HUP0203278A2 - Új berendezés és eljárás kristályos részecskék előállítására - Google Patents
Új berendezés és eljárás kristályos részecskék előállításáraInfo
- Publication number
- HUP0203278A2 HUP0203278A2 HU0203278A HUP0203278A HUP0203278A2 HU P0203278 A2 HUP0203278 A2 HU P0203278A2 HU 0203278 A HU0203278 A HU 0203278A HU P0203278 A HUP0203278 A HU P0203278A HU P0203278 A2 HUP0203278 A2 HU P0203278A2
- Authority
- HU
- Hungary
- Prior art keywords
- crystalline particles
- substance
- liquid
- stream
- solvent
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 7
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 239000007788 liquid Substances 0.000 abstract 4
- 239000000126 substance Substances 0.000 abstract 4
- 238000002664 inhalation therapy Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 239000000443 aerosol Substances 0.000 abstract 1
- 239000012296 anti-solvent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/10—Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Oxygen, Ozone, And Oxides In General (AREA)
- Steroid Compounds (AREA)
Abstract
A találmány tárgya eljárás inhalációs terápiában alkalmazható anyagkristályos részecskéinek előállítására. A találmányt az jellemzi, hogyaz anyag folyékony oldószerben készült oldatának áramát és az említettanyag folyékony anti-oldószerének áramát, amely a folyékonyoldószerrel elegyedik, tangenciálisan bevezetik egy hengereskeverőkamrába, amelynek axiális kiömlőnyílása van, hogy az említettáramok örvény képződése révén bensőségesen elkeveredjenek, és az anyagkristályos részecskéi ezáltal kicsapódjanak. A keletkező kristályosrészecskéket, amelyek a keverőkamra kiömlőnyílásán távozófolyadékáramban vannak szuszpendálva, összegyűjtik. A találmány tárgyatovábbá berendezés inhalációs terápiában alkalmazható anyag kristályosrészecskéinek előállítására, a találmány szerinti eljárássalelőállítható részecskepopuláció, valamint a részecskepopulációttartalmazó por és aeroszol alakú gyógyszerkészítmény. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9925934.3A GB9925934D0 (en) | 1999-11-03 | 1999-11-03 | Novel apparatus and process |
GBGB0024511.8A GB0024511D0 (en) | 1999-11-03 | 2000-10-06 | Novel apparatus and process |
PCT/GB2000/004237 WO2001032125A2 (en) | 1999-11-03 | 2000-11-03 | Apparatus and process for preparing crystalline particles |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0203278A2 true HUP0203278A2 (hu) | 2003-01-28 |
HUP0203278A3 HUP0203278A3 (en) | 2004-06-28 |
Family
ID=10863815
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0203278A HUP0203278A3 (en) | 1999-11-03 | 2000-11-03 | Apparatus and process for preparing crystalline particles |
Country Status (25)
Country | Link |
---|---|
EP (2) | EP1225875B1 (hu) |
JP (1) | JP4700247B2 (hu) |
KR (1) | KR20020047322A (hu) |
CN (1) | CN1409627A (hu) |
AT (1) | ATE271853T1 (hu) |
AU (1) | AU768915B2 (hu) |
BR (1) | BR0015271A (hu) |
CA (1) | CA2389908A1 (hu) |
CZ (1) | CZ20021555A3 (hu) |
DE (1) | DE60012558T2 (hu) |
DK (1) | DK1225875T3 (hu) |
ES (1) | ES2225247T3 (hu) |
GB (2) | GB9925934D0 (hu) |
HK (1) | HK1045268B (hu) |
HU (1) | HUP0203278A3 (hu) |
IL (1) | IL149366A0 (hu) |
MX (1) | MXPA02004394A (hu) |
