PL2894165T3 - Sposoby i kompozycje do leczenia zaburzeń układu dopełniacza - Google Patents
Sposoby i kompozycje do leczenia zaburzeń układu dopełniaczaInfo
- Publication number
- PL2894165T3 PL2894165T3 PL15152757.9T PL15152757T PL2894165T3 PL 2894165 T3 PL2894165 T3 PL 2894165T3 PL 15152757 T PL15152757 T PL 15152757T PL 2894165 T3 PL2894165 T3 PL 2894165T3
- Authority
- PL
- Poland
- Prior art keywords
- compositions
- methods
- associated disorders
- treating complement
- complement
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19880308P | 2008-11-10 | 2008-11-10 | |
US19956908P | 2008-11-18 | 2008-11-18 | |
US19956208P | 2008-11-18 | 2008-11-18 | |
US19956308P | 2008-11-18 | 2008-11-18 | |
US19976408P | 2008-11-19 | 2008-11-19 | |
US20063508P | 2008-12-01 | 2008-12-01 | |
US20064008P | 2008-12-01 | 2008-12-01 | |
US20063408P | 2008-12-01 | 2008-12-01 | |
US18178809P | 2009-05-28 | 2009-05-28 | |
US22804709P | 2009-07-23 | 2009-07-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2894165T3 true PL2894165T3 (pl) | 2023-04-17 |
Family
ID=42153320
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL15152757.9T PL2894165T3 (pl) | 2008-11-10 | 2009-11-10 | Sposoby i kompozycje do leczenia zaburzeń układu dopełniacza |
Country Status (20)
Country | Link |
---|---|
US (8) | US9447176B2 (pl) |
EP (6) | EP2894165B1 (pl) |
JP (8) | JP6223659B2 (pl) |
KR (1) | KR20110094029A (pl) |
CN (3) | CN109045296A (pl) |
AU (1) | AU2009313203B2 (pl) |
BR (1) | BRPI0921237A2 (pl) |
CA (2) | CA2742802C (pl) |
DK (1) | DK2894165T5 (pl) |
ES (1) | ES2940466T3 (pl) |
FI (1) | FI2894165T3 (pl) |
HR (1) | HRP20230167T1 (pl) |
HU (1) | HUE061548T2 (pl) |
LT (1) | LT2894165T (pl) |
NZ (3) | NZ606825A (pl) |
PL (1) | PL2894165T3 (pl) |
PT (1) | PT2894165T (pl) |
RS (1) | RS64039B1 (pl) |
SI (1) | SI2894165T1 (pl) |
WO (1) | WO2010054403A1 (pl) |
Families Citing this family (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050271660A1 (en) | 2002-09-06 | 2005-12-08 | Alexion Pharmaceuticals, Inc. | Nebulization of monoclonal antibodies for treating pulmonary diseases |
US9415102B2 (en) | 2002-09-06 | 2016-08-16 | Alexion Pharmaceuticals, Inc. | High concentration formulations of anti-C5 antibodies |
US8840893B2 (en) | 2004-06-10 | 2014-09-23 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
EP2006381B1 (en) | 2006-03-31 | 2016-02-03 | Chugai Seiyaku Kabushiki Kaisha | Method for controlling blood pharmacokinetics of antibodies |
EP3028716B1 (en) | 2006-10-10 | 2020-09-16 | Regenesance B.V. | Complement inhibition for improved nerve regeneration |
EP4368721A2 (en) | 2007-09-26 | 2024-05-15 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in cdr |
NO2708559T3 (pl) | 2008-04-11 | 2018-08-25 | ||
CN109045296A (zh) | 2008-11-10 | 2018-12-21 | 阿雷克森制药公司 | 用于治疗补体相关障碍的方法和组合物 |
ES2734746T3 (es) | 2008-12-22 | 2019-12-11 | Chemocentryx Inc | Antagonistas de C5aR |
JP2012531418A (ja) * | 2009-06-23 | 2012-12-10 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 補体タンパク質に結合する二重特異性抗体 |
SG183541A1 (en) * | 2010-03-01 | 2012-10-30 | Alexion Pharma Inc | Methods and compositions for treating degos' disease |
US9011852B2 (en) | 2010-04-30 | 2015-04-21 | Alexion Pharmaceuticals, Inc. | Anti-C5a antibodies |
HUE033644T2 (en) | 2010-06-24 | 2017-12-28 | Chemocentryx Inc | C5AR antagonists |
CN103237557A (zh) * | 2010-09-15 | 2013-08-07 | 赛尔戴克斯治疗公司 | 用可溶性I型补体受体(sCR1)治疗慢性肾病 |
AU2011337704B2 (en) | 2010-11-30 | 2017-06-15 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
US20150166676A1 (en) * | 2011-04-08 | 2015-06-18 | Omeros Corporation | Methods for Treating Conditions Associated with MASP-2 Dependent Complement Activation |
EP2694108B1 (en) * | 2011-04-08 | 2018-06-06 | University Of Leicester | Methods for treating conditions associated with masp-2 dependent complement activation |
