HK1219021A1 - 以類轉錄活化因子核酸酶為基礎的基因修正 - Google Patents
以類轉錄活化因子核酸酶為基礎的基因修正Info
- Publication number
- HK1219021A1 HK1219021A1 HK16107060.2A HK16107060A HK1219021A1 HK 1219021 A1 HK1219021 A1 HK 1219021A1 HK 16107060 A HK16107060 A HK 16107060A HK 1219021 A1 HK1219021 A1 HK 1219021A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- talen
- based gene
- gene correction
- correction
- gene
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361771735P | 2013-03-01 | 2013-03-01 | |
| PCT/US2014/019322 WO2014134412A1 (en) | 2013-03-01 | 2014-02-28 | Talen-based gene correction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1219021A1 true HK1219021A1 (zh) | 2017-03-24 |
Family
ID=51428832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16107060.2A HK1219021A1 (zh) | 2013-03-01 | 2016-06-20 | 以類轉錄活化因子核酸酶為基礎的基因修正 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US9393257B2 (zh) |
| EP (2) | EP3567104A1 (zh) |
| JP (3) | JP6480874B2 (zh) |
| AU (2) | AU2014223243B2 (zh) |
| CA (1) | CA2902954A1 (zh) |
| ES (1) | ES2750550T3 (zh) |
| HK (1) | HK1219021A1 (zh) |
| WO (1) | WO2014134412A1 (zh) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9850497B2 (en) * | 2013-11-04 | 2017-12-26 | Regents Of The University Of Minnesota | Gene targeting methods and tools |
| KR20220100078A (ko) | 2014-01-31 | 2022-07-14 | 팩터 바이오사이언스 인크. | 핵산 제조 및 송달을 위한 방법 및 산물 |
| MX2017006408A (es) | 2014-11-17 | 2018-03-23 | Adicet Bio Inc | Linfocitos t gamma delta modificados geneticamente. |
| US11241505B2 (en) | 2015-02-13 | 2022-02-08 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| CN104726495B (zh) * | 2015-03-25 | 2018-06-19 | 西北农林科技大学 | 一种基于talen介导的基因打靶敲除山羊blg的载体及重组细胞 |
| EP3277805A1 (en) | 2015-03-31 | 2018-02-07 | Exeligen Scientific, Inc. | Cas 9 retroviral integrase and cas 9 recombinase systems for targeted incorporation of a dna sequence into a genome of a cell or organism |
| CN108026566A (zh) | 2015-05-04 | 2018-05-11 | 特拉维夫大学拉莫特有限公司 | 用于使dna片段化的方法和试剂盒 |
| PL3298033T5 (pl) | 2015-05-18 | 2023-10-30 | TCR2 Therapeutics Inc. | Kompozycje i zastosowania medyczne do reprogramowania TCR z zastosowaniem białek fuzyjnych |
| IL295616A (en) | 2015-07-31 | 2022-10-01 | Us Health | Adapted cells and treatment methods |
| US20180296600A1 (en) * | 2015-10-27 | 2018-10-18 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of epidermolysis bullosa by injection of autologous collagen vii overexpressing leukocytes |
| PL3377637T3 (pl) | 2016-04-08 | 2020-09-07 | Krystal Biotech, Inc. | Kompozycje do stosowania w sposobach leczenia ran, zaburzeń i chorób skóry |
| WO2017197347A1 (en) | 2016-05-12 | 2017-11-16 | Adicet Bio, Inc. | METHODS FOR SELECTIVE EXPANSION OF γδ T-CELL POPULATIONS AND COMPOSITIONS THEREOF |
| JP7109789B2 (ja) | 2016-08-02 | 2022-08-01 | ティーシーアール２ セラピューティクス インク． | 融合タンパク質を使用したｔｃｒの再プログラム化のための組成物及び方法 |
| CA3033788A1 (en) | 2016-08-17 | 2018-02-22 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| IL292551B2 (en) | 2016-10-07 | 2023-10-01 | Tcr2 Therapeutics Inc | Preparations and methods for reprogramming T-cell receptors using fusion proteins |