NO (1) | NO20022059L (hu) |
NZ (1) | NZ518565A (hu) |
PL (1) | PL356746A1 (hu) |
PT (1) | PT1225875E (hu) |
SI (1) | SI1225875T1 (hu) |
TR (1) | TR200402709T4 (hu) |
WO (1) | WO2001032125A2 (hu) |
ZA (1) | ZA200203434B (hu) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2314082T3 (es) | 2001-08-02 | 2009-03-16 | Lg Life Sciences Limited | Procedimientos para la produccion de derivados amino protegidos de 4-aminometilenpirrolidin-3-ona, gemifloxacina y sus sales. |
EP1423096B1 (en) * | 2001-08-29 | 2006-08-16 | Dow Global Technologies Inc. | A process for preparing crystalline drug particles by means of precipitation |
GB0125604D0 (en) * | 2001-10-25 | 2001-12-19 | Glaxo Group Ltd | Novel process |
GB0202564D0 (en) * | 2002-02-04 | 2002-03-20 | Glaxo Group Ltd | Process |
JP3691459B2 (ja) * | 2002-06-14 | 2005-09-07 | 久光メディカル株式会社 | 粉末状吸入剤組成物 |
GB0216700D0 (en) * | 2002-07-18 | 2002-08-28 | Astrazeneca Ab | Process |
GB0300427D0 (en) * | 2003-01-09 | 2003-02-05 | Univ Strathclyde | Pharmaceutical composition |
PT1610878E (pt) * | 2003-02-21 | 2014-12-03 | Univ Bath | Processo para a produção de partículas |
WO2004073729A1 (ja) | 2003-02-21 | 2004-09-02 | Translational Research Ltd. | 薬物の経鼻投与用組成物 |
CA2517727C (en) * | 2003-03-04 | 2012-09-04 | Five Star Technologies, Inc. | Hydrodynamic cavitation crystallization device and process |
CN1758930B (zh) | 2003-03-27 | 2010-06-09 | 株式会社新日本科学 | 鼻腔用粉末药剂喷药装置 |
US8912174B2 (en) | 2003-04-16 | 2014-12-16 | Mylan Pharmaceuticals Inc. | Formulations and methods for treating rhinosinusitis |
US9808471B2 (en) | 2003-04-16 | 2017-11-07 | Mylan Specialty Lp | Nasal pharmaceutical formulations and methods of using the same |
US7811606B2 (en) | 2003-04-16 | 2010-10-12 | Dey, L.P. | Nasal pharmaceutical formulations and methods of using the same |
AU2004258971A1 (en) * | 2003-07-22 | 2005-02-03 | Baxter Healthcare S.A. | Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof |
GB0404586D0 (en) * | 2004-03-01 | 2004-04-07 | Britannia Pharmaceuticals Ltd | Improvements in or relating to organic materials |
JP4922762B2 (ja) | 2004-08-10 | 2012-04-25 | 株式会社新日本科学 | 速効性でかつ高い吸収性を可能とする経鼻投与用組成物 |
WO2006045795A2 (en) * | 2004-10-29 | 2006-05-04 | Akzo Nobel N.V. | Processes involving the use of antisolvent crystallization |
US20090259038A1 (en) * | 2004-12-08 | 2009-10-15 | Kuraray Co., Ltd. | Process for producing (5alpha7alpha)-3-spiro-2'-(1',3'-dioxolan)-24-oxocholest-22-en-7-yl benzoate |
KR20070119631A (ko) | 2005-02-10 | 2007-12-20 | 글락소 그룹 리미티드 | 사전-분류 기술을 이용한 락토오스 제조 공정 및 이로부터제조된 약제 제형 |
GB0507165D0 (en) * | 2005-04-08 | 2005-05-18 | Glaxo Group Ltd | Novel crystalline pharmaceutical product |
EP2116264B1 (en) | 2006-12-26 | 2017-09-27 | Shin Nippon Biomedical Laboratories, Ltd. | Preparation for transnasal application |
GB0705159D0 (en) * | 2007-03-19 | 2007-04-25 | Prosonix Ltd | Process for making crystals |
GB0707938D0 (en) | 2007-04-25 | 2007-05-30 | Univ Strathclyde | Precipitation stabilising compositions |
GB0724498D0 (en) | 2007-12-15 | 2008-01-30 | Univ Strathclyde | Slow release compositions |
CN102149437B (zh) * | 2008-07-18 | 2017-02-15 | 普罗索尼克斯有限公司 | 用于提高氟替卡松颗粒结晶度的方法 |
