IE45260L - Particulate medicament - Google Patents
Particulate medicamentInfo
- Publication number
- IE45260L IE45260L IE770014A IE1477A IE45260L IE 45260 L IE45260 L IE 45260L IE 770014 A IE770014 A IE 770014A IE 1477 A IE1477 A IE 1477A IE 45260 L IE45260 L IE 45260L
- Authority
- IE
- Ireland
- Prior art keywords
- esp
- granules
- inhalation
- devices
- tablets
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
New medicaments in the form of soft tablets of granules 10-1000 mu in dia. comprise an agglomeration of medicament particles of which =90% have a dia. of 10 mu. The tablets or granules have (a) a total transmitted load redn. (TTLR) of >100 g., and/or (b) a prod. of the TTLR and the response lag (RL exceeding 30 g./cm, and/or (c) an RL of >=0.3 cm. Pref. new medicaments are inhalation medicaments for the treatment of allergic disorders of the respiratory tract, esp. those contg. a pharmaceutically acceptable salt of 1, 3-bis(2-carboxychromon-5-yloxy)propan-2-ol, esp. disodium chromoglycate. Disodium chromoglycate contG. 12-25% water is claimed as a novel entity. Also claimed is disodium chromoglycate in tablet or granule form with an unstamped bulk density of below 0.3 g;/cc. (esp. 0.2-0.3 g./cc). The new granules or tablets are suitable for filling into devices of the "Spinhlaer" (RTM) type. Under the conditions in such devices at the time of inhalation, they break down into fine particles with good flow properties giving good inhalation. However, their agglomerated form facilitates filling into the capsules used in the devices.
[FR2361104A2]
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE1844/80A IE45262B1 (en) | 1976-01-23 | 1977-01-05 | Disodium cromoglycate in a novel from |
| IE1843/80A IE45261B1 (en) | 1976-01-23 | 1977-01-05 | Disodium cromoglycate pellets or granules |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB260876 | 1976-01-23 | ||
| GB260676A GB1569611A (en) | 1976-01-23 | 1976-01-23 | Pelletised or granular medicament formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE45260L true IE45260L (en) | 1977-07-23 |
| IE45260B1 IE45260B1 (en) | 1982-07-28 |
Family
ID=26237614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE14/77A IE45260B1 (en) | 1976-01-23 | 1977-01-05 | Pelletised or granular medicament formulation |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS5294413A (en) |
| AU (1) | AU506878B2 (en) |
| CA (1) | CA1116516A (en) |
| DK (1) | DK27177A (en) |
| ES (1) | ES455273A1 (en) |
| FI (1) | FI67663C (en) |
| FR (1) | FR2361104A2 (en) |
| IE (1) | IE45260B1 (en) |
| LU (1) | LU76618A1 (en) |
| NO (1) | NO148542C (en) |
| SE (1) | SE442950B (en) |
| ZA (1) | ZA77327B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3268533D1 (en) * | 1981-07-24 | 1986-02-27 | Fisons Plc | Inhalation drugs, methods for their production and pharmaceutical formulations containing them |
| US6102036A (en) * | 1994-04-12 | 2000-08-15 | Smoke-Stop | Breath activated inhaler |
-
1977
- 1977-01-05 IE IE14/77A patent/IE45260B1/en not_active IP Right Cessation
- 1977-01-11 FI FI770070A patent/FI67663C/en not_active IP Right Cessation
- 1977-01-20 FR FR7701501A patent/FR2361104A2/en active Granted
- 1977-01-20 ZA ZA770327A patent/ZA77327B/en unknown
- 1977-01-21 CA CA000270236A patent/CA1116516A/en not_active Expired
- 1977-01-21 NO NO770198A patent/NO148542C/en unknown
- 1977-01-21 LU LU76618A patent/LU76618A1/xx unknown
- 1977-01-21 DK DK27177A patent/DK27177A/en not_active Application Discontinuation
- 1977-01-21 SE SE7700665A patent/SE442950B/en not_active IP Right Cessation
- 1977-01-22 ES ES455273A patent/ES455273A1/en not_active Expired
- 1977-01-24 JP JP597877A patent/JPS5294413A/en active Granted
- 1977-01-24 AU AU21589/77A patent/AU506878B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2158977A (en) | 1978-08-03 |
| FI67663C (en) | 1985-05-10 |
| IE45260B1 (en) | 1982-07-28 |
| NO770198L (en) | 1977-07-26 |
| FR2361104B2 (en) | 1982-09-17 |
| FR2361104A2 (en) | 1978-03-10 |
| NO148542C (en) | 1983-11-02 |
| DK27177A (en) | 1977-07-24 |
| SE442950B (en) | 1986-02-10 |
| AU506878B2 (en) | 1980-01-24 |
| LU76618A1 (en) | 1977-08-12 |
| SE7700665L (en) | 1977-07-24 |
| CA1116516A (en) | 1982-01-19 |
| JPS5294413A (en) | 1977-08-09 |
| FI67663B (en) | 1985-01-31 |
| NO148542B (en) | 1983-07-25 |
| ES455273A1 (en) | 1978-04-01 |
| FI770070A (en) | 1977-07-24 |
| ZA77327B (en) | 1977-12-28 |
| JPS6228124B2 (en) | 1987-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK9A | Patent expired |