PL2228453T3 - Ochrona płodowych kwasów nukleinowych w osoczu matki - Google Patents

Ochrona płodowych kwasów nukleinowych w osoczu matki

Info

Publication number
PL2228453T3
PL2228453T3 PL10000518T PL10000518T PL2228453T3 PL 2228453 T3 PL2228453 T3 PL 2228453T3 PL 10000518 T PL10000518 T PL 10000518T PL 10000518 T PL10000518 T PL 10000518T PL 2228453 T3 PL2228453 T3 PL 2228453T3
Authority
PL
Poland
Prior art keywords
preservation
nucleic acids
maternal plasma
fetal nucleic
fetal
Prior art date
Application number
PL10000518T
Other languages
English (en)
Inventor
M. Rohan Fernando
Chen Kate Chao-Wei
Original Assignee
Streck Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42235130&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2228453(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Streck Inc. filed Critical Streck Inc.
Publication of PL2228453T3 publication Critical patent/PL2228453T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
PL10000518T 2009-01-21 2010-01-20 Ochrona płodowych kwasów nukleinowych w osoczu matki PL2228453T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14606509P 2009-01-21 2009-01-21
US22752909P 2009-07-22 2009-07-22
EP10000518.0A EP2228453B1 (en) 2009-01-21 2010-01-20 Preservation of fetal nucleic acids in maternal plasma

Publications (1)

Publication Number Publication Date
PL2228453T3 true PL2228453T3 (pl) 2017-08-31

Family

ID=42235130

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10000518T PL2228453T3 (pl) 2009-01-21 2010-01-20 Ochrona płodowych kwasów nukleinowych w osoczu matki

Country Status (7)

Country Link
US (2) US11634747B2 (pl)
EP (3) EP2228453B1 (pl)
DE (3) DE202010018524U1 (pl)
DK (2) DK2228453T3 (pl)
ES (2) ES2790398T3 (pl)
PL (1) PL2228453T3 (pl)
PT (1) PT2228453T (pl)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003254755B2 (en) 2002-10-16 2007-12-20 Streck, Inc. Method and device for collecting and preserving cells for analysis
US20100022414A1 (en) 2008-07-18 2010-01-28 Raindance Technologies, Inc. Droplet Libraries
US8515679B2 (en) * 2005-12-06 2013-08-20 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US8532930B2 (en) 2005-11-26 2013-09-10 Natera, Inc. Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US20070178501A1 (en) * 2005-12-06 2007-08-02 Matthew Rabinowitz System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
ATE540750T1 (de) 2006-05-11 2012-01-15 Raindance Technologies Inc Mikrofluidische vorrichtung und verfahren
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US20110033862A1 (en) * 2008-02-19 2011-02-10 Gene Security Network, Inc. Methods for cell genotyping
US20110092763A1 (en) * 2008-05-27 2011-04-21 Gene Security Network, Inc. Methods for Embryo Characterization and Comparison
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
CN102171565B (zh) 2008-08-04 2015-04-29 纳特拉公司 等位基因调用和倍性调用的方法
WO2010015377A1 (en) * 2008-08-04 2010-02-11 Nec Europe Ltd Method for facilitating communication in a mobile communication system and mobile communication system
WO2010078194A1 (en) * 2008-12-30 2010-07-08 Streck, Inc. Method for screening blood using a preservative that may be in a substantially solid state form
US11634747B2 (en) 2009-01-21 2023-04-25 Streck Llc Preservation of fetal nucleic acids in maternal plasma
DE202010018561U1 (de) 2009-01-21 2017-08-28 Streck Inc. Blutsammelröhrchen
ES2649572T3 (es) * 2009-02-18 2018-01-12 Streck Inc. Conservación de ácidos nucleicos fuera de las células
ES2640776T3 (es) 2009-09-30 2017-11-06 Natera, Inc. Métodos para denominar de forma no invasiva ploidía prenatal
WO2011057184A1 (en) * 2009-11-09 2011-05-12 Streck, Inc. Stabilization of rna in and extracting from intact cells within a blood sample
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
EP4435111A1 (en) 2010-02-12 2024-09-25 Bio-Rad Laboratories, Inc. Digital analyte analysis
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
WO2011113043A2 (en) * 2010-03-12 2011-09-15 University Of South Florida Sample storage for molecular and immunological detection
