PL188749B1 - Zastosowanie przeciwciała anty-4-1BB i kompozycjaleku - Google Patents
Zastosowanie przeciwciała anty-4-1BB i kompozycjalekuInfo
- Publication number
- PL188749B1 PL188749B1 PL97332699A PL33269997A PL188749B1 PL 188749 B1 PL188749 B1 PL 188749B1 PL 97332699 A PL97332699 A PL 97332699A PL 33269997 A PL33269997 A PL 33269997A PL 188749 B1 PL188749 B1 PL 188749B1
- Authority
- PL
- Poland
- Prior art keywords
- antibody
- cells
- binding
- mab
- antibodies
- Prior art date
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2827096P | 1996-10-11 | 1996-10-11 | |
| PCT/US1997/018035 WO1998016249A1 (en) | 1996-10-11 | 1997-10-03 | Methods and compositions for immunomodulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL332699A1 PL332699A1 (en) | 1999-09-27 |
| PL188749B1 true PL188749B1 (pl) | 2005-04-29 |
Family
ID=21842492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL97332699A PL188749B1 (pl) | 1996-10-11 | 1997-10-03 | Zastosowanie przeciwciała anty-4-1BB i kompozycjaleku |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6210669B1 (enExample) |
| EP (1) | EP0948353A1 (enExample) |
| JP (1) | JP2001502325A (enExample) |
| KR (1) | KR100520339B1 (enExample) |
| CN (1) | CN1232402A (enExample) |
| AU (1) | AU738981B2 (enExample) |
| BR (1) | BR9712278A (enExample) |
| CA (1) | CA2268340A1 (enExample) |
| HU (1) | HUP9904697A3 (enExample) |
| IL (1) | IL129138A0 (enExample) |
| NO (1) | NO991676D0 (enExample) |
| NZ (1) | NZ334691A (enExample) |
| PL (1) | PL188749B1 (enExample) |
| RU (1) | RU2192281C2 (enExample) |
| WO (1) | WO1998016249A1 (enExample) |
Families Citing this family (140)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6312700B1 (en) * | 1998-02-24 | 2001-11-06 | Andrew D. Weinberg | Method for enhancing an antigen specific immune response with OX-40L |
| KR20000034847A (ko) * | 1998-11-17 | 2000-06-26 | 성재갑 | 인간 4-1비비 분자에 대한 인간화 항체 및 이를 포함하는 약학조성물 |
| ES2629683T3 (es) | 1999-11-30 | 2017-08-14 | Mayo Foundation For Medical Education And Research | B7-H1, una nueva molécula inmunorreguladora |
| US7541184B2 (en) * | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| KR100468321B1 (ko) * | 2001-02-08 | 2005-01-27 | 학교법인 울산공업학원 | 종양 및 에이즈치료용 폴리펩타이드 |
| US7651686B2 (en) * | 2001-10-09 | 2010-01-26 | Mayo Foundation For Medical Education And Research | Enhancement of immune responses by 4-1bb-binding agents |
| KR100452954B1 (ko) * | 2002-02-26 | 2004-10-14 | 주식회사 엘지생명과학 | 가변영역 아미노산 치환을 통한 인간 4-1비비분자에 대한결합 특이성이 증가된 변형 인간화 항체의 제조방법 |
| US20040151704A1 (en) * | 2002-06-28 | 2004-08-05 | Xcyte Therapies, Inc. | Compositions and methods for restoring immune repertoire in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| US20050084967A1 (en) * | 2002-06-28 | 2005-04-21 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| US20040175373A1 (en) * | 2002-06-28 | 2004-09-09 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| WO2004006853A2 (en) * | 2002-07-15 | 2004-01-22 | Mayo Foundation For Medical Education And Research | Treatment and prophylaxis with 4-1bb-binding agents |
| PL375144A1 (en) * | 2002-07-30 | 2005-11-28 | Bristol-Myers Squibb Company | Humanized antibodies against human 4-1bb |
| WO2004055513A2 (en) * | 2002-12-16 | 2004-07-01 | Herbert Schwarz | Use of cd137 antagonists for the treatment of tumors |
