PL372971A1 - Pochodne tiazolu i oksazolu modulujące aktywność PPAR - Google Patents
Pochodne tiazolu i oksazolu modulujące aktywność PPARInfo
- Publication number
- PL372971A1 PL372971A1 PL03372971A PL37297103A PL372971A1 PL 372971 A1 PL372971 A1 PL 372971A1 PL 03372971 A PL03372971 A PL 03372971A PL 37297103 A PL37297103 A PL 37297103A PL 372971 A1 PL372971 A1 PL 372971A1
- Authority
- PL
- Poland
- Prior art keywords
- thiazole
- oxazole derivatives
- ppar activity
- modulate ppar
- modulate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/26—Radicals substituted by sulfur atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36240002P | 2002-03-07 | 2002-03-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL372971A1 true PL372971A1 (pl) | 2005-08-08 |
Family
ID=27789156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL03372971A PL372971A1 (pl) | 2002-03-07 | 2003-03-03 | Pochodne tiazolu i oksazolu modulujące aktywność PPAR |
Country Status (29)
Country | Link |
---|---|
US (1) | US6833380B2 (pl) |
EP (1) | EP1485091A1 (pl) |
JP (1) | JP2005524665A (pl) |
KR (1) | KR20040091694A (pl) |
CN (1) | CN1638768A (pl) |
AP (1) | AP2004003123A0 (pl) |
AR (1) | AR038883A1 (pl) |
AU (1) | AU2003207891A1 (pl) |
BR (1) | BR0308221A (pl) |
CA (1) | CA2476580A1 (pl) |
CO (1) | CO5601013A2 (pl) |
EA (1) | EA200401160A1 (pl) |
EC (1) | ECSP045275A (pl) |
GT (1) | GT200300053A (pl) |
HR (1) | HRP20040810A2 (pl) |
IL (1) | IL163768A0 (pl) |
IS (1) | IS7399A (pl) |
MA (1) | MA27182A1 (pl) |
MX (1) | MXPA04008624A (pl) |
NO (1) | NO20044245L (pl) |
OA (1) | OA12781A (pl) |
PA (1) | PA8568701A1 (pl) |
PE (1) | PE20031010A1 (pl) |
PL (1) | PL372971A1 (pl) |
TN (1) | TNSN04167A1 (pl) |
TW (1) | TW200400027A (pl) |
UY (1) | UY27704A1 (pl) |
WO (1) | WO2003074052A1 (pl) |
ZA (1) | ZA200406491B (pl) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6867224B2 (en) * | 2002-03-07 | 2005-03-15 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods of preparation |
US6875780B2 (en) * | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
US20050203151A1 (en) * | 2003-12-19 | 2005-09-15 | Kalypsys, Inc. | Novel compounds, compositions and uses thereof for treatment of metabolic disorders and related conditions |
WO2005105736A1 (en) | 2004-05-05 | 2005-11-10 | Novo Nordisk A/S | Novel compounds, their preparation and use |
DE602005024384D1 (de) | 2004-05-05 | 2010-12-09 | High Point Pharmaceuticals Llc | Neue verbindungen, ihre herstellung und verwendung |
EP1749000A4 (en) * | 2004-05-25 | 2009-12-30 | Metabolex Inc | BICYCLIC SUBSTITUTED TRIAZOLE AS PPAR MODULATORS AND METHOD FOR THE PRODUCTION THEREOF |
KR20070036076A (ko) * | 2004-05-25 | 2007-04-02 | 메타볼렉스, 인코포레이티드 | Ppar의 조절제로서의 치환된 트리아졸 및 이의제조방법 |
ATE529404T1 (de) | 2005-06-30 | 2011-11-15 | High Point Pharmaceuticals Llc | Phenoxyessigsäuren als ppar-delta-aktivatoren |
CN1896069B (zh) * | 2005-07-15 | 2011-10-05 | 中国科学院上海药物研究所 | 一类取代噻唑-4酮化合物、制备方法和用途 |
JP5054028B2 (ja) | 2005-12-22 | 2012-10-24 | ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー | 新規化合物、それらの製造および使用 |
US7943612B2 (en) | 2006-03-09 | 2011-05-17 | High Point Pharmaceuticals, Llc | Compounds that modulate PPAR activity, their preparation and use |
TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途 |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
KR20100065191A (ko) | 2007-09-14 | 2010-06-15 | 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 | 1,3-이치환된 4-(아릴-x-페닐)-1h-피리딘-2-온 |
SI2203439T1 (sl) | 2007-09-14 | 2011-05-31 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni |
EP2205565B1 (en) | 2007-09-14 | 2013-04-17 | Janssen Pharmaceuticals, Inc. | 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones |
US8785486B2 (en) | 2007-11-14 | 2014-07-22 | Janssen Pharmaceuticals, Inc. | Imidazo[1,2-A]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