EP2572003A4 (en) 2010-05-18 2016-01-13 Natera Inc METHOD FOR NONINVASIVE PRANATAL PLOIDIE ASSIGNMENT
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
AU2011277178B2 (en) 2010-07-16 2016-10-20 Stichting Vumc A method of analysing a blood sample of a subject for the presence of a disease marker
US9040255B2 (en) 2010-09-23 2015-05-26 Biocept, Inc. Use of diazolidinyl urea for anti-clumping of biological samples
ES2770342T3 (es) 2010-12-22 2020-07-01 Natera Inc Procedimientos para pruebas prenatales no invasivas de paternidad
JP6153874B2 (ja) 2011-02-09 2017-06-28 ナテラ， インコーポレイテッド 非侵襲的出生前倍数性呼び出しのための方法
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
CN103547920B (zh) 2011-03-18 2016-08-17 高等教育、科学研究及疾病护理协会 分析受试者的血液样品存在疾病标记物的方法
WO2012151391A2 (en) 2011-05-04 2012-11-08 Streck, Inc. Inactivated virus compositions and methods of preparing such compositions
EP3709018A1 (en) 2011-06-02 2020-09-16 Bio-Rad Laboratories, Inc. Microfluidic apparatus for identifying components of a chemical reaction
BR112013032629A2 (pt) 2011-06-19 2017-08-01 Abogen Inc dispositivos, soluções e métodos para coletamento de amostra
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
EP3444360A1 (en) * 2011-08-09 2019-02-20 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg A method of analysing a blood sample of a subject for the presence of a foetal disease or condition marker
AU2012314515B2 (en) 2011-09-26 2018-03-15 Preanalytix Gmbh Stabilisation and isolation of extracellular nucleic acids
ES2693672T3 (es) 2011-09-26 2018-12-13 Qiagen Gmbh Método rápido para aislar ácidos nucleicos extracelulares
EP4397770A1 (en) 2011-09-26 2024-07-10 PreAnalytiX GmbH Stabilisation and isolation of extracellular nucleic acids
US11021733B2 (en) * 2011-09-26 2021-06-01 Qiagen Gmbh Stabilization and isolation of extracellular nucleic acids
DK2814981T3 (en) 2012-02-13 2017-10-16 Streck Inc BLOOD COLLECTION UNIT FOR STABILIZING CELL-FREE PLASMA DNA
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
US10724074B2 (en) 2012-09-25 2020-07-28 Qiagen Gmbh Stabilisation of biological samples
US20140199681A1 (en) * 2013-01-14 2014-07-17 Streck, Inc. Blood collection device for stabilizing cell-free rna in blood during sample shipping and storage
US10052428B2 (en) * 2013-03-15 2018-08-21 Fenwal, Inc. Methods and systems for the filterless reduction of leukocytes in a biological fluid
CA2906818C (en) 2013-03-15 2022-08-16 Verinata Health, Inc. Generating cell-free dna libraries directly from blood
US11525155B2 (en) 2013-03-18 2022-12-13 Qiagen Gmbh Stabilisation of biological samples
JP6407248B2 (ja) 2013-03-18 2018-10-17 キアゲン ゲーエムベーハー 細胞外核酸の安定化および単離
ES2938048T3 (es) * 2013-07-24 2023-04-04 Streck Llc Composiciones y procedimientos para estabilizar las células tumorales circulantes
US9499870B2 (en) 2013-09-27 2016-11-22 Natera, Inc. Cell free DNA diagnostic testing standards
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
WO2015059065A1 (en) * 2013-10-22 2015-04-30 Roche Diagnostics Gmbh Methods for measuring cell-free virus particles from dried blood spots
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2015113725A1 (en) 2014-02-03 2015-08-06 Thermo Fisher Scientific Baltics Uab Method for controlled dna fragmentation
CA2940692A1 (en) 2014-03-18 2015-09-24 Qiagen Gmbh Stabilization and isolation of extracellular nucleic acids
RU2717641C2 (ru) 2014-04-21 2020-03-24 Натера, Инк. Обнаружение мутаций и плоидности в хромосомных сегментах
WO2015191632A1 (en) 2014-06-10 2015-12-17 Biomatrica, Inc. Stabilization of thrombocytes at ambient temperatures
AU2015289414B2 (en) 2014-07-18 2021-07-08 Illumina, Inc. Non-invasive prenatal diagnosis of fetal genetic condition using cellular DNA and cell free DNA
WO2016045022A1 (zh) * 2014-09-25 2016-03-31 深圳华大基因科技有限公司 用于孕妇外周血样的保存液和孕妇外周血样的保存方法
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
EP3294906B1 (en) 2015-05-11 2024-07-10 Natera, Inc. Methods for determining ploidy
