PL2364360T3 - Antysensowne kompozycje i sposoby ich wytwarzania i stosowania - Google Patents

Antysensowne kompozycje i sposoby ich wytwarzania i stosowania

Info

Publication number
PL2364360T3
PL2364360T3 PL09756431T PL09756431T PL2364360T3 PL 2364360 T3 PL2364360 T3 PL 2364360T3 PL 09756431 T PL09756431 T PL 09756431T PL 09756431 T PL09756431 T PL 09756431T PL 2364360 T3 PL2364360 T3 PL 2364360T3
Authority
PL
Poland
Prior art keywords
making
methods
same
antisense compositions
antisense
Prior art date
Application number
PL09756431T
Other languages
English (en)
Inventor
Sergio Baroni
Salvatore Bellinvia
Francesca Viti
Original Assignee
Nogra Pharma Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nogra Pharma Limited filed Critical Nogra Pharma Limited
Publication of PL2364360T3 publication Critical patent/PL2364360T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
PL09756431T 2008-11-13 2009-11-13 Antysensowne kompozycje i sposoby ich wytwarzania i stosowania PL2364360T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08425727 2008-11-13
US15229709P 2009-02-13 2009-02-13

Publications (1)

Publication Number Publication Date
PL2364360T3 true PL2364360T3 (pl) 2017-09-29

Family

ID=42101499

Family Applications (2)

Application Number Title Priority Date Filing Date
PL16187284.1T PL3121280T3 (pl) 2008-11-13 2009-11-13 Antysensowne kompozycje i sposoby ich wytwarzania i stosowania
PL09756431T PL2364360T3 (pl) 2008-11-13 2009-11-13 Antysensowne kompozycje i sposoby ich wytwarzania i stosowania

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL16187284.1T PL3121280T3 (pl) 2008-11-13 2009-11-13 Antysensowne kompozycje i sposoby ich wytwarzania i stosowania

Country Status (23)

