PL219493B1 - Zastosowanie kompozycji zawierającej fluorowcowany lotny środek znieczulający oraz kompozycja zawierająca fluorowcowany lotny związek znieczulający do zastosowania w leczeniu pacjenta - Google Patents
Zastosowanie kompozycji zawierającej fluorowcowany lotny środek znieczulający oraz kompozycja zawierająca fluorowcowany lotny związek znieczulający do zastosowania w leczeniu pacjentaInfo
- Publication number
- PL219493B1 PL219493B1 PL376217A PL37621703A PL219493B1 PL 219493 B1 PL219493 B1 PL 219493B1 PL 376217 A PL376217 A PL 376217A PL 37621703 A PL37621703 A PL 37621703A PL 219493 B1 PL219493 B1 PL 219493B1
- Authority
- PL
- Poland
- Prior art keywords
- tissue
- use according
- administration
- anesthetic
- ischemic
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 54
- 238000001990 intravenous administration Methods 0.000 title claims description 19
- 239000003193 general anesthetic agent Substances 0.000 title description 13
- 229940035674 anesthetics Drugs 0.000 title description 11
- 230000005961 cardioprotection Effects 0.000 title description 9
- 230000004112 neuroprotection Effects 0.000 title description 5
- 239000000203 mixture Substances 0.000 claims abstract description 83
- 230000000302 ischemic effect Effects 0.000 claims abstract description 63
- 238000009472 formulation Methods 0.000 claims abstract description 61
- 239000003983 inhalation anesthetic agent Substances 0.000 claims abstract description 30
- 210000001519 tissue Anatomy 0.000 claims description 62
- PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 claims description 51
- 229960002725 isoflurane Drugs 0.000 claims description 51
- DPYMFVXJLLWWEU-UHFFFAOYSA-N desflurane Chemical compound FC(F)OC(F)C(F)(F)F DPYMFVXJLLWWEU-UHFFFAOYSA-N 0.000 claims description 46
- 229960003537 desflurane Drugs 0.000 claims description 43
- DFEYYRMXOJXZRJ-UHFFFAOYSA-N sevoflurane Chemical compound FCOC(C(F)(F)F)C(F)(F)F DFEYYRMXOJXZRJ-UHFFFAOYSA-N 0.000 claims description 39
- JPGQOUSTVILISH-UHFFFAOYSA-N enflurane Chemical compound FC(F)OC(F)(F)C(F)Cl JPGQOUSTVILISH-UHFFFAOYSA-N 0.000 claims description 38
- 229960002078 sevoflurane Drugs 0.000 claims description 38
- 229960000305 enflurane Drugs 0.000 claims description 37
- 238000001802 infusion Methods 0.000 claims description 27
- 238000004945 emulsification Methods 0.000 claims description 16
- 208000010125 myocardial infarction Diseases 0.000 claims description 14
- 238000001356 surgical procedure Methods 0.000 claims description 14
- 208000006011 Stroke Diseases 0.000 claims description 13
- 239000003995 emulsifying agent Substances 0.000 claims description 13
- 229960003132 halothane Drugs 0.000 claims description 13
- BCQZXOMGPXTTIC-UHFFFAOYSA-N halothane Chemical compound FC(F)(F)C(Cl)Br BCQZXOMGPXTTIC-UHFFFAOYSA-N 0.000 claims description 13
- 239000003814 drug Substances 0.000 claims description 10
- 210000002216 heart Anatomy 0.000 claims description 10
- 208000007474 aortic aneurysm Diseases 0.000 claims description 7
- 230000002490 cerebral effect Effects 0.000 claims description 7
- 229940079593 drug Drugs 0.000 claims description 7
- 208000014674 injury Diseases 0.000 claims description 7
- 210000004351 coronary vessel Anatomy 0.000 claims description 6
- 238000002583 angiography Methods 0.000 claims description 5
- 210000004556 brain Anatomy 0.000 claims description 5
- 210000005003 heart tissue Anatomy 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 230000008733 trauma Effects 0.000 claims description 5
- 206010002388 Angina unstable Diseases 0.000 claims description 4
- 208000034486 Multi-organ failure Diseases 0.000 claims description 4