| US20040197312A1 (en) * | 2003-04-02 | 2004-10-07 | Marina Moskalenko | Cytokine-expressing cellular vaccine combinations |
| US7288638B2 (en) | 2003-10-10 | 2007-10-30 | Bristol-Myers Squibb Company | Fully human antibodies against human 4-1BB |
| AR046094A1 (es) * | 2003-10-10 | 2005-11-23 | Bristol Myers Squibb Co | Anticuerpos completamente humanos contra 4-1bb humano |
| KR20050082389A (ko) * | 2004-02-18 | 2005-08-23 | 메덱스젠 주식회사 | 직렬 연쇄체를 갖는 면역접합체를 포함하는 장기이식합병증 치료용 약제학적 조성물 |
| WO2005092927A1 (en) | 2004-03-23 | 2005-10-06 | Biogen Idec Ma Inc. | Receptor coupling agents and therapeutic uses thereof |
| US20070253961A1 (en) * | 2004-06-09 | 2007-11-01 | Ulsan Industrial Education Foundation | Pharmaceutical Composition Comprising the Anti-4-1Bb Antibody for Treating or Preventing Rheumatoid Arthritis |
| WO2006029220A2 (en) * | 2004-09-08 | 2006-03-16 | Ohio State University Research Foundation | Combination therapy with anti-ctla4 and anti-4-1bb antibodies |
| SI1810026T1 (en) | 2004-10-06 | 2018-08-31 | Mayo Foundation For Medical Education And Research | B7-H1 and PD-1 in the treatment of renal cell carcinoma |
| WO2006059904A1 (en) * | 2004-12-02 | 2006-06-08 | Unilever N.V. | Method for affinity purification |
| US20080019905A9 (en) * | 2005-02-18 | 2008-01-24 | Strome Scott E | Method of using an anti-CD137 antibody as an agent for radioimmunotherapy or radioimmunodetection |
| EP1851244A4 (en) * | 2005-02-15 | 2009-04-15 | Gtc Biotherapeutics Inc | ANTI-CD137 ANTIBODY AS A MEANS FOR THE TREATMENT OF CANCER, AND GLYCOSYLATION VARIANTS THEREOF |
| US20060182744A1 (en) * | 2005-02-15 | 2006-08-17 | Strome Scott E | Anti-CD137 antibody as an agent in the treatment of cancer and glycosylation variants thereof |
| EP2388273B1 (en) * | 2005-10-21 | 2017-07-05 | LFB USA, Inc. | Antibodies with enhanced antibody-dependent cellular cytoxicity activity, methods of their production and use |
| WO2007082154A2 (en) * | 2006-01-05 | 2007-07-19 | Mayo Foundation For Medical Education And Research | B7-h1 and b7-h4 in cancer |
| WO2007082144A2 (en) * | 2006-01-05 | 2007-07-19 | Mayo Foundation For Medical Education And Research | B7-h1 and survivin in cancer |
| WO2007124361A2 (en) * | 2006-04-20 | 2007-11-01 | Mayo Foundation For Medical Education And Research | Soluble b7-h1 |
| US20110020325A1 (en) * | 2008-02-29 | 2011-01-27 | Kwon Eugene D | Methods for reducing granulomatous inflammation |
| WO2010042433A1 (en) | 2008-10-06 | 2010-04-15 | Bristol-Myers Squibb Company | Combination of cd137 antibody and ctla-4 antibody for the treatment of proliferative diseases |
| US20120076722A1 (en) * | 2009-05-14 | 2012-03-29 | University Of Maryland, Baltimore | Methods for treating cancers and diseases associated with 4-1bb (cd137) expression |
| ES2377785B2 (es) | 2010-09-08 | 2012-09-26 | Universidad Miguel Hernández De Elche | Composición farmacéutica para el tratamiento del ojo seco. |
| BR112013005699B1 (pt) | 2010-09-09 | 2021-08-17 | Pfizer Inc | Anticorpo isolado ou porção de ligação ao antígeno do mesmo que se liga ao 4-1bb humano, combinação, usos dos mesmos, bem como composição farmacêutica, molécula de ácido nucleico isolada e vetor |
