BR0015271A - Aparelho e processo para a preparação de partìculas cristalinas - Google Patents

Aparelho e processo para a preparação de partìculas cristalinas

Info

Publication number
BR0015271A
BR0015271A BR0015271-4A BR0015271A BR0015271A BR 0015271 A BR0015271 A BR 0015271A BR 0015271 A BR0015271 A BR 0015271A BR 0015271 A BR0015271 A BR 0015271A
Authority
BR
Brazil
Prior art keywords
crystalline particles
mixing chamber
liquid
substance
solvent
Prior art date
Application number
BR0015271-4A
Other languages
English (en)
Inventor
Alan Ronald Ferrie
Andrew Patrick Savage
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BR0015271A publication Critical patent/BR0015271A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/10—Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Oxygen, Ozone, And Oxides In General (AREA)
  • Steroid Compounds (AREA)

Abstract

"APARELHO E PROCESSO PARA A PREPARAçãO DE PARTìCULAS CRISTALINAS". Um aparelho para a preparação de partículas cristalinas de uma substância adequada para terapia por inalação compreender: (i) um primeiro reservatório 3 da substância dissolvida em um solvente líquido; (ii) um segundo reservatório 3 de anti-solvente líquido para a substância, que seja miscível com o solvente líquido; (iii) uma câmara de misturação cilíndrica 2 com primeiro e segundo orifícios de entrada tangencial e um orifício de saída axial; (iv) meios para distribuição do conteúdo do primeiro e segundo reservatórios à câmara de misturação em uma corrente, pelos primeiro e segundo orifícios de entrada, respectivamente, a taxas de fluxo controladas independentes, as correntes de líquido dos orifícios de entrada e saída sendo intimamente misturadas na câmara de misturação cilíndrica mediante formação de um vórtice, causando, dessa forma, a precipitação das partículas cristalinas da substância; e (v) meios 5 para coleta de partículas cristalinas em suspensão na corrente de líquido descarregada pelo orifício de saída da câmara de misturação.
BR0015271-4A 1999-11-03 2000-11-03 Aparelho e processo para a preparação de partìculas cristalinas BR0015271A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9925934.3A GB9925934D0 (en) 1999-11-03 1999-11-03 Novel apparatus and process
GBGB0024511.8A GB0024511D0 (en) 1999-11-03 2000-10-06 Novel apparatus and process
PCT/GB2000/004237 WO2001032125A2 (en) 1999-11-03 2000-11-03 Apparatus and process for preparing crystalline particles

Publications (1)

Publication Number Publication Date
BR0015271A true BR0015271A (pt) 2002-12-31

Family

ID=10863815

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0015271-4A BR0015271A (pt) 1999-11-03 2000-11-03 Aparelho e processo para a preparação de partìculas cristalinas

Country Status (25)

Country Link
EP (2) EP1466595A1 (pt)
JP (1) JP4700247B2 (pt)
KR (1) KR20020047322A (pt)
CN (1) CN1409627A (pt)
AT (1) ATE271853T1 (pt)
AU (1) AU768915B2 (pt)
BR (1) BR0015271A (pt)
CA (1) CA2389908A1 (pt)
CZ (1) CZ20021555A3 (pt)
DE (1) DE60012558T2 (pt)
DK (1) DK1225875T3 (pt)
ES (1) ES2225247T3 (pt)
GB (2) GB9925934D0 (pt)
HK (1) HK1045268B (pt)
HU (1) HUP0203278A3 (pt)
IL (1) IL149366A0 (pt)
MX (1) MXPA02004394A (pt)
NO (1) NO20022059L (pt)
NZ (1) NZ518565A (pt)
PL (1) PL356746A1 (pt)
PT (1) PT1225875E (pt)
SI (1) SI1225875T1 (pt)
TR (1) TR200402709T4 (pt)
WO (1) WO2001032125A2 (pt)
ZA (1) ZA200203434B (pt)

