SI1225875T1 - Apparatus and process for preparing crystalline particles - Google Patents

Apparatus and process for preparing crystalline particles

Info

Publication number
SI1225875T1
SI1225875T1 SI200030500T SI200030500T SI1225875T1 SI 1225875 T1 SI1225875 T1 SI 1225875T1 SI 200030500 T SI200030500 T SI 200030500T SI 200030500 T SI200030500 T SI 200030500T SI 1225875 T1 SI1225875 T1 SI 1225875T1
Authority
SI
Slovenia
Prior art keywords
mixing chamber
crystalline particles
substance
liquid
reservoir
Prior art date
Application number
SI200030500T
Other languages
English (en)
Slovenian (sl)
Inventor
Alan Ronald Ferrie
Andrew Patrick Savage
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of SI1225875T1 publication Critical patent/SI1225875T1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/10—Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Oxygen, Ozone, And Oxides In General (AREA)
  • Steroid Compounds (AREA)
SI200030500T 1999-11-03 2000-11-03 Apparatus and process for preparing crystalline particles SI1225875T1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9925934.3A GB9925934D0 (en) 1999-11-03 1999-11-03 Novel apparatus and process
GBGB0024511.8A GB0024511D0 (en) 1999-11-03 2000-10-06 Novel apparatus and process
PCT/GB2000/004237 WO2001032125A2 (en) 1999-11-03 2000-11-03 Apparatus and process for preparing crystalline particles
EP00973049A EP1225875B1 (en) 1999-11-03 2000-11-03 Apparatus and process for preparing crystalline particles

Publications (1)

Publication Number Publication Date
SI1225875T1 true SI1225875T1 (en) 2004-12-31

Family

ID=10863815

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200030500T SI1225875T1 (en) 1999-11-03 2000-11-03 Apparatus and process for preparing crystalline particles

Country Status (25)

Country Link
EP (2) EP1466595A1 (pl)
JP (1) JP4700247B2 (pl)
KR (1) KR20020047322A (pl)
CN (1) CN1409627A (pl)
AT (1) ATE271853T1 (pl)
AU (1) AU768915B2 (pl)
BR (1) BR0015271A (pl)
CA (1) CA2389908A1 (pl)
CZ (1) CZ20021555A3 (pl)
DE (1) DE60012558T2 (pl)
DK (1) DK1225875T3 (pl)
ES (1) ES2225247T3 (pl)
GB (2) GB9925934D0 (pl)
HK (1) HK1045268B (pl)
HU (1) HUP0203278A3 (pl)
IL (1) IL149366A0 (pl)
MX (1) MXPA02004394A (pl)
NO (1) NO20022059L (pl)
NZ (1) NZ518565A (pl)
PL (1) PL356746A1 (pl)
PT (1) PT1225875E (pl)
SI (1) SI1225875T1 (pl)
TR (1) TR200402709T4 (pl)
WO (1) WO2001032125A2 (pl)
ZA (1) ZA200203434B (pl)