Country Link
US (7) US8912154B2 (pl)
EP (2) EP2364360B1 (pl)
JP (7) JP5719776B2 (pl)
KR (2) KR101921014B1 (pl)
CN (2) CN102216458B (pl)
AU (4) AU2009315898B2 (pl)
CA (2) CA2743329C (pl)
CY (1) CY1119140T1 (pl)
DK (2) DK2364360T3 (pl)
ES (2) ES2627745T3 (pl)
FI (1) FI3121280T3 (pl)
HR (2) HRP20170926T1 (pl)
HU (2) HUE071668T2 (pl)
LT (2) LT3121280T (pl)
MX (3) MX346335B (pl)
NZ (1) NZ592673A (pl)
PL (2) PL3121280T3 (pl)
PT (2) PT2364360T (pl)
RS (2) RS66973B1 (pl)
RU (2) RU2739302C2 (pl)
SI (2) SI3121280T1 (pl)
SM (2) SMT201700346T1 (pl)
WO (1) WO2010054826A1 (pl)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20030149A1 (it) 2003-04-02 2004-10-03 Giuliani Spa Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico
KR101921014B1 (ko) 2008-11-13 2018-11-21 노그라 파마 리미티드 안티센스 조성물 및 그의 제조 및 사용 방법
EP2748611B1 (en) 2011-09-15 2016-11-23 Nogra Pharma Limited Methods for monitoring responsiveness to anti-smad7 therapy
ITCO20120008A1 (it) * 2012-03-01 2013-09-02 Nuovo Pignone Srl Metodo e sistema per monitorare la condizione di un gruppo di impianti
ES2732252T3 (es) 2012-04-18 2019-11-21 Nogra Pharma Ltd Procedimientos para tratar diabetes y/o promover la supervivencia de los islotes pancreáticos después del trasplante
US20140122184A1 (en) * 2012-10-29 2014-05-01 Elwha Llc Food Supply Chain Automation Grocery Information System And Method
WO2014110225A1 (en) * 2013-01-09 2014-07-17 The Feinstein Institute For Medical Research Hmgb1-binding beads and uses thereof
US10006029B2 (en) 2013-03-15 2018-06-26 Nogra Pharma Limited Methods of treating colorectal cancer
RU2674147C2 (ru) * 2013-03-15 2018-12-05 Ногра Фарма Лимитед Способы лечения колоректального рака
US10473669B2 (en) 2014-05-09 2019-11-12 Nogra Pharma Limited Methods for treating inflammatory bowel disease
KR20250004174A (ko) 2014-06-27 2025-01-07 노그라 파마 리미티드 아릴 수용체 조정제, 및 그의 제조 및 사용 방법
MX2017004973A (es) 2014-10-17 2017-12-07 Nogra Pharma Ltd Metodos y composiciones para tratar a un sujeto con un oligonucleotido antisentido de smad7.
EP3693736A3 (en) 2014-10-17 2020-10-14 Nogra Pharma Limited Methods for dosing and monitoring smad7 antisense oligonucleotide treatment using biomarker levels
WO2015011694A2 (en) 2014-10-17 2015-01-29 Celgene Corporation Isotopologues of smad7 antisense oligonucleotides
MA41271A (fr) * 2014-12-26 2017-10-31 Celgene Alpine Invest Company Ii Llc Méthodes d'utilisation d'oligonucléotides antisens ciblant smad7
JP6583954B2 (ja) * 2015-01-08 2019-10-02 日東電工株式会社 展示装置および映像展示方法
US9688993B2 (en) 2015-02-13 2017-06-27 Idera Pharmaceuticals, Inc. Toll-like receptor 9 antagonist and methods of use thereof
JP2018531936A (ja) * 2015-09-30 2018-11-01 ノグラ ファーマ リミテッド バイオマーカー発現に基づいてｓｍａｄ７アンチセンスオリゴヌクレオチドを使用する方法
MA44309A (fr) 2015-11-25 2018-10-03 Nogra Pharma Ltd Oligonucléotides antisens il-34 et leurs procédés d'utilisation
EP3420082A4 (en) 2016-02-23 2019-10-16 Celgene Alpine Investment Company II, LLC METHOD FOR THE TREATMENT OF DARM FIBROSIS USING SMAD7 INHIBITION
JP7125350B2 (ja) 2016-02-26 2022-08-24 ノグラ ファーマ リミテッド ラクトース不耐性を処置する方法
WO2018111323A1 (en) * 2016-12-14 2018-06-21 Progenity Inc. Methods and ingestible devices for the regio-specific release of smad7 inhibitors at the site of gastrointestinal tract disease
EP3554345A1 (en) 2016-12-14 2019-10-23 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a smad7 inhibitor
JP2020503327A (ja) 2016-12-30 2020-01-30 ノグラ ファーマ リミテッド Ｓｍａｄ７アンチセンスオリゴヌクレオチドの組成物および乾癬を処置するまたは予防する方法
GB201707501D0 (en) * 2017-05-10 2017-06-21 Index Pharmaceuticals Ab New therapy 2
US10517889B2 (en) 2017-09-08 2019-12-31 Ionis Pharmaceuticals, Inc. Modulators of SMAD7 expression
EP3914227A1 (en) 2019-01-25 2021-12-01 Nogra Pharma Limited Compositions for use in preventing acne
CA3130854A1 (en) 2019-02-26 2020-09-03 Nogra Pharma Limited Fragile x mental retardation protein interfering oligonucleotides and methods of using same
CN114729363A (zh) 2019-11-15 2022-07-08 诺格拉制药有限公司 Il-34反义剂及其使用方法
EP4139459A2 (en) * 2020-04-24 2023-03-01 Nogra Pharma Limited Compositions of smad7 antisense oligonucleotides (aso) and methods of using the same
MX2023013563A (es) 2021-05-17 2023-11-29 Nogra Pharma Ltd Agentes antisentido de il-34 y metodos de uso de los mismos.
WO2022243299A1 (en) 2021-05-17 2022-11-24 Nogra Pharma Limited Il-34 antisense agents and methods of using same
CA3241316A1 (en) 2021-12-03 2023-06-08 Quralis Corporation Gapmer antisense oligonucleotides with modified backbone chemistries
WO2024200594A1 (en) 2023-03-28 2024-10-03 Nogra Pharma Limited Smad7 inhibitory antisense oligonucleotides (aso) for treating pouchitis and methods of using the same

