KR840000226A - 신규한 형태의 의약품의 제조방법 - Google Patents

신규한 형태의 의약품의 제조방법 Download PDF

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Publication number
KR840000226A
KR840000226A KR1019820003319A KR820003319A KR840000226A KR 840000226 A KR840000226 A KR 840000226A KR 1019820003319 A KR1019820003319 A KR 1019820003319A KR 820003319 A KR820003319 A KR 820003319A KR 840000226 A KR840000226 A KR 840000226A
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South Korea
Prior art keywords
particles
drug
spray drying
product particles
density
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KR1019820003319A
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English (en)
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KR890002908B1 (ko
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브리안 포레스터 레이몬드 (외 1)
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에프 머피
피존츠 피엘시
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Application filed by 에프 머피, 피존츠 피엘시 filed Critical 에프 머피
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

신규한 형태의 의약품의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 의약품의 용액을 분무 건조시켜서 직경이 60미크론 이하인 입자들의 일부 또는 전부를 수집하여 조립(組立) 담체와 웅괴되지도 않고 혼합되지도 않는 대다수의 입자들을 자동충전기에서 캡슐에 충진시키고 열려진 상태의 캡슐로 부터 흡입기에 약제를 흡인시킬 수 있도록 하여 폐(肺)에 깊이 침투될 수 있는 각 의약품의 입자들을 치료학적으로 효과적인 비율로 구성함을 특징으로 하는 미세분말로 된 흡입성 의약품의 제조방법.
  2. 제1항에 있어서, 각 의약품 입자들의 대부분이 구형, 붕괴된 구형 또는 링 도우넛형을 갖는 것을 특징으로 하는 방법.
  3. 제2항에 있어서, 의약품이 나트륨 크로글리케이트이고 그 입자들이 링도우넛형을 갖는 것을 특징으로 하는 방법.
  4. 전항들중에 어느 한항에 있어서, 제품입자들의 침투성 : BET 비율이 0.5 내지 1.0 범위인 것을 특징으로 하는 방법.
  5. 전항들중에 어느 한항에 있어서, 제품입자들의 입자밀도가 1.3 내지 1.7g/㎤ 인 것을 특징으로 하는 방법.
  6. 전항들중에 어느 한항에 있어서, 제품입자들이 0.3g/㎤ 이상의 소괴(燒塊) 밀도를 갖는 것을 특징으로 하는 방법.
  7. 전항들중에 어느 한항에 있어서, 제품입자들이 0.4 내지 0.75g/㎤의 치밀한 괴상밀도를 갖는 것을 특징으로 하는 방법.
  8. 전항들중에 어느 한항에 있어서, 의약품이 나트륨 크로몰리케이트와 기관지 확장제의 혼합물인 것을 특징으로 하는 방법.
  9. 전항들중에 어느 한항에 있어서, 의약품 입자들의 직경이 적어도 50% 이상이 10미크론 이하인 것을 특징으로 하는 방법.
  10. 전항들중에 어느 한항에 있어서, 분무건조를 분무기, 본실 및 적어도 한개 이상의 사이클론 또는 자루형 여과기들로 구성되는 분무식 건조장치 내에서 실시함을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8203319A 1981-07-24 1982-07-24 흡입 약품의 제조 방법 KR890002908B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8122846 1981-07-24
GB8122846 1981-07-24

Publications (2)

Publication Number Publication Date
KR840000226A true KR840000226A (ko) 1984-02-18
KR890002908B1 KR890002908B1 (ko) 1989-08-11

Family

ID=10523464

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8203319A KR890002908B1 (ko) 1981-07-24 1982-07-24 흡입 약품의 제조 방법

Country Status (26)

Country Link
US (1) US4590206A (ko)
EP (1) EP0072046B1 (ko)
JP (1) JPS5859914A (ko)
KR (1) KR890002908B1 (ko)
AU (1) AU540826B2 (ko)
BE (1) BE893912A (ko)
CA (1) CA1187415A (ko)
CH (1) CH657273A5 (ko)
DE (1) DE3268533D1 (ko)
DK (1) DK159716C (ko)
FI (1) FI822548L (ko)
FR (1) FR2510405B1 (ko)
GR (1) GR76229B (ko)
HK (1) HK10088A (ko)
HU (1) HU196904B (ko)
IE (1) IE53640B1 (ko)
IL (1) IL66375A0 (ko)
LU (1) LU84291A1 (ko)
MA (1) MA19548A1 (ko)
MY (1) MY8700857A (ko)
NO (1) NO156394C (ko)
NZ (1) NZ201341A (ko)
PH (1) PH22759A (ko)
PT (1) PT75310B (ko)
SG (1) SG68487G (ko)
ZA (1) ZA825222B (ko)

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Also Published As

Publication number Publication date
IE821770L (en) 1983-01-24
AU540826B2 (en) 1984-12-06
FI822548L (fi) 1983-01-25
NO156394C (no) 1987-09-16
PT75310A (en) 1982-08-01
SG68487G (en) 1988-02-19
IE53640B1 (en) 1989-01-04
DK159716C (da) 1991-04-29
FI822548A0 (fi) 1982-07-20
JPS5859914A (ja) 1983-04-09
KR890002908B1 (ko) 1989-08-11
EP0072046B1 (en) 1986-01-15
CA1187415A (en) 1985-05-21
MA19548A1 (fr) 1983-04-01
NO822556L (no) 1983-01-25
US4590206A (en) 1986-05-20
FR2510405A1 (fr) 1983-02-04
HK10088A (en) 1988-02-12
BE893912A (fr) 1983-01-24
DK159716B (da) 1990-11-26
NZ201341A (en) 1985-05-31
PH22759A (en) 1988-12-12
LU84291A1 (fr) 1983-02-07
HU196904B (en) 1989-02-28
MY8700857A (en) 1987-12-31
IL66375A0 (en) 1982-11-30
CH657273A5 (fr) 1986-08-29
FR2510405B1 (fr) 1985-07-26
NO156394B (no) 1987-06-09
PT75310B (en) 1985-11-29
GR76229B (ko) 1984-08-04
JPH0468285B2 (ko) 1992-11-02
EP0072046A1 (en) 1983-02-16
DK325982A (da) 1983-01-25
ZA825222B (en) 1983-05-25
DE3268533D1 (en) 1986-02-27
AU8635582A (en) 1983-02-10

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