US9644035B2 (en) | 2011-04-08 | 2017-05-09 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
EP2723361B1 (en) * | 2011-06-22 | 2019-10-30 | Apellis Pharmaceuticals, Inc. | Methods of treating chronic disorders with complement inhibitors |
LT2817329T (lt) | 2012-02-20 | 2019-04-10 | Swedish Orphan Biovitrum Ab (Publ) | Polipeptidai, prisijungiantys prie žmogaus komplemento c5 |
EA201400950A1 (ru) * | 2012-03-16 | 2014-12-30 | Алексион Фармасьютикалс, Инк. | Способы распространения комплемент-ингибирующих лекарственных средств среди пациентов, получающих ингибитор комплемента |
CN104717975A (zh) * | 2012-06-18 | 2015-06-17 | 奥默罗斯公司 | 用于治疗各种疾病和病症的抑制masp-1和/或masp-2和/或masp-3的组合物和方法 |
CN104870474B (zh) | 2012-10-04 | 2019-03-12 | 诺沃姆德治疗公司 | 用于治疗溶血性疾病的旁路途径特异性抗体 |
EP2912065A4 (en) | 2012-10-25 | 2016-10-19 | True North Therapeutics Inc | ANTI COMPLEMENT C1S ANTIBODIES AND USES THEREOF |
DK2914291T3 (da) * | 2012-11-02 | 2022-05-16 | Bioverativ Usa Inc | Anti-komplement-c1s-antistoffer og anvendelser deraf |
US20150330989A1 (en) * | 2012-11-15 | 2015-11-19 | The Brigham And Women's Hospital, Inc. | Method and system for diagnosing and treating preeclampsia |
WO2014110438A1 (en) * | 2013-01-11 | 2014-07-17 | Alexion Pharmaceuticals, Inc. | Compounds and methods related to the c5d domain of complement component c5 |
KR101638931B1 (ko) * | 2013-01-31 | 2016-07-12 | 서울대학교산학협력단 | 보체 관련 질환의 예방 및 치료를 위한 c5 항체 및 방법 |
LT2970974T (lt) | 2013-03-14 | 2017-12-11 | Alnylam Pharmaceuticals, Inc. | Komplemento komponento c5 irnr kompozicijos ir jų panaudojimas |
PL2968457T3 (pl) * | 2013-03-14 | 2018-12-31 | Baxalta Incorporated | Czynnik h do transplantacji |
EP2978451B1 (en) | 2013-03-29 | 2019-11-27 | Alexion Pharmaceuticals, Inc. | Compositions and methods for increasing the serum half-life of a therapeutic agent targeting complement c5 |
EP3290922A1 (en) | 2013-08-07 | 2018-03-07 | Alexion Pharmaceuticals, Inc. | Atypical hemolytic uremic syndrome (ahus) biomarker proteins |
EP3033093A1 (en) * | 2013-08-16 | 2016-06-22 | Alexion Pharmaceuticals, Inc. | Treatment of graft rejection by administering a complement inhibitor to an organ prior to transplant |
EP3046581B1 (en) * | 2013-09-16 | 2020-04-01 | Children's Hospital Medical Center | Compositions and methods for treatment of hsct-associated thrombotic microangiopathy |
IL283373B2 (en) * | 2013-10-17 | 2024-08-01 | Omeros Corp | Pharmaceutical preparations containing substances that suppress MASP-2 to suppress complement activation that depends on MASP-2 and related diseases |
IL294470B1 (en) | 2013-12-12 | 2024-08-01 | Alnylam Pharmaceuticals Inc | Complementary component iRNA compositions and methods for using them |
CA2939626C (en) * | 2014-02-20 | 2023-01-17 | Allergan, Inc. | Complement component c5 antibodies |
BR112016019286B1 (pt) * | 2014-02-26 | 2024-02-20 | Allergan, Inc. | Anticorpo anti-c5 |
NZ631007A (en) * | 2014-03-07 | 2015-10-30 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
US10155983B2 (en) | 2014-03-31 | 2018-12-18 | Machaon Diagnostics, Inc. | Method of diagnosis of complement-mediated thrombotic microangiopathies |
PT3628680T (pt) | 2014-06-12 | 2021-10-07 | Ra Pharmaceuticals Inc | Modulação da atividade do complemento |
EP3191591A1 (en) | 2014-09-12 | 2017-07-19 | Alnylam Pharmaceuticals, Inc. | Polynucleotide agents targeting complement component c5 and methods of use thereof |
EP3200791B1 (en) | 2014-09-29 | 2020-04-22 | ChemoCentryx, Inc. | Processes and intermediates in the preparation of c5ar antagonists |
US11031102B2 (en) | 2014-11-17 | 2021-06-08 | Alexion Pharmaceuticals, Inc. | Risk evaluation and management strategy involving patient follow-ups relating to the use or discontinuation of a complement inhibitor |
WO2016094834A2 (en) * | 2014-12-12 | 2016-06-16 | Alexion Pharmaceuticals, Inc. | A method for treating a complement mediated disorder caused by an infectious agent in a patient |
