HUP0000755A2 - Terbutalin-szulfátot tartalmazó, 0,28-0,38 g/ml szórósűrűségű, új inhalációs gyógyszerforma, eljárás előállítására és alkalmazása - Google Patents

Terbutalin-szulfátot tartalmazó, 0,28-0,38 g/ml szórósűrűségű, új inhalációs gyógyszerforma, eljárás előállítására és alkalmazása

Info

Publication number
HUP0000755A2
HUP0000755A2 HU0000755A HUP0000755A HUP0000755A2 HU P0000755 A2 HUP0000755 A2 HU P0000755A2 HU 0000755 A HU0000755 A HU 0000755A HU P0000755 A HUP0000755 A HU P0000755A HU P0000755 A2 HUP0000755 A2 HU P0000755A2
Authority
HU
Hungary
Prior art keywords
formulation
bulk density
inhalation
preparing
terbutaline sulphate
Prior art date
Application number
HU0000755A
Other languages
English (en)
Inventor
Jan Trofast
Original Assignee
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag
Publication of HUP0000755A2 publication Critical patent/HUP0000755A2/hu
Publication of HUP0000755A3 publication Critical patent/HUP0000755A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)

Abstract

A találmány tárgyát új inhalációs gyógyszerforma, amely terbutalin-szulfát és egy hordozó alapvetően egyenletes, finom eloszlású,mikronizált részecskéit tartalmazó, 0,28-0,38 g/ml szórási sűrűségűporkészítmény, az előállítására szolgáló eljárás -, amelyben a) aterbutalin-szulfátot és a hordozót mikronizálják, b) adott esetben aterméket kondicionálják; és c) a porkeveréket szferonizálják, amíg akívánt térfogatsűrűséget elérik - és a porkészítmény gyógyászatialkalmazása képezi. Ó
HU0000755A 1997-01-20 1998-01-13 New formulation for inhalation having a poured bulk density of from 0,28 to 0,38 g/ml, comprising terbutaline sulphate, a process for preparing the formulation and the use thereof HUP0000755A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9700136A SE9700136D0 (sv) 1997-01-20 1997-01-20 New formulation
PCT/SE1998/000041 WO1998031353A1 (en) 1997-01-20 1998-01-13 New formulation for inhalation having a poured bulk density of from 0.28 to 0.38 g/ml, comprising terbutaline sulphate, a process for preparing the formulation and the use thereof

Publications (2)

Publication Number Publication Date
HUP0000755A2 true HUP0000755A2 (hu) 2000-10-28
HUP0000755A3 HUP0000755A3 (en) 2001-03-28

Family

ID=20405456

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0000755A HUP0000755A3 (en) 1997-01-20 1998-01-13 New formulation for inhalation having a poured bulk density of from 0,28 to 0,38 g/ml, comprising terbutaline sulphate, a process for preparing the formulation and the use thereof

Country Status (30)