EP3885438A1 (en) 2015-06-10 2021-09-29 QIAGEN GmbH Method for isolating extracellular nucleic acids using anion exchange particles
JP7166169B2 (ja) 2015-11-20 2022-11-07 キアゲン ゲーエムベーハー 細胞外核酸の滅菌のための滅菌組成物を調製する方法
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
CN113588501A (zh) 2015-12-08 2021-11-02 生物马特里卡公司 降低红细胞沉降速率
US11767522B2 (en) * 2016-05-27 2023-09-26 Norgen Biotek Corp. Preservation of cell-free nucleic acids in biological samples
US11506655B2 (en) 2016-07-29 2022-11-22 Streck, Inc. Suspension composition for hematology analysis control
US11485996B2 (en) 2016-10-04 2022-11-01 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
US10894976B2 (en) 2017-02-21 2021-01-19 Natera, Inc. Compositions, methods, and kits for isolating nucleic acids
CN107201307B (zh) * 2017-05-27 2019-09-13 广州基赛生物科技有限公司 一种采血管及其应用
US12084720B2 (en) 2017-12-14 2024-09-10 Natera, Inc. Assessing graft suitability for transplantation
JP2021520816A (ja) 2018-04-14 2021-08-26 ナテラ， インコーポレイテッド 循環腫瘍ｄｎａの個別化された検出を用いる癌検出およびモニタリングの方法
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
CN109055353A (zh) * 2018-07-17 2018-12-21 无锡百泰克生物技术有限公司 一种血液游离dna的保护剂
KR20210071983A (ko) 2018-09-07 2021-06-16 일루미나, 인코포레이티드 임산부로부터 분리된 순환 페탈 세포가 현재 또는 과거의 임신의 것인지 확인하는 방법
WO2021072410A2 (en) * 2019-10-11 2021-04-15 Sio2 Medical Products, Inc. Blood sample collection tube and uses thereof
WO2022036174A1 (en) 2020-08-13 2022-02-17 Streck, Inc. Sample collection containers, processes and collected samples
CN112662662A (zh) * 2021-01-05 2021-04-16 南昌艾迪康医学检验实验室有限公司 一种游离dna保存试剂及制备方法
IL293202A (en) 2022-05-22 2023-12-01 Nucleix Ltd Useful combinations of restriction enzymes
WO2024092158A1 (en) * 2022-10-27 2024-05-02 Microgenics Corporation Stabilization of nucleic acids in body fluids

Family Cites Families (189)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1432249A (en) 1922-02-06 1922-10-17 Howard S Borden Article of manufacture
US1922799A (en) 1932-12-16 1933-08-15 George E Gaus Method for affixing identification tags
US2250666A (en) 1938-10-31 1941-07-29 Godefroy Mfg Company Combined label, cap loosener, and auxiliary container
US2690624A (en) 1949-09-15 1954-10-05 Ollie W Phillips Sign
US2930570A (en) 1959-01-30 1960-03-29 Herbert R Leedy Pinch clamp
US3867521A (en) * 1970-08-26 1975-02-18 Scherer Corp R P Method for absorption of drugs
US3781120A (en) 1970-09-14 1973-12-25 Technicon Instr Self-locating sample receptacle having integral identification label
US3874384A (en) 1971-11-01 1975-04-01 American Hospital Supply Corp Improved blood storage unit and method of storing blood
US3872730A (en) 1972-03-10 1975-03-25 Becton Dickinson Co Sampling apparatus
US3879295A (en) 1973-08-17 1975-04-22 Eastman Kodak Co Vacutainer with positive separation barrier
US3973913A (en) 1976-01-29 1976-08-10 Louderback Allan Lee Blood control standard
US3994085A (en) 1976-03-29 1976-11-30 Groselak Robert E Baggage tag
US4043453A (en) 1976-05-11 1977-08-23 The Wright Tool & Forge Company Holder and display device for wrench sockets
US4318090A (en) 1980-10-27 1982-03-02 Sensormatic Electronics Corporation Apparatus for deactivating a surveillance tag
US4513522A (en) 1982-09-16 1985-04-30 Selenke William M Label with particular application to laboratory specimen container identification
US4515890A (en) * 1982-11-08 1985-05-07 Abbott Laboratories Immunoassay of terminal deoxynucleotidyl transferase
DE8407967U1 (de) 1984-03-15 1984-06-07 Idento - Gesellschaft für industrielle Kennzeichnung mbH, 6074 Rödermark Beschriftbarer Kabelmarkierungsstreifen
US4584219A (en) 1984-11-09 1986-04-22 Baartmans Hans R Web of labels
US4675159A (en) 1985-09-29 1987-06-23 Al Sioufi Habib Method and device for disinfecting biological fluids and container for same
US5110908A (en) 1986-12-31 1992-05-05 Praxis Biologics, Inc. Haemophilus influenzae peptides and proteins
US5084384A (en) * 1987-04-23 1992-01-28 Monsanto Company Secretion of insulin-like growth factor-I