- 208000010718 Multiple Organ Failure Diseases 0.000 claims description 4
- 206010040047 Sepsis Diseases 0.000 claims description 4
- 208000032109 Transient ischaemic attack Diseases 0.000 claims description 4
- 208000007814 Unstable Angina Diseases 0.000 claims description 4
- 238000002399 angioplasty Methods 0.000 claims description 4
- 230000000747 cardiac effect Effects 0.000 claims description 4
- 210000001508 eye Anatomy 0.000 claims description 4
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims description 4
- 210000000936 intestine Anatomy 0.000 claims description 4
- 210000003734 kidney Anatomy 0.000 claims description 4
- 210000004185 liver Anatomy 0.000 claims description 4
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 4
- 201000010875 transient cerebral ischemia Diseases 0.000 claims description 4
- 208000018262 Peripheral vascular disease Diseases 0.000 claims description 3
- 208000027032 Renal vascular disease Diseases 0.000 claims description 3
- 238000013172 carotid endarterectomy Methods 0.000 claims description 3
- 208000015670 renal artery disease Diseases 0.000 claims description 3
- 230000002792 vascular Effects 0.000 claims description 3
- 230000001419 dependent effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000002107 myocardial effect Effects 0.000 abstract description 5
- 230000001537 neural effect Effects 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 description 38
- 238000002360 preparation method Methods 0.000 description 26
- 230000003444 anaesthetic effect Effects 0.000 description 23
- 210000004369 blood Anatomy 0.000 description 22
- 239000008280 blood Substances 0.000 description 22
- 206010061216 Infarction Diseases 0.000 description 21
- 241000283973 Oryctolagus cuniculus Species 0.000 description 21
- 230000007574 infarction Effects 0.000 description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 19
- 239000012071 phase Substances 0.000 description 17
- 230000004224 protection Effects 0.000 description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 13
- 239000007789 gas Substances 0.000 description 12
- 239000003921 oil Substances 0.000 description 12
- 235000019198 oils Nutrition 0.000 description 12
- 208000028867 ischemia Diseases 0.000 description 11
- 230000010410 reperfusion Effects 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 9
- 210000004165 myocardium Anatomy 0.000 description 9
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 8
- 235000010445 lecithin Nutrition 0.000 description 8
- 239000000787 lecithin Substances 0.000 description 8
- 229940067606 lecithin Drugs 0.000 description 8
- 206010039897 Sedation Diseases 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- 230000036280 sedation Effects 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000006378 damage Effects 0.000 description 6
- 235000012424 soybean oil Nutrition 0.000 description 6
- 239000003549 soybean oil Substances 0.000 description 6
- 239000003981 vehicle Substances 0.000 description 6
- 206010002091 Anaesthesia Diseases 0.000 description 5
- 230000037005 anaesthesia Effects 0.000 description 5
- 230000036760 body temperature Effects 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- 230000001965 increasing effect Effects 0.000 description 5
- 230000002669 organ and tissue protective effect Effects 0.000 description 5
- 238000002405 diagnostic procedure Methods 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000004817 gas chromatography Methods 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 230000000004 hemodynamic effect Effects 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 230000036961 partial effect Effects 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 239000012929 tonicity agent Substances 0.000 description 4
