PL374218A1 - Związki pirazolo-pirymidynoaniliny użyteczne jakoinhibitory kinazy - Google Patents
Związki pirazolo-pirymidynoaniliny użyteczne jakoinhibitory kinazyInfo
- Publication number
- PL374218A1 PL374218A1 PL03374218A PL37421803A PL374218A1 PL 374218 A1 PL374218 A1 PL 374218A1 PL 03374218 A PL03374218 A PL 03374218A PL 37421803 A PL37421803 A PL 37421803A PL 374218 A1 PL374218 A1 PL 374218A1
- Authority
- PL
- Poland
- Prior art keywords
- pyrazolo
- kinase inhibitors
- compounds useful
- aniline compounds
- pyrimidine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- AIDS & HIV (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38201402P | 2002-05-20 | 2002-05-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL374218A1 true PL374218A1 (pl) | 2005-10-03 |
Family
ID=29584346
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL03374218A PL374218A1 (pl) | 2002-05-20 | 2003-05-16 | Związki pirazolo-pirymidynoaniliny użyteczne jakoinhibitory kinazy |
Country Status (13)
Country | Link |
---|---|
US (1) | US6962915B2 (pl) |
EP (1) | EP1507780B1 (pl) |
JP (1) | JP2005531584A (pl) |
AR (1) | AR040031A1 (pl) |
AU (1) | AU2003241561A1 (pl) |
ES (1) | ES2391948T3 (pl) |
IS (1) | IS7534A (pl) |
MY (1) | MY135309A (pl) |
NO (1) | NO20044866L (pl) |
PE (1) | PE20040512A1 (pl) |
PL (1) | PL374218A1 (pl) |
TW (1) | TW200400034A (pl) |
WO (1) | WO2003099820A1 (pl) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200300350A (en) * | 2001-11-14 | 2003-06-01 | Bristol Myers Squibb Co | C-5 modified indazolylpyrrolotriazines |
EP2289894A3 (en) * | 2002-04-23 | 2011-07-20 | Bristol-Myers Squibb Company | Pyrrolo-triazine compounds useful as kinase inhibitors |
ES2318122T3 (es) | 2002-04-23 | 2009-05-01 | Bristol-Myers Squibb Company | Compuestos de aril cetona pirrolo-triazina utiles como inhibidores de quinasa. |
TW200401638A (en) * | 2002-06-20 | 2004-02-01 | Bristol Myers Squibb Co | Heterocyclic inhibitors of kinases |
TWI329112B (en) * | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
AU2003265349A1 (en) * | 2002-08-02 | 2004-02-23 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
TW200420565A (en) * | 2002-12-13 | 2004-10-16 | Bristol Myers Squibb Co | C-6 modified indazolylpyrrolotriazines |
JP2006516653A (ja) | 2003-02-05 | 2006-07-06 | ブリストル−マイヤーズ スクイブ カンパニー | キナーゼ阻害剤ピロロトリアジンの製造方法 |
US7419978B2 (en) * | 2003-10-22 | 2008-09-02 | Bristol-Myers Squibb Company | Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors |
BRPI0418112A (pt) * | 2003-12-23 | 2007-04-17 | Novartis Ag | inibidores de p-38 quinase bicìclico heterocìclicos |
AU2005219518A1 (en) | 2004-02-27 | 2005-09-15 | F. Hoffmann-La Roche Ag | Indazole derivatives and pharmaceutical compositions containing them |
KR100844864B1 (ko) | 2004-02-27 | 2008-07-09 | 에프. 호프만-라 로슈 아게 | 헤테로아릴-융합 피라졸로 유도체 |
CN1926139A (zh) * | 2004-02-27 | 2007-03-07 | 霍夫曼-拉罗奇有限公司 | 稠合吡唑衍生物 |
US7067659B2 (en) * | 2004-04-23 | 2006-06-27 | Duke University | Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof |
US7439246B2 (en) * | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
US7253167B2 (en) * | 2004-06-30 | 2007-08-07 | Bristol-Myers Squibb Company | Tricyclic-heteroaryl compounds useful as kinase inhibitors |
TW200600513A (en) * | 2004-06-30 | 2006-01-01 | Bristol Myers Squibb Co | A method for preparing pyrrolotriazine compounds |
US7504521B2 (en) * | 2004-08-05 | 2009-03-17 | Bristol-Myers Squibb Co. | Methods for the preparation of pyrrolotriazine compounds |
TW200618803A (en) | 2004-08-12 | 2006-06-16 | Bristol Myers Squibb Co | Process for preparing pyrrolotriazine aniline compounds useful as kinase inhibitors |
EP1797096B1 (en) | 2004-09-06 | 2011-07-27 | Bayer Schering Pharma Aktiengesellschaft | Pyrazolopyrimidines as inhibitors of protein kinase b (akt) |
GB0425035D0 (en) * | 2004-11-12 | 2004-12-15 | Novartis Ag | Organic compounds |
GB0427604D0 (en) * | 2004-12-16 | 2005-01-19 | Novartis Ag | Organic compounds |
WO2006074984A1 (en) * | 2005-01-14 | 2006-07-20 | Janssen Pharmaceutica N.V. | Pyrazolopyrimidines as cell cycle kinase inhibitors |
ES2411975T3 (es) | 2005-01-14 | 2013-07-09 | Janssen Pharmaceutica Nv | Pirimidinas heterocíclicas anilladas de 5 miembros como inhibidores de cinasas |
