PL371766A1 - Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives - Google Patents

Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Info

Publication number
PL371766A1
PL371766A1 PL02371766A PL37176602A PL371766A1 PL 371766 A1 PL371766 A1 PL 371766A1 PL 02371766 A PL02371766 A PL 02371766A PL 37176602 A PL37176602 A PL 37176602A PL 371766 A1 PL371766 A1 PL 371766A1
Authority
PL
Poland
Prior art keywords
homoerythromycin
deoxo
aza
derivatives
substituted
Prior art date
Application number
PL02371766A
Other languages
English (en)
Polish (pl)
Inventor
Constantine Sklavounos
John Lloyd Tucker
Lulin Wei
Kerry Peter Mahon Jr.
Philip Dietrich Hammen
Joanna Teresa Negri
Richard Shelton Lehner
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of PL371766A1 publication Critical patent/PL371766A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PL02371766A 2001-04-27 2002-04-11 Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives PL371766A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28720301P 2001-04-27 2001-04-27

Publications (1)

Publication Number Publication Date
PL371766A1 true PL371766A1 (en) 2005-06-27

Family

ID=23101880

Family Applications (2)

Application Number Title Priority Date Filing Date
PL02371766A PL371766A1 (en) 2001-04-27 2002-04-11 Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
PL353633A PL213731B1 (pl) 2001-04-27 2002-04-25 Sposób wytwarzania pochodnej 4"-podstawionej-9-deoksy-9A-aza-9A-homoerytromecyny

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL353633A PL213731B1 (pl) 2001-04-27 2002-04-25 Sposób wytwarzania pochodnej 4"-podstawionej-9-deoksy-9A-aza-9A-homoerytromecyny

Country Status (22)

Country Link
US (1) US6825327B2 (https=)
EP (2) EP1383780A1 (https=)
JP (3) JP4104463B2 (https=)
KR (1) KR100474225B1 (https=)
CN (4) CN100413879C (https=)
AR (1) AR035871A1 (https=)
AU (1) AU784362B2 (https=)
BR (2) BR0209241A (https=)
CA (2) CA2445306C (https=)
CZ (1) CZ303716B6 (https=)
DK (1) DK1253153T3 (https=)
ES (1) ES2608848T3 (https=)
HU (1) HU230717B1 (https=)
IL (3) IL158059A0 (https=)
MX (2) MXPA03009786A (https=)
PL (2) PL371766A1 (https=)
PT (1) PT1253153T (https=)
RU (2) RU2263117C2 (https=)
SG (1) SG100789A1 (https=)
WO (1) WO2002088158A1 (https=)
YU (1) YU29502A (https=)
ZA (2) ZA200203252B (https=)

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US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
JP4792032B2 (ja) 2004-08-13 2011-10-12 シェーリング−プラウ・リミテッド 抗生物質、トリアゾールおよびコルチコステロイドを含む薬学的処方物
AU2005286723A1 (en) 2004-09-23 2006-03-30 Schering-Plough Pty. Limited Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives
DE602005017419D1 (de) 2004-11-19 2009-12-10 Schering Plough Ltd Kontrolle von parasiten bei tieren mittels verwendung von parasitiziden 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitril-derivaten
ATE429921T1 (de) * 2005-01-14 2009-05-15 Glaxosmithkline Zagreb 9a-carbamoyl- und thiocarbamoylazalide mit antimalariawirkung
CA2609574A1 (en) * 2005-06-09 2006-12-21 Schering-Plough Ltd. Control of parasites in animals by n-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and n-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
CN101605756A (zh) * 2006-12-13 2009-12-16 先灵-普劳有限公司 氟苯尼考及其类似物的水溶性前药
CA2672795A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
ES2549731T3 (es) 2007-06-27 2015-11-02 E. I. Du Pont De Nemours And Company Método para el control de plagas en animales
TWI401023B (zh) 2008-02-06 2013-07-11 Du Pont 中離子農藥
CN102131772B (zh) * 2008-07-30 2015-03-11 英特威国际有限公司 用作氟苯尼考的中间体的*唑啉-保护的氨基二醇化合物的制备方法
WO2010086351A1 (en) * 2009-01-30 2010-08-05 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 3'-n-substituted 9-deoxo-9a-methyl-9a-aza-homoerythromycin having antimalarial activity
MX2012001646A (es) 2009-08-05 2012-03-21 Du Pont Pesticidas mesoionicos.
AU2010279574A1 (en) 2009-08-05 2012-02-09 E. I. Du Pont De Nemours And Company Mesoionic pesticides
UA107804C2 (xx) 2009-08-05 2015-02-25 Du Pont Суміші мезоіонних пестицидів
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
RS54677B1 (sr) 2010-05-27 2016-08-31 E. I. Du Pont De Nemours And Company Kristalni oblici 4-[5-[3-hloro-5-(trifluorometil)fenil]-4,5 -dihidro-5-(trifluorometil)-3-izoksazolil]-n-[2-okso-2-[(2,2,2-trifluoroetil)amino]etil]-1-naftalenkarboksamida
US20130102551A1 (en) * 2010-07-01 2013-04-25 Andreas Hotte Antibiotic compositions
WO2012038372A1 (en) 2010-09-20 2012-03-29 Novartis Ag Novel process for the preparation of 9-deoxo-9a-aza- 9a-homoerythromycin a modified in the c-4'' of the cladinose ring by an epoxide group
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
CN102295672B (zh) * 2011-07-13 2014-06-04 武汉回盛生物科技有限公司 一种泰拉菌素的合成方法
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
EP2736915A1 (en) * 2011-07-27 2014-06-04 Farma GRS, d.o.o. New crystalline forms of tulathromycin
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
CN103965273B (zh) 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
WO2017124222A1 (zh) * 2016-01-18 2017-07-27 浙江海正药业股份有限公司 一种泰拉霉素的制备方法及其中间体
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN106434797A (zh) * 2016-08-25 2017-02-22 艾美科健（中国）生物医药有限公司 一种酶法合成泰拉霉素的工艺
CN106939029B (zh) * 2017-04-28 2020-10-13 艾美科健（中国）生物医药有限公司 一种泰拉霉素的制备方法
CN107556351B (zh) * 2017-08-29 2019-10-18 博瑞生物医药（苏州）股份有限公司 一种泰拉菌素的制备方法
CN107400152B (zh) * 2017-08-29 2019-10-15 博瑞生物医药（苏州）股份有限公司 泰拉菌素草酸盐
CN109535210A (zh) * 2018-12-19 2019-03-29 江苏威凌生化科技有限公司 一种合成纯化泰拉霉素杂质e的方法
EP3955937A4 (en) 2019-04-18 2023-01-18 Azura Ophthalmics Ltd. COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF EYE DISEASES
CN111072730B (zh) * 2019-12-16 2021-01-12 浙江国邦药业有限公司 一种泰拉霉素中间体盐的制备方法及应用
CN112225769A (zh) * 2020-09-21 2021-01-15 江苏威凌生化科技有限公司 一种合成纯化泰拉霉素杂质e的方法
CN113493483A (zh) * 2021-07-05 2021-10-12 上海应用技术大学 一种泰拉霉素的合成方法