- 208000001778 Coronary Occlusion Diseases 0.000 description 3
- 206010011086 Coronary artery occlusion Diseases 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 230000004872 arterial blood pressure Effects 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 238000004868 gas analysis Methods 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 3
- 210000002381 plasma Anatomy 0.000 description 3
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- DTBDAFLSBDGPEA-UHFFFAOYSA-N 3-Methylquinoline Natural products C1=CC=CC2=CC(C)=CN=C21 DTBDAFLSBDGPEA-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
- 206010063837 Reperfusion injury Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 238000000540 analysis of variance Methods 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 238000001647 drug administration Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 229960002897 heparin Drugs 0.000 description 2
- 229920000669 heparin Polymers 0.000 description 2
- 230000007954 hypoxia Effects 0.000 description 2
- 239000005457 ice water Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000010253 intravenous injection Methods 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000002483 medication Methods 0.000 description 2
- RFKMCNOHBTXSMU-UHFFFAOYSA-N methoxyflurane Chemical compound COC(F)(F)C(Cl)Cl RFKMCNOHBTXSMU-UHFFFAOYSA-N 0.000 description 2
- 229960002455 methoxyflurane Drugs 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000036284 oxygen consumption Effects 0.000 description 2
- 229960001412 pentobarbital Drugs 0.000 description 2
- 150000003904 phospholipids Chemical class 0.000 description 2
- OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 description 2
- 229960004134 propofol Drugs 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 230000002861 ventricular Effects 0.000 description 2
- LCJINPXTMHVZGV-UHFFFAOYSA-N 2,3,5-triphenyl-1h-tetrazol-4-ium;chloride Chemical compound [Cl-].[NH2+]1N(C=2C=CC=CC=2)N(C=2C=CC=CC=2)N=C1C1=CC=CC=C1 LCJINPXTMHVZGV-UHFFFAOYSA-N 0.000 description 1
- 206010001526 Air embolism Diseases 0.000 description 1
- 208000007257 Budd-Chiari syndrome Diseases 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 208000012661 Dyskinesia Diseases 0.000 description 1
- 208000010496 Heart Arrest Diseases 0.000 description 1
- 206010019713 Hepatic vein thrombosis Diseases 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 206010024769 Local reaction Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 102000008299 Nitric Oxide Synthase Human genes 0.000 description 1
- 108010021487 Nitric Oxide Synthase Proteins 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- SJEYSFABYSGQBG-UHFFFAOYSA-M Patent blue Chemical compound [Na+].C1=CC(N(CC)CC)=CC=C1C(C=1C(=CC(=CC=1)S([O-])(=O)=O)S([O-])(=O)=O)=C1C=CC(=[N+](CC)CC)C=C1 SJEYSFABYSGQBG-UHFFFAOYSA-M 0.000 description 1
- 208000004531 Renal Artery Obstruction Diseases 0.000 description 1
- 206010038378 Renal artery stenosis Diseases 0.000 description 1
- 206010038731 Respiratory tract irritation Diseases 0.000 description 1
- 238000010161 Student-Newman-Keuls test Methods 0.000 description 1
- 206010054880 Vascular insufficiency Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003994 anesthetic gas Substances 0.000 description 1
- 210000003423 ankle Anatomy 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 230000008321 arterial blood flow Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229940125717 barbiturate Drugs 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 238000009530 blood pressure measurement Methods 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 239000001045 blue dye Substances 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000003293 cardioprotective effect Effects 0.000 description 1
