LT3532486T - Prie antikūno prijungti ciklinio peptido-tirozino-tirozino junginiai kaip neuropeptido y receptorių moduliatoriai - Google Patents
Prie antikūno prijungti ciklinio peptido-tirozino-tirozino junginiai kaip neuropeptido y receptorių moduliatoriaiInfo
- Publication number
- LT3532486T LT3532486T LTEPPCT/US2017/058455T LT17058455T LT3532486T LT 3532486 T LT3532486 T LT 3532486T LT 17058455 T LT17058455 T LT 17058455T LT 3532486 T LT3532486 T LT 3532486T
- Authority
- LT
- Lithuania
- Prior art keywords
- tyrosine
- neuropeptide
- modulators
- receptors
- antibody
- Prior art date
Links
- 108010069514 Cyclic Peptides Proteins 0.000 title 1
- 102000001189 Cyclic Peptides Human genes 0.000 title 1
- 108050002826 Neuropeptide Y Receptor Proteins 0.000 title 1
- 102000012301 Neuropeptide Y receptor Human genes 0.000 title 1
- JAQGKXUEKGKTKX-HOTGVXAUSA-N Tyr-Tyr Chemical class C([C@H](N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)C1=CC=C(O)C=C1 JAQGKXUEKGKTKX-HOTGVXAUSA-N 0.000 title 1
Classifications
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- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
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US201662413613P | 2016-10-27 | 2016-10-27 | |
US201662413586P | 2016-10-27 | 2016-10-27 | |
PCT/US2017/058455 WO2018081370A1 (en) | 2016-10-27 | 2017-10-26 | Antibody-coupled cyclic peptide tyrosine tyrosine compounds as modulators of neuropeptide y receptors |
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LT3532486T true LT3532486T (lt) | 2021-11-10 |
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CA (3) | CA3041672A1 (lt) |
CL (3) | CL2019001110A1 (lt) |
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CR (3) | CR20190210A (lt) |
CY (1) | CY1124732T1 (lt) |
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DO (3) | DOP2019000107A (lt) |
EC (3) | ECSP19029995A (lt) |
ES (1) | ES2897480T3 (lt) |
HR (1) | HRP20211626T1 (lt) |
HU (1) | HUE056442T2 (lt) |
IL (4) | IL301843A (lt) |
JO (3) | JOP20190097A1 (lt) |
LT (1) | LT3532486T (lt) |
MA (3) | MA46672A (lt) |
MD (1) | MD3532486T2 (lt) |
MX (6) | MX2019004952A (lt) |
NI (2) | NI201900044A (lt) |
PE (3) | PE20190916A1 (lt) |
PH (3) | PH12019500723A1 (lt) |
PL (1) | PL3532486T3 (lt) |
PT (1) | PT3532486T (lt) |
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SG (4) | SG11201902873RA (lt) |
SI (1) | SI3532486T1 (lt) |
TW (4) | TWI781118B (lt) |
UY (3) | UY37457A (lt) |
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Families Citing this family (12)
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EP3546474B1 (en) | 2013-12-18 | 2021-07-07 | President and Fellows of Harvard College | Crp capture/detection of gram positive bacteria |
JOP20190097A1 (ar) * | 2016-10-27 | 2019-04-28 | Janssen Pharmaceutica Nv | الجلوبولينات المناعية واستخداماتها |
EP3784692A1 (en) | 2018-04-25 | 2021-03-03 | Janssen Pharmaceutica N.V. | Glucagon like peptide 1 (glp-1) fusion peptide coupled cyclic peptide tyrosine tyrosine conjugates and uses thereof |
US11780900B2 (en) | 2018-04-25 | 2023-10-10 | Janssen Sciences Ireland Unlimited Company | Glucagon like peptide 1 (GLP-1) fusion peptide coupled cyclic peptide tyrosine tyrosine conjugates and uses thereof |
JPWO2020262590A1 (lt) * | 2019-06-28 | 2020-12-30 | ||
CA3156452A1 (en) | 2019-11-11 | 2021-05-20 | Boehringer Ingelheim International Gmbh | NPY2 RECEPTOR AGONISTS |
CN111494606B (zh) * | 2020-04-24 | 2021-12-14 | 广州医科大学 | 神经肽y的新应用 |
CR20230074A (es) | 2020-08-07 | 2023-04-19 | Boehringer Ingelheim Int | Agonistas del receptor npy2 solubles |
CN115073556A (zh) * | 2021-03-12 | 2022-09-20 | 上海天慈生命科学发展有限公司 | 一类阿片/神经肽ff受体多靶点环肽分子及其制备和应用 |
AU2022292569A1 (en) * | 2021-06-14 | 2024-01-04 | Darbix Llc | Glp-1 receptor agonists having improved pharmacological and drug delivery properties |
WO2023097363A1 (en) * | 2021-11-30 | 2023-06-08 | Garvan Institute Of Medical Research | Improved binding proteins and uses thereof |
CN115028551B (zh) * | 2022-07-15 | 2024-01-05 | 成都普康生物科技有限公司 | 一种叠氮-九甘醇-丙酸的制备方法 |
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