PL2217572T3 - Modulatory izochinolinowe transporterów zawierających kasetę wiążącą ATP - Google Patents

Modulatory izochinolinowe transporterów zawierających kasetę wiążącą ATP

Info

Publication number
PL2217572T3
PL2217572T3 PL08849242T PL08849242T PL2217572T3 PL 2217572 T3 PL2217572 T3 PL 2217572T3 PL 08849242 T PL08849242 T PL 08849242T PL 08849242 T PL08849242 T PL 08849242T PL 2217572 T3 PL2217572 T3 PL 2217572T3
Authority
PL
Poland
Prior art keywords
isoquinoline
atp
modulators
binding cassette
cassette transporters
Prior art date
Application number
PL08849242T
Other languages
English (en)
Polish (pl)
Inventor
Ruah Sara Hadida
Mark Miller
Jinglan Zhou
Brian Bear
Peter D J Grootenhuis
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of PL2217572T3 publication Critical patent/PL2217572T3/pl

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/47—Quinolines; Isoquinolines
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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PL08849242T 2007-11-16 2008-11-14 Modulatory izochinolinowe transporterów zawierających kasetę wiążącą ATP PL2217572T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98855907P 2007-11-16 2007-11-16
EP20080849242 EP2217572B1 (en) 2007-11-16 2008-11-14 Isoquinoline modulators of atp-binding cassette transporters
PCT/US2008/083517 WO2009064959A1 (en) 2007-11-16 2008-11-14 Isoquinoline modulators of atp-binding cassette transporters

Publications (1)

Publication Number Publication Date
PL2217572T3 true PL2217572T3 (pl) 2014-04-30

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PL12181370T PL2578571T3 (pl) 2007-11-16 2008-11-14 Modulatory izochinolinowe transporterów zawierających kasetę wiążącą ATP
PL08849242T PL2217572T3 (pl) 2007-11-16 2008-11-14 Modulatory izochinolinowe transporterów zawierających kasetę wiążącą ATP

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PL12181370T PL2578571T3 (pl) 2007-11-16 2008-11-14 Modulatory izochinolinowe transporterów zawierających kasetę wiążącą ATP

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US (4) US8507524B2 (enExample)
EP (3) EP2578571B1 (enExample)
JP (3) JP5646338B2 (enExample)
CN (2) CN102743385B (enExample)
AU (1) AU2008322616B2 (enExample)
CA (1) CA2705562C (enExample)
CY (1) CY1115318T1 (enExample)
DK (2) DK2578571T3 (enExample)
ES (3) ES2445447T3 (enExample)
HR (2) HRP20140103T1 (enExample)
HU (1) HUE026334T2 (enExample)
NZ (2) NZ585980A (enExample)
PL (2) PL2578571T3 (enExample)
PT (2) PT2578571E (enExample)
SI (2) SI2578571T1 (enExample)
WO (1) WO2009064959A1 (enExample)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200602755B (en) 2003-09-06 2007-06-27 Vertex Pharma Modulators of ATP-binding cassette transporters
JP4869072B2 (ja) * 2003-11-14 2012-02-01 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｐ結合カセットトランスポーターのモジュレーターとして有用なチアゾールおよびオキサゾール
US7977322B2 (en) 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
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BR112013004443A8 (pt) * 2010-08-23 2018-01-02 Vertex Pharma composições farmacêuticas de (r)-1-(2,2-difluorbenzo[d] [1,3]dioxol-5-il)-n-(1-(2,3-di-hidróxipropil)-6-flúor-2-(1-hidróxi-2-metilpropan-2-il)-1h-indol-5-il)ciclopropano carboxamida e administração das mesmas
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AU2013226076B2 (en) 2012-02-27 2017-11-16 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administration thereof
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WO2013185112A1 (en) 2012-06-08 2013-12-12 Vertex Pharmaceuticals Incorporated Pharmaceuticl compositions for the treatment of cftr -mediated disorders
EP2872122A1 (en) 2012-07-16 2015-05-20 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof
SMT202500078T1 (it) 2012-11-02 2025-03-12 Vertex Pharma Composizioni farmaceutiche per il trattamento di malattie mediate da cftr
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IL313498A (en) 2014-10-06 2024-08-01 Vertex Pharma Modulators of the cystic fibrosis transmembrane conductance regulator
KR20170063954A (ko) 2014-10-07 2017-06-08 버텍스 파마슈티칼스 인코포레이티드 낭성 섬유증 막횡단 전도도 조절자의 조정제의 공-결정

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