PL186714B1 - Kompozycja farmaceutyczna do regulowania stężenialipidów do ssaka - Google Patents
Kompozycja farmaceutyczna do regulowania stężenialipidów do ssakaInfo
- Publication number
- PL186714B1 PL186714B1 PL96326365A PL32636596A PL186714B1 PL 186714 B1 PL186714 B1 PL 186714B1 PL 96326365 A PL96326365 A PL 96326365A PL 32636596 A PL32636596 A PL 32636596A PL 186714 B1 PL186714 B1 PL 186714B1
- Authority
- PL
- Poland
- Prior art keywords
- phenyl
- cholesterol
- methylethyl
- hmg
- coa reductase
- Prior art date
Links
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- 238000000034 method Methods 0.000 title claims description 6
- 125000003473 lipid group Chemical group 0.000 title 1
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- -1 2,6-bis(1-methylethyl)phenyl ester Chemical class 0.000 claims abstract description 29
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Classifications
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US615595P | 1995-11-02 | 1995-11-02 | |
| PCT/US1996/015854 WO1997016184A1 (en) | 1995-11-02 | 1996-10-02 | Method and pharmaceutical composition for regulating lipid concentration |
Publications (2)
| Publication Number | Publication Date |
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| PL326365A1 PL326365A1 (en) | 1998-09-14 |
| PL186714B1 true PL186714B1 (pl) | 2004-02-27 |
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| PL96326365A PL186714B1 (pl) | 1995-11-02 | 1996-10-02 | Kompozycja farmaceutyczna do regulowania stężenialipidów do ssaka |
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Families Citing this family (51)
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| US6268392B1 (en) * | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| CN1217656C (zh) * | 1995-11-02 | 2005-09-07 | 沃尼尔·朗伯公司 | 用于调节脂浓度的方法和药物组合物 |
| EP1514543A1 (en) * | 1997-08-29 | 2005-03-16 | Pfizer Inc. | Combination therapy comprising atorvastatin and an antihypertensive agent |
| GT199800126A (es) * | 1997-08-29 | 2000-01-29 | Terapia de combinacion. | |
| GT199800127A (es) | 1997-08-29 | 2000-02-01 | Combinaciones terapeuticas. | |
| KR20010041916A (ko) * | 1998-03-17 | 2001-05-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 스타틴-매트릭스 메탈로프로테이나제 저해제 복합제제 |
| US6221897B1 (en) * | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| CZ20011035A3 (cs) * | 1998-09-30 | 2001-10-17 | Warner-Lambert Company | Léčivo pro prevenci nebo oddálení revaskularizace pomocí katetru u pacientů postiľených chorobou koronární artérie |
| CO5140104A1 (es) * | 1999-02-16 | 2002-03-22 | Novartis Ag | Derivados de mevinolina y preparacion farmaceuticas que los contienen |
| US20010006656A1 (en) * | 1999-02-17 | 2001-07-05 | University Of Washington | Methods and compositions for inhibiting inflammation associated with pulmonary disease |
| AU7717500A (en) * | 1999-09-30 | 2001-04-30 | Merck & Co., Inc. | Anti-hypercholesterolemic drug combination |
| EP1092432A1 (fr) | 1999-10-15 | 2001-04-18 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A. (S.C.R.A.S.) | Composes anti-ischemiques |
| KR20020050257A (ko) * | 1999-11-05 | 2002-06-26 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | Ａｃａｔ 저해제에 의한 플라크 파열의 방지 |
| WO2002020009A1 (en) * | 2000-09-01 | 2002-03-14 | Sankyo Company, Limited | Medicinal compositions |
| MXPA03003022A (es) | 2000-10-11 | 2003-07-14 | Esperion Therapeutics Inc | Compuestos de sulfuro y disulfuro y composiciones para el control del colesterol y usos relacionados. |
| US7304093B2 (en) * | 2000-10-11 | 2007-12-04 | Esperion Therapeutics, Inc. | Ketone compounds and compositions for cholesterol management and related uses |
| CA2425678A1 (en) | 2000-10-11 | 2002-04-18 | Jean-Louis H. Dasseux | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses |
| JP2004529069A (ja) | 2000-10-11 | 2004-09-24 | エスペリオン セラピューティクス，インコーポレイテッド | コレステロール管理用のエーテル化合物及び組成物ならびに関連する使用 |
| EP1326822A2 (en) | 2000-10-11 | 2003-07-16 | Esperion Therapeutics Inc. | Ketone compounds and compositions for cholesterol management and related uses |
