PT2364360T - Composições em sentido reverso e métodos de as fabricar e utilizar - Google Patents
Composições em sentido reverso e métodos de as fabricar e utilizarInfo
- Publication number
- PT2364360T PT2364360T PT97564314T PT09756431T PT2364360T PT 2364360 T PT2364360 T PT 2364360T PT 97564314 T PT97564314 T PT 97564314T PT 09756431 T PT09756431 T PT 09756431T PT 2364360 T PT2364360 T PT 2364360T
- Authority
- PT
- Portugal
- Prior art keywords
- making
- methods
- same
- antisense compositions
- antisense
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08425727 | 2008-11-13 | ||
US15229709P | 2009-02-13 | 2009-02-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2364360T true PT2364360T (pt) | 2017-06-27 |
Family
ID=42101499
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT97564314T PT2364360T (pt) | 2008-11-13 | 2009-11-13 | Composições em sentido reverso e métodos de as fabricar e utilizar |
Country Status (21)
Country | Link |
---|---|
US (7) | US8912154B2 (pt) |
EP (2) | EP3121280A1 (pt) |
JP (7) | JP5719776B2 (pt) |
KR (2) | KR101767145B1 (pt) |
CN (2) | CN107007616A (pt) |
AU (4) | AU2009315898B2 (pt) |
CA (2) | CA2743329C (pt) |
CY (1) | CY1119140T1 (pt) |
DK (1) | DK2364360T3 (pt) |
ES (1) | ES2627745T3 (pt) |
HR (1) | HRP20170926T1 (pt) |
HU (1) | HUE032368T2 (pt) |
LT (1) | LT2364360T (pt) |
MX (3) | MX346335B (pt) |
NZ (1) | NZ592673A (pt) |
PL (1) | PL2364360T3 (pt) |
PT (1) | PT2364360T (pt) |
RS (1) | RS56049B1 (pt) |
RU (2) | RU2739302C2 (pt) |
SI (1) | SI2364360T1 (pt) |
WO (1) | WO2010054826A1 (pt) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITRM20030149A1 (it) | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
PT2364360T (pt) | 2008-11-13 | 2017-06-27 | Nogra Pharma Ltd | Composições em sentido reverso e métodos de as fabricar e utilizar |
EP2748611B1 (en) | 2011-09-15 | 2016-11-23 | Nogra Pharma Limited | Methods for monitoring responsiveness to anti-smad7 therapy |
ITCO20120008A1 (it) * | 2012-03-01 | 2013-09-02 | Nuovo Pignone Srl | Metodo e sistema per monitorare la condizione di un gruppo di impianti |
NZ630914A (en) | 2012-04-18 | 2017-01-27 | Nogra Pharma Ltd | Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation |
US20140122184A1 (en) * | 2012-10-29 | 2014-05-01 | Elwha Llc | Food Supply Chain Automation Grocery Information System And Method |
US20150335763A1 (en) * | 2013-01-09 | 2015-11-26 | The Feinstein Institute For Medical Research | Hmgb1-binding beads and uses thereof |
EP2970419B8 (en) * | 2013-03-15 | 2019-12-11 | Nogra Pharma Limited | Methods of treating colorectal cancer |
US10006029B2 (en) | 2013-03-15 | 2018-06-26 | Nogra Pharma Limited | Methods of treating colorectal cancer |
WO2015169966A2 (en) * | 2014-05-09 | 2015-11-12 | Nogra Pharma Limited | Methods for treating inflammatory bowel disease |
WO2015011694A2 (en) | 2014-10-17 | 2015-01-29 | Celgene Corporation | Isotopologues of smad7 antisense oligonucleotides |
EA201790867A1 (ru) | 2014-10-17 | 2017-08-31 | Ногра Фарма Лимитед | Способы и композиции для лечения субъекта антисмысловым олигонуклеотидом smad7 |
CA2964673A1 (en) * | 2014-10-17 | 2016-04-21 | Nogra Pharma Limited | Methods for dosing and monitoring smad7 antisense oligonucleotide treatment using biomarker levels |
MA41271A (fr) * | 2014-12-26 | 2017-10-31 | Celgene Alpine Invest Company Ii Llc | Méthodes d'utilisation d'oligonucléotides antisens ciblant smad7 |
JP6583954B2 (ja) * | 2015-01-08 | 2019-10-02 | 日東電工株式会社 | 展示装置および映像展示方法 |
WO2016130832A1 (en) * | 2015-02-13 | 2016-08-18 | Idera Pharmaceuticals, Inc. | Toll-like receptor 9 antagonist and methods of use thereof |
CA3000569A1 (en) * | 2015-09-30 | 2017-04-06 | Nogra Pharma Limited | Methods of using smad7 antisense oligonucleotides based on biomarker expression |
MA44309A (fr) | 2015-11-25 | 2018-10-03 | Nogra Pharma Ltd | Oligonucléotides antisens il-34 et leurs procédés d'utilisation |
WO2017147276A1 (en) * | 2016-02-23 | 2017-08-31 | Celgene Corporation | Methods of treating intestinal fibrosis using smad7 inhibition |