US4884827A (en) 1988-01-22 1989-12-05 Norfolk Scientific Inc. Partially transparent label
US4921277A (en) 1988-10-24 1990-05-01 Academy Of Applied Science, Inc. Method of labeling needle syringes and medication vials and novel labels therefor
HU201865B (en) 1989-04-28 1991-01-28 Pecsi Dohanygyar Tobacco-smoke filter of high efficiency
US5000484A (en) 1989-08-30 1991-03-19 Phelan James C Identification and monitoring system for surgical specimens
US5153117A (en) * 1990-03-27 1992-10-06 Genetype A.G. Fetal cell recovery method
JP2540649B2 (ja) * 1990-04-27 1996-10-09 テルモ株式会社 採血管
US5250438A (en) * 1990-05-09 1993-10-05 Streck Laboratories, Inc. Method for differential determination of white blood cells using diazolidinyl urea to stabilize white blood cells
US5135125A (en) 1991-02-15 1992-08-04 Tapecon, Inc. Hanging label
US5260048A (en) * 1991-05-08 1993-11-09 Streck Laboratories, Inc. Tissue fixative solution and method
US5196182A (en) * 1991-05-08 1993-03-23 Streck Laboratories, Inc. Tissue fixative
US5460797A (en) * 1991-05-08 1995-10-24 Streck Laboratories, Inc. Method for fixing tissues and cells for analysis using oxazolidine compounds
US5849517A (en) 1991-05-08 1998-12-15 Streck Laboratories, Inc. Method and composition for preserving antigens and nucleic acids and process for utilizing cytological material produced by same
US5459073A (en) * 1991-05-08 1995-10-17 Streck Laboratories, Inc. Method and composition for preserving antigens and process for utilizing cytological material produced by same
US5459253A (en) * 1991-07-19 1995-10-17 Pharmacia P-L Biochemicals Inc. M-RNA purification
US5343647A (en) 1991-09-03 1994-09-06 Moore Business Forms, Inc. Pressure sensitive pricing tag/label
US5998483A (en) * 1991-09-20 1999-12-07 Camiener; Gerald W. Glyoxal-containing preservative compositions
CA2119554C (en) 1991-09-20 2003-05-06 Gerald W. Camiener Method and compositions with aldehyde stabilizing solution
DE4134231A1 (de) 1991-10-16 1993-04-22 Fix Gmbh Gepaeckstreifenanhaenger fuer einzelbeschriftung
US5257633A (en) * 1992-06-23 1993-11-02 Becton, Dickinson And Company Surface modified blood collection tubes
US5629147A (en) * 1992-07-17 1997-05-13 Aprogenex, Inc. Enriching and identifying fetal cells in maternal blood for in situ hybridization
EP0662152A1 (en) 1992-07-17 1995-07-12 Aprogenex, Inc. Enriching and identyfying fetal cells in maternal blood for in situ hybridization
GB9223035D0 (en) 1992-11-03 1992-12-16 Kiessling Cooper Ann A Preservation of peripheral blood & semen in fixatives that inactivate human pathogens
US5688516A (en) 1992-11-12 1997-11-18 Board Of Regents, The University Of Texas System Non-glycopeptide antimicrobial agents in combination with an anticoagulant, an antithrombotic or a chelating agent, and their uses in, for example, the preparation of medical devices
AU669754B2 (en) * 1992-12-18 1996-06-20 Becton Dickinson & Company Barrier coating
US5457024A (en) * 1993-01-22 1995-10-10 Aprogenex, Inc. Isolation of fetal erythrocytes
WO1994018156A1 (en) * 1993-02-01 1994-08-18 University Of Iowa Research Foundation Quartenary amine surfactants and methods of using same in isolation of rna
US6197540B1 (en) * 1993-07-05 2001-03-06 Northern General Hospital N.H.S. Trust Preparation and stabilization of cells using aged transition metal solutions
US6043032A (en) * 1993-09-22 2000-03-28 Tosoh Corporation Method of extracting nucleic acids and method of detecting specified nucleic acid sequences
EP0804614A1 (en) 1994-03-29 1997-11-05 Genzyme Corporation Culture and isolation of fetal cells from maternal peripheral blood
JPH10503008A (ja) * 1994-04-05 1998-03-17 ノーザン ジェネラル ホスピタル エヌ．エイチ．エス．トラスト 細胞懸濁液の安定化および調製
US5501954A (en) * 1994-06-13 1996-03-26 Genzyme Corporation Method of detecting cellular material
US5468022A (en) 1994-06-14 1995-11-21 Massachusetts Institute Of Technology Sample tube identification flag
FR2722506B1 (fr) * 1994-07-13 1996-08-14 Rhone Poulenc Rorer Sa Composition contenant des acides nucleiques, preparation et utilisations