| WO2018075664A1 (en) | 2016-10-18 | 2018-04-26 | Regents Of The University Of Minnesota | Tumor infiltrating lymphocytes and methods of therapy |
| US11851491B2 (en) | 2016-11-22 | 2023-12-26 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
| CN110234343A (zh) | 2016-12-21 | 2019-09-13 | T细胞受体治疗公司 | 用于治疗癌症的经工程改造t细胞 |
| TW201839136A (zh) | 2017-02-06 | 2018-11-01 | 瑞士商諾華公司 | 治療血色素異常症之組合物及方法 |
| US20190365929A1 (en) * | 2017-02-22 | 2019-12-05 | Crispr Therapeutics Ag | Materials and methods for treatment of dystrophic epidermolysis bullosa (deb) and other collagen type vii alpha 1 chain (col7a1) gene related conditions or disorders |
| EP3638776A1 (en) | 2017-06-14 | 2020-04-22 | Technische Universität Dresden | Methods and means for genetic alteration of genomes utilizing designer dna recombining enzymes |
| WO2019006418A2 (en) | 2017-06-30 | 2019-01-03 | Intima Bioscience, Inc. | ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY |
| AU2018370120B2 (en) | 2017-11-15 | 2023-11-09 | Adicet Therapeutics, Inc. | Methods for selective expansion of d3 yd T-cell populations and compositions thereof |
| WO2019200163A1 (en) | 2018-04-12 | 2019-10-17 | Krystal Biotech, Inc. | Compositions and methods for the treatment of autosomal recessive congenital ichthyosis |
| KR20210005141A (ko) | 2018-04-27 | 2021-01-13 | 크리스탈 바이오테크, 인크. | 미적 적용을 위한 미용 단백질(들)을 인코딩하는 재조합 핵산 |
| EP4252759A3 (en) | 2018-05-11 | 2023-11-08 | Memorial Sloan Kettering Cancer Center | T cell receptors targeting pik3ca mutations and uses thereof |
| EP3802839A1 (en) | 2018-06-07 | 2021-04-14 | The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) | Nucleic acid constructs and methods of using same |
| CA3102975A1 (en) | 2018-06-07 | 2019-12-12 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Methods of regenerating and transforming cannabis |
| WO2020068862A1 (en) | 2018-09-24 | 2020-04-02 | Krystal Biotech, Inc. | Compositions and methods for the treatment of netherton syndrome |
| EP3887395A4 (en) | 2018-11-30 | 2022-07-27 | Intima Bioscience, Inc. | METHODS FOR IDENTIFICATION OF IMMUNOMODULATORY GENES |
| BR112021010804A2 (pt) | 2018-12-03 | 2021-11-16 | Adicet Bio Inc | Métodos para expansão seletiva in vivo de populações de células t gama delta e composições das mesmas |
| AU2020219343A1 (en) | 2019-02-08 | 2021-08-19 | Krystal Biotech, Inc. | Compositions and methods for delivering CFTR polypeptides |
| WO2020257684A1 (en) | 2019-06-20 | 2020-12-24 | University Of Massachusetts | Compositions and methods for improved gene editing |
| EP3999627A2 (en) | 2019-07-18 | 2022-05-25 | University of Rochester | Cell-type selective immunoprotection of cells |
| US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
| GB2605276A (en) | 2019-09-03 | 2022-09-28 | Myeloid Therapeutics Inc | Methods and compositions for genomic integration |
| WO2022051418A1 (en) | 2020-09-01 | 2022-03-10 | 64-X, Inc. | Mammalian cells and methods for engineering the same |
| KR20230088833A (ko) | 2020-10-23 | 2023-06-20 | 루트패스 제노믹스, 인크. | T-세포 수용체 식별을 위한 조성물 및 방법 |
| AU2022235341A1 (en) | 2021-03-12 | 2023-09-21 | Mendus B.V. | Methods of vaccination and use of cd47 blockade |