US20190046490A1 (en) | 2016-02-26 | 2019-02-14 | Nogra Pharma Limited | Methods of treating lactose intolerance |
WO2018111323A1 (en) * | 2016-12-14 | 2018-06-21 | Progenity Inc. | Methods and ingestible devices for the regio-specific release of smad7 inhibitors at the site of gastrointestinal tract disease |
US11134889B2 (en) | 2016-12-14 | 2021-10-05 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a SMAD7 inhibitor |
US20190328770A1 (en) | 2016-12-30 | 2019-10-31 | Nogra Pharma Limited | Compositions of smad7 antisense oligonucleotide and methods of treating or preventing psoriasis |
GB201707501D0 (en) * | 2017-05-10 | 2017-06-21 | Index Pharmaceuticals Ab | New therapy 2 |
WO2019051173A1 (en) | 2017-09-08 | 2019-03-14 | Ionis Pharmaceuticals, Inc. | MODULATORS OF SMAD7 EXPRESSION |
US20220000818A1 (en) | 2019-01-25 | 2022-01-06 | Nogra Pharma Limited | Compositions for use in preventing acne |
BR112021016907A2 (pt) | 2019-02-26 | 2021-11-03 | Nogra Pharma Ltd | Oligonucleotídeos de interferência com proteína de retardo mental do x frágil e métodos de sua utilização |
JP2023503804A (ja) | 2019-11-15 | 2023-02-01 | ノグラ ファーマ リミテッド | Il-34アンチセンス薬剤、およびこれを使用する方法 |
WO2022243299A1 (en) | 2021-05-17 | 2022-11-24 | Nogra Pharma Limited | Il-34 antisense agents and methods of using same |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
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US5276019A (en) * | 1987-03-25 | 1994-01-04 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibitors for replication of retroviruses and for the expression of oncogene products |
IT1230576B (it) | 1988-10-20 | 1991-10-28 | Angeli Inst Spa | Formulazioni farmaceutiche per via orale a liberazione selettiva nel colon |
IT1246382B (it) | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon |
JP2916978B2 (ja) * | 1993-08-25 | 1999-07-05 | エスエス製薬株式会社 | 放出開始制御型製剤 |
EP0729360B1 (en) | 1993-09-24 | 2004-05-26 | Advanced Immuni T, Inc. | Linear and cyclic peptides for treatment or prevention of crohn's disease and/or ulcerative colitis |
WO1997045091A2 (en) | 1996-05-31 | 1997-12-04 | Euro-Celtique, S.A. | Sustained release oxycodone formulations with no fed/fast effect |
KR20010020370A (ko) | 1997-04-30 | 2001-03-15 | 파샬 비. 린네 | 향상된 생체이용률을 갖는 올리고뉴클레오티드 |
IE970794A1 (en) * | 1997-09-24 | 2000-08-23 | Elan Corp Plc | Composition and method for enhancing paracellular transport across cell layers |
EP1017404B1 (en) | 1997-09-26 | 2004-06-23 | Medeva Europe Limited | Pharmaceutical composition for the treatment of inflammatory bowel disease |
US7192589B2 (en) * | 1998-09-16 | 2007-03-20 | Genentech, Inc. | Treatment of inflammatory disorders with STIgMA immunoadhesins |
JPH11335269A (ja) | 1998-05-19 | 1999-12-07 | Hisamitsu Pharmaceut Co Inc | 遺伝子関連医薬の経口投与固形製剤 |
JP2003524586A (ja) | 1998-05-21 | 2003-08-19 | アイシス・ファーマシューティカルス・インコーポレーテッド | オリゴヌクレオチドの非−非経口投与のための組成物と方法 |
JP4210454B2 (ja) | 2001-03-27 | 2009-01-21 | 日本たばこ産業株式会社 | 炎症性腸疾患治療剤 |
US6159697A (en) * | 2000-01-19 | 2000-12-12 | Isis Pharmaceuticals, Inc. | Antisense modulation of Smad7 expression |
US20030124196A1 (en) * | 2001-08-22 | 2003-07-03 | Susan Weinbach | Pulsatile release compositions and methods for enhanced intestinal drug absorption |
DK1456380T3 (da) | 2001-11-02 | 2012-07-30 | Giuliani Int Ltd | SMAD7-inhibitorer til behandling af CNS-sygdomme |
CN1713897B (zh) * | 2002-10-16 | 2012-07-04 | 武田药品工业株式会社 | 控释制剂 |
CA2510465A1 (en) * | 2002-12-18 | 2004-07-08 | Pain Therapeutics | Oral dosage forms with therapeutically active agents in controlled release cores and immediate release gelatin capsule coats |
ITRM20030149A1 (it) * | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
DK2446881T3 (da) * | 2003-07-24 | 2014-06-02 | Glaxosmithkline Llc | Oral opløselige film |
ITRM20030393A1 (it) | 2003-08-11 | 2005-02-12 | Giuliani Spa | Uso di oligonucleotidi (odn) antisenso per smad7 per il trattamento delle patologie mediate dal fattore di trascrizione nucleare nf-kb. |
CN1956707B (zh) | 2004-03-26 | 2010-12-29 | 力奇制药公司 | 包含n-(2-(2-苯二酰亚氨基乙氧基)-乙酰基)-l-丙氨酰基-d-谷氨酸(lk-423)的耐胃酸的药物剂型 |