US5512343A (en) 1994-08-01 1996-04-30 Diagraph Corporation Label assembly
US5540358A (en) 1994-12-19 1996-07-30 The Procter And Gamble Company Flexible planar gusseted package for dispensing a product through a fitment
US5490658A (en) 1995-03-02 1996-02-13 Avery Dennison Corporation Label hangers for intravenous bottles
US5560657A (en) 1995-03-08 1996-10-01 Morgan; Brian R. Tamper-indicating label
USD382343S (en) 1995-06-06 1997-08-12 Home Access Health Corporation Filmstrip for enhancing blood flow
US6527957B1 (en) * 1995-08-09 2003-03-04 Baxter International Inc. Methods for separating, collecting and storing red blood cells
US5817519A (en) * 1995-12-28 1998-10-06 Bayer Corporation Automated method and device for identifying and quantifying platelets and for determining platelet activation state using whole blood samples
CA2248981C (en) * 1996-03-15 2009-11-24 The Penn State Research Foundation Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays
US6630301B1 (en) * 1997-03-14 2003-10-07 The Penn State Research Foundation Detection of extracellular tumor-associated nucleic acid in blood plasma or serum
CA2250118C (en) * 1996-03-26 2009-09-29 Michael S. Kopreski Method enabling use of extracellular rna extracted from plasma or serum to detect, monitor or evaluate cancer
US6759217B2 (en) * 1996-03-26 2004-07-06 Oncomedx, Inc. Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer
US6072086A (en) 1996-04-12 2000-06-06 Intergen Company Method and composition for controlling formaldehyde fixation by delayed quenching
GB2313288B (en) * 1996-05-24 2000-07-12 North Gen Hospital Nhs Trust Specimen collection fluid
IT1294964B1 (it) 1996-07-12 1999-04-23 Domenico Valerio Isolamento e cultura di cellule fetali dal sangue periferico materno
US6074827A (en) 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
US5731156A (en) * 1996-10-21 1998-03-24 Applied Imaging, Inc. Use of anti-embryonic hemoglobin antibodies to identify fetal cells
US6190609B1 (en) * 1996-11-19 2001-02-20 Baxter International Inc. Methods and apparatus for inactivating contaminants in biological fluid
US5783093A (en) * 1997-01-02 1998-07-21 Haemonetics Corporation Blood cell concentrates using a single solution for anticoagulation and preservation
WO1998031219A1 (en) * 1997-01-21 1998-07-23 The American National Red Cross Intracellular and extracellular decontamination of whole blood and blood components by amphiphilic phenothiazin-5-ium dyes plus light
US6125563A (en) 1997-02-14 2000-10-03 Girerd; Philippe H. Container label with handle flap
GB9704444D0 (en) * 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
US20010051341A1 (en) 1997-03-04 2001-12-13 Isis Innovation Limited Non-invasive prenatal diagnosis
ATE251306T1 (de) * 1997-03-25 2003-10-15 Immunivest Corp Gerät und methoden zum einfnag und zur analyse von partikel-einheiten
SE514350C2 (sv) 1997-04-07 2001-02-12 Resemino System Ab Metod för affischering samt för metoden anpassat system för affischering
US5939259A (en) * 1997-04-09 1999-08-17 Schleicher & Schuell, Inc. Methods and devices for collecting and storing clinical samples for genetic analysis
US5906744A (en) * 1997-04-30 1999-05-25 Becton Dickinson And Company Tube for preparing a plasma specimen for diagnostic assays and method of making thereof
US5976014A (en) 1997-05-28 1999-11-02 Moore U.S.A., Inc. Integrity seal form/label combination
EP1634966B1 (en) 1997-05-30 2010-11-03 TrovaGene, Inc. Methods for detection of nucleic acid sequences in urine
US6083731A (en) 1997-06-24 2000-07-04 Washington State University Research Foundation Recombinant materials and methods for the production of limonene hydroxylases
US6218531B1 (en) * 1997-06-25 2001-04-17 Promega Corporation Method of isolating RNA
WO1999007174A1 (en) 1997-07-28 1999-02-11 Northern Telecom Limited Soft handoff method and apparatus