RU2510396C2 (ru) | 2008-09-02 | 2014-03-27 | Янссен Фармасьютикалз, Инк. | 3-азабицикло[3.1.0]гексильные производные в качестве модуляторов метаботропных глутаматных рецепторов |
ES2466341T3 (es) | 2008-10-16 | 2014-06-10 | Janssen Pharmaceuticals, Inc. | Derivados de indol y benzomorfolina como moduladores de receptores de glutamato metabotrópicos |
EP2373649B1 (en) | 2008-11-28 | 2013-01-23 | Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
EA020671B1 (ru) | 2009-05-12 | 2014-12-30 | Янссен Фармасьютикалз, Инк. | ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 |
CA2760741C (en) | 2009-05-12 | 2018-05-01 | Addex Pharma S.A. | 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
JP5852666B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | 1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
CA2814998C (en) | 2010-11-08 | 2019-10-29 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
PT2649069E (pt) | 2010-11-08 | 2015-11-20 | Janssen Pharmaceuticals Inc | Derivados de 1,2,4-triazolo[4,3-a]piridina e sua utilização como moduladores alostéricos positivos de recetores mglur2 |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
EP3756661A1 (en) | 2013-09-09 | 2020-12-30 | vTv Therapeutics LLC | Use of a ppar-delta agonist for treating muscle atrophy |
ME03518B (me) | 2014-01-21 | 2020-04-20 | Janssen Pharmaceutica Nv | Kombinacije koje obuhvataju pozitivne alosterične modulatore ili ortosterične agoniste metabotropnog glutamatergičnog receptora podtipa 2 i njihova primjena |
PL3096790T3 (pl) | 2014-01-21 | 2020-01-31 | Janssen Pharmaceutica, N.V. | Kombinacje zawierające pozytywne modulatory allosteryczne lub agonistów ortosterycznych metabotropowego receptora glutaminergicznego podtypu 2 i ich zastosowanie |
CN113045523B (zh) * | 2019-12-27 | 2022-09-23 | 上海泓博智源医药股份有限公司 | 一种咪唑啉吡啶化合物中间体的制备方法 |
WO2023147309A1 (en) | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Use of ppar-delta agonists in the treatment of disease |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU708055B2 (en) | 1996-02-02 | 1999-07-29 | Merck & Co., Inc. | Heterocyclic derivatives as antidiabetic and antiobesity agents |
AU1856997A (en) | 1996-02-02 | 1997-08-22 | Merck & Co., Inc. | Method for raising hdl cholesterol levels |
RU2174121C2 (ru) | 1996-08-19 | 2001-09-27 | Джапан Тобакко Инк. | Производные пропионовой кислоты и фармацевтическая композиция на их основе |
GB9914977D0 (en) | 1999-06-25 | 1999-08-25 | Glaxo Group Ltd | Chemical compounds |
ES2204684T3 (es) | 1999-08-27 | 2004-05-01 | Eli Lilly And Company | Derivados de biaril-oxa(tia)zol y su uso como modulares de ppar. |
PL360744A1 (pl) | 2000-08-23 | 2004-09-20 | Eli Lilly And Company | Pochodne kwasu oksazolilo-arylopropionowego i ichstosowanie jako agonistów PPAR |
US6982278B2 (en) | 2000-08-23 | 2006-01-03 | Eli Lilly And Company | Oxazolyl-aryloxyacetic acid derivatives and their use as ppar agonists |
AU2002233271A1 (en) | 2000-12-20 | 2002-07-01 | Glaxo Group Limited | Substitued oxazoles and thiazoles as hppar alpha agonists |
GB0031107D0 (en) | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
GB0031109D0 (en) | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
GB0111523D0 (en) | 2001-05-11 | 2001-07-04 | Glaxo Group Ltd | Chemical compounds |
CZ20033415A3 (cs) | 2001-05-29 | 2004-06-16 | Kyoto Pharmaceutical Industries, Ltd. | Nové heterocyklické deriváty a jejich lékařské použití |
CN1578659A (zh) | 2001-06-07 | 2005-02-09 | 伊莱利利公司 | 过氧化物酶体增殖剂激活的受体(ppar)的调节剂 |
JPWO2002102780A1 (ja) | 2001-06-18 | 2004-09-30 | 小野薬品工業株式会社 | テトラヒドロキノリン誘導体化合物およびその化合物を有効成分として含有する薬剤 |