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DE60229255D1 (de) 2001-08-02 2008-11-20 Lg Life Sciences Ltd Verfahren zur herstellung von amino-geschützten 4-aminomethylene-pyrrolidin-3-on-derivaten, gemifloxacin und deren salze
WO2003032951A1 (en) * 2001-08-29 2003-04-24 Dow Global Technologies Inc. A process for preparing crystalline drug particles by means of precipitation
GB0125604D0 (en) * 2001-10-25 2001-12-19 Glaxo Group Ltd Novel process
GB0202564D0 (en) * 2002-02-04 2002-03-20 Glaxo Group Ltd Process
JP3691459B2 (ja) * 2002-06-14 2005-09-07 久光メディカル株式会社 粉末状吸入剤組成物
GB0216700D0 (en) * 2002-07-18 2002-08-28 Astrazeneca Ab Process
GB0300427D0 (en) * 2003-01-09 2003-02-05 Univ Strathclyde Pharmaceutical composition
WO2004073827A1 (en) * 2003-02-21 2004-09-02 The University Of Bath Process for the production of particles
WO2004073729A1 (ja) 2003-02-21 2004-09-02 Translational Research Ltd. 薬物の経鼻投与用組成物
EP2165745A1 (en) * 2003-03-04 2010-03-24 Five Star Technologies, Inc. Hydrodynamic cavitation crystallization device
CA2519287A1 (en) 2003-03-27 2004-10-14 Bioactis Limited Powder medicine applicator for nasal cavity
US9808471B2 (en) * 2003-04-16 2017-11-07 Mylan Specialty Lp Nasal pharmaceutical formulations and methods of using the same
US7811606B2 (en) * 2003-04-16 2010-10-12 Dey, L.P. Nasal pharmaceutical formulations and methods of using the same
US8912174B2 (en) 2003-04-16 2014-12-16 Mylan Pharmaceuticals Inc. Formulations and methods for treating rhinosinusitis
JP2007508240A (ja) * 2003-07-22 2007-04-05 バクスター・インターナショナル・インコーポレイテッド 低分子量有機分子の小球状粒子ならびにその調製方法および使用方法
GB0404586D0 (en) * 2004-03-01 2004-04-07 Britannia Pharmaceuticals Ltd Improvements in or relating to organic materials
US8673360B2 (en) 2004-08-10 2014-03-18 Shin Nippon Biomedical Laboratories, Ltd. Compositions that enable rapid-acting and highly absorptive intranasal administration
WO2006045795A2 (en) * 2004-10-29 2006-05-04 Akzo Nobel N.V. Processes involving the use of antisolvent crystallization
US20090259038A1 (en) * 2004-12-08 2009-10-15 Kuraray Co., Ltd. Process for producing (5alpha7alpha)-3-spiro-2'-(1',3'-dioxolan)-24-oxocholest-22-en-7-yl benzoate
MX2007009656A (es) 2005-02-10 2007-11-07 Glaxo Group Ltd Proceso para elaborar lactosa utilizando tecnicas de clasificacion previa y formulaciones farmaceuticas formadas de la misma.
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
CN101668544B (zh) 2006-12-26 2013-04-24 株式会社新日本科学 经鼻投用制剂
GB0705159D0 (en) * 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals
GB0707938D0 (en) 2007-04-25 2007-05-30 Univ Strathclyde Precipitation stabilising compositions
GB0724498D0 (en) 2007-12-15 2008-01-30 Univ Strathclyde Slow release compositions
MX2011000410A (es) 2008-07-18 2011-03-24 Prosonix Ltd Proceso para mejorar la cristalinidad de particulas de fluticasona.
EP2429495A4 (en) 2009-05-15 2014-01-22 Shin Nippon Biomedical Lab Ltd INTRANASAL PHARMACEUTICAL COMPOSITIONS WITH ENHANCED PHARMACOKINETICS
WO2011013003A2 (en) 2009-07-31 2011-02-03 Shin Nippon Biomedical Laboratories, Ltd. Intranasal granisetron and nasal applicator
PT105058B (pt) 2010-04-21 2013-04-17 Hovione Farmaciencia S A Processo para processamento de partículas de ingredientes activos farmacêuticos
AU2012282936B2 (en) * 2011-07-08 2016-11-10 Pfizer Limited Process for the preparation of fluticasone propionate form 1
CN102366405A (zh) * 2011-10-21 2012-03-07 江阴长风医药科技有限公司 以氢氟烷烃为抛射剂的氟替卡松丙酸酯气雾剂制剂
EP2802314B1 (en) * 2012-01-13 2020-11-25 XSpray Microparticles AB A method for producing stable, amorphous hybrid nanoparticles comprising at least one protein kinase inhibitor and at least one polymeric stabilizing and matrix- forming component.
EP2847207B1 (en) 2012-05-08 2019-03-27 Nicox Ophthalmics, Inc. Fluticasone propionate nanocrystals
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
EP2705838A1 (en) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
US9815865B2 (en) 2013-01-07 2017-11-14 Nicox Ophthalmics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
CA2910697A1 (en) * 2013-04-29 2014-11-06 Sanofi Sa Inhalable pharmaceutical compositions and the inhaler devices containing them
PT108368B (pt) * 2015-03-31 2018-11-05 Hovione Farm S A Produção contínua de partículas
PT108885B (pt) * 2015-10-12 2019-02-13 Hovione Farm S A Método de produção de partículas compósitas inaláveis mediante a utilização de um atomizador de três fluidos
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
CN110960504A (zh) * 2019-10-31 2020-04-07 上海新黄河制药有限公司 中空颗粒制备方法及干粉吸入制剂
AU2021341829A1 (en) * 2020-09-08 2023-04-06 BioNTech SE Systems and methods for producing pharmaceutical compositions using peristaltic pumps and dampeners
CN112755301B (zh) * 2021-01-20 2022-03-29 孙洪坤 一种血液病造血干细胞移植用皮肤清洁器

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Also Published As

Publication number Publication date
HUP0203278A2 (hu) 2003-01-28
TR200402709T4 (tr) 2004-11-22
EP1466595A1 (en) 2004-10-13
DE60012558D1 (de) 2004-09-02
CA2389908A1 (en) 2001-05-10
SI1225875T1 (en) 2004-12-31
NO20022059D0 (no) 2002-04-30
PL356746A1 (en) 2004-06-28
IL149366A0 (en) 2002-11-10
GB9925934D0 (en) 1999-12-29
AU768915B2 (en) 2004-01-08
EP1225875B1 (en) 2004-07-28
DK1225875T3 (da) 2004-11-22
DE60012558T2 (de) 2005-07-28
HK1045268A1 (en) 2002-11-22
GB0024511D0 (en) 2000-11-22
ES2225247T3 (es) 2005-03-16
HK1045268B (zh) 2005-02-18
CN1409627A (zh) 2003-04-09
MXPA02004394A (es) 2002-09-02
HUP0203278A3 (en) 2004-06-28
ATE271853T1 (de) 2004-08-15
JP2003512892A (ja) 2003-04-08
KR20020047322A (ko) 2002-06-21
WO2001032125A3 (en) 2002-05-16
EP1225875A2 (en) 2002-07-31
JP4700247B2 (ja) 2011-06-15
PT1225875E (pt) 2004-12-31
WO2001032125A2 (en) 2001-05-10
NZ518565A (en) 2004-04-30
NO20022059L (no) 2002-06-14
AU1160401A (en) 2001-05-14
CZ20021555A3 (cs) 2002-11-13
ZA200203434B (en) 2003-02-25

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009.