PL3328844T3 - Pochodne sulfamidu 1,3,4-oksadiazolu jako inhibitor deacetylazy histonowej 6 i zawierająca je kompozycja farmaceutyczna - Google Patents
Pochodne sulfamidu 1,3,4-oksadiazolu jako inhibitor deacetylazy histonowej 6 i zawierająca je kompozycja farmaceutycznaInfo
- Publication number
- PL3328844T3 PL3328844T3 PL16830838T PL16830838T PL3328844T3 PL 3328844 T3 PL3328844 T3 PL 3328844T3 PL 16830838 T PL16830838 T PL 16830838T PL 16830838 T PL16830838 T PL 16830838T PL 3328844 T3 PL3328844 T3 PL 3328844T3
- Authority
- PL
- Poland
- Prior art keywords
- inhibitor
- pharmaceutical composition
- same
- histone deacetylase
- sulfamide derivatives
- Prior art date
Links
- UYJSDFHXPYMBBN-UHFFFAOYSA-N 1,3,4-oxadiazole sulfamide Chemical class NS(N)(=O)=O.c1nnco1 UYJSDFHXPYMBBN-UHFFFAOYSA-N 0.000 title 1
- 229940122617 Histone deacetylase 6 inhibitor Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20150106177 | 2015-07-27 | ||
PCT/KR2016/008218 WO2017018805A1 (en) | 2015-07-27 | 2016-07-27 | 1,3,4-oxadiazole sulfamide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
EP16830838.5A EP3328844B1 (en) | 2015-07-27 | 2016-07-27 | 1,3,4-oxadiazole sulfamide derivatives as histone deacetylase 6 inhibitor and pharmaceutical composition comprising the same |
Publications (1)
Publication Number | Publication Date |
---|---|
PL3328844T3 true PL3328844T3 (pl) | 2020-07-27 |
Family
ID=57885712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL16830838T PL3328844T3 (pl) | 2015-07-27 | 2016-07-27 | Pochodne sulfamidu 1,3,4-oksadiazolu jako inhibitor deacetylazy histonowej 6 i zawierająca je kompozycja farmaceutyczna |
Country Status (22)
Country | Link |
---|---|
US (1) | US10464911B2 (pl) |
EP (1) | EP3328844B1 (pl) |
JP (1) | JP6538266B2 (pl) |
KR (1) | KR101799005B1 (pl) |
CN (1) | CN107980040B (pl) |
AU (1) | AU2016299486B2 (pl) |
BR (1) | BR112017027798B1 (pl) |
CA (1) | CA2987570C (pl) |
DK (1) | DK3328844T3 (pl) |
ES (1) | ES2774510T3 (pl) |
HK (1) | HK1251549A1 (pl) |
HR (1) | HRP20200280T1 (pl) |
HU (1) | HUE048534T2 (pl) |
MX (1) | MX2017017090A (pl) |
MY (1) | MY194018A (pl) |
NZ (1) | NZ736432A (pl) |
PH (1) | PH12017501939B1 (pl) |
PL (1) | PL3328844T3 (pl) |
PT (1) | PT3328844T (pl) |
RU (1) | RU2695227C9 (pl) |
TW (1) | TWI694074B (pl) |
WO (1) | WO2017018805A1 (pl) |
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KR20180002730A (ko) | 2015-05-07 | 2018-01-08 | 씨에이치디아이 파운데이션, 인코포레이티드 | 히스톤 탈아세틸효소 억제제 및 그것의 조성물 및 사용 방법 |
US10053434B2 (en) | 2015-05-07 | 2018-08-21 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
EP3328844B1 (en) | 2015-07-27 | 2019-11-27 | Chong Kun Dang Pharmaceutical Corp. | 1,3,4-oxadiazole sulfamide derivatives as histone deacetylase 6 inhibitor and pharmaceutical composition comprising the same |
MY197262A (en) | 2015-07-27 | 2023-06-08 | Chong Kun Dang Pharmaceutical Corp | 1,3,4-oxadiazole sulfonamide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
PL3330259T3 (pl) | 2015-07-27 | 2021-02-08 | Chong Kun Dang Pharmaceutical Corp. | Związek pochodna amidowa 1,3,4-oksadiazolu jako inhibitor deacetylazy histonowej 6 i kompozycja farmaceutyczna go zawierająca |
MY197738A (en) | 2015-08-04 | 2023-07-12 | Chong Kun Dang Pharmaceutical Corp | 1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
NZ740809A (en) | 2015-10-12 | 2019-04-26 | Chong Kun Dang Pharmaceutical Corp | Oxadiazole amine derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
TW201910328A (zh) * | 2017-07-31 | 2019-03-16 | 日商武田藥品工業股份有限公司 | 雜環化合物 |
KR102059027B1 (ko) * | 2018-01-12 | 2019-12-24 | 주식회사 비엔에이치리서치 | Hdac6 억제제를 유효성분으로 포함하는 가려움증 예방 또는 치료용 약제학적 조성물 |
KR102316234B1 (ko) * | 2018-07-26 | 2021-10-22 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
JP7470058B2 (ja) | 2019-01-30 | 2024-04-17 | 武田薬品工業株式会社 | 複素環化合物 |
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KR102537616B1 (ko) * | 2020-02-25 | 2023-05-26 | 주식회사 종근당 | 히스톤 탈아세틸화 효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
