PL2212330T3 - Nowe związki stanowiące mimetyki zakrętu beta i ich zastosowanie - Google Patents

Nowe związki stanowiące mimetyki zakrętu beta i ich zastosowanie

Info

Publication number
PL2212330T3
PL2212330T3 PL08840475T PL08840475T PL2212330T3 PL 2212330 T3 PL2212330 T3 PL 2212330T3 PL 08840475 T PL08840475 T PL 08840475T PL 08840475 T PL08840475 T PL 08840475T PL 2212330 T3 PL2212330 T3 PL 2212330T3
Authority
PL
Poland
Prior art keywords
novel compounds
reverse turn
turn mimetics
mimetics
reverse
Prior art date
Application number
PL08840475T
Other languages
English (en)
Inventor
Jae Uk Chung
Kyung-Yun Jung
Min-Wook Jeong
Hee-Kyung Jung
Hyun-Ju La
Original Assignee
Jw Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jw Pharmaceutical Corp filed Critical Jw Pharmaceutical Corp
Publication of PL2212330T3 publication Critical patent/PL2212330T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
PL08840475T 2007-10-15 2008-10-15 Nowe związki stanowiące mimetyki zakrętu beta i ich zastosowanie PL2212330T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/974,941 US7671054B1 (en) 2001-10-12 2007-10-15 Reverse-turn mimetics and method relating thereto
PCT/KR2008/006070 WO2009051397A2 (en) 2007-10-15 2008-10-15 Novel compounds of reverse turn mimetics and the use thereof (3)
EP08840475.1A EP2212330B1 (en) 2007-10-15 2008-10-15 Novel compounds of reverse turn mimetics and the use thereof (3)

Publications (1)

Publication Number Publication Date
PL2212330T3 true PL2212330T3 (pl) 2015-09-30

Family

ID=40567948

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08840475T PL2212330T3 (pl) 2007-10-15 2008-10-15 Nowe związki stanowiące mimetyki zakrętu beta i ich zastosowanie

Country Status (13)

Country Link
US (4) US7671054B1 (pl)
EP (3) EP2212330B1 (pl)
JP (3) JP5222948B2 (pl)
KR (3) KR101542921B1 (pl)
CN (4) CN101827849B (pl)
AU (2) AU2008312193B2 (pl)
BR (2) BRPI0818647B1 (pl)
CA (2) CA2702461C (pl)
ES (3) ES2509042T3 (pl)
MX (2) MX2010004046A (pl)
PL (1) PL2212330T3 (pl)
RU (2) RU2457210C2 (pl)
WO (3) WO2009051399A2 (pl)

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US8691819B2 (en) 2008-10-14 2014-04-08 Prism Biolab Corporation Alpha helix mimetic compositions for treating cancer and other CBP/catenin-mediated diseases and conditions
JP5657642B2 (ja) * 2009-04-15 2015-01-21 ジェイダブリュ ファーマセウティカル コーポレーション リバースターン類似体の新規な化合物およびその製造方法と用途
CN102482258B (zh) 2009-05-07 2014-06-25 株式会社棱镜制药 α-螺旋模拟物和与其相关的方法
JPWO2011096440A1 (ja) 2010-02-03 2013-06-10 株式会社 ＰＲＩＳＭ ＢｉｏＬａｂ 天然変性タンパク質に結合する化合物およびそのスクリーニング方法
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WO2012068299A2 (en) 2010-11-16 2012-05-24 University Of Southern California Cbp/catenin antagonists for enhancing asymmetric division of somatic stem cells
TWI531573B (zh) * 2010-10-14 2016-05-01 Ｊｗ製藥公司 新穎反轉模擬物之化合物及其用途
WO2012115286A1 (en) * 2011-02-25 2012-08-30 Prism Biolab Corporation Alpha helix mimetics and methods relating thereto
WO2012136492A1 (en) * 2011-04-04 2012-10-11 Siena Biotech S.P.A. Wnt pathway antagonists
KR101441406B1 (ko) * 2011-05-25 2014-11-04 주식회사 바이오이미징코리아 디아릴이오도늄 염 전구체를 이용한 플로오린-18이 표지된 플루마제닐의 제조 방법
US9353119B2 (en) * 2011-08-09 2016-05-31 Jw Pharmaceutical Corporation Composition for preventing and treating non-small cell lung cancer, containing pyrazino-triazine derivatives
PT2754441E (pt) * 2011-08-09 2016-06-24 Jw Pharmaceutical Corp Composição para a prevenção e tratamento de cancro do pulmão de não pequenas células, contendo derivados de pirazino-triazina
US20140179633A1 (en) * 2011-08-26 2014-06-26 Jw Pharmaceutical Corporation Composition comprising pyrazino-triazine derivatives
KR20140094528A (ko) 2011-10-07 2014-07-30 유니버시티 오브 써던 캘리포니아 체세포 줄기 세포의 비대칭 분열을 향상시키기 위한 cbp/카테닌 길항제
GB201315335D0 (en) 2013-08-29 2013-10-09 Of Singapore Amino diacids containing peptide modifiers
SG11201601767YA (en) * 2013-09-11 2016-04-28 Prism Pharma Co Ltd Method of producing pyrazino[2,1-c][1,2,4]triazine compound
US9174998B2 (en) 2013-12-25 2015-11-03 Eisai R&D Management Co., Ltd. (6S,9aS)-N-benzyl-6-[(4-hydroxyphenyl)methyl]-4,7-dioxo-8-({6-[3-(piperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-2-(prop-2-en-1-yl)-octahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide compound
AU2016279474B2 (en) 2015-06-16 2021-09-09 Eisai R&D Management Co., Ltd. Anticancer agent
WO2016208576A1 (ja) 2015-06-23 2016-12-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 （６Ｓ，９ａＳ）－Ｎ－ベンジル－６－［（４－ヒドロキシフェニル）メチル］－４，７－ジオキソ－８－（｛６－［３－（ピペラジン－１－イル）アゼチジン－１－イル］ピリジン－２－イル｝メチル）－２－（プロプ－２－エン－１－イル）－オクタヒドロ－１Ｈ－ピラジノ［２，１－ｃ］［１，２，４］トリアジン－１－カルボキサミド化合物の結晶
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy
JP6785487B2 (ja) * 2015-09-18 2020-11-18 国立大学法人鳥取大学 低分子化合物による癌と線維化の抑制と再生促進の効果
WO2017184808A1 (en) * 2016-04-20 2017-10-26 University Of Southern California Compounds and methods for increasing hematopoiesis
CN110950873A (zh) * 2019-12-10 2020-04-03 河南大学 坡尔吲哚的合成新方法
TW202200582A (zh) 2020-03-12 2022-01-01 美商3+2製藥公司 Cbp/連環蛋白訊息傳遞路徑抑制劑及其用途
WO2023027888A1 (en) * 2021-08-26 2023-03-02 3+2 Pharma, Llc Pyrazole-containing cbp/catenin antagonists and uses thereof
GB202209228D0 (en) 2022-06-23 2022-08-10 Univ Strathclyde Modified amino acids and uses thereof