EP1827455A1 (en) | 2004-11-26 | 2007-09-05 | Medicure International Inc. | Novel formulation of pyridoxal 5'-phosphate and method of preparation |
CN101151035A (zh) * | 2004-12-02 | 2008-03-26 | Isis制药公司 | 用于治疗炎性肠病的治疗性反义寡核苷酸组合物 |
US20060258610A1 (en) * | 2005-05-12 | 2006-11-16 | Isis Pharmaceuticals, Inc. | Modulation of STAT 6 expression for the treatment of airway hyperresponsiveness |
JP2009502957A (ja) | 2005-07-28 | 2009-01-29 | スパーナス ファーマシューティカルズ インコーポレイテッド | 機械的特性の向上した徐放性錠剤配合物 |
WO2007047553A2 (en) | 2005-10-14 | 2007-04-26 | Zweig Jack I | Methods and compositions for treatment of prostate intraepithelial neoplasia |
CN1850135A (zh) * | 2006-03-09 | 2006-10-25 | 陈世忠 | 一种鸦胆子油肠溶软胶囊制剂及其制备方法和其应用 |
GB0607534D0 (en) | 2006-04-13 | 2006-05-24 | Univ London Pharmacy | Colonic drug delivery formulation |
CA2683409A1 (en) * | 2007-04-04 | 2008-10-16 | Sigmoid Pharma Limited | A pharmaceutical composition of tacrolimus |
PT2364360T (pt) | 2008-11-13 | 2017-06-27 | Nogra Pharma Ltd | Composições em sentido reverso e métodos de as fabricar e utilizar |
EP2490699A1 (en) * | 2009-10-20 | 2012-08-29 | Santaris Pharma A/S | Oral delivery of therapeutically effective lna oligonucleotides |
EP2748611B1 (en) | 2011-09-15 | 2016-11-23 | Nogra Pharma Limited | Methods for monitoring responsiveness to anti-smad7 therapy |
NZ630914A (en) | 2012-04-18 | 2017-01-27 | Nogra Pharma Ltd | Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation |
EP2970419B8 (en) | 2013-03-15 | 2019-12-11 | Nogra Pharma Limited | Methods of treating colorectal cancer |
US10006029B2 (en) | 2013-03-15 | 2018-06-26 | Nogra Pharma Limited | Methods of treating colorectal cancer |
WO2015169966A2 (en) | 2014-05-09 | 2015-11-12 | Nogra Pharma Limited | Methods for treating inflammatory bowel disease |
JP2017529321A (ja) | 2014-07-28 | 2017-10-05 | ノグラ ファーマ リミテッド | 炎症性腸疾患を診断ならびに処置するための方法および組成物 |
EA201790867A1 (ru) | 2014-10-17 | 2017-08-31 | Ногра Фарма Лимитед | Способы и композиции для лечения субъекта антисмысловым олигонуклеотидом smad7 |
CA2964673A1 (en) | 2014-10-17 | 2016-04-21 | Nogra Pharma Limited | Methods for dosing and monitoring smad7 antisense oligonucleotide treatment using biomarker levels |
CA3000569A1 (en) | 2015-09-30 | 2017-04-06 | Nogra Pharma Limited | Methods of using smad7 antisense oligonucleotides based on biomarker expression |
US20210207143A1 (en) | 2016-02-24 | 2021-07-08 | Nogra Pharma Limited | Methods of Treating Celiac Disease Using SMAD7 Inhibition |
US20190328770A1 (en) | 2016-12-30 | 2019-10-31 | Nogra Pharma Limited | Compositions of smad7 antisense oligonucleotide and methods of treating or preventing psoriasis |
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2009
- 2009-11-13 PT PT97564314T patent/PT2364360T/pt unknown
- 2009-11-13 RS RS20170564A patent/RS56049B1/sr unknown
- 2009-11-13 EP EP16187284.1A patent/EP3121280A1/en active Pending
- 2009-11-13 KR KR1020117013391A patent/KR101767145B1/ko active IP Right Grant
- 2009-11-13 WO PCT/EP2009/008087 patent/WO2010054826A1/en active Application Filing
- 2009-11-13 KR KR1020177021816A patent/KR101921014B1/ko active IP Right Grant
- 2009-11-13 RU RU2016127232A patent/RU2739302C2/ru active
- 2009-11-13 JP JP2011535922A patent/JP5719776B2/ja active Active
- 2009-11-13 NZ NZ592673A patent/NZ592673A/xx unknown
- 2009-11-13 PL PL09756431T patent/PL2364360T3/pl unknown
- 2009-11-13 DK DK09756431.4T patent/DK2364360T3/en active
- 2009-11-13 LT LTEP09756431.4T patent/LT2364360T/lt unknown
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2011
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2014
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2015
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2016
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2017
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2019
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2020
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2021
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2023
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