US5962234A (en) * 1997-10-20 1999-10-05 Applied Imaging Corporation Use of anti-embryonic epsilon hemoglobin antibodies to identify fetal cells
CA2260402C (en) 1998-01-22 2001-10-23 Pierre Boisvert Display card
US6210889B1 (en) * 1998-01-28 2001-04-03 The Universite Laval Method for enrichment of fetal cells from maternal blood and use of same in determination of fetal sex and detection of chromosomal abnormalities
JP2002503814A (ja) * 1998-02-12 2002-02-05 イムニベスト・コーポレイション 循環ガン細胞の迅速かつ効率的な単離のための方法および試薬
US20010018192A1 (en) * 1998-02-12 2001-08-30 Terstappen Leon W.M.M. Labeled cells for use as an internal functional control in rare cell detection assays
US6177163B1 (en) 1998-06-22 2001-01-23 Tricor Direct, Inc. Markable repositionable adhesive sheet dispensing roll for use in an industrial setting
US6204375B1 (en) 1998-07-31 2001-03-20 Ambion, Inc. Methods and reagents for preserving RNA in cell and tissue samples
US20080261292A1 (en) * 1998-09-22 2008-10-23 Oncomedx, Inc. Method Enabling the Use of Extracellular Ribonucleic Acid (RNA) Extracted from Plasma or Serum to Detect, Monitor or Evaluate Cancer or Premalignant Conditions
US6077235A (en) * 1999-02-23 2000-06-20 Becton, Dickinson And Company Blood collection assembly and method therefor
US7683035B1 (en) 1999-02-23 2010-03-23 Qiagen, Gmbh Method of stabilizing and/or isolating nucleic acids
WO2000075647A1 (en) 1999-06-04 2000-12-14 Bioseparations, Inc. System and method for prenatal diagnostic screening
AU5620600A (en) 1999-06-16 2001-01-02 University Of Cincinnati, The Agent and process for isolation of extra-chromosomal nucleic acids
DE19928820A1 (de) 1999-06-17 2000-12-21 Ulrich Groth Fixiermittel für Zellen und Gewebe von Lebewesen
WO2001008546A2 (en) * 1999-07-29 2001-02-08 Baxter International Inc. Sampling tube holder for blood sampling system
US6664379B1 (en) * 1999-09-24 2003-12-16 Ambion, Inc. Nuclease inhibitor cocktail
US20010049895A1 (en) 2000-01-06 2001-12-13 Burke Doyle G. Promotional hanger
US6337189B1 (en) * 2000-02-08 2002-01-08 Streck Laboratories, Inc. Fixative system, method and composition for biological testing
DE10006662A1 (de) * 2000-02-15 2001-08-23 Antigen Produktions Gmbh Gefäß zur Nukleinsäureanalytik
GB0009179D0 (en) 2000-04-13 2000-05-31 Imp College Innovations Ltd Non-invasive prenatal diagnosis
GB0009784D0 (en) 2000-04-20 2000-06-07 Simeg Limited Methods for clinical diagnosis
US20020045196A1 (en) * 2000-05-12 2002-04-18 Walt Mahoney Methods of isolating trophoblast cells from maternal blood
US6860513B2 (en) 2000-06-08 2005-03-01 Scriptchek Visual Verification Systems, Inc. Verification of prescription information and warning label
AU1548802A (en) 2000-06-21 2002-01-02 Digene Corp Universal collection medium
AU2001290528A1 (en) 2000-08-10 2002-02-18 Baxa Corporation Method, system, and apparatus for handling, labeling, filling, and capping syringes
US6664056B2 (en) 2000-10-17 2003-12-16 The Chinese University Of Hong Kong Non-invasive prenatal monitoring
US20020076773A1 (en) 2000-10-17 2002-06-20 Chiklis Gregory R. Nucleic acid amplification controls
US6551267B1 (en) * 2000-10-18 2003-04-22 Becton, Dickinson And Company Medical article having blood-contacting surface
EP1356302B1 (en) * 2000-11-08 2008-01-23 Becton Dickinson and Company Method and device for collecting and stabilizing a biological sample
US6602718B1 (en) * 2000-11-08 2003-08-05 Becton, Dickinson And Company Method and device for collecting and stabilizing a biological sample
EP1368369A4 (en) 2000-11-15 2006-02-22 Hoffmann La Roche METHOD AND REAGENTS FOR IDENTIFYING RARE FOETAL CELLS IN THE MATERIAL CIRCUIT
EP1207208A3 (en) 2000-11-15 2003-12-10 Becton Dickinson and Company Method for preservation of cells and nucleic acid targets
US20020066216A1 (en) 2000-12-01 2002-06-06 Delacruz Cedric G. Baby birth announcement
US6794152B2 (en) 2000-12-22 2004-09-21 Streck Laboratories Inc. Flow cytometry reagent and system
US6581973B2 (en) 2001-03-30 2003-06-24 Cheringal Associates, Inc. Double blind study label