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DK1412078T3 (da) 2001-08-02 2009-02-02 Lg Life Sciences Ltd Fremgangsmåde til fremstilling af amino-beskyttede derivater af 4-aminomethylen-pyrrolidin-3-on, Gemifloxacin eller salte deraf
ATE336231T1 (de) * 2001-08-29 2006-09-15 Dow Global Technologies Inc Verfahren zur herstellung kristalliner arzneimittelteilchen durch ausfällung
GB0125604D0 (en) * 2001-10-25 2001-12-19 Glaxo Group Ltd Novel process
GB0202564D0 (en) * 2002-02-04 2002-03-20 Glaxo Group Ltd Process
JP3691459B2 (ja) * 2002-06-14 2005-09-07 久光メディカル株式会社 粉末状吸入剤組成物
GB0216700D0 (en) * 2002-07-18 2002-08-28 Astrazeneca Ab Process
GB0300427D0 (en) * 2003-01-09 2003-02-05 Univ Strathclyde Pharmaceutical composition
EP1610878B1 (en) * 2003-02-21 2014-09-03 University Of Bath Process for the production of particles
US7638138B2 (en) 2003-02-21 2009-12-29 Translational Research, Ltd. Compositions for nasal administration of pharmaceuticals
JP5090729B2 (ja) * 2003-03-04 2012-12-05 ファイブ・スター・テクノロジーズ・インコーポレイテッド 流体力学的キャビテーション結晶化装置および方法
AU2003220808B2 (en) 2003-03-27 2008-08-21 Bioactis Limited Powder medicine applicator for nasal cavity
US8912174B2 (en) 2003-04-16 2014-12-16 Mylan Pharmaceuticals Inc. Formulations and methods for treating rhinosinusitis
US7811606B2 (en) * 2003-04-16 2010-10-12 Dey, L.P. Nasal pharmaceutical formulations and methods of using the same
US9808471B2 (en) * 2003-04-16 2017-11-07 Mylan Specialty Lp Nasal pharmaceutical formulations and methods of using the same
US20050048127A1 (en) * 2003-07-22 2005-03-03 Larry Brown Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof
GB0404586D0 (en) * 2004-03-01 2004-04-07 Britannia Pharmaceuticals Ltd Improvements in or relating to organic materials
JP4922762B2 (ja) 2004-08-10 2012-04-25 株式会社新日本科学 速効性でかつ高い吸収性を可能とする経鼻投与用組成物
WO2006045795A2 (en) * 2004-10-29 2006-05-04 Akzo Nobel N.V. Processes involving the use of antisolvent crystallization
EP1837343A4 (en) * 2004-12-08 2009-07-29 Kuraray Co PROCESS FOR PRODUCING BENZOATE (5 ALPHA, 7 ALPHA) -3-SPIRO-2 '- (1', 3'-DIOXOLAN) -24-OXOCHOLEST-22-EN-7-YLE
RU2007133547A (ru) 2005-02-10 2009-03-20 Глаксо Груп Лимитед (GB) Способы получения лактозы с использованием методов предварительной сортировки и приготовляемые из нее фармацевтические композиции
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
CN101668544B (zh) 2006-12-26 2013-04-24 株式会社新日本科学 经鼻投用制剂
GB0705159D0 (en) 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals
GB0707938D0 (en) 2007-04-25 2007-05-30 Univ Strathclyde Precipitation stabilising compositions
GB0724498D0 (en) 2007-12-15 2008-01-30 Univ Strathclyde Slow release compositions
MX2011000405A (es) 2008-07-18 2011-03-04 Prosonix Ltd Proceso para mejorar la cristalinidad.
EP2429495A4 (en) 2009-05-15 2014-01-22 Shin Nippon Biomedical Lab Ltd INTRANASAL PHARMACEUTICAL COMPOSITIONS WITH ENHANCED PHARMACOKINETICS
WO2011013003A2 (en) 2009-07-31 2011-02-03 Shin Nippon Biomedical Laboratories, Ltd. Intranasal granisetron and nasal applicator
PT105058B (pt) * 2010-04-21 2013-04-17 Hovione Farmaciencia S A Processo para processamento de partículas de ingredientes activos farmacêuticos
JP2014520848A (ja) 2011-07-08 2014-08-25 ファイザー・リミテッド １型プロピオン酸フルチカゾンの調製のための方法
CN102366405A (zh) * 2011-10-21 2012-03-07 江阴长风医药科技有限公司 以氢氟烷烃为抛射剂的氟替卡松丙酸酯气雾剂制剂
FI3181128T3 (fi) * 2012-01-13 2023-06-02 Xspray Pharma Ab Publ Nilotinibin farmaseuttinen koostumus
DK3517541T3 (da) 2012-05-08 2020-09-07 Nicox Ophthalmics Inc Polymorf form af fluticasonpropionat
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
EP2705838A1 (en) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
US9815865B2 (en) 2013-01-07 2017-11-14 Nicox Ophthalmics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
JP2016523823A (ja) * 2013-04-29 2016-08-12 サノフィ・ソシエテ・アノニム 吸入可能な医薬組成物およびこれを含む吸入器デバイス
PT108368B (pt) * 2015-03-31 2018-11-05 Hovione Farm S A Produção contínua de partículas
PT108885B (pt) * 2015-10-12 2019-02-13 Hovione Farm S A Método de produção de partículas compósitas inaláveis mediante a utilização de um atomizador de três fluidos
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
CN110960504A (zh) * 2019-10-31 2020-04-07 上海新黄河制药有限公司 中空颗粒制备方法及干粉吸入制剂
AU2021341829A1 (en) * 2020-09-08 2023-04-06 BioNTech SE Systems and methods for producing pharmaceutical compositions using peristaltic pumps and dampeners
CN112755301B (zh) * 2021-01-20 2022-03-29 孙洪坤 一种血液病造血干细胞移植用皮肤清洁器