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Also Published As

Publication number Publication date
AU2008312193B2 (en) 2012-10-18
CA2702461C (en) 2012-12-11
CN103539797A (zh) 2014-01-29
RU2457210C2 (ru) 2012-07-27
CA2701735A1 (en) 2009-04-23
RU2010119468A (ru) 2011-11-27
US20100240662A1 (en) 2010-09-23
US7671054B1 (en) 2010-03-02
EP2212329A2 (en) 2010-08-04
CA2702461A1 (en) 2009-04-23
WO2009051399A2 (en) 2009-04-23
WO2009051399A3 (en) 2009-06-04
KR20100085107A (ko) 2010-07-28
CN103539797B (zh) 2016-05-18
WO2009051398A2 (en) 2009-04-23
ES2622703T3 (es) 2017-07-07
JP5222948B2 (ja) 2013-06-26
RU2470024C2 (ru) 2012-12-20
EP2212328A4 (en) 2011-11-30
BRPI0818647B1 (pt) 2021-10-26
EP2212330B1 (en) 2015-04-08
WO2009051398A3 (en) 2009-06-04
KR101229504B1 (ko) 2013-02-04
US8071764B2 (en) 2011-12-06
AU2008312191B2 (en) 2012-07-05
AU2008312191A1 (en) 2009-04-23
BRPI0818647A2 (pt) 2015-04-07
EP2212328A2 (en) 2010-08-04
US20100222303A1 (en) 2010-09-02
EP2212329A4 (en) 2011-11-30
MX2010004046A (es) 2010-06-25
WO2009051397A9 (en) 2010-05-27
US8138337B2 (en) 2012-03-20
CN101827849B (zh) 2013-07-24
JP2011500666A (ja) 2011-01-06
AU2008312193A1 (en) 2009-04-23
EP2212330A4 (en) 2011-11-30
JP5400785B2 (ja) 2014-01-29
KR20100085102A (ko) 2010-07-28
BRPI0818511B1 (pt) 2021-09-21
RU2010119447A (ru) 2011-11-27
EP2212329B1 (en) 2014-07-30
JP2011500667A (ja) 2011-01-06
WO2009051397A3 (en) 2009-06-04
EP2212328B1 (en) 2017-01-25
JP2011500668A (ja) 2011-01-06
KR101542921B1 (ko) 2015-08-11
BRPI0818511A2 (pt) 2015-06-16
CN101827849A (zh) 2010-09-08
MX2010004045A (es) 2010-07-06
JP5222949B2 (ja) 2013-06-26
CN101896485A (zh) 2010-11-24
KR101269420B1 (ko) 2013-05-30
CN101827850B (zh) 2014-03-12
KR20100099116A (ko) 2010-09-10
WO2009051397A2 (en) 2009-04-23
US8049008B2 (en) 2011-11-01
ES2509042T3 (es) 2014-10-16
ES2541459T3 (es) 2015-07-20
EP2212330A2 (en) 2010-08-04
CN101827850A (zh) 2010-09-08
US20100228027A1 (en) 2010-09-09
CA2701735C (en) 2012-12-11

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