EP2429495A4 (en) | 2009-05-15 | 2014-01-22 | Shin Nippon Biomedical Lab Ltd | INTRANASAL PHARMACEUTICAL COMPOSITIONS WITH ENHANCED PHARMACOKINETICS |
GB2472327B (en) | 2009-07-31 | 2013-03-13 | Shin Nippon Biomedical Lab Ltd | Intranasal granisetron and nasal applicator |
PT105058B (pt) | 2010-04-21 | 2013-04-17 | Hovione Farmaciencia S A | Processo para processamento de partículas de ingredientes activos farmacêuticos |
US10370402B2 (en) * | 2011-07-08 | 2019-08-06 | Pfizer Limited | Process for the preparation of fluticasone propionate form 1 |
CN102366405A (zh) * | 2011-10-21 | 2012-03-07 | 江阴长风医药科技有限公司 | 以氢氟烷烃为抛射剂的氟替卡松丙酸酯气雾剂制剂 |
DK3181122T3 (da) * | 2012-01-13 | 2023-06-06 | Xspray Pharma Ab Publ | Farmaceutisk dasatinib-sammensætning |
MX361886B (es) | 2012-05-08 | 2018-12-18 | Nicox Ophthalmics Inc | Preparaciones de agentes terapéuticos hidrófobos, métodos de elaboración y uso de los mismos. |
US8765725B2 (en) | 2012-05-08 | 2014-07-01 | Aciex Therapeutics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
EP2705838A1 (en) * | 2012-09-06 | 2014-03-12 | Xspray Microparticles Ab | Tiotropium preparations |
US9815865B2 (en) | 2013-01-07 | 2017-11-14 | Nicox Ophthalmics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
MX2015015150A (es) * | 2013-04-29 | 2016-02-18 | Sanofi Sa | Composiciones farmaceuticas inhalables y los dispositivos inhaladores que las contienen. |
PT108368B (pt) * | 2015-03-31 | 2018-11-05 | Hovione Farm S A | Produção contínua de partículas |
PT108885B (pt) * | 2015-10-12 | 2019-02-13 | Hovione Farm S A | Método de produção de partículas compósitas inaláveis mediante a utilização de um atomizador de três fluidos |
US11744967B2 (en) | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
CN110960504A (zh) * | 2019-10-31 | 2020-04-07 | 上海新黄河制药有限公司 | 中空颗粒制备方法及干粉吸入制剂 |
BR112023004247A2 (pt) * | 2020-09-08 | 2023-04-11 | Genentech Inc | Kits de tubulação para formar uma mistura, sistemas para formar uma composição farmacêutica, métodos para transferir composições farmacêuticas e para fabricar uma composição farmacêutica e amortecedor de pulsação |
CN112755301B (zh) * | 2021-01-20 | 2022-03-29 | 孙洪坤 | 一种血液病造血干细胞移植用皮肤清洁器 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8404749D0 (en) | 1984-02-23 | 1984-03-28 | Atomic Energy Authority Uk | Fluidic contactor |
CA1282405C (en) * | 1984-05-21 | 1991-04-02 | Michael R. Violante | Method for making uniformly sized particles from water-insoluble organic compounds |
US4826689A (en) * | 1984-05-21 | 1989-05-02 | University Of Rochester | Method for making uniformly sized particles from water-insoluble organic compounds |
US4826589A (en) * | 1988-06-30 | 1989-05-02 | Gene Hirs | Bar screen filter |
GB8911259D0 (en) * | 1989-05-17 | 1989-07-05 | Fisons Plc | Inhalation medicament |
GB9004781D0 (en) | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
GB9007027D0 (en) | 1990-03-29 | 1990-05-30 | Atomic Energy Authority Uk | Precipitation apparatus and method |
GB9101967D0 (en) | 1991-01-30 | 1991-03-13 | Atomic Energy Authority Uk | Reagent mixing |
GB9320455D0 (en) | 1993-10-05 | 1993-11-24 | Atomic Energy Authority Uk | Vortex mixer |
