HUP0203278A2 - Új berendezés és eljárás kristályos részecskék előállítására - Google Patents

Új berendezés és eljárás kristályos részecskék előállítására

Info

Publication number
HUP0203278A2
HUP0203278A2 HU0203278A HUP0203278A HUP0203278A2 HU P0203278 A2 HUP0203278 A2 HU P0203278A2 HU 0203278 A HU0203278 A HU 0203278A HU P0203278 A HUP0203278 A HU P0203278A HU P0203278 A2 HUP0203278 A2 HU P0203278A2
Authority
HU
Hungary
Prior art keywords
crystalline particles
substance
liquid
stream
solvent
Prior art date
Application number
HU0203278A
Other languages
English (en)
Inventor
Alan Ronald Ferrie
Andrew Patrick Savage
Original Assignee
Glaxo Group Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd. filed Critical Glaxo Group Ltd.
Publication of HUP0203278A2 publication Critical patent/HUP0203278A2/hu
Publication of HUP0203278A3 publication Critical patent/HUP0203278A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/10—Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Steroid Compounds (AREA)
  • Oxygen, Ozone, And Oxides In General (AREA)

Abstract

A találmány tárgya eljárás inhalációs terápiában alkalmazható anyagkristályos részecskéinek előállítására. A találmányt az jellemzi, hogyaz anyag folyékony oldószerben készült oldatának áramát és az említettanyag folyékony anti-oldószerének áramát, amely a folyékonyoldószerrel elegyedik, tangenciálisan bevezetik egy hengereskeverőkamrába, amelynek axiális kiömlőnyílása van, hogy az említettáramok örvény képződése révén bensőségesen elkeveredjenek, és az anyagkristályos részecskéi ezáltal kicsapódjanak. A keletkező kristályosrészecskéket, amelyek a keverőkamra kiömlőnyílásán távozófolyadékáramban vannak szuszpendálva, összegyűjtik. A találmány tárgyatovábbá berendezés inhalációs terápiában alkalmazható anyag kristályosrészecskéinek előállítására, a találmány szerinti eljárássalelőállítható részecskepopuláció, valamint a részecskepopulációttartalmazó por és aeroszol alakú gyógyszerkészítmény. Ó
HU0203278A 1999-11-03 2000-11-03 Apparatus and process for preparing crystalline particles HUP0203278A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9925934.3A GB9925934D0 (en) 1999-11-03 1999-11-03 Novel apparatus and process
GBGB0024511.8A GB0024511D0 (en) 1999-11-03 2000-10-06 Novel apparatus and process
PCT/GB2000/004237 WO2001032125A2 (en) 1999-11-03 2000-11-03 Apparatus and process for preparing crystalline particles

Publications (2)

Publication Number Publication Date
HUP0203278A2 true HUP0203278A2 (hu) 2003-01-28
HUP0203278A3 HUP0203278A3 (en) 2004-06-28

Family

ID=10863815

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0203278A HUP0203278A3 (en) 1999-11-03 2000-11-03 Apparatus and process for preparing crystalline particles

Country Status (25)

Country Link
EP (2) EP1225875B1 (hu)
JP (1) JP4700247B2 (hu)
KR (1) KR20020047322A (hu)
CN (1) CN1409627A (hu)
AT (1) ATE271853T1 (hu)
AU (1) AU768915B2 (hu)
BR (1) BR0015271A (hu)
CA (1) CA2389908A1 (hu)
CZ (1) CZ20021555A3 (hu)
DE (1) DE60012558T2 (hu)
DK (1) DK1225875T3 (hu)
ES (1) ES2225247T3 (hu)
GB (2) GB9925934D0 (hu)
HK (1) HK1045268B (hu)
HU (1) HUP0203278A3 (hu)
IL (1) IL149366A0 (hu)
MX (1) MXPA02004394A (hu)
NO (1) NO20022059L (hu)
NZ (1) NZ518565A (hu)
PL (1) PL356746A1 (hu)
PT (1) PT1225875E (hu)
SI (1) SI1225875T1 (hu)
TR (1) TR200402709T4 (hu)
WO (1) WO2001032125A2 (hu)
ZA (1) ZA200203434B (hu)

