PL366918A1 - 6-Podstawione pirydopirymidyny - Google Patents

6-Podstawione pirydopirymidyny

Info

Publication number
PL366918A1
PL366918A1 PL02366918A PL36691802A PL366918A1 PL 366918 A1 PL366918 A1 PL 366918A1 PL 02366918 A PL02366918 A PL 02366918A PL 36691802 A PL36691802 A PL 36691802A PL 366918 A1 PL366918 A1 PL 366918A1
Authority
PL
Poland
Prior art keywords
pyrimidines
substituted pyrido
pyrido
substituted
Prior art date
Application number
PL02366918A
Other languages
English (en)
Inventor
Jian Jeffrey Chen
James Patrick Dunn
David Michael Goldstein
Christoph Martin Stahl
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of PL366918A1 publication Critical patent/PL366918A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL02366918A 2001-02-12 2002-02-04 6-Podstawione pirydopirymidyny PL366918A1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26837501P 2001-02-12 2001-02-12
US33465401P 2001-11-30 2001-11-30

Publications (1)

Publication Number Publication Date
PL366918A1 true PL366918A1 (pl) 2005-02-07

Family

ID=26953040

Family Applications (1)

Application Number Title Priority Date Filing Date
PL02366918A PL366918A1 (pl) 2001-02-12 2002-02-04 6-Podstawione pirydopirymidyny

Country Status (31)

Country Link
US (3) US6696566B2 (pl)
EP (1) EP1361880B1 (pl)
JP (1) JP4064818B2 (pl)
KR (1) KR100639772B1 (pl)
CN (1) CN100376571C (pl)
AR (1) AR035854A1 (pl)
AT (1) ATE305303T1 (pl)
AU (1) AU2002256615B2 (pl)
BR (1) BRPI0207172B8 (pl)
CA (1) CA2434834C (pl)
CZ (1) CZ20032416A3 (pl)
DE (1) DE60206363T2 (pl)
DK (1) DK1361880T3 (pl)
ES (1) ES2249574T3 (pl)
HR (1) HRP20030624B1 (pl)
HU (1) HU229604B1 (pl)
IL (2) IL156872A0 (pl)
JO (1) JO2410B1 (pl)
MA (1) MA26993A1 (pl)
MX (1) MXPA03007166A (pl)
MY (1) MY131518A (pl)
NO (1) NO326133B1 (pl)
NZ (1) NZ526961A (pl)
PA (1) PA8539201A1 (pl)
PE (1) PE20020976A1 (pl)
PL (1) PL366918A1 (pl)
RU (1) RU2269527C2 (pl)
SK (1) SK11322003A3 (pl)
WO (1) WO2002064594A2 (pl)
YU (1) YU63703A (pl)
ZA (1) ZA200305938B (pl)