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YU43116B (en) 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
SI8110592A8 (en) 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
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Also Published As

Publication number Publication date
CA2383409C (en) 2007-01-02
RU2003131351A (ru) 2005-02-27
YU29502A (sh) 2005-03-15
IL149226A (en) 2008-06-05
ZA200307506B (en) 2005-01-26
HU0201385D0 (https=) 2002-06-29
IL158059A0 (en) 2004-03-28
EP1253153A1 (en) 2002-10-30
HK1050370A1 (en) 2003-06-20
CN1530370A (zh) 2004-09-22
CN1167708C (zh) 2004-09-22
EP1253153B1 (en) 2016-11-02
AR035871A1 (es) 2004-07-21
BRPI0201437B1 (pt) 2017-11-28
CN1297564C (zh) 2007-01-31
CN1503804A (zh) 2004-06-09
CA2445306C (en) 2008-02-12
CN1295240C (zh) 2007-01-17
IL149226A0 (en) 2002-11-10
MXPA03009786A (es) 2004-01-29
MXPA02004231A (es) 2002-11-13
HUP0201385A2 (hu) 2003-12-29
HK1065803A1 (en) 2005-03-04
RU2263117C2 (ru) 2005-10-27
AU784362B2 (en) 2006-03-16
ZA200203252B (en) 2003-10-24
AU3563002A (en) 2002-10-31
CZ20021417A3 (cs) 2003-05-14
CN100413879C (zh) 2008-08-27
CN1715289A (zh) 2006-01-04
BRPI0201437B8 (pt) 2021-05-25
JP4100955B2 (ja) 2008-06-11
CN1384108A (zh) 2002-12-11
JP2004528353A (ja) 2004-09-16
JP2002326998A (ja) 2002-11-15
KR100474225B1 (ko) 2005-03-08
KR20020083474A (ko) 2002-11-02
JP2007091754A (ja) 2007-04-12
US6825327B2 (en) 2004-11-30
EP1383780A1 (en) 2004-01-28
BR0209241A (pt) 2004-06-15
PL213731B1 (pl) 2013-04-30
PT1253153T (pt) 2016-12-29
RU2233287C2 (ru) 2004-07-27
CZ303716B6 (cs) 2013-04-03
US20030064939A1 (en) 2003-04-03
IL182418A (en) 2012-07-31
HU230717B1 (hu) 2017-11-28
BR0201437A (pt) 2003-06-10
PL353633A1 (en) 2002-11-04
WO2002088158A1 (en) 2002-11-07
DK1253153T3 (da) 2017-01-02
SG100789A1 (en) 2003-12-26
CA2445306A1 (en) 2002-11-07
JP4104463B2 (ja) 2008-06-18
ES2608848T3 (es) 2017-04-17
IL182418A0 (en) 2008-01-06
CA2383409A1 (en) 2002-10-27

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