| EP2699598B1 (en) * | 2011-04-19 | 2019-03-06 | Pfizer Inc | Combinations of anti-4-1bb antibodies and adcc-inducing antibodies for the treatment of cancer |
| US20140234320A1 (en) * | 2011-06-20 | 2014-08-21 | La Jolla Institute For Allergy And Immunology | Modulators of 4-1bb and immune responses |
| RU2493873C1 (ru) * | 2012-06-07 | 2013-09-27 | Сергей Михайлович Юдин | Инъекционный препарат для повышения спермопродукции у производителей сельскохозяйственных животных и петухов и способ его применения |
| US9302005B2 (en) | 2013-03-14 | 2016-04-05 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| WO2015050663A1 (en) | 2013-10-01 | 2015-04-09 | Mayo Foundation For Medical Education And Research | Methods for treating cancer in patients with elevated levels of bim |
| EA201690746A1 (ru) | 2013-10-25 | 2016-12-30 | Фармасайкликс Элэлси | Лечение с применением ингибиторов тирозинкиназы брутона и иммунотерапии |
| EP3066127A1 (en) | 2013-11-06 | 2016-09-14 | Bristol-Myers Squibb Company | Immunotherapeutic dosing regimens and combinations thereof |
| EP3686219A1 (en) | 2014-02-04 | 2020-07-29 | Pfizer Inc | Combination of a pd-1 antagonist and a 4-1bb agonist for treating cancer |
| US10302653B2 (en) | 2014-05-22 | 2019-05-28 | Mayo Foundation For Medical Education And Research | Distinguishing antagonistic and agonistic anti B7-H1 antibodies |
| US10517875B2 (en) | 2014-07-23 | 2019-12-31 | Mayo Foundation for Medical Engineering and Research | Targeting DNA-PKcs and B7-H1 to treat cancer |
| JP6991857B2 (ja) | 2014-10-10 | 2022-01-13 | イデラ ファーマシューティカルズ インコーポレイテッド | Tlr9アゴニストをチェックポイント阻害剤と共に用いるがんの治療 |
| RS60753B1 (sr) | 2015-04-17 | 2020-10-30 | Bristol Myers Squibb Co | Kompozicije koje sadrže kombinaciju ipilimumaba i nivolumaba |
| JP6688551B2 (ja) | 2015-05-21 | 2020-04-28 | ハープーン セラピューティクス,インク. | 三重特異性結合タンパク質と使用方法 |
| EP3744340A3 (en) | 2015-07-16 | 2021-03-03 | Biokine Therapeutics Ltd. | Compositions and methods for treating cancer |
| WO2017025871A1 (en) | 2015-08-07 | 2017-02-16 | Glaxosmithkline Intellectual Property Development Limited | Combination therapy comprising anti ctla-4 antibodies |
| WO2017046746A1 (en) | 2015-09-15 | 2017-03-23 | Acerta Pharma B.V. | Therapeutic combinations of a btk inhibitor and a gitr binding molecule, a 4-1bb agonist, or an ox40 agonist |
| US10875923B2 (en) | 2015-10-30 | 2020-12-29 | Mayo Foundation For Medical Education And Research | Antibodies to B7-H1 |
| AU2017234163B2 (en) | 2016-03-15 | 2023-01-19 | Mersana Therapeutics, Inc. | NaPi2b-targeted antibody-drug conjugates and methods of use thereof |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| RS65474B1 (sr) | 2016-05-20 | 2024-05-31 | Biohaven Therapeutics Ltd | Primena riluzola, prolekova riluzola ili analoga riluzola sa imunoterapijama za lečenje kancera |
| IL263744B2 (en) | 2016-06-17 | 2023-11-01 | Magenta Therapeutics Inc | Compositions and methods for the depletion of cd117 plus cells |
| TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
| US11135307B2 (en) | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
| AU2017363337B2 (en) | 2016-11-23 | 2021-07-01 | Translational Drug Development, Llc | Benzamide and active compound compositions and methods of use |
| JP7780248B2 (ja) | 2017-01-06 | 2025-12-04 | アイオバンス バイオセラピューティクス,インコーポレイテッド | 腫瘍壊死因子受容体スーパーファミリー(tnfrsf)アゴニストによる腫瘍浸潤リンパ球(til)の拡大培養及びtilとtnfrsfアゴニストとの治療的併用 |