- 210000001715 carotid artery Anatomy 0.000 description 1
- 210000001627 cerebral artery Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000000586 desensitisation Methods 0.000 description 1
- 238000012631 diagnostic technique Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000010102 embolization Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- -1 glycerol Chemical class 0.000 description 1
- 230000001435 haemodynamic effect Effects 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000003601 intercostal effect Effects 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 208000037906 ischaemic injury Diseases 0.000 description 1
- 210000004731 jugular vein Anatomy 0.000 description 1
- 210000005240 left ventricle Anatomy 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000002960 lipid emulsion Substances 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 230000003137 locomotive effect Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 210000003975 mesenteric artery Anatomy 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229940035363 muscle relaxants Drugs 0.000 description 1
- 230000003680 myocardial damage Effects 0.000 description 1
- 239000003158 myorelaxant agent Substances 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 210000000944 nerve tissue Anatomy 0.000 description 1
- 238000011587 new zealand white rabbit Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229940005483 opioid analgesics Drugs 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 229950011087 perflunafene Drugs 0.000 description 1
- UWEYRJFJVCLAGH-IJWZVTFUSA-N perfluorodecalin Chemical compound FC1(F)C(F)(F)C(F)(F)C(F)(F)[C@@]2(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)[C@@]21F UWEYRJFJVCLAGH-IJWZVTFUSA-N 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000036387 respiratory rate Effects 0.000 description 1
- 230000026416 response to pain Effects 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008227 sterile water for injection Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 208000023577 vascular insufficiency disease Diseases 0.000 description 1
- 208000003663 ventricular fibrillation Diseases 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41793402P | 2002-10-11 | 2002-10-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL376217A1 PL376217A1 (en) | 2005-12-27 |
| PL219493B1 true PL219493B1 (pl) | 2015-05-29 |
Family
ID=32094122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL376217A PL219493B1 (pl) | 2002-10-11 | 2003-10-09 | Zastosowanie kompozycji zawierającej fluorowcowany lotny środek znieczulający oraz kompozycja zawierająca fluorowcowany lotny związek znieczulający do zastosowania w leczeniu pacjenta |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7999011B2 (enExample) |
| EP (1) | EP1558226B1 (enExample) |
| JP (1) | JP5210486B2 (enExample) |
| KR (2) | KR101403264B1 (enExample) |
| CN (2) | CN1703209A (enExample) |
| AT (1) | ATE546136T1 (enExample) |
| AU (1) | AU2003282464B2 (enExample) |
| BR (1) | BR0314617A (enExample) |
| CA (1) | CA2500310C (enExample) |
| DK (1) | DK1558226T3 (enExample) |
| ES (1) | ES2382911T3 (enExample) |
| HK (1) | HK1079703A1 (enExample) |
| IL (1) | IL167472A (enExample) |
| MX (1) | MXPA05003741A (enExample) |
| NZ (1) | NZ539298A (enExample) |
| PL (1) | PL219493B1 (enExample) |
| RU (1) | RU2350323C2 (enExample) |
| WO (1) | WO2004032858A2 (enExample) |
