ES455273A1 - Soft pellet or granular medicine - Google Patents

Soft pellet or granular medicine

Info

Publication number
ES455273A1
ES455273A1 ES455273A ES455273A ES455273A1 ES 455273 A1 ES455273 A1 ES 455273A1 ES 455273 A ES455273 A ES 455273A ES 455273 A ES455273 A ES 455273A ES 455273 A1 ES455273 A1 ES 455273A1
Authority
ES
Spain
Prior art keywords
esp
granules
inhalation
devices
tablets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES455273A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fisons Ltd
Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB260676A external-priority patent/GB1569611A/en
Application filed by Fisons Ltd filed Critical Fisons Ltd
Publication of ES455273A1 publication Critical patent/ES455273A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

New medicaments in the form of soft tablets of granules 10-1000 mu in dia. comprise an agglomeration of medicament particles of which =90% have a dia. of 10 mu. The tablets or granules have (a) a total transmitted load redn. (TTLR) of >100 g., and/or (b) a prod. of the TTLR and the response lag (RL exceeding 30 g./cm, and/or (c) an RL of >=0.3 cm. Pref. new medicaments are inhalation medicaments for the treatment of allergic disorders of the respiratory tract, esp. those contg. a pharmaceutically acceptable salt of 1, 3-bis(2-carboxychromon-5-yloxy)propan-2-ol, esp. disodium chromoglycate. Disodium chromoglycate contG. 12-25% water is claimed as a novel entity. Also claimed is disodium chromoglycate in tablet or granule form with an unstamped bulk density of below 0.3 g/cc. (esp. 0.2-0.3 g./cc). The new granules or tablets are suitable for filling into devices of the "Spinhlaer" (RTM) type. Under the conditions in such devices at the time of inhalation, they break down into fine particles with good flow properties giving good inhalation. However, their agglomerated form facilitates filling into the capsules used in the devices.
ES455273A 1976-01-23 1977-01-22 Soft pellet or granular medicine Expired ES455273A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB260876 1976-01-23
GB260676A GB1569611A (en) 1976-01-23 1976-01-23 Pelletised or granular medicament formulation

Publications (1)

Publication Number Publication Date
ES455273A1 true ES455273A1 (en) 1978-04-01

Family

ID=26237614

Family Applications (1)

Application Number Title Priority Date Filing Date
ES455273A Expired ES455273A1 (en) 1976-01-23 1977-01-22 Soft pellet or granular medicine

Country Status (12)

Country Link
JP (1) JPS5294413A (en)
AU (1) AU506878B2 (en)
CA (1) CA1116516A (en)
DK (1) DK27177A (en)
ES (1) ES455273A1 (en)
FI (1) FI67663C (en)
FR (1) FR2361104A2 (en)
IE (1) IE45260B1 (en)
LU (1) LU76618A1 (en)
NO (1) NO148542C (en)
SE (1) SE442950B (en)
ZA (1) ZA77327B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3268533D1 (en) * 1981-07-24 1986-02-27 Fisons Plc Inhalation drugs, methods for their production and pharmaceutical formulations containing them
US6102036A (en) * 1994-04-12 2000-08-15 Smoke-Stop Breath activated inhaler

Also Published As

Publication number Publication date
DK27177A (en) 1977-07-24
SE7700665L (en) 1977-07-24
JPS5294413A (en) 1977-08-09
FI67663B (en) 1985-01-31
AU2158977A (en) 1978-08-03
IE45260L (en) 1977-07-23
FR2361104B2 (en) 1982-09-17
LU76618A1 (en) 1977-08-12
CA1116516A (en) 1982-01-19
NO770198L (en) 1977-07-26
FI67663C (en) 1985-05-10
IE45260B1 (en) 1982-07-28
FR2361104A2 (en) 1978-03-10
NO148542B (en) 1983-07-25
NO148542C (en) 1983-11-02
FI770070A (en) 1977-07-24
SE442950B (en) 1986-02-10
AU506878B2 (en) 1980-01-24
ZA77327B (en) 1977-12-28
JPS6228124B2 (en) 1987-06-18

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