| MA47331A (fr) | 2017-01-20 | 2019-11-27 | Magenta Therapeutics Inc | Compositions et procédés pour la déplétion des cellules cd137+ |
| WO2018160538A1 (en) | 2017-02-28 | 2018-09-07 | Mersana Therapeutics, Inc. | Combination therapies of her2-targeted antibody-drug conjugates |
| CA3058175A1 (en) | 2017-03-31 | 2018-10-04 | Bristol-Myers Squibb Company | Methods of treating tumor |
| US11242385B2 (en) | 2017-04-13 | 2022-02-08 | Agenus Inc. | Anti-CD137 antibodies and methods of use thereof |
| CN110891974B (zh) | 2017-05-12 | 2021-08-06 | 哈普恩治疗公司 | 间皮素结合蛋白质 |
| TW201919662A (zh) | 2017-06-05 | 2019-06-01 | 美商艾歐凡斯生物治療公司 | 對雙重難治性黑色素瘤使用腫瘤浸潤性淋巴細胞之方法 |
| KR20240147708A (ko) | 2017-07-11 | 2024-10-08 | 콤파스 테라퓨틱스 엘엘씨 | 인간 cd137에 결합하는 작동자 항체 및 이의 용도 |
| BR112020001441A2 (pt) | 2017-08-01 | 2020-08-04 | Eli Lilly And Company | anticorpos anti-cd137 |
| US11512134B2 (en) | 2017-08-01 | 2022-11-29 | Eli Lilly And Company | Anti-CD137 antibodies |
| PE20201183A1 (es) | 2017-10-13 | 2020-11-03 | Harpoon Therapeutics Inc | Proteinas trispecificas y metodos de uso |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| EP3694884A1 (en) | 2017-10-15 | 2020-08-19 | Bristol-Myers Squibb Company | Methods of treating tumor |
| WO2019089753A2 (en) | 2017-10-31 | 2019-05-09 | Compass Therapeutics Llc | Cd137 antibodies and pd-1 antagonists and uses thereof |
| ES3013486T3 (en) | 2017-11-17 | 2025-04-14 | Iovance Biotherapeutics Inc | Til expansion from fine needle aspirates and small biopsies |
| EP3713961A2 (en) | 2017-11-20 | 2020-09-30 | Compass Therapeutics LLC | Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof |
| US11638760B2 (en) | 2017-11-27 | 2023-05-02 | Mersana Therapeutics, Inc. | Pyrrolobenzodiazepine antibody conjugates |
| WO2019126691A1 (en) | 2017-12-21 | 2019-06-27 | Mersana Therapeutics, Inc. | Pyrrolobenzodiazepine antibody conjugates |
| CA3087771A1 (en) | 2018-01-08 | 2019-07-11 | Iovance Biotherapeutics, Inc. | Processes for generating til products enriched for tumor antigen-specific t-cells |
| WO2019136459A1 (en) | 2018-01-08 | 2019-07-11 | Iovance Biotherapeutics, Inc. | Processes for generating til products enriched for tumor antigen-specific t-cells |
| US11713446B2 (en) | 2018-01-08 | 2023-08-01 | Iovance Biotherapeutics, Inc. | Processes for generating TIL products enriched for tumor antigen-specific T-cells |
| JP2021510533A (ja) * | 2018-01-22 | 2021-04-30 | 江蘇恒瑞医薬股▲ふん▼有限公司 | 抗4−1bb抗体、その抗原結合フラグメント、およびその医学的使用 |
| WO2019160829A1 (en) | 2018-02-13 | 2019-08-22 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes (tils) with adenosine a2a receptor antagonists and therapeutic combinations of tils and adenosine a2a receptor antagonists |
| EP3768715A1 (en) | 2018-03-23 | 2021-01-27 | Bristol-Myers Squibb Company | Antibodies against mica and/or micb and uses thereof |
| US12037406B2 (en) | 2018-03-23 | 2024-07-16 | Eli Lilly And Company | Anti-CD137 antibodies for combination with anti-PD-L1 antibodies |
| ES2982509T3 (es) | 2018-03-29 | 2024-10-16 | Iovance Biotherapeutics Inc | Procedimientos para la preparación de linfocitos infiltrantes de tumor y usos de los mismos en inmunoterapia |
| US20210032344A1 (en) | 2018-03-30 | 2021-02-04 | Bristol-Myers Squibb Company | Methods of treating tumor |
