PL356746A1 - Urządzenie i sposób do wytwarzania cząstek krystalicznych - Google Patents

Urządzenie i sposób do wytwarzania cząstek krystalicznych

Info

Publication number
PL356746A1
PL356746A1 PL00356746A PL35674600A PL356746A1 PL 356746 A1 PL356746 A1 PL 356746A1 PL 00356746 A PL00356746 A PL 00356746A PL 35674600 A PL35674600 A PL 35674600A PL 356746 A1 PL356746 A1 PL 356746A1
Authority
PL
Poland
Prior art keywords
crystalline particles
mixing chamber
substance
liquid
reservoir
Prior art date
Application number
PL00356746A
Other languages
English (en)
Inventor
Alan Ronald Ferrie
Andrew Patrick Savage
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of PL356746A1 publication Critical patent/PL356746A1/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/10—Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Oxygen, Ozone, And Oxides In General (AREA)
  • Steroid Compounds (AREA)
PL00356746A 1999-11-03 2000-11-03 Urządzenie i sposób do wytwarzania cząstek krystalicznych PL356746A1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9925934.3A GB9925934D0 (en) 1999-11-03 1999-11-03 Novel apparatus and process
GBGB0024511.8A GB0024511D0 (en) 1999-11-03 2000-10-06 Novel apparatus and process

Publications (1)

Publication Number Publication Date
PL356746A1 true PL356746A1 (pl) 2004-06-28

Family

ID=10863815

Family Applications (1)

Application Number Title Priority Date Filing Date
PL00356746A PL356746A1 (pl) 1999-11-03 2000-11-03 Urządzenie i sposób do wytwarzania cząstek krystalicznych

Country Status (25)

Country Link
EP (2) EP1466595A1 (pl)
JP (1) JP4700247B2 (pl)
KR (1) KR20020047322A (pl)
CN (1) CN1409627A (pl)
AT (1) ATE271853T1 (pl)
AU (1) AU768915B2 (pl)
BR (1) BR0015271A (pl)
CA (1) CA2389908A1 (pl)
CZ (1) CZ20021555A3 (pl)
DE (1) DE60012558T2 (pl)
DK (1) DK1225875T3 (pl)
ES (1) ES2225247T3 (pl)
GB (2) GB9925934D0 (pl)
HK (1) HK1045268B (pl)
HU (1) HUP0203278A3 (pl)
IL (1) IL149366A0 (pl)
MX (1) MXPA02004394A (pl)
NO (1) NO20022059L (pl)
NZ (1) NZ518565A (pl)
PL (1) PL356746A1 (pl)
PT (1) PT1225875E (pl)
SI (1) SI1225875T1 (pl)
TR (1) TR200402709T4 (pl)
WO (1) WO2001032125A2 (pl)
ZA (1) ZA200203434B (pl)

Families Citing this family (43)

