * | 2002-04-23 | 2005-03-01 | Bristol Myers Squibb Co | Compostos de anilina de pirrolo-triazina úteis como inibidores de cinase |
| DE60325469D1 (de) | 2002-04-23 | 2009-02-05 | Bristol Myers Squibb Co | Als kinase inhibitoren geeignete arylketonpyrrolotriazin-verbindungen |
| TW200401638A (en) * | 2002-06-20 | 2004-02-01 | Bristol Myers Squibb Co | Heterocyclic inhibitors of kinases |
| TWI329112B (en) * | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
| AU2003265349A1 (en) * | 2002-08-02 | 2004-02-23 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| TW200420565A (en) * | 2002-12-13 | 2004-10-16 | Bristol Myers Squibb Co | C-6 modified indazolylpyrrolotriazines |
| KR20050099525A (ko) | 2003-02-05 | 2005-10-13 | 브리스톨-마이어스 스큅 컴퍼니 | 피롤로트리아진 키나제 억제제의 제조 방법 |
| US7419978B2 (en) * | 2003-10-22 | 2008-09-02 | Bristol-Myers Squibb Company | Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors |
| US7569571B2 (en) * | 2003-12-23 | 2009-08-04 | Novartis Ag | Substituted pyrazolo [3,4-d]pyrimidines as cytokine modulators |
| AU2005219518A1 (en) | 2004-02-27 | 2005-09-15 | F. Hoffmann-La Roche Ag | Indazole derivatives and pharmaceutical compositions containing them |
| JP2007523938A (ja) | 2004-02-27 | 2007-08-23 | エフ.ホフマン−ラ ロシュ アーゲー | ピラゾールの縮合誘導体 |
| MXPA06009462A (es) | 2004-02-27 | 2007-03-15 | Hoffmann La Roche | Derivados pirazolo heteroaril fusionados. |
| US7067659B2 (en) * | 2004-04-23 | 2006-06-27 | Duke University | Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof |
| US7439246B2 (en) * | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
| TW200600513A (en) * | 2004-06-30 | 2006-01-01 | Bristol Myers Squibb Co | A method for preparing pyrrolotriazine compounds |
| US7253167B2 (en) * | 2004-06-30 | 2007-08-07 | Bristol-Myers Squibb Company | Tricyclic-heteroaryl compounds useful as kinase inhibitors |
| US7504521B2 (en) * | 2004-08-05 | 2009-03-17 | Bristol-Myers Squibb Co. | Methods for the preparation of pyrrolotriazine compounds |
| TW200618803A (en) | 2004-08-12 | 2006-06-16 | Bristol Myers Squibb Co | Process for preparing pyrrolotriazine aniline compounds useful as kinase inhibitors |
| EP1797096B1 (en) | 2004-09-06 | 2011-07-27 | Bayer Schering Pharma Aktiengesellschaft | Pyrazolopyrimidines as inhibitors of protein kinase b (akt) |
| GB0425035D0 (en) * | 2004-11-12 | 2004-12-15 | Novartis Ag | Organic compounds |
| GB0427604D0 (en) * | 2004-12-16 | 2005-01-19 | Novartis Ag | Organic compounds |
| US7947694B2 (en) | 2005-01-14 | 2011-05-24 | Janssen Pharmaceutica Nv | Substituted pyrazolo[3,4-D]pyrimidines as cell cycle kinase inhibitors |
| US7947695B2 (en) | 2005-01-14 | 2011-05-24 | Janssen Pharmaceutica Nv | 5-membered annelated heterocyclic pyrimidines as kinase inhibitors |
| US20060178388A1 (en) | 2005-02-04 | 2006-08-10 | Wrobleski Stephen T | Phenyl-substituted pyrimidine compounds useful as kinase inhibitors |
| GB0507575D0 (en) * | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
| US20060264431A1 (en) * | 2005-05-11 | 2006-11-23 | Array Biopharma Inc. | P38 inhibitors and methods of use thereof |