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5276019A (en) * 1987-03-25 1994-01-04 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors for replication of retroviruses and for the expression of oncogene products
IT1230576B (it) 1988-10-20 1991-10-28 Angeli Inst Spa Formulazioni farmaceutiche per via orale a liberazione selettiva nel colon
IT1246382B (it) * 1990-04-17 1994-11-18 Eurand Int Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
JP2916978B2 (ja) * 1993-08-25 1999-07-05 エスエス製薬株式会社 放出開始制御型製剤
DK0729360T3 (da) 1993-09-24 2004-09-27 Advanced Immuni T Inc Lineære og cykliske peptider til behandling eller forebyggelse af Crohn's sygdom og /eller ulcerativ colitis
AU3404997A (en) 1996-05-31 1998-01-05 Euro-Celtique S.A. Sustained release oxycodone formulations with no fed/fast effect
WO1998049348A1 (en) 1997-04-30 1998-11-05 Isis Pharmaceuticals, Inc. Oligonucleotides for enhanced bioavailability
IE970794A1 (en) 1997-09-24 2000-08-23 Elan Corp Plc Composition and method for enhancing paracellular transport across cell layers
EP1017404B1 (en) * 1997-09-26 2004-06-23 Medeva Europe Limited Pharmaceutical composition for the treatment of inflammatory bowel disease
US7192589B2 (en) * 1998-09-16 2007-03-20 Genentech, Inc. Treatment of inflammatory disorders with STIgMA immunoadhesins
JPH11335269A (ja) * 1998-05-19 1999-12-07 Hisamitsu Pharmaceut Co Inc 遺伝子関連医薬の経口投与固形製剤
CA2329130A1 (en) 1998-05-21 1999-11-25 Isis Pharmaceuticals Inc. Compositions and methods for non-parenteral delivery of oligonucleotides
JP4210454B2 (ja) 2001-03-27 2009-01-21 日本たばこ産業株式会社 炎症性腸疾患治療剤
US6159697A (en) 2000-01-19 2000-12-12 Isis Pharmaceuticals, Inc. Antisense modulation of Smad7 expression
US20030124196A1 (en) * 2001-08-22 2003-07-03 Susan Weinbach Pulsatile release compositions and methods for enhanced intestinal drug absorption
ATE554169T1 (de) 2001-11-02 2012-05-15 Giuliani Int Ltd Smad7-inhibitoren zur behandlung von krankheiten des zns
CN1713897B (zh) * 2002-10-16 2012-07-04 武田药品工业株式会社 控释制剂
US20040224020A1 (en) * 2002-12-18 2004-11-11 Schoenhard Grant L. Oral dosage forms with therapeutically active agents in controlled release cores and immediate release gelatin capsule coats
ITRM20030149A1 (it) 2003-04-02 2004-10-03 Giuliani Spa Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico
MXPA06000852A (es) * 2003-07-24 2006-03-30 Smithkline Beecham Corp Peliculas que se disuelven oralmente.
ITRM20030393A1 (it) 2003-08-11 2005-02-12 Giuliani Spa Uso di oligonucleotidi (odn) antisenso per smad7 per il trattamento delle patologie mediate dal fattore di trascrizione nucleare nf-kb.