US20060178388A1 (en) | 2005-02-04 | 2006-08-10 | Wrobleski Stephen T | Phenyl-substituted pyrimidine compounds useful as kinase inhibitors |
GB0507575D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
TW200716561A (en) * | 2005-05-11 | 2007-05-01 | Array Biopharma Inc | P38 inhibitors and methods of use thereof |
MX2008002385A (es) * | 2005-08-25 | 2008-03-18 | Hoffmann La Roche | Inhibidores de proteinas cinasas activads por mitogenos p38 y metodos para utilizarlos. |
WO2007023111A2 (en) | 2005-08-25 | 2007-03-01 | F. Hoffmann-La Roche Ag | P38 map kinase inhibitors and methods for using the same |
JP2009506004A (ja) | 2005-08-25 | 2009-02-12 | エフ.ホフマン−ラ ロシュ アーゲー | p38MAPキナーゼ阻害剤としての縮合ピラゾール |
GB0522880D0 (en) * | 2005-11-09 | 2005-12-21 | Glaxo Group Ltd | Novel compounds |
GB0524436D0 (en) * | 2005-11-30 | 2006-01-11 | Novartis Ag | Organic compounds |
US7795427B2 (en) * | 2006-02-14 | 2010-09-14 | New York University | Methods for inhibiting osteoclast differentiation, formation, or function and for increasing bone mass |
MX2008011220A (es) * | 2006-03-07 | 2008-09-11 | Array Biopharma Inc | Compuestos de pirazol heterobiciclicos y metodos de uso. |
JP5078986B2 (ja) | 2006-03-30 | 2012-11-21 | テイボテク・フアーマシユーチカルズ | Hivを阻害する5−アミド置換されたピリミジン |
US8426568B2 (en) * | 2006-05-22 | 2013-04-23 | University Of Virginia Patent Foundation | Rhamnose substituents of SL0101 and therapeutic uses thereof |
MX2009003985A (es) | 2006-10-16 | 2009-04-27 | Novartis Ag | Fenil-acetamidas utiles como inhibidores de cinasa de proteina. |
WO2008060907A2 (en) | 2006-11-10 | 2008-05-22 | Bristol-Myers Squibb Company | Pyrrolo-pyridine kinase inhibitors |
EP2091952A1 (en) * | 2006-12-19 | 2009-08-26 | F. Hoffmann-Roche AG | Pyrazolo ý3, 4 -d¨pyrimidine p38 map kinase inhibitors |
WO2009023053A2 (en) * | 2007-05-18 | 2009-02-19 | University Of Virginia Patent Foundation | Use of rsk inhibitors to impede intracellular pathogen infections |
ES2734288T3 (es) * | 2007-11-28 | 2019-12-05 | Dana Farber Cancer Inst Inc | Inhibidores de miristato de moléculas pequeñas de Bcr-abl y métodos de uso |
ES2494365T3 (es) * | 2008-01-30 | 2014-09-15 | Genentech, Inc. | Compuestos de pirazolopirimidina que inhiben PI3K y métodos de uso |
US8188098B2 (en) * | 2008-05-19 | 2012-05-29 | Hoffmann-La Roche Inc. | GPR119 receptor agonists |
PT2299821E (pt) | 2008-06-10 | 2016-03-11 | Abbvie Inc | Compostos tricíclicos |
US20100015141A1 (en) * | 2008-07-21 | 2010-01-21 | Wyeth | 4-phenoxy-6-aryl-1h-pyrazolo[3,4-d]pyrimidine and n-aryl-6-aryl-1h-pyrazolo[3,4-d]pyrimidin-4-amine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses |
US8653098B2 (en) | 2008-11-20 | 2014-02-18 | Genentech, Inc. | Pyrazolopyridine PI3K inhibitor compounds and methods of use |
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2003
- 2003-05-14 TW TW092113120A patent/TW200400034A/zh unknown
- 2003-05-16 PL PL03374218A patent/PL374218A1/pl not_active Application Discontinuation
- 2003-05-16 AU AU2003241561A patent/AU2003241561A1/en not_active Abandoned
- 2003-05-16 MY MYPI20031804A patent/MY135309A/en unknown
- 2003-05-16 WO PCT/US2003/016072 patent/WO2003099820A1/en active Application Filing
- 2003-05-16 AR ARP030101712A patent/AR040031A1/es unknown
- 2003-05-16 EP EP03731307A patent/EP1507780B1/en not_active Expired - Lifetime
- 2003-05-16 JP JP2004507477A patent/JP2005531584A/ja not_active Withdrawn
- 2003-05-16 ES ES03731307T patent/ES2391948T3/es not_active Expired - Lifetime
- 2003-05-19 US US10/440,864 patent/US6962915B2/en not_active Expired - Lifetime
- 2003-05-20 PE PE2003000490A patent/PE20040512A1/es not_active Application Discontinuation
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2004
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EP1507780B1 (en) | 2012-08-22 |
PE20040512A1 (es) | 2004-08-25 |
IS7534A (is) | 2004-11-16 |
AR040031A1 (es) | 2005-03-09 |
EP1507780A4 (en) | 2006-08-02 |
MY135309A (en) | 2008-03-31 |
AU2003241561A1 (en) | 2003-12-12 |
TW200400034A (en) | 2004-01-01 |
EP1507780A1 (en) | 2005-02-23 |
WO2003099820A1 (en) | 2003-12-04 |
US6962915B2 (en) | 2005-11-08 |
ES2391948T3 (es) | 2012-12-03 |
NO20044866L (no) | 2004-12-17 |
JP2005531584A (ja) | 2005-10-20 |
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