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CA2458889C (en) * 2001-08-29 2011-06-21 Dow Global Technologies Inc. A process for preparing crystalline drug particles by means of precipitation
GB0125604D0 (en) * 2001-10-25 2001-12-19 Glaxo Group Ltd Novel process
GB0202564D0 (en) * 2002-02-04 2002-03-20 Glaxo Group Ltd Process
JP3691459B2 (ja) * 2002-06-14 2005-09-07 久光メディカル株式会社 粉末状吸入剤組成物
GB0216700D0 (en) * 2002-07-18 2002-08-28 Astrazeneca Ab Process
GB0300427D0 (en) * 2003-01-09 2003-02-05 Univ Strathclyde Pharmaceutical composition
DK1610878T3 (da) * 2003-02-21 2014-12-01 Univ Bath Fremgangsmåde til fremstilling af partikler
US7638138B2 (en) 2003-02-21 2009-12-29 Translational Research, Ltd. Compositions for nasal administration of pharmaceuticals
CA2517727C (en) * 2003-03-04 2012-09-04 Five Star Technologies, Inc. Hydrodynamic cavitation crystallization device and process
WO2004087243A1 (ja) 2003-03-27 2004-10-14 Bioactis Limited 鼻腔用粉末薬剤施薬装置
US7811606B2 (en) 2003-04-16 2010-10-12 Dey, L.P. Nasal pharmaceutical formulations and methods of using the same
US9808471B2 (en) * 2003-04-16 2017-11-07 Mylan Specialty Lp Nasal pharmaceutical formulations and methods of using the same
US8912174B2 (en) 2003-04-16 2014-12-16 Mylan Pharmaceuticals Inc. Formulations and methods for treating rhinosinusitis
JP2007508240A (ja) * 2003-07-22 2007-04-05 バクスター・インターナショナル・インコーポレイテッド 低分子量有機分子の小球状粒子ならびにその調製方法および使用方法
GB0404586D0 (en) * 2004-03-01 2004-04-07 Britannia Pharmaceuticals Ltd Improvements in or relating to organic materials
WO2006016530A1 (ja) 2004-08-10 2006-02-16 Translational Research, Ltd. 速効性でかつ高い吸収性を可能とする経鼻投与用組成物
WO2006045795A2 (en) * 2004-10-29 2006-05-04 Akzo Nobel N.V. Processes involving the use of antisolvent crystallization
WO2006062129A1 (ja) * 2004-12-08 2006-06-15 Kuraray Co., Ltd. （５α，７α）－３－スピロ－２’－（１’，３’－ジオキソラン）－２４－オキソコレスト－２２－エン－７－イル ベンゾアートの製造方法
US9365905B2 (en) 2005-02-10 2016-06-14 Dmv-Fonterra Excipients Technology Gmbh Processes for making lactose utilizing pre-classification techniques and pharmaceutical formulations formed therefrom
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
JP5415769B2 (ja) 2006-12-26 2014-02-12 株式会社新日本科学 経鼻投与用製剤
GB0705159D0 (en) 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals
GB0707938D0 (en) 2007-04-25 2007-05-30 Univ Strathclyde Precipitation stabilising compositions
GB0724498D0 (en) 2007-12-15 2008-01-30 Univ Strathclyde Slow release compositions
JP5936353B2 (ja) * 2008-07-18 2016-06-22 プロソニックス リミテッドＰｒｏｓｏｎｉｘ Ｌｉｍｉｔｅｄ フルチカゾン粒子の結晶化度を改善する方法
US9101539B2 (en) 2009-05-15 2015-08-11 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetics
US8827946B2 (en) 2009-07-31 2014-09-09 Shin Nippon Biomedical Laboratories, Ltd. Intranasal granisetron and nasal applicator
PT105058B (pt) * 2010-04-21 2013-04-17 Hovione Farmaciencia S A Processo para processamento de partículas de ingredientes activos farmacêuticos
CA2840401C (en) * 2011-07-08 2016-05-17 Pfizer Limited Process for the preparation of fluticasone propionate form 1
CN102366405A (zh) * 2011-10-21 2012-03-07 江阴长风医药科技有限公司 以氢氟烷烃为抛射剂的氟替卡松丙酸酯气雾剂制剂
DK3181128T3 (da) * 2012-01-13 2023-06-06 Xspray Pharma Ab Publ Farmaceutisk nilotinib-sammensætning
BR112014027681B8 (pt) 2012-05-08 2023-10-31 Aciex Therapeutics Inc Nanocristais de propionato de fluticasona, composição tópica farmacêutica compreendendo os mesmos, seu uso e método de fabricação
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
EP2705838A1 (en) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
US9815865B2 (en) 2013-01-07 2017-11-14 Nicox Ophthalmics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
CN105338965A (zh) * 2013-04-29 2016-02-17 赛诺菲股份有限公司 可吸入药用组合物和含有该药用组合物的吸入器装置
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CN110960504A (zh) * 2019-10-31 2020-04-07 上海新黄河制药有限公司 中空颗粒制备方法及干粉吸入制剂
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Also Published As

Publication number Publication date
KR20020047322A (ko) 2002-06-21
JP2003512892A (ja) 2003-04-08
DE60012558T2 (de) 2005-07-28
SI1225875T1 (en) 2004-12-31
PT1225875E (pt) 2004-12-31
HUP0203278A3 (en) 2004-06-28
CN1409627A (zh) 2003-04-09
AU768915B2 (en) 2004-01-08
ES2225247T3 (es) 2005-03-16
MXPA02004394A (es) 2002-09-02
WO2001032125A3 (en) 2002-05-16
BR0015271A (pt) 2002-12-31
ZA200203434B (en) 2003-02-25
GB9925934D0 (en) 1999-12-29
GB0024511D0 (en) 2000-11-22
DK1225875T3 (da) 2004-11-22
CA2389908A1 (en) 2001-05-10
WO2001032125A2 (en) 2001-05-10
HK1045268B (zh) 2005-02-18
PL356746A1 (en) 2004-06-28
EP1225875A2 (en) 2002-07-31
DE60012558D1 (de) 2004-09-02
NO20022059L (no) 2002-06-14
NO20022059D0 (no) 2002-04-30
JP4700247B2 (ja) 2011-06-15
EP1466595A1 (en) 2004-10-13
IL149366A0 (en) 2002-11-10
HK1045268A1 (en) 2002-11-22
AU1160401A (en) 2001-05-14
CZ20021555A3 (cs) 2002-11-13
ATE271853T1 (de) 2004-08-15
NZ518565A (en) 2004-04-30
TR200402709T4 (tr) 2004-11-22
EP1225875B1 (en) 2004-07-28

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