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RU2269527C2 (ru) 2001-02-12 2006-02-10 Ф.Хоффманн-Ля Рош Аг Производные пиридопиримидинов, способы их получения и фармацевтическая композиция на их основе
ATE314370T1 (de) 2002-01-22 2006-01-15 Warner Lambert Co 2-(pyridin-2-ylamino)-pyrido(2,3-d)pyrimidin-7- one
MXPA04009585A (es) 2002-04-03 2005-01-11 Hoffmann La Roche Compuestos imidazo fusionados.
EP1539755B1 (en) 2002-08-06 2007-09-26 F. Hoffmann-La Roche Ag 6-alkoxy-pyrido-pyrimidines as p-38 map kinase inhibitors
DE60331367D1 (de) 2002-12-30 2010-04-01 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
DK1603570T5 (da) * 2003-02-26 2013-12-09 Sugen Inc Aminoheteroarylforbindelser som proteinkinaseinhibitorer
WO2004091625A1 (en) * 2003-04-16 2004-10-28 F. Hoffmann-La Roche Ag (6-(phenoxy)-pyrido`3,4-d! pyrimidin-2-yl)-amine derivatives as p38 kinase inhibitors for the treatment of inflammatoryy conditions such as rheumatois artritis
DE602004005238T2 (de) * 2003-11-13 2007-11-08 F. Hoffmann-La Roche Ag Hydroxyalkylsubstituierte pyrido-7-pyrimidin-7-one
WO2006056863A1 (en) * 2004-11-23 2006-06-01 Ranbaxy Laboratories Limited Pyrido’2, 3-d!pyrimidines as anti-inflammatory agents
US20060142312A1 (en) * 2004-12-23 2006-06-29 Pfizer Inc C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones
US20090036472A1 (en) * 2005-02-02 2009-02-05 Palle Venkata P Azabicyclo derivatives as anti-inflammatory agents
US7745451B2 (en) * 2005-05-04 2010-06-29 Renovis, Inc. Tetrahydronaphthyridine and tetrahydropyrido[4,3-d]pyrimidine compounds and compositions thereof useful in the treatment of conditions associated with neurological and inflammatory disorders and dysfunctions
AU2006271809B2 (en) * 2005-07-21 2010-03-18 F. Hoffmann-La Roche Ag Pyrido [2 , 3-D] pyrimidine-2 , 4-diamine compounds as PTP1B inhibitors
ES2351939T3 (es) * 2005-08-09 2011-02-14 Irm Llc Compuestos y composiciones como inhibidores de proteínas cinasas.
WO2007022946A1 (de) 2005-08-21 2007-03-01 Abbott Gmbh & Co. Kg Heterocyclische verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
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WO2007138974A1 (ja) * 2006-05-26 2007-12-06 Toyama Chemical Co., Ltd. 新規な複素環化合物またはその塩ならびにその中間体
WO2008150260A1 (en) * 2007-06-06 2008-12-11 Gpc Biotech, Inc. 8-oxy-2-aminopyrido (2, 3-d) pyrimidin-7-one derivatives as kinase inhibitors and anticancer agents
WO2008078249A1 (en) * 2006-12-21 2008-07-03 Ranbaxy Laboratories Limited Anti-inflammatory agents
US8022085B2 (en) 2007-05-07 2011-09-20 Amgen Inc. Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof
WO2008151992A2 (en) 2007-06-15 2008-12-18 F. Hoffmann-La Roche Ag A novel process for the preparation of 3-amino-pentan-1,5-diol
WO2009117156A1 (en) 2008-03-21 2009-09-24 Amgen Inc. Pyrazolo-pyrazinone compounds and methods of use thereof
EP2112150B1 (en) 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Improved raf inhibitors
JP2012505927A (ja) * 2008-10-22 2012-03-08 エフ．ホフマン−ラ ロシュ アーゲー Ｊｎｋのピリミジニルピリドン阻害剤
WO2010071846A2 (en) 2008-12-19 2010-06-24 Afraxis, Inc. Compounds for treating neuropsychiatric conditions
EP2486037A4 (en) * 2009-10-09 2013-01-16 Afraxis Inc 8-ETHYL-6- (ARYL) PYRIDO [2,3-D] PYRIMIDIN-7 (8H) -ONES FOR THE TREATMENT OF CNS DISORDERS
WO2011075616A1 (en) 2009-12-18 2011-06-23 Temple University - Of The Commonwealth System Of Higher Education Substituted pyrido[2,3-d]pyrimidin-7(8h)-ones and therapeutic uses thereof
EP3172214B1 (en) 2014-07-26 2020-05-13 Sunshine Lake Pharma Co., Ltd. 2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as cdk inhibitors and uses thereof
CN115105601A (zh) 2016-06-08 2022-09-27 投资支持有限公司 用于治疗癌症的药物组合
ES2876411T3 (es) 2016-08-15 2021-11-12 Pfizer Inhibidores de piridopirimdinona CDK2/4/6
JP2019528273A (ja) 2016-08-17 2019-10-10 サポート−ヴェンチャー ゲゼルシャフト ミット ベシュレンクター ハフトゥング 聴力損失を予防又は治療する方法
WO2018132550A1 (en) * 2017-01-11 2018-07-19 The General Hospital Corporation Voltage gated sodium channel imaging agents
MX395169B (es) * 2017-04-04 2025-03-25 Kinarus Ag Metodos para prevenir o tratar enfermedades oftalmicas
CA3074459A1 (en) 2017-08-31 2019-03-07 Dana-Farber Cancer Institute, Inc. Inhibitors of egfr and/or her2 and methods of use
WO2019071144A1 (en) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. USE OF P38 INHIBITORS TO REDUCE DUX4 EXPRESSION
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
US12312346B2 (en) 2018-06-27 2025-05-27 Tufts Medical Center, Inc. Pyridopyrimidine compounds and methods of their use
US20210267983A1 (en) 2018-07-13 2021-09-02 Kinarus Ag Combinations of ppar agonists and p38 kinase inhibitors for preventing or treating fibrotic diseases
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ATE314370T1 (de) * 2002-01-22 2006-01-15 Warner Lambert Co 2-(pyridin-2-ylamino)-pyrido(2,3-d)pyrimidin-7- one

Also Published As

Publication number Publication date
BR0207172A (pt) 2004-03-30
NO326133B1 (no) 2008-10-06
SK11322003A3 (en) 2004-10-05
CZ20032416A3 (cs) 2004-07-14
NO20033540D0 (no) 2003-08-11
PA8539201A1 (es) 2004-08-31
AU2002256615B2 (en) 2007-09-13
KR100639772B1 (ko) 2006-10-30
AR035854A1 (es) 2004-07-21
EP1361880A2 (en) 2003-11-19
DE60206363D1 (de) 2006-02-09
HU229604B1 (en) 2014-02-28
JP2004525896A (ja) 2004-08-26
RU2269527C2 (ru) 2006-02-10
JO2410B1 (en) 2007-06-17
WO2002064594A3 (en) 2003-01-09
CN1503672A (zh) 2004-06-09
IL156872A0 (en) 2004-02-08
US20030171584A1 (en) 2003-09-11
IL156872A (en) 2009-07-20
JP4064818B2 (ja) 2008-03-19
NO20033540L (no) 2003-08-11
US20070135458A1 (en) 2007-06-14
DK1361880T3 (da) 2006-01-23
KR20040018254A (ko) 2004-03-02
BRPI0207172B1 (pt) 2019-04-09
DE60206363T2 (de) 2006-07-06
CN100376571C (zh) 2008-03-26
US7449581B2 (en) 2008-11-11
CA2434834A1 (en) 2002-08-22
ZA200305938B (en) 2005-01-26
HK1066170A1 (en) 2005-03-18
WO2002064594A2 (en) 2002-08-22
MA26993A1 (fr) 2004-12-20
PE20020976A1 (es) 2002-10-29
CA2434834C (en) 2010-09-14
MXPA03007166A (es) 2003-11-18
ES2249574T3 (es) 2006-04-01
US20040116698A1 (en) 2004-06-17
HRP20030624B1 (en) 2007-03-31
HUP0303458A2 (hu) 2004-01-28
RU2003125887A (ru) 2005-03-20
EP1361880B1 (en) 2005-09-28
HUP0303458A3 (en) 2012-12-28
ATE305303T1 (de) 2005-10-15
NZ526961A (en) 2005-03-24
HRP20030624A2 (en) 2005-06-30
US6696566B2 (en) 2004-02-24
BRPI0207172B8 (pt) 2021-05-25
MY131518A (en) 2007-08-30
US7169794B2 (en) 2007-01-30
YU63703A (sh) 2006-05-25

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