| CA2620105A1 (en) * | 2005-08-25 | 2007-03-01 | F. Hoffman-La Roche Ag | P38 map kinase inhibitors and methods for using the same |
| MX2008002385A (es) * | 2005-08-25 | 2008-03-18 | Hoffmann La Roche | Inhibidores de proteinas cinasas activads por mitogenos p38 y metodos para utilizarlos. |
| MX2008002383A (es) | 2005-08-25 | 2008-03-18 | Hoffmann La Roche | Pirazol fusionado como inhibidores de proteinas cinasas activadas por mitogenos p38. |
| GB0522880D0 (en) * | 2005-11-09 | 2005-12-21 | Glaxo Group Ltd | Novel compounds |
| GB0524436D0 (en) * | 2005-11-30 | 2006-01-11 | Novartis Ag | Organic compounds |
| WO2007095161A2 (en) * | 2006-02-14 | 2007-08-23 | New York University | Methods and compositions for treating disorders associated with increased bone turnover and osteopenia |
| MX2008011220A (es) * | 2006-03-07 | 2008-09-11 | Array Biopharma Inc | Compuestos de pirazol heterobiciclicos y metodos de uso. |
| AU2007233737B2 (en) | 2006-03-30 | 2012-11-29 | Janssen Sciences Ireland Uc | HIV inhibiting 5-amido substituted pyrimidines |
| WO2007139778A2 (en) * | 2006-05-22 | 2007-12-06 | University Of Virginia Patent Foundation | Rhamnose substituents of sl0101 and therapeutic uses thereof |
| CN101558068A (zh) | 2006-10-16 | 2009-10-14 | 诺瓦提斯公司 | 用作蛋白激酶抑制剂的苯乙酰胺类 |
| CN101600714B (zh) | 2006-11-10 | 2013-08-21 | 百时美施贵宝公司 | 吡咯并吡啶激酶抑制剂 |
| CA2672719A1 (en) | 2006-12-19 | 2008-06-26 | F. Hoffmann-La Roche Ag | Pyrazolo [3, 4 -d] pyrimidine p38 map kinase inhibitors |
| WO2009023053A2 (en) * | 2007-05-18 | 2009-02-19 | University Of Virginia Patent Foundation | Use of rsk inhibitors to impede intracellular pathogen infections |
| ES2610190T3 (es) * | 2007-11-28 | 2017-04-26 | Dana-Farber Cancer Institute, Inc. | Inhibidores de miristato de moléculas pequeñas de Bcr-abl y métodos de uso |
| CN101981037B (zh) * | 2008-01-30 | 2013-09-04 | 吉宁特有限公司 | 吡唑并嘧啶pi3k抑制剂化合物及使用方法 |
| US8188098B2 (en) * | 2008-05-19 | 2012-05-29 | Hoffmann-La Roche Inc. | GPR119 receptor agonists |
| UY31881A (es) * | 2008-06-10 | 2010-01-29 | Abbott Lab | Derivados sustituidos de imidazo[1,5-a]pirrolo[2,3-e]pirazinas e imidazo[1,2-a]pirrolo[2,3-e]pirazinas, sus sales, prodrogas, metabolitos biológicalmente activos, estereoisómeros e isómeros farmacéuticamente aceptables. |
| US20100015141A1 (en) * | 2008-07-21 | 2010-01-21 | Wyeth | 4-phenoxy-6-aryl-1h-pyrazolo[3,4-d]pyrimidine and n-aryl-6-aryl-1h-pyrazolo[3,4-d]pyrimidin-4-amine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses |
| JP5689069B2 (ja) | 2008-11-20 | 2015-03-25 | ジェネンテック, インコーポレイテッド | ピラゾロピリジンpi3k阻害剤化合物及び使用方法 |
| WO2010114894A1 (en) | 2009-03-31 | 2010-10-07 | Arqule, Inc. | Substituted heterocyclic compounds |
| CA2991896A1 (en) | 2009-12-01 | 2011-06-09 | Abbvie Inc. | Novel tricyclic compounds as protein kinase inhibitors |
| KR20120102724A (ko) * | 2009-12-01 | 2012-09-18 | 아보트 러보러터리즈 | 신규한 트리사이클릭 화합물 |
| US8637529B2 (en) | 2010-06-11 | 2014-01-28 | AbbYie Inc. | Pyrazolo[3,4-d]pyrimidine compounds |