SI3233921T1 (sl) | 2014-12-19 | 2022-01-31 | Chugai Seiyaku Kabushiki Kaisha | Protitelesa proti C5 in postopki za uporabo |
JP2018511557A (ja) * | 2015-01-22 | 2018-04-26 | 中外製薬株式会社 | 2種以上の抗c5抗体の組み合わせおよび使用方法 |
RS62630B9 (sr) | 2015-01-28 | 2022-04-29 | Ra Pharmaceuticals Inc | Modulatori aktivnosti komplementa |
EP4212175A1 (en) | 2015-04-06 | 2023-07-19 | Bioverativ USA Inc. | Humanized anti-c1s antibodies and methods of use thereof |
EP3288586A1 (en) * | 2015-05-01 | 2018-03-07 | Alexion Pharmaceuticals, Inc. | Efficacy of an anti-c5 antibody in the prevention of antibody mediated rejection in sensitized recipients of kindney thansplant |
US11840564B2 (en) | 2015-06-09 | 2023-12-12 | Children's Hospital Medical Center | Dosing algorithm for complement inhibitor |
EP4365291A3 (en) | 2015-06-12 | 2024-08-14 | Alnylam Pharmaceuticals, Inc. | Complement component c5 irna compositions and methods of use thereof |
WO2017048495A1 (en) | 2015-09-14 | 2017-03-23 | Children's Hospital Medical Center | Methods and compositions for treatment of gaucher disease via modulation of c5a receptor |
EP3368073B1 (en) * | 2015-10-30 | 2024-05-15 | Alexion Pharmaceuticals, Inc. | A method of inhibiting exacerbations of t cell-mediated allograft vasculopathy |
CN108697759B (zh) | 2015-12-16 | 2022-08-02 | Ra制药公司 | 补体活性的调节剂 |
JP6771568B2 (ja) | 2015-12-23 | 2020-10-21 | グリーンオヴェイション・バイオテック・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングGreenovation Biotech Gmbh | 補体活性化を抑制するポリペプチド |
KR20180102642A (ko) | 2016-01-14 | 2018-09-17 | 케모센트릭스, 인크. | C3 사구체병증을 치료하는 방법 |
US20190151414A1 (en) * | 2016-05-10 | 2019-05-23 | Annexon, Inc. | Anti-complement factor c4/c4b antibodies and uses thereof |
AU2017269839A1 (en) * | 2016-05-27 | 2018-11-22 | Alexion Pharmaceuticals, Inc. | Methods for treatment of refractory generalized myasthenia gravis |
RU2018146847A (ru) * | 2016-06-07 | 2020-07-09 | Новартис Аг | Тесидолумаб для применения в лечении отторжения трансплантата |
EP3464351A1 (en) * | 2016-06-07 | 2019-04-10 | Novartis AG | Anti-c5 antibody for treating patients with complement c5 polymorphism |
CN109310760A (zh) * | 2016-06-07 | 2019-02-05 | 诺华股份有限公司 | 抗c5抗体给药方案 |
EP3469083A1 (en) | 2016-06-10 | 2019-04-17 | Alnylam Pharmaceuticals, Inc. | COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH) |
CA3027487A1 (en) | 2016-06-14 | 2017-12-21 | Regeneron Pharmaceuticals, Inc. | Anti-c5 antibodies and uses thereof |
CA3026050A1 (en) | 2016-08-05 | 2018-02-08 | Chugai Seiyaku Kabushiki Kaisha | Composition for prophylaxis or treatment of il-8 related diseases |
EP3532845A1 (en) | 2016-10-27 | 2019-09-04 | Alexion Pharmaceuticals, Inc. | Assay for c5b-9 deposition in complement-associated disorders |
BR112019011053A2 (pt) | 2016-12-07 | 2019-10-15 | Ra Pharmaceuticals Inc | moduladores da atividade do complemento |
TW202412841A (zh) | 2017-01-31 | 2024-04-01 | 日商中外製藥股份有限公司 | 抗c5抗體在製造用於治療或預防c5相關疾病的醫藥組合物之用途 |
AU2018225745B2 (en) | 2017-02-27 | 2023-12-07 | Regeneron Pharmaceuticals, Inc. | Humanized model of kidney and liver disorders |
WO2018165062A1 (en) * | 2017-03-06 | 2018-09-13 | The Trustees Of The University Of Pensylvania | Anti-c5 antibodies and uses thereof |
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2017
- 2017-09-11 US US15/700,805 patent/US20170369562A1/en not_active Abandoned
- 2017-11-21 JP JP2017223597A patent/JP2018030882A/ja not_active Withdrawn
-
2019
- 2019-03-20 US US16/358,779 patent/US11807678B2/en active Active
- 2019-09-09 JP JP2019163678A patent/JP2019203036A/ja not_active Withdrawn
- 2019-10-11 US US16/599,482 patent/US20200140531A1/en not_active Abandoned
-
2021
- 2021-07-30 JP JP2021125414A patent/JP2021167362A/ja not_active Withdrawn
-
2024
- 2024-06-07 JP JP2024093214A patent/JP2024107240A/ja active Pending
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