Country Link
EP (1) EP1014955B1 (hu)
JP (1) JP2001509812A (hu)
KR (1) KR100528415B1 (hu)
CN (1) CN1195507C (hu)
AT (1) ATE263552T1 (hu)
AU (1) AU728768B2 (hu)
BE (1) BE1012009A5 (hu)
BR (1) BR9806893A (hu)
CA (1) CA2277891C (hu)
CZ (1) CZ295665B6 (hu)
DE (1) DE69823045T2 (hu)
EE (1) EE03950B1 (hu)
ES (2) ES2217535T3 (hu)
FR (1) FR2759905B1 (hu)
GR (1) GR980100023A (hu)
HU (1) HUP0000755A3 (hu)
ID (1) ID21929A (hu)
IE (1) IE980026A1 (hu)
IL (1) IL130839A (hu)
IS (1) IS2072B (hu)
NL (1) NL1008020C2 (hu)
NO (1) NO993540L (hu)
NZ (1) NZ336595A (hu)
PL (1) PL189551B1 (hu)
RU (1) RU2180562C2 (hu)
SE (1) SE9700136D0 (hu)
SK (1) SK283943B6 (hu)
TR (1) TR199901689T2 (hu)
UA (1) UA57765C2 (hu)
WO (1) WO1998031353A1 (hu)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI991582A1 (it) 1999-07-16 2001-01-16 Chiesi Farma Spa Polveri costituite da particelle aventi la superficie perfettamente levigata da utilizzare come veicoli per la preparazione di miscele inala
JP2001151673A (ja) * 1999-09-06 2001-06-05 Nikken Chem Co Ltd 吸入用粉末製剤の製造方法
GB0009469D0 (en) 2000-04-17 2000-06-07 Vectura Ltd Improvements in or relating to formalities for use in inhaler devices
PE20011227A1 (es) 2000-04-17 2002-01-07 Chiesi Farma Spa Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros
GB0012261D0 (en) * 2000-05-19 2000-07-12 Astrazeneca Ab Novel process
SE0200657D0 (sv) * 2002-03-04 2002-03-04 Astrazeneca Ab Novel Formulation
GB0219511D0 (en) 2002-08-21 2002-10-02 Norton Healthcare Ltd Method of preparing dry powder inhalation compositions
EP1599209B1 (en) 2002-08-21 2011-08-17 Norton Healthcare Limited Inhalation composition
DE102007049931A1 (de) 2007-10-18 2009-04-23 Pharmatech Gmbh Vorrichtung und Verfahren zur kontinuierlichen Herstellung von sphärischen Pulveragglomeraten
EP2255807A1 (en) 2009-05-26 2010-12-01 Sanofi-Aventis Method of treating sleep disorders using the combination of eplivanserin and zolpidem
US20110262502A1 (en) * 2010-02-08 2011-10-27 Prairie Pharmaceuticals LLC Pulmonary delivery of 17-hydroxyprogesterone caproate (17-hpc)
GB201305825D0 (en) 2013-03-28 2013-05-15 Vectura Ltd New use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0072046B1 (en) * 1981-07-24 1986-01-15 FISONS plc Inhalation drugs, methods for their production and pharmaceutical formulations containing them
ATE17441T1 (de) * 1981-07-24 1986-02-15 Fisons Plc Inhalierbare arzneimittel, verfahren zu deren herstellung und pharmazeutische formulierungen diese enthaltend.
IL111080A (en) * 1993-10-01 1999-08-17 Astra Ab Method for treating a finely divided powder medicament
SE9603669D0 (sv) * 1996-10-08 1996-10-08 Astra Ab New combination

Also Published As

Publication number Publication date
NZ336595A (en) 2001-01-26
HUP0000755A3 (en) 2001-03-28
CZ295665B6 (cs) 2005-09-14
CN1195507C (zh) 2005-04-06
BE1012009A5 (fr) 2000-04-04
CA2277891C (en) 2006-08-29
TR199901689T2 (xx) 1999-09-21
IL130839A (en) 2004-12-15
WO1998031353A1 (en) 1998-07-23
IS5107A (is) 1999-07-06
FR2759905B1 (fr) 2001-03-09
ID21929A (id) 1999-08-12
IS2072B (is) 2005-12-15
NL1008020C2 (nl) 2000-01-18
KR100528415B1 (ko) 2005-11-15
CA2277891A1 (en) 1998-07-23
SK96099A3 (en) 2000-01-18
FR2759905A1 (fr) 1998-08-28
SE9700136D0 (sv) 1997-01-20
ES2149083A1 (es) 2000-10-16
NL1008020A1 (nl) 1998-07-22
ATE263552T1 (de) 2004-04-15
JP2001509812A (ja) 2001-07-24
AU5786098A (en) 1998-08-07
RU2180562C2 (ru) 2002-03-20
CZ255899A3 (cs) 1999-10-13
DE69823045T2 (de) 2004-10-21
EE9900293A (et) 2000-02-15
NO993540D0 (no) 1999-07-19
SK283943B6 (sk) 2004-05-04
NO993540L (no) 1999-09-20
UA57765C2 (uk) 2003-07-15
GR980100023A (el) 1998-09-30
EE03950B1 (et) 2003-02-17
EP1014955B1 (en) 2004-04-07
ES2217535T3 (es) 2004-11-01
PL189551B1 (pl) 2005-08-31
PL334526A1 (en) 2000-02-28
KR20000070189A (ko) 2000-11-25
DE69823045D1 (de) 2004-05-13
IL130839A0 (en) 2001-01-28
ES2149083B1 (es) 2001-05-16
BR9806893A (pt) 2000-05-16
CN1244120A (zh) 2000-02-09
AU728768B2 (en) 2001-01-18
IE980026A1 (en) 1998-10-07
EP1014955A1 (en) 2000-07-05

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