| KR20140009259A (ko) * | 2010-11-19 | 2014-01-22 | 에프. 호프만-라 로슈 아게 | 피라졸로피리딘 및 tyk2 억제제로서 이의 용도 |
| TWI399205B (zh) * | 2011-01-14 | 2013-06-21 | Univ Kaohsiung Medical | 茶鹼化合物之抑制骨質疏鬆症活性 |
| EP2548878A1 (en) * | 2011-07-21 | 2013-01-23 | Laboratorios Del. Dr. Esteve, S.A. | Pyrazolo[3,4-d]pyrimidine compounds, their preparation and use as sigma ligands |
| CN102746306B (zh) * | 2012-07-09 | 2014-11-19 | 四川国康药业有限公司 | 别嘌醇类衍生物及其制备方法和用途 |
| CN103570723B (zh) * | 2012-07-27 | 2016-07-13 | 广西梧州制药(集团)股份有限公司 | 吡唑并嘧啶衍生物及其制备方法和在药物制备中的用途 |
| ES2652514T3 (es) | 2012-11-08 | 2018-02-02 | Pfizer Inc. | Compuestos heteroaromáticos como ligandos de dopamina D1 |
| CN103601722B (zh) * | 2013-09-13 | 2016-03-02 | 南京华威医药科技开发有限公司 | 新型抗肿瘤化合物 |
| WO2015137887A1 (en) * | 2014-03-13 | 2015-09-17 | Agency For Science, Technology And Research | Fused pyrimidine-based hydroxamate derivatives |
| US11773106B2 (en) | 2015-10-16 | 2023-10-03 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11524964B2 (en) | 2015-10-16 | 2022-12-13 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US10550126B2 (en) | 2015-10-16 | 2020-02-04 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11365198B2 (en) | 2015-10-16 | 2022-06-21 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| SG10201913989QA (en) | 2015-10-16 | 2020-03-30 | Abbvie Inc | PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF |
| US11512092B2 (en) | 2015-10-16 | 2022-11-29 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US12365689B2 (en) | 2015-10-16 | 2025-07-22 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| CN110325188A (zh) * | 2016-10-26 | 2019-10-11 | 印第安纳大学理事会 | 小分子蛋白质精氨酸甲基转移酶5(prmt5)抑制剂和治疗方法 |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| CA3127373A1 (en) | 2017-10-05 | 2019-04-11 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd |
| CN117865965B (zh) * | 2024-01-08 | 2024-06-28 | 贵州省天然产物研究中心 | 吡咯并嘧啶-4-胺和吡唑并嘧啶-4-胺衍生物及制备方法和应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3720674A (en) * | 1970-09-02 | 1973-03-13 | Squibb & Sons Inc | 4-amino-1h-pyrazolo(3,4-d)pyrimidine derivatives |
| GB1544419A (en) * | 1975-11-19 | 1979-04-19 | Science Union & Cie | Purines and pyrazolo-pyrimidines a process for their preparation and pharmaceutical compositions containing them |
| TW370529B (en) | 1992-12-17 | 1999-09-21 | Pfizer | Pyrazolopyrimidines |
| US5593997A (en) * | 1995-05-23 | 1997-01-14 | Pfizer Inc. | 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors |
| US6147080A (en) * | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| US5723608A (en) * | 1996-12-31 | 1998-03-03 | Neurogen Corporation | 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands |
| ES2188005T3 (es) | 1997-09-23 | 2003-06-16 | Astrazeneca Ab | Derivados de amidas para el tratamiento de enfermedades mediadas por citoquinas. |
| US6184226B1 (en) * | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| GB9906566D0 (en) | 1999-03-23 | 1999-05-19 | Zeneca Ltd | Chemical compounds |
| WO2000071129A1 (en) | 1999-05-21 | 2000-11-30 | Bristol-Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