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SI1412078T1 (sl) 2001-08-02 2009-04-30 Lg Life Sciences Ltd Lg Twin T Postopki za pripravo amino-zaščitenih derivatov 4-aminometilen-pirolidin-3-ona, gemifloksacina ali njegove soli
CA2458889C (en) * 2001-08-29 2011-06-21 Dow Global Technologies Inc. A process for preparing crystalline drug particles by means of precipitation
GB0125604D0 (en) * 2001-10-25 2001-12-19 Glaxo Group Ltd Novel process
GB0202564D0 (en) * 2002-02-04 2002-03-20 Glaxo Group Ltd Process
JP3691459B2 (ja) * 2002-06-14 2005-09-07 久光メディカル株式会社 粉末状吸入剤組成物
GB0216700D0 (en) * 2002-07-18 2002-08-28 Astrazeneca Ab Process
GB0300427D0 (en) * 2003-01-09 2003-02-05 Univ Strathclyde Pharmaceutical composition
US7638138B2 (en) 2003-02-21 2009-12-29 Translational Research, Ltd. Compositions for nasal administration of pharmaceuticals
WO2004073827A1 (en) * 2003-02-21 2004-09-02 The University Of Bath Process for the production of particles
JP5090729B2 (ja) * 2003-03-04 2012-12-05 ファイブ・スター・テクノロジーズ・インコーポレイテッド 流体力学的キャビテーション結晶化装置および方法
CA2519287A1 (en) 2003-03-27 2004-10-14 Bioactis Limited Powder medicine applicator for nasal cavity
US8912174B2 (en) 2003-04-16 2014-12-16 Mylan Pharmaceuticals Inc. Formulations and methods for treating rhinosinusitis
US9808471B2 (en) * 2003-04-16 2017-11-07 Mylan Specialty Lp Nasal pharmaceutical formulations and methods of using the same
US7811606B2 (en) * 2003-04-16 2010-10-12 Dey, L.P. Nasal pharmaceutical formulations and methods of using the same
CA2532874A1 (en) * 2003-07-22 2005-02-03 Baxter International Inc. Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof
GB0404586D0 (en) * 2004-03-01 2004-04-07 Britannia Pharmaceuticals Ltd Improvements in or relating to organic materials
WO2006016530A1 (ja) 2004-08-10 2006-02-16 Translational Research, Ltd. 速効性でかつ高い吸収性を可能とする経鼻投与用組成物
WO2006045795A2 (en) * 2004-10-29 2006-05-04 Akzo Nobel N.V. Processes involving the use of antisolvent crystallization
EP1837343A4 (en) * 2004-12-08 2009-07-29 Kuraray Co PROCESS FOR PRODUCING BENZOATE (5 ALPHA, 7 ALPHA) -3-SPIRO-2 '- (1', 3'-DIOXOLAN) -24-OXOCHOLEST-22-EN-7-YLE
ES2613391T3 (es) 2005-02-10 2017-05-24 Glaxo Group Limited Procedimientos de fabricación de lactosa que utilizan técnicas de preclasificación y formulaciones farmacéuticas formadas a partir de la misma
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
WO2008078730A1 (ja) 2006-12-26 2008-07-03 Translational Research, Ltd. 経鼻投与用製剤
GB0705159D0 (en) * 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals
GB0707938D0 (en) 2007-04-25 2007-05-30 Univ Strathclyde Precipitation stabilising compositions
GB0724498D0 (en) 2007-12-15 2008-01-30 Univ Strathclyde Slow release compositions
MX2011000405A (es) * 2008-07-18 2011-03-04 Prosonix Ltd Proceso para mejorar la cristalinidad.
JP2012526726A (ja) 2009-05-15 2012-11-01 株式会社新日本科学 薬物動態が改善された鼻腔内用薬学的組成物
GB2472327B (en) 2009-07-31 2013-03-13 Shin Nippon Biomedical Lab Ltd Intranasal granisetron and nasal applicator
PT105058B (pt) * 2010-04-21 2013-04-17 Hovione Farmaciencia S A Processo para processamento de partículas de ingredientes activos farmacêuticos
EP2729480A4 (en) * 2011-07-08 2014-12-31 Pfizer Ltd PROCESS FOR THE PREPARATION OF FLUTICASONE PROPIONATE, FORM 1
CN102366405A (zh) * 2011-10-21 2012-03-07 江阴长风医药科技有限公司 以氢氟烷烃为抛射剂的氟替卡松丙酸酯气雾剂制剂
WO2013105894A1 (en) * 2012-01-13 2013-07-18 Xspray Microparticles Ab A method for producing stable, amorphous hybrid nanoparticles comprising at least one protein kinase inhibitor and at least one polymeric stabilizing and matrix- forming component.
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
PT3517541T (pt) 2012-05-08 2020-08-28 Nicox Ophthalmics Inc Forma polimórfica de propionato de fluticasona
EP2705838A1 (en) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
US9815865B2 (en) 2013-01-07 2017-11-14 Nicox Ophthalmics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
KR20160030086A (ko) * 2013-04-29 2016-03-16 사노피 에스에이 흡입식 약학적 조성물 및 그를 포함하는 흡입기 장치
PT108368B (pt) * 2015-03-31 2018-11-05 Hovione Farm S A Produção contínua de partículas
PT108885B (pt) * 2015-10-12 2019-02-13 Hovione Farm S A Método de produção de partículas compósitas inaláveis mediante a utilização de um atomizador de três fluidos
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
CN110960504A (zh) * 2019-10-31 2020-04-07 上海新黄河制药有限公司 中空颗粒制备方法及干粉吸入制剂
IL300997A (en) * 2020-09-08 2023-04-01 Genentech Inc Systems and methods for the production of pharmaceutical preparations using peristaltic pumps and restraints
CN112755301B (zh) * 2021-01-20 2022-03-29 孙洪坤 一种血液病造血干细胞移植用皮肤清洁器

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8404749D0 (en) 1984-02-23 1984-03-28 Atomic Energy Authority Uk Fluidic contactor
CA1282405C (en) * 1984-05-21 1991-04-02 Michael R. Violante Method for making uniformly sized particles from water-insoluble organic compounds
US4826689A (en) * 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
US4826589A (en) * 1988-06-30 1989-05-02 Gene Hirs Bar screen filter
GB8911259D0 (en) * 1989-05-17 1989-07-05 Fisons Plc Inhalation medicament
GB9004781D0 (en) 1990-03-02 1990-04-25 Glaxo Group Ltd Device
GB9007027D0 (en) 1990-03-29 1990-05-30 Atomic Energy Authority Uk Precipitation apparatus and method
GB9101967D0 (en) 1991-01-30 1991-03-13 Atomic Energy Authority Uk Reagent mixing
GB9320455D0 (en) 1993-10-05 1993-11-24 Atomic Energy Authority Uk Vortex mixer
GB9620187D0 (en) * 1996-09-27 1996-11-13 Minnesota Mining & Mfg Medicinal aerosol formulations

Also Published As

Publication number Publication date
CA2389908A1 (en) 2001-05-10
WO2001032125A2 (en) 2001-05-10
EP1225875B1 (en) 2004-07-28
AU768915B2 (en) 2004-01-08
BR0015271A (pt) 2002-12-31
HUP0203278A2 (hu) 2003-01-28
CN1409627A (zh) 2003-04-09
NO20022059L (no) 2002-06-14
ES2225247T3 (es) 2005-03-16
DK1225875T3 (da) 2004-11-22
NZ518565A (en) 2004-04-30
HK1045268A1 (en) 2002-11-22
TR200402709T4 (tr) 2004-11-22
EP1225875A2 (en) 2002-07-31
HUP0203278A3 (en) 2004-06-28
MXPA02004394A (es) 2002-09-02
NO20022059D0 (no) 2002-04-30
AU1160401A (en) 2001-05-14
HK1045268B (zh) 2005-02-18
DE60012558D1 (de) 2004-09-02
KR20020047322A (ko) 2002-06-21
IL149366A0 (en) 2002-11-10
GB9925934D0 (en) 1999-12-29
ATE271853T1 (de) 2004-08-15
EP1466595A1 (en) 2004-10-13
JP4700247B2 (ja) 2011-06-15
ZA200203434B (en) 2003-02-25
JP2003512892A (ja) 2003-04-08
WO2001032125A3 (en) 2002-05-16
PT1225875E (pt) 2004-12-31
SI1225875T1 (en) 2004-12-31
CZ20021555A3 (cs) 2002-11-13
GB0024511D0 (en) 2000-11-22
DE60012558T2 (de) 2005-07-28

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Legal Events

Date Code Title Description
REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)