US6617180B1 (en) * 2001-04-16 2003-09-09 Taiwan Semiconductor Manufacturing Company Test structure for detecting bridging of DRAM capacitors
FR2824144B1 (fr) * 2001-04-30 2004-09-17 Metagenex S A R L Methode de diagnostic prenatal sur cellule foetale isolee du sang maternel
ATE502119T1 (de) * 2001-07-25 2011-04-15 Oncomedx Inc Verfahren zur bewertung pathologischer krankheitszustände unter verwendung extrazellulärer rna
WO2008111981A1 (en) 2007-03-14 2008-09-18 Sierra Molecular Corporation Compositions, systems, and methods for preservation of macromolecules
US7863012B2 (en) 2004-02-17 2011-01-04 Veridex, Llc Analysis of circulating tumor cells, fragments, and debris
WO2003018757A2 (en) 2001-08-23 2003-03-06 Immunivest Corporation Stabilization of cells and biological specimens for analysis
US6884573B2 (en) * 2001-08-31 2005-04-26 The University Of North Carolina At Chapel Hill Fixed dried red blood cells and method of use
US6527242B1 (en) 2001-10-01 2003-03-04 Netta Kennedy Brace for a picture frame
CA2474555A1 (en) * 2002-02-01 2003-08-07 Gambro, Inc. Whole blood collection and processing method
GB0203280D0 (en) 2002-02-12 2002-03-27 Ic Innovations Ltd Anti-glycolytic composition
GB2386038A (en) 2002-02-27 2003-09-03 Motorola Inc Channel estimation in a radio receiver
US6977162B2 (en) * 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
WO2003095974A2 (en) 2002-05-07 2003-11-20 Becton, Dickinson And Company Collection assembly
US7442506B2 (en) * 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
US20070178478A1 (en) 2002-05-08 2007-08-02 Dhallan Ravinder S Methods for detection of genetic disorders
US7022478B2 (en) 2002-05-14 2006-04-04 The Chinese University Of Hong Kong Methods for evaluating stroke or cardiac ischemia by nucleic acid detection
AU2003239543A1 (en) * 2002-05-22 2003-12-12 Duke University Rnp immunoprecipitation assay
WO2003106623A2 (en) 2002-06-13 2003-12-24 New York University Early noninvasive prenatal test for aneuploidies and heritable conditions
US20060008807A1 (en) 2002-08-23 2006-01-12 O'hara Shawn M Multiparameter analysis of comprehensive nucleic acids and morphological features on the same sample
US6913932B2 (en) * 2002-08-23 2005-07-05 Beckman Coulter, Inc. Formaldehyde-ammonium salt complexes for the stabilization of blood cells
EP1816461B1 (en) 2002-10-16 2020-01-08 Streck Laboratories, Inc. Method and device for collecting and preserving cells for analysis
AU2003254755B2 (en) 2002-10-16 2007-12-20 Streck, Inc. Method and device for collecting and preserving cells for analysis
KR100471183B1 (ko) * 2002-10-29 2005-03-10 삼성전자주식회사 오프 세트 트랜지스터를 갖는 반도체 기억소자 및 그제조방법
WO2004078999A1 (en) * 2003-03-05 2004-09-16 Genetic Technologies Limited Identification of fetal dna and fetal cell markers in maternal plasma or serum
US7267980B1 (en) * 2003-04-04 2007-09-11 Research & Diagnostic Systems, Inc. Stabilizing solution for cells and tissues
US20050277204A1 (en) 2003-08-12 2005-12-15 Massachusetts Institute Of Technology Sample preparation methods and devices
US7318293B2 (en) 2003-09-19 2008-01-15 Ardern Ii William B Binder clip sleeve
US20070111233A1 (en) * 2003-10-30 2007-05-17 Bianchi Diana W Prenatal diagnosis using cell-free fetal DNA in amniotic fluid
US20050164208A1 (en) * 2004-01-22 2005-07-28 Paul Poulin Storage of genetic information
US20050181353A1 (en) * 2004-02-17 2005-08-18 Rao Galla C. Stabilization of cells and biological specimens for analysis
US20100216153A1 (en) * 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
WO2005108411A2 (en) * 2004-05-05 2005-11-17 Isis Pharmaceuticals, Inc. Substituted pixyl protecting groups for oligonucleotide synthesis
US8497134B2 (en) * 2004-08-19 2013-07-30 Blood Cell Storage, Inc. Fluorescent detector systems for the detection of chemical perturbations in sterile storage devices
ES2251307B2 (es) 2004-10-05 2006-12-16 Universidad Complutense De Madrid Solucion para el mantenimiento indefinido de los acidos nucleicos en su celula de origen.