EP1734933B1 (en) 2004-03-26 2010-05-26 LEK Pharmaceuticals d.d. Gastroresistant pharmaceutical dosage form comprising n-(2-(2-phthalimidoethoxy)-acetyl)-l-alanyl-d-glutamic acid (lk-423)
WO2006056078A1 (en) 2004-11-26 2006-06-01 Medicure International Inc. Novel formulation of pyridoxal 5'-phosphate and method of preparation
CN101151035A (zh) * 2004-12-02 2008-03-26 Isis制药公司 用于治疗炎性肠病的治疗性反义寡核苷酸组合物
US20060258610A1 (en) * 2005-05-12 2006-11-16 Isis Pharmaceuticals, Inc. Modulation of STAT 6 expression for the treatment of airway hyperresponsiveness
JP2009502957A (ja) 2005-07-28 2009-01-29 スパーナス ファーマシューティカルズ インコーポレイテッド 機械的特性の向上した徐放性錠剤配合物
WO2007047553A2 (en) 2005-10-14 2007-04-26 Zweig Jack I Methods and compositions for treatment of prostate intraepithelial neoplasia
CN1850135A (zh) * 2006-03-09 2006-10-25 陈世忠 一种鸦胆子油肠溶软胶囊制剂及其制备方法和其应用
GB0607534D0 (en) * 2006-04-13 2006-05-24 Univ London Pharmacy Colonic drug delivery formulation
CN103120653B (zh) * 2007-04-04 2015-09-30 希格默伊德药业有限公司 一种口服药物组合物
KR101921014B1 (ko) 2008-11-13 2018-11-21 노그라 파마 리미티드 안티센스 조성물 및 그의 제조 및 사용 방법
EP2490699A1 (en) * 2009-10-20 2012-08-29 Santaris Pharma A/S Oral delivery of therapeutically effective lna oligonucleotides
EP2748611B1 (en) 2011-09-15 2016-11-23 Nogra Pharma Limited Methods for monitoring responsiveness to anti-smad7 therapy
ES2732252T3 (es) 2012-04-18 2019-11-21 Nogra Pharma Ltd Procedimientos para tratar diabetes y/o promover la supervivencia de los islotes pancreáticos después del trasplante
RU2674147C2 (ru) 2013-03-15 2018-12-05 Ногра Фарма Лимитед Способы лечения колоректального рака
US10006029B2 (en) 2013-03-15 2018-06-26 Nogra Pharma Limited Methods of treating colorectal cancer
US10473669B2 (en) 2014-05-09 2019-11-12 Nogra Pharma Limited Methods for treating inflammatory bowel disease
EP3174895A1 (en) 2014-07-28 2017-06-07 Nogra Pharma Limited Methods and compositions for diagnosing and treating inflammatory bowel disorders
MX2017004973A (es) 2014-10-17 2017-12-07 Nogra Pharma Ltd Metodos y composiciones para tratar a un sujeto con un oligonucleotido antisentido de smad7.
EP3693736A3 (en) 2014-10-17 2020-10-14 Nogra Pharma Limited Methods for dosing and monitoring smad7 antisense oligonucleotide treatment using biomarker levels
JP2018531936A (ja) 2015-09-30 2018-11-01 ノグラ ファーマ リミテッド バイオマーカー発現に基づいてｓｍａｄ７アンチセンスオリゴヌクレオチドを使用する方法
JP2019507755A (ja) 2016-02-24 2019-03-22 ノグラ ファーマ リミテッド Ｓｍａｄ７阻害を使用するセリアック病の処置の方法
JP2020503327A (ja) 2016-12-30 2020-01-30 ノグラ ファーマ リミテッド Ｓｍａｄ７アンチセンスオリゴヌクレオチドの組成物および乾癬を処置するまたは予防する方法