| TWI831776B (zh) | 2018-04-27 | 2024-02-11 | 美商艾歐凡斯生物治療公司 | 腫瘤浸潤性淋巴細胞之基因編輯和彼於免疫治療之用途 |
| WO2019217753A1 (en) | 2018-05-10 | 2019-11-14 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| TW202031273A (zh) | 2018-08-31 | 2020-09-01 | 美商艾歐凡斯生物治療公司 | 抗pd-1抗體難治療性之非小細胞肺癌(nsclc)病患的治療 |
| KR20210064269A (ko) | 2018-09-20 | 2021-06-02 | 이오반스 바이오테라퓨틱스, 인크. | 동결보존된 종양 샘플로부터의 til의 확장 |
| WO2020061482A1 (en) | 2018-09-21 | 2020-03-26 | Harpoon Therapeutics, Inc. | Egfr binding proteins and methods of use |
| IL314988A (en) | 2018-09-25 | 2024-10-01 | Harpoon Therapeutics Inc | Dll3 binding proteins and methods of use |
| US20230021500A1 (en) | 2018-10-29 | 2023-01-26 | Mersana Therapeutics, Inc. | Cysteine engineered antibody-drug conjugates with peptide-containing linkers |
| EP3873540A4 (en) | 2018-10-31 | 2022-07-27 | Mayo Foundation for Medical Education and Research | METHODS AND MATERIALS FOR THE TREATMENT OF CANCER |
| WO2020092839A1 (en) | 2018-10-31 | 2020-05-07 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| KR20210099573A (ko) | 2018-11-05 | 2021-08-12 | 이오반스 바이오테라퓨틱스, 인크. | 개선된 종양 반응성 t-세포의 선택 |
| AU2019374761A1 (en) | 2018-11-05 | 2021-06-10 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy |
| BR112021008549A2 (pt) | 2018-11-05 | 2022-01-04 | Iovance Biotherapeutics Inc | Método de tratamento de carcinoma pulmonar de células não pequenas com uma população de linfócitos infiltrantes de tumor |
| EP3877511A1 (en) | 2018-11-05 | 2021-09-15 | Iovance Biotherapeutics, Inc. | Expansion of tils utilizing akt pathway inhibitors |
| JP7710372B2 (ja) | 2018-12-19 | 2025-07-18 | アイオバンス バイオセラピューティクス,インコーポレイテッド | 操作されたサイトカイン受容体対を使用して腫瘍浸潤リンパ球を拡大培養する方法及びその使用 |
| BR112021019328A2 (pt) | 2019-03-29 | 2021-11-30 | Myst Therapeutics Llc | Métodos ex vivo para produzir um produto terapêutico de célula t e composições e métodos relacionados |
| WO2020232029A1 (en) | 2019-05-13 | 2020-11-19 | Iovance Biotherapeutics, Inc. | Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy |
| KR20220016157A (ko) | 2019-05-30 | 2022-02-08 | 브리스톨-마이어스 스큅 컴퍼니 | 세포 국재화 시그너쳐 및 조합 요법 |
| CN114174538A (zh) | 2019-05-30 | 2022-03-11 | 百时美施贵宝公司 | 适合于免疫肿瘤学疗法的多肿瘤基因特征 |
| EP3976832A1 (en) | 2019-05-30 | 2022-04-06 | Bristol-Myers Squibb Company | Methods of identifying a subject suitable for an immuno-oncology (i-o) therapy |
| JP2022553389A (ja) | 2019-10-25 | 2022-12-22 | アイオバンス バイオセラピューティクス,インコーポレイテッド | 腫瘍浸潤リンパ球の遺伝子編集及び免疫療法におけるその使用 |
| JP2023504042A (ja) | 2019-11-27 | 2023-02-01 | ミスト セラピューティクス リミテッド ライアビリティ カンパニー | 調節物質を使用した腫瘍反応性t細胞組成物の生成方法 |
| EP4073236A1 (en) | 2019-12-11 | 2022-10-19 | Iovance Biotherapeutics, Inc. | Processes for the production of tumor infiltrating lymphocytes (tils) and methods of using the same |
| WO2021167908A1 (en) | 2020-02-17 | 2021-08-26 | Board Of Regents, The University Of Texas System | Methods for expansion of tumor infiltrating lymphocytes and use thereof |
| KR20220158727A (ko) | 2020-02-27 | 2022-12-01 | 미스트 쎄라퓨틱스, 엘엘씨 | 종양 반응성 t 세포의 생체외 농축 및 확장 방법 및 이의 관련 조성물 |
| CA3177413A1 (en) | 2020-05-04 | 2021-11-11 | Michelle SIMPSON-ABELSON | Selection of improved tumor reactive t-cells |
| WO2021226061A1 (en) | 2020-05-04 | 2021-11-11 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy |
| EP4153316A1 (en) | 2020-05-19 | 2023-03-29 | Boehringer Ingelheim International GmbH | Binding molecules for the treatment of cancer |
| WO2022047412A1 (en) | 2020-08-31 | 2022-03-03 | Bristol-Myers Squibb Company | Cell localization signature and immunotherapy |
| WO2022076606A1 (en) | 2020-10-06 | 2022-04-14 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| US20230372397A1 (en) | 2020-10-06 | 2023-11-23 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| WO2022120179A1 (en) | 2020-12-03 | 2022-06-09 | Bristol-Myers Squibb Company | Multi-tumor gene signatures and uses thereof |
| JP2024501452A (ja) | 2020-12-11 | 2024-01-12 | アイオバンス バイオセラピューティクス,インコーポレイテッド | Braf阻害剤及び/またはmek阻害剤と併用した腫瘍浸潤リンパ球治療によるがん患者の治療 |
| US20240299539A1 (en) | 2020-12-17 | 2024-09-12 | Iovance Biotherapeutics, Inc. | Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors |
| US20240123067A1 (en) | 2020-12-17 | 2024-04-18 | Iovance Biotherapeutics, Inc. | Treatment of cancers with tumor infiltrating lymphocyte therapies |
| AU2021416156A1 (en) | 2020-12-28 | 2023-06-22 | Bristol-Myers Squibb Company | Methods of treating tumors |
| US20220233693A1 (en) | 2020-12-28 | 2022-07-28 | Bristol-Myers Squibb Company | Antibody Compositions and Methods of Use Thereof |
| EP4288140A1 (en) | 2021-02-05 | 2023-12-13 | Iovance Biotherapeutics, Inc. | Adjuvant therapy for cancer |
| WO2022187741A2 (en) | 2021-03-05 | 2022-09-09 | Iovance Biotherapeutics, Inc. | Tumor storage and cell culture compositions |
| US20240376224A1 (en) | 2021-04-02 | 2024-11-14 | The Regents Of The University Of California | Antibodies against cleaved cdcp1 and uses thereof |
| BR112023021665A2 (pt) | 2021-04-19 | 2023-12-19 | Iovance Biotherapeutics Inc | Método para tratar um câncer, e, composição |
| WO2022245754A1 (en) | 2021-05-17 | 2022-11-24 | Iovance Biotherapeutics, Inc. | Pd-1 gene-edited tumor infiltrating lymphocytes and uses of same in immunotherapy |
| CA3226942A1 (en) | 2021-07-28 | 2023-02-02 | Iovance Biotherapeutics, Inc. | Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors |
| WO2023049862A1 (en) | 2021-09-24 | 2023-03-30 | Iovance Biotherapeutics, Inc. | Expansion processes and agents for tumor infiltrating lymphocytes |
| WO2023077015A2 (en) | 2021-10-27 | 2023-05-04 | Iovance Biotherapeutics, Inc. | Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy |
| CA3237410A1 (en) | 2021-11-10 | 2023-05-19 | Friedrich Graf Finck VON FINCKENSTEIN | Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes |
| WO2023147486A1 (en) | 2022-01-28 | 2023-08-03 | Iovance Biotherapeutics, Inc. | Tumor infiltrating lymphocytes engineered to express payloads |
| US20250206775A1 (en) | 2022-03-18 | 2025-06-26 | Bristol-Myers Squibb Company | Methods of isolating polypeptides |
| EP4507704A1 (en) | 2022-04-15 | 2025-02-19 | Iovance Biotherapeutics, Inc. | Til expansion processes using specific cytokine combinations and/or akti treatment |
| EP4531916A1 (en) | 2022-06-02 | 2025-04-09 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
| EP4565683A1 (en) | 2022-08-01 | 2025-06-11 | Iovance Biotherapeutics, Inc. | Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies |
| WO2024151885A1 (en) | 2023-01-13 | 2024-07-18 | Iovance Biotherapeutics, Inc. | Use of til as maintenance therapy for nsclc patients who achieved pr/cr after prior therapy |