EP1809744B1 (en) * 2004-11-05 2018-06-06 QIAGEN North American Holdings, Inc. Compositions and methods for purifying nucleic acids from stabilization reagents
JP2008524986A (ja) 2004-12-10 2008-07-17 バイエル・ヘルスケア・アクチェンゲゼルシャフト タキサンに基づく薬物療法に対する悪性腫瘍の応答予測に有用な遺伝子変化
US7390663B2 (en) * 2005-02-23 2008-06-24 Streck, Inc. Process, composition and kit for providing a stable whole blood calibrator/control
US7419832B2 (en) 2005-03-10 2008-09-02 Streck, Inc. Blood collection tube with surfactant
DE102005013261A1 (de) 2005-03-22 2006-09-28 Adnagen Ag Reagenz und Verfahren zur Verhinderung der zeitabhängigen Expression in biologischen Zellen
WO2007022483A2 (en) 2005-08-19 2007-02-22 Bioventures, Inc. Method and device for the collection and isolation of nucleic acid
WO2007053491A2 (en) 2005-10-28 2007-05-10 The Trustees Of Columbia University In The City Of New York Method and kit for evaluating rna quality
SI2385143T1 (sl) * 2006-02-02 2016-11-30 The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Neinvazivni genetski presejalni test ploda z digitalno analizo
DE602007014335D1 (de) * 2006-02-28 2011-06-16 Univ Louisville Res Found Erkennung von chromosomabnormalitäten im fötus mit hilfe der tandem-einzelnukleotid-polymorphismen
WO2007121276A2 (en) * 2006-04-12 2007-10-25 Biocept, Inc. Enrichment of circulating fetal dna
ES2264403B1 (es) 2006-06-22 2007-11-01 Grifols S.A. Medio de suspension de hematies.
WO2008006086A2 (en) * 2006-07-07 2008-01-10 Atlantic City Coin & Slot Service Company, Inc. Gaming device and method of use
EP2057181B1 (en) 2006-08-30 2012-02-08 Bioventures, Inc. Methods and substances for isolation and detection of small polynucleotides
US8080645B2 (en) 2007-10-01 2011-12-20 Longhorn Vaccines & Diagnostics Llc Biological specimen collection/transport compositions and methods
US20080108071A1 (en) * 2006-10-10 2008-05-08 Katherine Thompson Methods and Systems to Determine Fetal Sex and Detect Fetal Abnormalities
GB0704488D0 (en) 2007-03-08 2007-04-18 Univ Nottingham Platelet viability kit
US8537789B2 (en) 2007-08-01 2013-09-17 Harris Corporation Mobile ad-hoc network providing communication latency reduction features and related methods
US20110300608A1 (en) * 2007-09-21 2011-12-08 Streck, Inc. Nucleic acid isolation in preserved whole blood
US20090308303A1 (en) 2008-06-13 2009-12-17 Burlando Albert A Identification marker
WO2010078194A1 (en) * 2008-12-30 2010-07-08 Streck, Inc. Method for screening blood using a preservative that may be in a substantially solid state form
US11634747B2 (en) 2009-01-21 2023-04-25 Streck Llc Preservation of fetal nucleic acids in maternal plasma
ES2649572T3 (es) 2009-02-18 2018-01-12 Streck Inc. Conservación de ácidos nucleicos fuera de las células
EP2411808B1 (en) 2009-03-24 2015-11-11 Biocept, Inc. Devices and methods of cell capture and analysis
US20110027771A1 (en) * 2009-07-31 2011-02-03 Artemis Health, Inc. Methods and compositions for cell stabilization
US20110053208A1 (en) 2009-08-31 2011-03-03 Streck, Inc. Biological sample identification system
WO2011057184A1 (en) 2009-11-09 2011-05-12 Streck, Inc. Stabilization of rna in and extracting from intact cells within a blood sample
WO2011082415A2 (en) 2010-01-04 2011-07-07 Qiagen Gaithersburg, Inc. Methods, compositions, and kits for recovery of nucleic acids or proteins from fixed tissue samples
US9040255B2 (en) 2010-09-23 2015-05-26 Biocept, Inc. Use of diazolidinyl urea for anti-clumping of biological samples
EP2699352A1 (en) 2011-04-21 2014-02-26 Streck Inc. Improved sample tube having particular utility for nucleic acid amplification
WO2012166913A1 (en) 2011-06-01 2012-12-06 Streck, Inc. Rapid thermocycler system for rapid amplification of nucleic acids and related methods
CA2858689A1 (en) 2011-12-09 2013-06-13 The Scripps Research Institute Apparatus, system and method for identifying circulating tumor cells
DK2814981T3 (en) 2012-02-13 2017-10-16 Streck Inc BLOOD COLLECTION UNIT FOR STABILIZING CELL-FREE PLASMA DNA
US20150225712A1 (en) 2012-08-21 2015-08-13 Qiagen Gmbh Method for isolating nucleic acids from a formaldehyde releaser stabilized sample
US20140199681A1 (en) 2013-01-14 2014-07-17 Streck, Inc. Blood collection device for stabilizing cell-free rna in blood during sample shipping and storage
ES2938048T3 (es) 2013-07-24 2023-04-04 Streck Llc Composiciones y procedimientos para estabilizar las células tumorales circulantes
JP6302772B2 (ja) 2014-06-30 2018-03-28 日立建機株式会社 建設機械の油圧システム

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