FR2361104B2 - - Google Patents

Info

Publication number
FR2361104B2
FR2361104B2 FR7701501A FR7701501A FR2361104B2 FR 2361104 B2 FR2361104 B2 FR 2361104B2 FR 7701501 A FR7701501 A FR 7701501A FR 7701501 A FR7701501 A FR 7701501A FR 2361104 B2 FR2361104 B2 FR 2361104B2
Authority
FR
France
Prior art keywords
hereinafter defined
pellet
medicament
cms
pellets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7701501A
Other languages
French (fr)
Other versions
FR2361104A2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fisons Ltd
Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB260676A external-priority patent/GB1569611A/en
Application filed by Fisons Ltd filed Critical Fisons Ltd
Publication of FR2361104A2 publication Critical patent/FR2361104A2/en
Application granted granted Critical
Publication of FR2361104B2 publication Critical patent/FR2361104B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient

Abstract

BA 2606/76 MEDICAMENT COMPOSITION IN SOFT PELLET OR GRANULE FORM There is described a medicament in pellet or granule form, wherein the pellet or granule is soft, is from 10 to 1,000, preferably 30 to 500, microns in diameter and comprises an agglomeration of individual medicament particles, at least 90% and preferably at least 95% by weight of which have a diameter of less than 10 microns, characterised in that the pellets or granules have (i) a 'Total Transmitted Load Reduction' (as hereinafter defined) of greater than 100 gms, or (ii) a product of 'Total Transmitted Load Reduction' (as hereinafter defined) and 'Response Lag' (as hereinafter defined) of greater than 30 g/cms, or (iii) a 'Response Lag' (as hereinafter defined) of at least 0.3 cms. The pellets and granules are particularly suitable for inhalation, e.g. in the treatment of asthma or hay fever.
FR7701501A 1976-01-23 1977-01-20 Soft tablets or granules for inhalation administration - of e.g. disodium cromoglycate Granted FR2361104A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB260676A GB1569611A (en) 1976-01-23 1976-01-23 Pelletised or granular medicament formulation
GB260876 1976-01-23

Publications (2)

Publication Number Publication Date
FR2361104A2 FR2361104A2 (en) 1978-03-10
FR2361104B2 true FR2361104B2 (en) 1982-09-17

Family

ID=26237614

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7701501A Granted FR2361104A2 (en) 1976-01-23 1977-01-20 Soft tablets or granules for inhalation administration - of e.g. disodium cromoglycate

Country Status (12)

Country Link
JP (1) JPS5294413A (en)
AU (1) AU506878B2 (en)
CA (1) CA1116516A (en)
DK (1) DK27177A (en)
ES (1) ES455273A1 (en)
FI (1) FI67663C (en)
FR (1) FR2361104A2 (en)
IE (1) IE45260B1 (en)
LU (1) LU76618A1 (en)
NO (1) NO148542C (en)
SE (1) SE442950B (en)
ZA (1) ZA77327B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0072046B1 (en) * 1981-07-24 1986-01-15 FISONS plc Inhalation drugs, methods for their production and pharmaceutical formulations containing them
US6102036A (en) * 1994-04-12 2000-08-15 Smoke-Stop Breath activated inhaler

Also Published As

Publication number Publication date
NO770198L (en) 1977-07-26
NO148542C (en) 1983-11-02
AU2158977A (en) 1978-08-03
ZA77327B (en) 1977-12-28
DK27177A (en) 1977-07-24
JPS6228124B2 (en) 1987-06-18
NO148542B (en) 1983-07-25
FI770070A (en) 1977-07-24
FI67663C (en) 1985-05-10
AU506878B2 (en) 1980-01-24
CA1116516A (en) 1982-01-19
SE442950B (en) 1986-02-10
LU76618A1 (en) 1977-08-12
JPS5294413A (en) 1977-08-09
IE45260B1 (en) 1982-07-28
IE45260L (en) 1977-07-23
ES455273A1 (en) 1978-04-01
FI67663B (en) 1985-01-31
FR2361104A2 (en) 1978-03-10
SE7700665L (en) 1977-07-24

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Legal Events

Date Code Title Description
CA Change of address
CD Change of name or company name