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GB8404749D0 (en) 1984-02-23 1984-03-28 Atomic Energy Authority Uk Fluidic contactor
US4826689A (en) * 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
CA1282405C (en) * 1984-05-21 1991-04-02 Michael R. Violante Method for making uniformly sized particles from water-insoluble organic compounds
US4826589A (en) * 1988-06-30 1989-05-02 Gene Hirs Bar screen filter
GB8911259D0 (en) * 1989-05-17 1989-07-05 Fisons Plc Inhalation medicament
GB9004781D0 (en) 1990-03-02 1990-04-25 Glaxo Group Ltd Device
GB9007027D0 (en) 1990-03-29 1990-05-30 Atomic Energy Authority Uk Precipitation apparatus and method
GB9101967D0 (en) 1991-01-30 1991-03-13 Atomic Energy Authority Uk Reagent mixing
GB9320455D0 (en) 1993-10-05 1993-11-24 Atomic Energy Authority Uk Vortex mixer
GB9620187D0 (en) * 1996-09-27 1996-11-13 Minnesota Mining & Mfg Medicinal aerosol formulations

Also Published As

Publication number Publication date
AU768915B2 (en) 2004-01-08
ATE271853T1 (de) 2004-08-15
IL149366A0 (en) 2002-11-10
ES2225247T3 (es) 2005-03-16
CZ20021555A3 (cs) 2002-11-13
GB0024511D0 (en) 2000-11-22
MXPA02004394A (es) 2002-09-02
JP2003512892A (ja) 2003-04-08
KR20020047322A (ko) 2002-06-21
NO20022059D0 (no) 2002-04-30
NZ518565A (en) 2004-04-30
CA2389908A1 (en) 2001-05-10
JP4700247B2 (ja) 2011-06-15
DE60012558D1 (de) 2004-09-02
BR0015271A (pt) 2002-12-31
WO2001032125A2 (en) 2001-05-10
HK1045268A1 (en) 2002-11-22
TR200402709T4 (tr) 2004-11-22
HK1045268B (zh) 2005-02-18
DE60012558T2 (de) 2005-07-28
EP1225875B1 (en) 2004-07-28
PL356746A1 (pl) 2004-06-28
WO2001032125A3 (en) 2002-05-16
PT1225875E (pt) 2004-12-31
ZA200203434B (en) 2003-02-25
HUP0203278A3 (en) 2004-06-28
GB9925934D0 (en) 1999-12-29
HUP0203278A2 (hu) 2003-01-28
EP1225875A2 (en) 2002-07-31
CN1409627A (zh) 2003-04-09
NO20022059L (no) 2002-06-14
EP1466595A1 (en) 2004-10-13
DK1225875T3 (da) 2004-11-22
AU1160401A (en) 2001-05-14

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