| ZA (1) | ZA200502741B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003026611A2 (en) | 2001-09-26 | 2003-04-03 | Baxter International Inc. | Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal |
| US7449616B2 (en) | 2002-12-24 | 2008-11-11 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
| ES2573253T3 (es) * | 2006-09-20 | 2016-06-06 | The Board Of Regents Of The University Of Texas System | Métodos para el suministro de anestésicos volátiles para anestesia regional y/o alivio del dolor |
| GB0619499D0 (en) | 2006-10-03 | 2006-11-08 | Lucent Technologies Inc | Encrypted data in a wireless telecommunications system |
| DE112008002914A5 (de) * | 2007-11-06 | 2010-09-30 | B. Braun Melsungen Ag | Einen hydrophoben Wirkstoff enthaltende wässrige Emulsionen |
| CN107661293A (zh) * | 2008-01-22 | 2018-02-06 | 得克萨斯大学体系董事会 | 用于局部麻醉和/或疼痛缓解的含有萃取溶剂的挥发性麻醉剂组合物 |
| AU2015200210B2 (en) * | 2008-01-22 | 2016-08-11 | The Board Of Regents Of The University Of Texas System | Volatile anesthetic compositions comprising extractive solvents for regional anesthesia and/or pain relief |
| US20110159078A1 (en) * | 2008-01-22 | 2011-06-30 | Vapogenix, Inc | Volatile Anesthetic Compositions and Methods of Use |
| AU2010245932B2 (en) * | 2009-05-05 | 2015-08-06 | Board Of Regents, The University Of Texas System | Novel formulations of volatile anesthetics and methods of use for reducing inflammation |
| RU2408396C1 (ru) * | 2009-07-30 | 2011-01-10 | Государственное образовательное учреждение высшего профессионального образования "Тверская государственная медицинская академия Федерального агентства по здравоохранению и федеральному развитию" | Комбинированная двухсегментарная регионарная анестезия при выполнении каротидной эндартерэктомии у больных критической ишемией нижних конечностей и выраженным болевым синдромом |
| US20120219596A1 (en) | 2009-07-30 | 2012-08-30 | Wendelin Stark | Injectable formulation for treatment and protection of patients having an inflammatory reaction or an ischemia-reperfusion event |
| FR2956323B1 (fr) * | 2010-02-15 | 2013-12-20 | Air Liquide | Medicament gazeux inhalable a base d'argon contre les deficiences ou defaillances d'organes peripheriques |
| JP2014520157A (ja) | 2011-06-24 | 2014-08-21 | ベイポジェニックス インコーポレイテッド | 皮膚科障害または皮膚科疾患を処置するための新規製剤および方法 |
| EP3854389A1 (en) * | 2013-03-15 | 2021-07-28 | Vapogenix, Inc. | Novel analgesic compositions |
| ITMO20130075A1 (it) * | 2013-03-22 | 2014-09-23 | Enrico Giuliani | Dispositivo di somministrazione |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1018773A (en) * | 1962-09-13 | 1966-02-02 | Bellon Labor Sa Roger | ª‡-phenyl-ª‰-2-furyl-propionitrile derivatives |
| US4073943A (en) | 1974-09-11 | 1978-02-14 | Apoteksvarucentralen Vitrum Ab | Method of enhancing the administration of pharmalogically active agents |
| US5628930A (en) | 1992-10-27 | 1997-05-13 | Alliance Pharmaceutical Corp. | Stabilization of fluorocarbon emulsions |
| US5635538A (en) | 1993-03-16 | 1997-06-03 | Alliance Pharmaceutical Corp. | Fluorocarbon emulsions with reduced pulmonary gas-trapping properties |
| JP2961034B2 (ja) * | 1993-09-16 | 1999-10-12 | アルプス電気株式会社 | 磁気ヘッド |
| DE69429524T2 (de) | 1993-09-24 | 2002-08-08 | The University Of British Columbia, Vancouver | Aminocyclohexylester und ihre anwendung |
| FR2726267B1 (fr) * | 1994-10-26 | 1998-01-02 | Smithkline Beecham Lab | Nouveaux agents anti-arythmiques, compositions pharmaceutiques les contenant, et procede pour les preparer |
| GB2350297A (en) * | 1999-05-27 | 2000-11-29 | Abbott Lab | Injectable halogenated anesthetic formulation in emulsion form |
| CA2416535C (en) * | 2000-07-26 | 2010-11-16 | Taro Pharmaceutical Industries Ltd. | Non-sedating barbiturate compounds as neuroprotective agents |