GB9620187D0 (en) * | 1996-09-27 | 1996-11-13 | Minnesota Mining & Mfg | Medicinal aerosol formulations |
-
1999
- 1999-11-03 GB GBGB9925934.3A patent/GB9925934D0/en not_active Ceased
-
2000
- 2000-10-06 GB GBGB0024511.8A patent/GB0024511D0/en not_active Ceased
- 2000-11-03 ES ES00973049T patent/ES2225247T3/es not_active Expired - Lifetime
- 2000-11-03 NZ NZ518565A patent/NZ518565A/en unknown
- 2000-11-03 CZ CZ20021555A patent/CZ20021555A3/cs unknown
- 2000-11-03 AU AU11604/01A patent/AU768915B2/en not_active Ceased
- 2000-11-03 KR KR1020027005660A patent/KR20020047322A/ko not_active Application Discontinuation
- 2000-11-03 AT AT00973049T patent/ATE271853T1/de not_active IP Right Cessation
- 2000-11-03 EP EP00973049A patent/EP1225875B1/en not_active Expired - Lifetime
- 2000-11-03 SI SI200030500T patent/SI1225875T1/xx unknown
- 2000-11-03 CA CA002389908A patent/CA2389908A1/en not_active Abandoned
- 2000-11-03 DE DE60012558T patent/DE60012558T2/de not_active Expired - Lifetime
- 2000-11-03 EP EP04077077A patent/EP1466595A1/en not_active Withdrawn
- 2000-11-03 PL PL00356746A patent/PL356746A1/xx not_active Application Discontinuation
- 2000-11-03 HU HU0203278A patent/HUP0203278A3/hu unknown
- 2000-11-03 IL IL14936600A patent/IL149366A0/xx unknown
- 2000-11-03 PT PT00973049T patent/PT1225875E/pt unknown
- 2000-11-03 CN CN00817088A patent/CN1409627A/zh active Pending
- 2000-11-03 WO PCT/GB2000/004237 patent/WO2001032125A2/en active IP Right Grant
- 2000-11-03 TR TR2004/02709T patent/TR200402709T4/xx unknown
- 2000-11-03 DK DK00973049T patent/DK1225875T3/da active
- 2000-11-03 BR BR0015271-4A patent/BR0015271A/pt not_active IP Right Cessation
- 2000-11-03 MX MXPA02004394A patent/MXPA02004394A/es unknown
- 2000-11-03 JP JP2001534333A patent/JP4700247B2/ja not_active Expired - Fee Related
-
2002
- 2002-04-30 NO NO20022059A patent/NO20022059L/no not_active Application Discontinuation
- 2002-04-30 ZA ZA200203434A patent/ZA200203434B/xx unknown
- 2002-09-25 HK HK02106989.8A patent/HK1045268B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
TR200402709T4 (tr) | 2004-11-22 |
AU768915B2 (en) | 2004-01-08 |
GB0024511D0 (en) | 2000-11-22 |
CZ20021555A3 (cs) | 2002-11-13 |
BR0015271A (pt) | 2002-12-31 |
WO2001032125A3 (en) | 2002-05-16 |
EP1225875A2 (en) | 2002-07-31 |
MXPA02004394A (es) | 2002-09-02 |
EP1466595A1 (en) | 2004-10-13 |
PT1225875E (pt) | 2004-12-31 |
GB9925934D0 (en) | 1999-12-29 |
KR20020047322A (ko) | 2002-06-21 |
WO2001032125A2 (en) | 2001-05-10 |
DE60012558T2 (de) | 2005-07-28 |
ZA200203434B (en) | 2003-02-25 |
CA2389908A1 (en) | 2001-05-10 |
JP2003512892A (ja) | 2003-04-08 |
IL149366A0 (en) | 2002-11-10 |
HUP0203278A3 (en) | 2004-06-28 |
ES2225247T3 (es) | 2005-03-16 |
NO20022059L (no) | 2002-06-14 |
HK1045268B (zh) | 2005-02-18 |
DE60012558D1 (de) | 2004-09-02 |
PL356746A1 (en) | 2004-06-28 |
CN1409627A (zh) | 2003-04-09 |
NO20022059D0 (no) | 2002-04-30 |
DK1225875T3 (da) | 2004-11-22 |
SI1225875T1 (en) | 2004-12-31 |
ATE271853T1 (de) | 2004-08-15 |
JP4700247B2 (ja) | 2011-06-15 |
AU1160401A (en) | 2001-05-14 |
NZ518565A (en) | 2004-04-30 |
EP1225875B1 (en) | 2004-07-28 |
HK1045268A1 (en) | 2002-11-22 |
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