Also Published As

Publication number Publication date
RU2011123876A (ru) 2012-12-20
AU2017279624B2 (en) 2020-02-06
WO2010054826A1 (en) 2010-05-20
PL3121280T3 (pl) 2025-09-01
JP6095744B2 (ja) 2017-03-15
NZ592673A (en) 2013-01-25
EP3121280A1 (en) 2017-01-25
MX2023008408A (es) 2023-10-19
US20150232854A1 (en) 2015-08-20
SMT201700346T1 (it) 2017-09-07
US9314434B2 (en) 2016-04-19
EP2364360B1 (en) 2017-03-22
JP2019151658A (ja) 2019-09-12
HRP20250744T1 (hr) 2025-08-15
CA3085272A1 (en) 2010-05-20
HRP20170926T1 (hr) 2017-09-22
US10272047B2 (en) 2019-04-30
HUE032368T2 (en) 2017-09-28
US20190374472A1 (en) 2019-12-12
CN102216458B (zh) 2017-05-24
US9499819B2 (en) 2016-11-22
US20120015033A1 (en) 2012-01-19
CN102216458A (zh) 2011-10-12
JP2015232039A (ja) 2015-12-24
PT2364360T (pt) 2017-06-27
EP2364360A1 (en) 2011-09-14
JP2014196356A (ja) 2014-10-16
MX2011005042A (es) 2011-08-17
US20150125523A1 (en) 2015-05-07
US9982264B2 (en) 2018-05-29
FI3121280T3 (fi) 2025-07-02
CN107007616A (zh) 2017-08-04
KR101921014B1 (ko) 2018-11-21
AU2020202813A1 (en) 2020-05-21
ES3034412T3 (en) 2025-08-18
AU2015246097A1 (en) 2015-11-12
RU2016127232A3 (pl) 2019-12-18
CA2743329C (en) 2020-09-01
JP2012508705A (ja) 2012-04-12
CA2743329A1 (en) 2010-05-20
SI2364360T1 (sl) 2017-08-31
LT3121280T (lt) 2025-07-25
DK2364360T3 (en) 2017-06-19
SMT202500239T1 (it) 2025-09-12
JP2021138778A (ja) 2021-09-16
HUE071668T2 (hu) 2025-09-28
JP6530772B2 (ja) 2019-06-12
AU2009315898B2 (en) 2015-07-23
LT2364360T (lt) 2017-08-10
AU2009315898A1 (en) 2010-05-20
PT3121280T (pt) 2025-07-01
KR20110086599A (ko) 2011-07-28
MX346335B (es) 2017-03-14
RS66973B1 (sr) 2025-07-31
RS56049B1 (sr) 2017-09-29
US20170107520A1 (en) 2017-04-20
KR20170092719A (ko) 2017-08-11
KR101767145B1 (ko) 2017-08-11
EP3121280B1 (en) 2025-04-09
JP7377624B2 (ja) 2023-11-10
RU2593939C2 (ru) 2016-08-10
AU2015246097B2 (en) 2018-01-18
JP2017075184A (ja) 2017-04-20
DK3121280T3 (da) 2025-06-30
SI3121280T1 (sl) 2025-08-29
CY1119140T1 (el) 2018-02-14
ES2627745T3 (es) 2017-07-31
JP2023138750A (ja) 2023-10-02
US20210290656A1 (en) 2021-09-23
US8912154B2 (en) 2014-12-16
RU2739302C2 (ru) 2020-12-22
US20160222383A1 (en) 2016-08-04
AU2017279624A1 (en) 2018-01-18
JP5719776B2 (ja) 2015-05-20
RU2016127232A (ru) 2018-12-06

Similar Documents

Publication Publication Date Title
SMT202500239T1 (it) Composizioni antisenso e metodi per la loro preparazione e loro uso
EG27167A (en) Microemulsifiers and methods of making and using same
EP2334185A4 (en) COMPOSITIONS AND METHODS FOR USE OF (R) -PRAMIPEXOL
IL245172A0 (en) Pharmaceutical preparations and methods for transferring them related to them
ZA201008232B (en) Lipid-containing compositions and methods of use thereof
EP2231665A4 (en) NEW COMPOSITIONS AND METHODS OF USE
EP2346324A4 (en) ANTIMICROBIAL COMPOSITION AND METHODS OF MAKING AND USING
HRP20160902T1 (hr) Pripravci i postupci uporabe forbolskih estera
IL201364A0 (en) Gas-effusing compositions and methods of making and using same
EP2271750A4 (en) URICASE COMPOSITIONS AND METHODS OF USE
GB0812890D0 (en) Compositions and methods of making compositions
IL247929B (en) Stable compositions of 595–sns and methods for their preparation
ZA201102207B (en) Cinnamandehyde-allicin compositions and their method of use
IL207827A0 (en) Apoaequorin-containing compositions and methods of using same
EP2379637A4 (en) IMPROVED PROCESSES FOR MAKING STYRENE POLYMER COMPOSITIONS AND METHODS OF USE THEREOF
ZA201100114B (en) Nutritive compositions and methods of using same
EP2381950A4 (en) COMPOSITIONS AND METHOD FOR THEIR USE
PL2366013T3 (pl) Kompozycje do prania i sposoby ich zastosowania
EP2315802A4 (en) AZIUM COMPOSITIONS AND METHOD FOR THEIR PREPARATION AND USE
IL195845A0 (en) Methods of making and using rubidium-81-containing compositions
GB0820804D0 (en) Perinropril composition and method of use thereof