| BR112023020209A2 (pt) | 2021-04-02 | 2023-12-19 | Krystal Biotech Inc | Genoma do vírus do herpes recombinante, vírus do herpes, composição farmacêutica, uso do vírus do herpes ou da composição farmacêutica, método para expressar, realçar, aumentar, ampliar e/ou suplementar os níveis de um polipeptídeo imunomodulatório, método para prover alívio profilático, paliativo ou terapêutico, e, método para tratar câncer |
| US11753677B2 (en) | 2021-11-10 | 2023-09-12 | Encodia, Inc. | Methods for barcoding macromolecules in individual cells |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040161817A1 (en) | 2001-06-04 | 2004-08-19 | Corixa Corporation | Compositions and methods for high-level, large-scale production of recombinant proteins |
| SG181601A1 (en) | 2009-12-10 | 2012-07-30 | Univ Minnesota | Tal effector-mediated dna modification |
| WO2012033462A1 (en) * | 2010-09-06 | 2012-03-15 | Temasek Life Sciences Laboratory Limited | Molecular interaction between xa10 and avrxa10 |
| JP6336755B2 (ja) * | 2010-11-12 | 2018-06-06 | ザ ジェネラル ホスピタル コーポレイション | ポリコームに関連する非コードｒｎａ |
| CN103917644A (zh) * | 2011-09-21 | 2014-07-09 | 桑格摩生物科学股份有限公司 | 调控转基因表达的方法和组合物 |
-
2014
- 2014-02-28 JP JP2015560341A patent/JP6480874B2/ja not_active Expired - Fee Related
- 2014-02-28 CA CA2902954A patent/CA2902954A1/en not_active Abandoned
- 2014-02-28 EP EP19180371.7A patent/EP3567104A1/en not_active Withdrawn
- 2014-02-28 EP EP14756449.6A patent/EP2961262B1/en active Active
- 2014-02-28 AU AU2014223243A patent/AU2014223243B2/en not_active Ceased
- 2014-02-28 WO PCT/US2014/019322 patent/WO2014134412A1/en active Application Filing
- 2014-02-28 ES ES14756449T patent/ES2750550T3/es active Active
- 2014-02-28 US US14/193,037 patent/US9393257B2/en active Active
-
2016
- 2016-06-15 US US15/182,773 patent/US10172880B2/en not_active Expired - Fee Related
- 2016-06-20 HK HK16107060.2A patent/HK1219021A1/zh unknown
-
2018
- 2018-10-31 US US16/176,073 patent/US10973844B2/en active Active
-
2019
- 2019-02-08 JP JP2019021260A patent/JP6893945B2/ja active Active
-
2020
- 2020-01-16 AU AU2020200307A patent/AU2020200307A1/en not_active Abandoned
-
2021
- 2021-02-03 JP JP2021015441A patent/JP2021088565A/ja active Pending
- 2021-03-04 US US17/191,864 patent/US20210187006A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP6480874B2 (ja) | 2019-03-13 |
| EP2961262B1 (en) | 2019-07-24 |
| JP2019089821A (ja) | 2019-06-13 |
| EP2961262A4 (en) | 2016-10-12 |
| CA2902954A1 (en) | 2014-09-04 |
| US20210187006A1 (en) | 2021-06-24 |
| US20140256798A1 (en) | 2014-09-11 |
| US10973844B2 (en) | 2021-04-13 |
| EP3567104A1 (en) | 2019-11-13 |
| US20160367588A1 (en) | 2016-12-22 |
| EP2961262A1 (en) | 2016-01-06 |
| US9393257B2 (en) | 2016-07-19 |
| AU2020200307A1 (en) | 2020-02-06 |
| AU2014223243A1 (en) | 2015-09-10 |
| NZ711254A (en) | 2021-02-26 |
| WO2014134412A1 (en) | 2014-09-04 |
| JP2021088565A (ja) | 2021-06-10 |
| JP2016512960A (ja) | 2016-05-12 |
| ES2750550T3 (es) | 2020-03-26 |
| JP6893945B2 (ja) | 2021-06-23 |
| US20190054111A1 (en) | 2019-02-21 |
| US10172880B2 (en) | 2019-01-08 |
| AU2014223243B2 (en) | 2019-10-17 |
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