PL208283B1 - Pochodna indolinonu, sposób jej wytwarzania, jej zastosowanie, kompozycja farmaceutyczna ją zawierająca i zastosowanie tej kompozycji - Google Patents
Pochodna indolinonu, sposób jej wytwarzania, jej zastosowanie, kompozycja farmaceutyczna ją zawierająca i zastosowanie tej kompozycjiInfo
- Publication number
- PL208283B1 PL208283B1 PL369602A PL36960202A PL208283B1 PL 208283 B1 PL208283 B1 PL 208283B1 PL 369602 A PL369602 A PL 369602A PL 36960202 A PL36960202 A PL 36960202A PL 208283 B1 PL208283 B1 PL 208283B1
- Authority
- PL
- Poland
- Prior art keywords
- compound
- formula
- dimethyl
- pyrrol
- dihydroindol
- Prior art date
Links
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- 239000001257 hydrogen Substances 0.000 claims description 12
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 11
- 125000006239 protecting group Chemical group 0.000 claims description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims description 9
- KVIAIJLTPHXNEB-UHFFFAOYSA-N 3-[[3,5-dimethyl-4-(3-oxo-3-piperazin-1-ylpropyl)-1h-pyrrol-2-yl]methylidene]-1h-indol-2-one Chemical compound CC=1NC(C=C2C3=CC=CC=C3NC2=O)=C(C)C=1CCC(=O)N1CCNCC1 KVIAIJLTPHXNEB-UHFFFAOYSA-N 0.000 claims description 8
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34381301P | 2001-12-27 | 2001-12-27 | |
| US34374601P | 2001-12-27 | 2001-12-27 |
Publications (2)
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|---|---|
| PL369602A1 PL369602A1 (en) | 2005-05-02 |
| PL208283B1 true PL208283B1 (pl) | 2011-04-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| PL369602A PL208283B1 (pl) | 2001-12-27 | 2002-12-20 | Pochodna indolinonu, sposób jej wytwarzania, jej zastosowanie, kompozycja farmaceutyczna ją zawierająca i zastosowanie tej kompozycji |
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|---|---|
| US (3) | US6686362B2 (de) |
| EP (1) | EP1458713B1 (de) |
| JP (1) | JP4363985B2 (de) |
| KR (1) | KR100965519B1 (de) |
| CN (1) | CN1290844C (de) |
| AT (1) | ATE302771T1 (de) |
| AU (1) | AU2002360753B2 (de) |
| BR (1) | BR0215360A (de) |
| CA (1) | CA2470480C (de) |
| CO (1) | CO5611126A2 (de) |
| DE (1) | DE60205776T2 (de) |
| DK (1) | DK1458713T3 (de) |
| ES (1) | ES2247411T3 (de) |
| HU (1) | HUP0500111A3 (de) |
| IL (1) | IL162203A0 (de) |
| MX (1) | MXPA04006271A (de) |
| NO (1) | NO327550B1 (de) |
| NZ (1) | NZ533219A (de) |
| PL (1) | PL208283B1 (de) |
| RU (1) | RU2316554C2 (de) |
| WO (1) | WO2003057690A1 (de) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004015082A2 (en) * | 2002-08-09 | 2004-02-19 | Theravance, Inc. | Oncokinase fusion polypeptides associated with hyperproliferative and related disorders, nucleic acids encoding the same and methods for detecting and identifying the same |
| US7105563B2 (en) | 2003-10-24 | 2006-09-12 | Schering Aktiengesellschaft | Indolinone derivatives and their use in treating disease-states such as cancer |
| JP2007513967A (ja) * | 2003-12-11 | 2007-05-31 | セラヴァンス， インコーポレーテッド | 変異レセプターチロシンキナーゼが駆動する細胞増殖性疾患の処置において使用するための組成物 |
| SE0401790D0 (sv) * | 2004-07-07 | 2004-07-07 | Forskarpatent I Syd Ab | Tamoxifen response in pre- and postmenopausal breast cancer patients |
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| WO2000038519A1 (en) | 1998-12-31 | 2000-07-06 | Sugen, Inc. | 3-heteroarylidenyl-2-indolinone compounds for modulating protein kinase activity and for use in cancer chemotherapy |
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