CN116133658A (zh) * | 2020-07-14 | 2023-05-16 | 株式会社 钟根堂 | 作为组蛋白去乙酰酶6抑制剂的新化合物及包含该化合物的药物组合物 |
WO2022029041A1 (en) | 2020-08-07 | 2022-02-10 | Italfarmaco S.P.A. | 2-(4-((5-(benzo[b]thiophen-3-yl)-1h-tetrazol-1-yl)methyl)phenyl)-5-(difluoromethyl)-1,3,4-oxadiazole derivatives and similar compounds as selective inhibitors of histone deacetylase 6 (hdac6) for use in treating e.g. peripheral neuropathy |
KR20240013098A (ko) | 2021-04-23 | 2024-01-30 | 테나야 테라퓨틱스, 인코포레이티드 | 확장성 심근병증의 치료에 사용하기 위한 hdac6 억제제 |
TW202308619A (zh) * | 2021-05-04 | 2023-03-01 | 美商特納亞治療股份有限公司 | 用於治療代謝疾病和hfpef的hdac6抑制劑 |
WO2024017897A1 (en) | 2022-07-19 | 2024-01-25 | Italfarmaco S.P.A. | 1,3,4-oxadiazole derivatives as selective histone deacetylase 6 inhibitors |
WO2024033293A1 (en) | 2022-08-08 | 2024-02-15 | Italfarmaco S.P.A. | Difluoro- and trifluoro-acetyl hydrazides as selective hdac6 inhibitors |
KR20240035172A (ko) * | 2022-09-08 | 2024-03-15 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이의 용도 |
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PL3330259T3 (pl) | 2015-07-27 | 2021-02-08 | Chong Kun Dang Pharmaceutical Corp. | Związek pochodna amidowa 1,3,4-oksadiazolu jako inhibitor deacetylazy histonowej 6 i kompozycja farmaceutyczna go zawierająca |
EP3328844B1 (en) | 2015-07-27 | 2019-11-27 | Chong Kun Dang Pharmaceutical Corp. | 1,3,4-oxadiazole sulfamide derivatives as histone deacetylase 6 inhibitor and pharmaceutical composition comprising the same |
MY197262A (en) * | 2015-07-27 | 2023-06-08 | Chong Kun Dang Pharmaceutical Corp | 1,3,4-oxadiazole sulfonamide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
MY197738A (en) | 2015-08-04 | 2023-07-12 | Chong Kun Dang Pharmaceutical Corp | 1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
NZ740809A (en) | 2015-10-12 | 2019-04-26 | Chong Kun Dang Pharmaceutical Corp | Oxadiazole amine derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
-
2016
- 2016-07-27 EP EP16830838.5A patent/EP3328844B1/en active Active
- 2016-07-27 ES ES16830838T patent/ES2774510T3/es active Active
- 2016-07-27 WO PCT/KR2016/008218 patent/WO2017018805A1/en active Application Filing
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- 2016-07-27 NZ NZ736432A patent/NZ736432A/en unknown
- 2016-07-27 JP JP2018504096A patent/JP6538266B2/ja active Active
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- 2016-07-27 HU HUE16830838A patent/HUE048534T2/hu unknown
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- 2016-07-27 US US15/747,850 patent/US10464911B2/en active Active
- 2016-07-27 TW TW105123853A patent/TWI694074B/zh active
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Publication number | Publication date |
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CA2987570A1 (en) | 2017-02-02 |
KR20170013186A (ko) | 2017-02-06 |
JP6538266B2 (ja) | 2019-07-03 |
CN107980040A (zh) | 2018-05-01 |
BR112017027798B1 (pt) | 2023-12-19 |
RU2695227C1 (ru) | 2019-07-22 |
EP3328844B1 (en) | 2019-11-27 |
BR112017027798A2 (pt) | 2018-08-28 |
HRP20200280T1 (hr) | 2020-05-29 |
MX2017017090A (es) | 2018-12-11 |
PT3328844T (pt) | 2020-03-04 |
JP2018521092A (ja) | 2018-08-02 |
CA2987570C (en) | 2021-06-15 |
CN107980040B (zh) | 2021-11-26 |
US20180230113A1 (en) | 2018-08-16 |
TWI694074B (zh) | 2020-05-21 |
EP3328844A4 (en) | 2018-12-19 |
TW201712007A (zh) | 2017-04-01 |
AU2016299486A1 (en) | 2017-11-09 |
US10464911B2 (en) | 2019-11-05 |
HUE048534T2 (hu) | 2020-07-28 |
NZ736432A (en) | 2019-01-25 |
RU2695227C9 (ru) | 2020-03-04 |
DK3328844T3 (da) | 2020-03-02 |
KR101799005B1 (ko) | 2017-11-17 |
PH12017501939A1 (en) | 2018-03-19 |
HK1251549A1 (zh) | 2019-02-01 |
PH12017501939B1 (en) | 2018-03-19 |
AU2016299486B2 (en) | 2019-08-01 |
ES2774510T3 (es) | 2020-07-21 |
WO2017018805A1 (en) | 2017-02-02 |
MY194018A (en) | 2022-11-08 |
EP3328844A1 (en) | 2018-06-06 |
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