PL3532486T3 - Sprzężone z przeciwciałami związki cyklicznego peptydu tyrozyna tyrozyna jako modulatory receptorów neuropeptydowych y - Google Patents
Sprzężone z przeciwciałami związki cyklicznego peptydu tyrozyna tyrozyna jako modulatory receptorów neuropeptydowych yInfo
- Publication number
- PL3532486T3 PL3532486T3 PL17864112T PL17864112T PL3532486T3 PL 3532486 T3 PL3532486 T3 PL 3532486T3 PL 17864112 T PL17864112 T PL 17864112T PL 17864112 T PL17864112 T PL 17864112T PL 3532486 T3 PL3532486 T3 PL 3532486T3
- Authority
- PL
- Poland
- Prior art keywords
- tyrosine
- neuropeptide
- modulators
- receptors
- antibody
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57545—Neuropeptide Y
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- A61K38/22—Hormones
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- C07K—PEPTIDES
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- C—CHEMISTRY; METALLURGY
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- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
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Applications Claiming Priority (4)
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| PCT/US2017/058455 WO2018081370A1 (en) | 2016-10-27 | 2017-10-26 | Antibody-coupled cyclic peptide tyrosine tyrosine compounds as modulators of neuropeptide y receptors |
| EP17864112.2A EP3532486B8 (en) | 2016-10-27 | 2017-10-26 | Antibody-coupled cyclic peptide tyrosine tyrosine compounds as modulators of neuropeptide y receptors |
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| US11780900B2 (en) | 2018-04-25 | 2023-10-10 | Janssen Sciences Ireland Unlimited Company | Glucagon like peptide 1 (GLP-1) fusion peptide coupled cyclic peptide tyrosine tyrosine conjugates and uses thereof |
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| CN114853908B (zh) * | 2019-05-16 | 2024-06-07 | 浙江道尔生物科技有限公司 | 一种治疗代谢疾病的融合蛋白 |
| JPWO2020262590A1 (pl) * | 2019-06-28 | 2020-12-30 | ||
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| AU2020397917A1 (en) * | 2019-12-04 | 2022-06-23 | The Scripps Research Institute | GLP2 receptor agonists and methods of use |
| CN111494606B (zh) * | 2020-04-24 | 2021-12-14 | 广州医科大学 | 神经肽y的新应用 |
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| CN116098987A (zh) * | 2023-02-09 | 2023-05-12 | 华东医院 | 甘丙肽在制备治疗非酒精性脂肪性肝病药物中的用途 |
| CN121064327A (zh) * | 2024-06-03 | 2025-12-05 | 信达生物制药(苏州)有限公司 | Gipr、glp1r和/或gcgr的调节剂及其用途 |
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2021
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2023
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2024
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