| JP4623483B2 (ja) | 1999-08-23 | 2011-02-02 | 塩野義製薬株式会社 | sPLA2阻害作用を有するピロロトリアジン誘導体 |
| GB9924092D0 (en) | 1999-10-13 | 1999-12-15 | Zeneca Ltd | Pyrimidine derivatives |
| US6548509B2 (en) * | 1999-10-22 | 2003-04-15 | Neurogen Corporation | 3-aryl substituted pyrazolo[4,3-D]pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands |
| PT1140939E (pt) | 1999-11-10 | 2005-05-31 | Ortho Mcneil Pharm Inc | 2-aril-3-(heteroaril)- imidazo [1,2-alfa] pirimidinas substituidas, e formulacoes farmaceuticas e metodos relacionados |
| WO2002016348A1 (en) | 2000-08-09 | 2002-02-28 | Astrazeneca Ab | Antiangiogenic bicyclic derivatives |
| AU7652101A (en) | 2000-08-09 | 2002-02-18 | Astrazeneca Ab | Cinnoline compounds |
| BR0113056A (pt) | 2000-08-09 | 2003-07-08 | Astrazeneca Ab | Composto, processo papa a preparação do mesmo, composição farmacêutica, e, método para produzir um efeito antiangiogênico e/ou redutor da permeabilidade vascular em um animal de sangue quente, e, uso de um composto |
| JP2004505965A (ja) | 2000-08-09 | 2004-02-26 | アストラゼネカ アクチボラグ | 化合物 |
| US6670357B2 (en) * | 2000-11-17 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
| BR0309669A (pt) | 2002-04-23 | 2005-03-01 | Bristol Myers Squibb Co | Compostos de anilina de pirrolo-triazina úteis como inibidores de cinase |
| DE60325469D1 (de) | 2002-04-23 | 2009-02-05 | Bristol Myers Squibb Co | Als kinase inhibitoren geeignete arylketonpyrrolotriazin-verbindungen |
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2003
- 2003-05-14 TW TW092113120A patent/TW200400034A/zh unknown
- 2003-05-16 ES ES03731307T patent/ES2391948T3/es not_active Expired - Lifetime
- 2003-05-16 AU AU2003241561A patent/AU2003241561A1/en not_active Abandoned
- 2003-05-16 WO PCT/US2003/016072 patent/WO2003099820A1/en not_active Ceased
- 2003-05-16 EP EP03731307A patent/EP1507780B1/en not_active Expired - Lifetime
- 2003-05-16 AR ARP030101712A patent/AR040031A1/es unknown
- 2003-05-16 JP JP2004507477A patent/JP2005531584A/ja not_active Withdrawn
- 2003-05-16 PL PL03374218A patent/PL374218A1/xx not_active Application Discontinuation
- 2003-05-16 MY MYPI20031804A patent/MY135309A/en unknown
- 2003-05-19 US US10/440,864 patent/US6962915B2/en not_active Expired - Lifetime
- 2003-05-20 PE PE2003000490A patent/PE20040512A1/es not_active Application Discontinuation
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2004
- 2004-11-09 NO NO20044866A patent/NO20044866L/no not_active Application Discontinuation
- 2004-11-16 IS IS7534A patent/IS7534A/is unknown
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| TW200400034A (en) | 2004-01-01 |
| AR040031A1 (es) | 2005-03-09 |
| IS7534A (is) | 2004-11-16 |
| ES2391948T3 (es) | 2012-12-03 |
| US20040023992A1 (en) | 2004-02-05 |
| EP1507780A4 (en) | 2006-08-02 |
| WO2003099820A1 (en) | 2003-12-04 |
| EP1507780B1 (en) | 2012-08-22 |
| PE20040512A1 (es) | 2004-08-25 |
| JP2005531584A (ja) | 2005-10-20 |
| MY135309A (en) | 2008-03-31 |
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