| WO2025038763A1 (en) | 2023-08-15 | 2025-02-20 | Bristol-Myers Squibb Company | Ceramic hydroxyapatite chromatography flow through method |
| WO2025101484A1 (en) | 2023-11-06 | 2025-05-15 | Iovance Biotherapeutics, Inc. | Treatment of endometrial cancers with tumor infiltrating lymphocyte therapies |
| WO2025145207A1 (en) | 2023-12-29 | 2025-07-03 | Bristol-Myers Squibb Company | Combination therapy of kras inhibitor and treg-depleting agent |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3815472A1 (de) * | 1988-05-06 | 1989-11-16 | Centre Regional De Transfusion | Monoklonaler antikoerper und seine verwendung |
| US5474771A (en) * | 1991-11-15 | 1995-12-12 | The Trustees Of Columbia University In The City Of New York | Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same |
| NO933860L (no) | 1992-10-30 | 1994-05-02 | Bristol Myers Squibb Co | Ekstracellulære matriks-reseptorligander som modulerer leukocyttfunksjon |
| KR100244960B1 (ko) * | 1993-09-16 | 2000-02-15 | 왈터 엘 쿤, 주니어 | 인간 수용체 h4-1bb |
| AU5369996A (en) | 1995-03-23 | 1996-10-08 | Indiana University Foundation | Monoclonal antibody against human receptor protein 4-1bb and methods of its use for treatment of diseases |
| KR960035080U (ko) * | 1995-04-25 | 1996-11-21 | 보일러용 연소 버너 | |
| US5928893A (en) * | 1995-04-08 | 1999-07-27 | Lg Chemical Ltd. | Monoclonal antibody specific for human 4-1BB and cell line producing same |
-
1997
- 1997-10-03 HU HU9904697A patent/HUP9904697A3/hu unknown
- 1997-10-03 EP EP97909987A patent/EP0948353A1/en not_active Withdrawn
- 1997-10-03 AU AU47470/97A patent/AU738981B2/en not_active Expired
- 1997-10-03 JP JP10518414A patent/JP2001502325A/ja not_active Ceased
- 1997-10-03 US US08/943,529 patent/US6210669B1/en not_active Expired - Lifetime
- 1997-10-03 KR KR10-1999-7003114A patent/KR100520339B1/ko not_active Expired - Lifetime
- 1997-10-03 PL PL97332699A patent/PL188749B1/pl unknown
- 1997-10-03 CA CA002268340A patent/CA2268340A1/en not_active Abandoned
- 1997-10-03 RU RU99109594/14A patent/RU2192281C2/ru active
- 1997-10-03 NZ NZ334691A patent/NZ334691A/xx not_active IP Right Cessation
- 1997-10-03 CN CN97198565A patent/CN1232402A/zh active Pending
- 1997-10-03 BR BR9712278-5A patent/BR9712278A/pt not_active Application Discontinuation
- 1997-10-03 IL IL12913897A patent/IL129138A0/xx unknown
- 1997-10-03 WO PCT/US1997/018035 patent/WO1998016249A1/en not_active Ceased
-
1999
- 1999-04-09 NO NO991676A patent/NO991676D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO991676L (no) | 1999-04-09 |
| EP0948353A1 (en) | 1999-10-13 |
| NZ334691A (en) | 2000-12-22 |
| US6210669B1 (en) | 2001-04-03 |
| CA2268340A1 (en) | 1998-04-23 |
| CN1232402A (zh) | 1999-10-20 |
| AU738981B2 (en) | 2001-10-04 |
| KR100520339B1 (ko) | 2005-10-12 |
| EP0948353A4 (enExample) | 1999-10-13 |
| PL332699A1 (en) | 1999-09-27 |
| RU2192281C2 (ru) | 2002-11-10 |
| BR9712278A (pt) | 1999-08-31 |
| IL129138A0 (en) | 2000-02-17 |
| HUP9904697A3 (en) | 2001-06-28 |
| AU4747097A (en) | 1998-05-11 |
| KR20000049045A (ko) | 2000-07-25 |
| HUP9904697A2 (hu) | 2000-08-28 |
| WO1998016249A1 (en) | 1998-04-23 |
| NO991676D0 (no) | 1999-04-09 |
| JP2001502325A (ja) | 2001-02-20 |
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