EP3532486B8 - Antibody-coupled cyclic peptide tyrosine tyrosine compounds as modulators of neuropeptide y receptors - Google Patents
Antibody-coupled cyclic peptide tyrosine tyrosine compounds as modulators of neuropeptide y receptors Download PDFInfo
- Publication number
- EP3532486B8 EP3532486B8 EP17864112.2A EP17864112A EP3532486B8 EP 3532486 B8 EP3532486 B8 EP 3532486B8 EP 17864112 A EP17864112 A EP 17864112A EP 3532486 B8 EP3532486 B8 EP 3532486B8
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- Prior art keywords
- tyrosine
- neuropeptide
- modulators
- receptors
- antibody
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
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| SI201730982T SI3532486T1 (sl) | 2016-10-27 | 2017-10-26 | S protitelesom spojene ciklične peptidne tirozin-tirozin spojine kot modulatorji nevropeptidnih Y receptorjev |
| EP25160021.9A EP4574166A3 (en) | 2016-10-27 | 2017-10-26 | Antibody-coupled cyclic peptide tyrosine tyrosine compounds as modulators of neuropeptide y receptors |
| EP21198106.3A EP3988123B1 (en) | 2016-10-27 | 2017-10-26 | Antibody-coupled cyclic peptide tyrosine tyrosine compounds as modulators of neuropeptide y receptors |
| PL17864112T PL3532486T3 (pl) | 2016-10-27 | 2017-10-26 | Sprzężone z przeciwciałami związki cyklicznego peptydu tyrozyna tyrozyna jako modulatory receptorów neuropeptydowych y |
| RS20211419A RS62677B1 (sr) | 2016-10-27 | 2017-10-26 | Ciklična jedinjenja tirozin-tirozina uparena sa antitelom kao modulatori neuropeptidnog y receptora |
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| US11780900B2 (en) | 2018-04-25 | 2023-10-10 | Janssen Sciences Ireland Unlimited Company | Glucagon like peptide 1 (GLP-1) fusion peptide coupled cyclic peptide tyrosine tyrosine conjugates and uses thereof |
| TWI847981B (zh) | 2018-04-25 | 2024-07-11 | 比利時商健生藥品公司 | 類升糖素肽1 (glp-1)融合肽偶合環狀酪酪肽接合物及其用途 |
| EP3941936A2 (en) * | 2019-03-19 | 2022-01-26 | Enzene Biosciences Ltd. | Process of preparation of glucagon-like peptide-1 (glp-1) receptor agonists and their analogs |
| CN114853908B (zh) * | 2019-05-16 | 2024-06-07 | 浙江道尔生物科技有限公司 | 一种治疗代谢疾病的融合蛋白 |
| JPWO2020262590A1 (pl) * | 2019-06-28 | 2020-12-30 | ||
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| AU2020397917A1 (en) * | 2019-12-04 | 2022-06-23 | The Scripps Research Institute | GLP2 receptor agonists and methods of use |
| CN111494606B (zh) * | 2020-04-24 | 2021-12-14 | 广州医科大学 | 神经肽y的新应用 |
| UA130066C2 (uk) | 2020-08-07 | 2025-10-29 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Розчинні агоністи рецепторів npy2 |
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| CN115073556A (zh) * | 2021-03-12 | 2022-09-20 | 上海天慈生命科学发展有限公司 | 一类阿片/神经肽ff受体多靶点环肽分子及其制备和应用 |
| MX2023015103A (es) * | 2021-06-14 | 2024-05-29 | Darbix Llc | Agonistas del receptor de glp-1 con propiedades farmacológicas y de suministro de fármacos mejoradas. |
| KR20230004135A (ko) * | 2021-06-30 | 2023-01-06 | 한미약품 주식회사 | 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체를 포함하는 조합물의 치료학적 용도 |
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| CN115028551B (zh) * | 2022-07-15 | 2024-01-05 | 成都普康生物科技有限公司 | 一种叠氮-九甘醇-丙酸的制备方法 |
| CN116098987A (zh) * | 2023-02-09 | 2023-05-12 | 华东医院 | 甘丙肽在制备治疗非酒精性脂肪性肝病药物中的用途 |
| CN121064327A (zh) * | 2024-06-03 | 2025-12-05 | 信达生物制药(苏州)有限公司 | Gipr、glp1r和/或gcgr的调节剂及其用途 |
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