-
2003
- 2003-10-09 HK HK05112083.8A patent/HK1079703A1/zh unknown
- 2003-10-09 MX MXPA05003741A patent/MXPA05003741A/es active IP Right Grant
- 2003-10-09 BR BR0314617-0A patent/BR0314617A/pt not_active Application Discontinuation
- 2003-10-09 AU AU2003282464A patent/AU2003282464B2/en not_active Ceased
- 2003-10-09 JP JP2004543499A patent/JP5210486B2/ja not_active Expired - Lifetime
- 2003-10-09 ES ES03774657T patent/ES2382911T3/es not_active Expired - Lifetime
- 2003-10-09 EP EP03774657A patent/EP1558226B1/en not_active Expired - Lifetime
- 2003-10-09 AT AT03774657T patent/ATE546136T1/de active
- 2003-10-09 WO PCT/US2003/031826 patent/WO2004032858A2/en not_active Ceased
- 2003-10-09 NZ NZ539298A patent/NZ539298A/en not_active IP Right Cessation
- 2003-10-09 DK DK03774657.5T patent/DK1558226T3/da active
- 2003-10-09 US US10/682,303 patent/US7999011B2/en active Active
- 2003-10-09 KR KR1020057006049A patent/KR101403264B1/ko not_active Expired - Fee Related
- 2003-10-09 CN CNA2003801012256A patent/CN1703209A/zh active Pending
- 2003-10-09 CA CA2500310A patent/CA2500310C/en not_active Expired - Fee Related
- 2003-10-09 PL PL376217A patent/PL219493B1/pl unknown
- 2003-10-09 KR KR1020127005009A patent/KR20120030598A/ko not_active Ceased
- 2003-10-09 CN CN2011101820964A patent/CN102283821A/zh active Pending
- 2003-10-09 RU RU2005114008/14A patent/RU2350323C2/ru not_active IP Right Cessation
-
2005
- 2005-03-16 IL IL167472A patent/IL167472A/en active IP Right Grant
- 2005-04-05 ZA ZA200502741A patent/ZA200502741B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003282464B2 (en) | 2010-02-25 |
| CA2500310A1 (en) | 2004-04-22 |
| AU2003282464A1 (en) | 2004-05-04 |
| HK1079703A1 (zh) | 2006-04-13 |
| ATE546136T1 (de) | 2012-03-15 |
| RU2005114008A (ru) | 2005-10-27 |
| US20040127578A1 (en) | 2004-07-01 |
| NZ539298A (en) | 2008-11-28 |
| KR20050056230A (ko) | 2005-06-14 |
| WO2004032858A3 (en) | 2004-09-23 |
| EP1558226A4 (en) | 2008-04-02 |
| IL167472A (en) | 2013-10-31 |
| KR20120030598A (ko) | 2012-03-28 |
| KR101403264B1 (ko) | 2014-06-02 |
| CN1703209A (zh) | 2005-11-30 |
| CA2500310C (en) | 2013-03-12 |
| US7999011B2 (en) | 2011-08-16 |
| JP5210486B2 (ja) | 2013-06-12 |
| ES2382911T3 (es) | 2012-06-14 |
| RU2350323C2 (ru) | 2009-03-27 |
| DK1558226T3 (da) | 2012-05-07 |
| EP1558226A2 (en) | 2005-08-03 |
| ZA200502741B (en) | 2006-02-22 |
| EP1558226B1 (en) | 2012-02-22 |
| CN102283821A (zh) | 2011-12-21 |
| BR0314617A (pt) | 2005-08-02 |
| MXPA05003741A (es) | 2005-06-17 |
| JP2006504740A (ja) | 2006-02-09 |
| PL376217A1 (en) | 2005-12-27 |
| WO2004032858A2 (en) | 2004-04-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102027613B1 (ko) | 호르몬 함유 유화액 | |
| PL219493B1 (pl) | Zastosowanie kompozycji zawierającej fluorowcowany lotny środek znieczulający oraz kompozycja zawierająca fluorowcowany lotny związek znieczulający do zastosowania w leczeniu pacjenta | |
| BG64583B1 (bg) | Лекарствен препарат, съдържащ липофилен инертен газ | |
| CA2217742A1 (en) | Homogeneous water-in-perfluorochemical stable liquid dispersion for administration of a drug to the lung of an animal | |
| JP2011102290A (ja) | 人工心肺に関連する神経障害を制御するためのキセノンの使用 | |
| JP2006504740A5 (enExample) | ||
| ES2597959T3 (es) | Emulsión de Ciclosporina | |
| US20250161215A1 (en) | Lipid emulsions and uses thereof | |
| JP6629850B2 (ja) | 汎用心停止液（変種） | |
| US11357743B2 (en) | Ketamine and propofol admixture | |
| JP6220383B2 (ja) | 非経口エスモロール製剤 | |
| JP7752425B2 (ja) | ２，２，６，６－テトラメチル－１－ピペリジニルオキシルの揮発使用による細胞死抑制と組織保護 | |
| Sheikhi et al. | Balancing risk and outcome in pediatric cardiac anesthesia. |