AR036237A1 (es) | 2001-07-27 | 2004-08-25 | Bayer Corp | Derivados del acido indan acetico, intermediarios, y metodo para su preparacion, composicion farmaceutica y el uso de dichos derivados para la manufactura de un medicamento |
MXPA04002330A (es) | 2001-09-14 | 2005-04-08 | Japan Tobacco Inc | Compuestos biarilo ligados. |
US20030207924A1 (en) | 2002-03-07 | 2003-11-06 | Xue-Min Cheng | Compounds that modulate PPAR activity and methods of preparation |
US6867224B2 (en) | 2002-03-07 | 2005-03-15 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods of preparation |
US6875780B2 (en) | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
-
2002
- 2002-12-19 US US10/324,278 patent/US6833380B2/en not_active Expired - Fee Related
-
2003
- 2003-03-03 EA EA200401160A patent/EA200401160A1/ru unknown
- 2003-03-03 CA CA002476580A patent/CA2476580A1/en not_active Abandoned
- 2003-03-03 JP JP2003572569A patent/JP2005524665A/ja not_active Withdrawn
- 2003-03-03 AU AU2003207891A patent/AU2003207891A1/en not_active Abandoned
- 2003-03-03 AP APAP/P/2004/003123A patent/AP2004003123A0/en unknown
- 2003-03-03 EP EP03704893A patent/EP1485091A1/en not_active Withdrawn
- 2003-03-03 IL IL16376803A patent/IL163768A0/xx unknown
- 2003-03-03 KR KR10-2004-7013962A patent/KR20040091694A/ko not_active Application Discontinuation
- 2003-03-03 BR BR0308221-0A patent/BR0308221A/pt not_active IP Right Cessation
- 2003-03-03 WO PCT/IB2003/000817 patent/WO2003074052A1/en not_active Application Discontinuation
- 2003-03-03 CN CNA038054639A patent/CN1638768A/zh active Pending
- 2003-03-03 OA OA1200400233A patent/OA12781A/en unknown
- 2003-03-03 PL PL03372971A patent/PL372971A1/pl not_active Application Discontinuation
- 2003-03-03 MX MXPA04008624A patent/MXPA04008624A/es active IP Right Grant
- 2003-03-05 AR ARP030100739A patent/AR038883A1/es unknown
- 2003-03-05 PE PE2003000214A patent/PE20031010A1/es not_active Application Discontinuation
- 2003-03-06 TW TW092104847A patent/TW200400027A/zh unknown
- 2003-03-07 UY UY27704A patent/UY27704A1/es not_active Application Discontinuation
- 2003-03-07 GT GT200300053A patent/GT200300053A/es unknown
- 2003-03-07 PA PA20038568701A patent/PA8568701A1/es unknown
-
2004
- 2004-08-12 IS IS7399A patent/IS7399A/is unknown
- 2004-08-16 ZA ZA200406491A patent/ZA200406491B/en unknown
- 2004-08-24 CO CO04082303A patent/CO5601013A2/es not_active Application Discontinuation
- 2004-08-30 MA MA27840A patent/MA27182A1/fr unknown
- 2004-09-03 TN TNP2004000167A patent/TNSN04167A1/fr unknown
- 2004-09-07 HR HRP20040810 patent/HRP20040810A2/hr not_active Application Discontinuation
- 2004-09-24 EC EC2004005275A patent/ECSP045275A/es unknown
- 2004-10-06 NO NO20044245A patent/NO20044245L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PA8568701A1 (es) | 2003-11-12 |
NO20044245L (no) | 2004-10-06 |
PE20031010A1 (es) | 2003-12-12 |
UY27704A1 (es) | 2003-10-31 |
IS7399A (is) | 2004-08-12 |
US20030207916A1 (en) | 2003-11-06 |
CN1638768A (zh) | 2005-07-13 |
CA2476580A1 (en) | 2003-09-12 |
WO2003074052A1 (en) | 2003-09-12 |
HRP20040810A2 (en) | 2004-12-31 |
CO5601013A2 (es) | 2006-01-31 |
ZA200406491B (en) | 2006-05-31 |
OA12781A (en) | 2006-07-07 |
TW200400027A (en) | 2004-01-01 |
GT200300053A (es) | 2003-10-10 |
TNSN04167A1 (fr) | 2007-03-12 |
EP1485091A1 (en) | 2004-12-15 |
KR20040091694A (ko) | 2004-10-28 |
ECSP045275A (es) | 2004-10-26 |
AU2003207891A1 (en) | 2003-09-16 |
AR038883A1 (es) | 2005-02-02 |
BR0308221A (pt) | 2005-01-04 |
IL163768A0 (en) | 2005-12-18 |
AP2004003123A0 (en) | 2004-09-30 |
MXPA04008624A (es) | 2004-12-06 |
US6833380B2 (en) | 2004-12-21 |
EA200401160A1 (ru) | 2005-02-24 |
MA27182A1 (fr) | 2005-01-03 |
JP2005524665A (ja) | 2005-08-18 |
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Legal Events
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REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |