PL2956477T5 - Zoptymalizowany gen czynnika viii - Google Patents

Zoptymalizowany gen czynnika viii

Info

Publication number
PL2956477T5
PL2956477T5 PL14751254.5T PL14751254T PL2956477T5 PL 2956477 T5 PL2956477 T5 PL 2956477T5 PL 14751254 T PL14751254 T PL 14751254T PL 2956477 T5 PL2956477 T5 PL 2956477T5
Authority
PL
Poland
Prior art keywords
factor viii
viii gene
optimized factor
optimized
gene
Prior art date
Application number
PL14751254.5T
Other languages
English (en)
Polish (pl)
Other versions
PL2956477T3 (pl
Inventor
Siyuan Tan
Robert T. Peters
Original Assignee
Bioverativ Therapeutics Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51354568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2956477(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bioverativ Therapeutics Inc. filed Critical Bioverativ Therapeutics Inc.
Publication of PL2956477T3 publication Critical patent/PL2956477T3/pl
Publication of PL2956477T5 publication Critical patent/PL2956477T5/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL14751254.5T 2013-02-15 2014-02-14 Zoptymalizowany gen czynnika viii PL2956477T5 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361765626P 2013-02-15 2013-02-15
PCT/US2014/016441 WO2014127215A1 (fr) 2013-02-15 2014-02-14 Gène du facteur viii optimisé
EP14751254.5A EP2956477B2 (fr) 2013-02-15 2014-02-14 Gène du facteur viii optimisé

Publications (2)

Publication Number Publication Date
PL2956477T3 PL2956477T3 (pl) 2021-06-14
PL2956477T5 true PL2956477T5 (pl) 2024-05-27

Family

ID=51354568

Family Applications (2)

Application Number Title Priority Date Filing Date
PL14751254.5T PL2956477T5 (pl) 2013-02-15 2014-02-14 Zoptymalizowany gen czynnika viii
PL20204866.6T PL3889173T3 (pl) 2013-02-15 2014-02-14 Zoptymalizowany gen czynnika viii

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL20204866.6T PL3889173T3 (pl) 2013-02-15 2014-02-14 Zoptymalizowany gen czynnika viii

Country Status (13)

Country Link
US (3) US10370431B2 (fr)
EP (3) EP2956477B2 (fr)
DK (2) DK3889173T3 (fr)
ES (2) ES2959747T3 (fr)
FI (2) FI3889173T3 (fr)
HR (2) HRP20231183T1 (fr)
HU (2) HUE063051T2 (fr)
LT (2) LT3889173T (fr)
PL (2) PL2956477T5 (fr)
PT (2) PT2956477T (fr)
RS (2) RS64664B1 (fr)
SI (2) SI2956477T2 (fr)
WO (1) WO2014127215A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2959747T3 (es) 2013-02-15 2024-02-28 Bioverativ Therapeutics Inc Gen del factor VIII optimizado
SG11201701033QA (en) * 2014-08-13 2017-03-30 Philadelphia Children Hospital An improved expression cassette for packaging and expression of variant factor viii for the treatment of hemostasis disorders
EP3611186A1 (fr) * 2015-02-06 2020-02-19 The University of North Carolina at Chapel Hill Cassettes optimisées d'expression génétique du facteur viii de coagulation humain et leur utilisation
US10058624B2 (en) 2015-04-16 2018-08-28 Emory University Recombinant promoters and vectors for protein expression in liver and use thereof
US10189889B2 (en) 2015-11-13 2019-01-29 Baxalta Incorporated Viral vectors encoding recombinant FVIII variants with increased expression for gene therapy of hemophilia A
TWI777175B (zh) 2015-11-13 2022-09-11 日商武田藥品工業股份有限公司 用於ａ型血友病基因治療之編碼表現增加之重組ｆｖｉｉｉ變異體之病毒載體
LT3411478T (lt) * 2016-02-01 2022-09-26 Bioverativ Therapeutics Inc. Optimizuoti viii faktoriaus genai
CA3055900A1 (fr) 2016-03-20 2017-09-28 The Trustees Of The University Of Pennsylvania Optimisation des codons et profilage ribosomique permettant d'accroitre l'expression transgenique dans les chloroplastes de plantes superieures
WO2019152692A1 (fr) 2018-02-01 2019-08-08 Bioverativ Therapeutics, Inc. Utilisation de vecteurs lentiviraux exprimant le facteur viii
MX2021000582A (es) 2018-07-16 2021-04-12 Baxalta Inc Terapia genica de hemofilia a mediante el uso de vectores virales que codifican variantes del factor viii (fviii) recombinantes con mayor expresion.
TW202039546A (zh) 2019-01-16 2020-11-01 美商巴克斯歐塔公司 用於a型血友病基因治療之編碼表現增加之重組fviii變異體的病毒載體
KR20210151785A (ko) * 2019-03-13 2021-12-14 제너레이션 바이오 컴퍼니 비바이러스성 dna 벡터 및 fviii 치료제 발현을 위한 이의 용도
CN110295150A (zh) * 2019-07-17 2019-10-01 天津润德生物科技有限公司 一类腺依赖病毒病毒重组质粒、重组病毒及构建方法
WO2021043757A1 (fr) * 2019-09-02 2021-03-11 Biotest Ag Protéine du facteur viii à demi-vie accrue
JP2023506171A (ja) 2019-12-12 2023-02-15 武田薬品工業株式会社 発現が上昇した組換えｆｖｉｉｉバリアントをコードするウイルスベクターを使用する、血友病ａの遺伝子療法
CN117858895A (zh) 2021-06-14 2024-04-09 武田药品工业株式会社 使用表达增强的编码重组fviii变体的病毒载体的血友病a基因疗法
TW202323274A (zh) * 2021-08-23 2023-06-16 美商百歐維拉提夫治療公司 優化因子viii基因
WO2023135273A2 (fr) 2022-01-14 2023-07-20 Anjarium Biosciences Ag Compositions de molécules d'adn codant pour le facteur viii, leurs procédés de préparation et leurs méthodes d'utilisation
WO2023205300A2 (fr) * 2022-04-20 2023-10-26 Asklepios Biopharmaceutical, Inc. Virus adéno-associé thérapeutique utilisant un acide nucléique à codons optimisés codant pour un facteur viii

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