| US20040122091A1 (en) * | 2000-10-11 | 2004-06-24 | Esperion Therapeutics, Inc. | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses |
| CA2369967A1 (en) * | 2001-02-12 | 2002-08-12 | Joseph Anthony Cornicelli | Methods of treating nuclear factor-kappa b mediated diseases and disorders |
| PE20030324A1 (es) * | 2001-07-31 | 2003-04-03 | Warner Lambert Co | Composiciones farmaceuticas de amlodipina y atorvastatina |
| US20040204502A1 (en) * | 2001-10-11 | 2004-10-14 | Dasseux Jean-Louis Henri | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses |
| US20040192771A1 (en) * | 2001-10-11 | 2004-09-30 | Dasseux Jean-Louis Henri | Ether compounds and compositions for cholesterol management and related uses |
| US20050020694A1 (en) * | 2001-10-11 | 2005-01-27 | Dasseux Jean-Louis Henri | Sulfide and disulfide compounds and compositions for cholesterol management and related uses |
| EP1485077A4 (en) * | 2002-03-12 | 2007-07-18 | Merck & Co Inc | DRUGS COMBINATION THERAPY |
| CA2480410A1 (en) * | 2002-04-10 | 2003-10-23 | Esperion Therapeutics, Inc. | Mimics of acyl coenzyme-a comprising pantolactone and pantothenic acid derivatives, compositions thereof, and methods of cholesterol management and related uses |
| JP4187141B2 (ja) * | 2002-04-12 | 2008-11-26 | 興和株式会社 | 新規なトロンボモジュリン発現促進剤 |
| US7119221B2 (en) | 2003-01-23 | 2006-10-10 | Esperion Therapeutics, Inc. | Cycloalkyl-hydroxyl compounds and compositions for cholesterol management and related uses |
| RU2358734C2 (ru) | 2003-08-29 | 2009-06-20 | Кова Ко., Лтд. | Способ стабилизации бляшки с высоким содержанием липидов и способ профилактики ее разрушения |
| EP1688140A1 (en) * | 2003-11-17 | 2006-08-09 | Toyo Shinyaku Co., Ltd. | Lipometabolism improver containing pine bark extract |
| AU2003304703A1 (en) * | 2003-12-24 | 2005-08-03 | Esperion Therapeutics, Inc. | Ketone compounds and compositions for cholesterol management and related uses |
| WO2005102348A1 (en) * | 2004-04-19 | 2005-11-03 | Loma Linda University | Composition and method of decreasing renal ischemic damage |
| TW200605890A (en) * | 2004-07-28 | 2006-02-16 | Sankyo Co | Pharmaceutical compositions for inhibiting arteriosclerosis |
| KR101021828B1 (ko) * | 2004-10-27 | 2011-03-17 | 다이이찌 산쿄 가부시키가이샤 | 2 이상의 치환기를 갖는 벤젠 화합물 |
| TW200619204A (en) * | 2004-12-10 | 2006-06-16 | Kowa Co | Method for reduction, stabilization and prevention of rupture of lipid rich plaque |
| KR101329112B1 (ko) * | 2005-11-08 | 2013-11-14 | 랜박시 래보러터리스 리미티드 | (3ｒ,5ｒ)-7-〔2-(4-플루오로페닐)-5-이소프로필-3-페닐-4-〔(4-히드록시 메틸 페닐 아미노)카르보닐〕-피롤-1-일〕-3,5-디히드록시 헵탄산 헤미 칼슘염의 제조 방법 |
| RU2308947C1 (ru) * | 2006-02-26 | 2007-10-27 | Новосибирский институт органической химии им. Н.Н. Ворожцова СО РАН (НИОХ СО РАН) | Лекарственное средство с гиполипидемическим эффектом "симваглизин" |
| PL2018153T3 (pl) | 2006-04-26 | 2012-09-28 | Rosemont Pharmaceuticals Ltd | Ciekłe kompozycje doustne |
| US20130254787A1 (en) | 2006-05-02 | 2013-09-26 | Invidi Technologies Corporation | Method and apparatus to perform real-time audience estimation and commercial selection suitable for targeted advertising |
| US20070269503A1 (en) * | 2006-05-16 | 2007-11-22 | James Walter Burgess | Combinations of HMG CoA reductase inhibitors and negatively charged phospholipids and uses thereof |
| US8314080B2 (en) | 2010-04-06 | 2012-11-20 | Kuwait University | Method of treating type I diabetes |
| CN102424663B (zh) * | 2010-12-03 | 2013-08-14 | 天津滨江药物研发有限公司 | 一种阿托伐他汀氨基酸盐及其制备方法 |
| US8586527B2 (en) * | 2011-10-20 | 2013-11-19 | Jaipal Singh | Cerivastatin to treat pulmonary disorders |
| SG11201401849QA (en) | 2011-10-28 | 2014-05-29 | Lumena Pharmaceuticals Inc | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| SG10201406155QA (en) | 2011-10-28 | 2014-11-27 | Lumena Pharmaceuticals Inc | Bile Acid Recycling Inhibitors For Treatment Of Pediatric Cholestatic Liver Diseases |
| CN103304496A (zh) * | 2012-03-08 | 2013-09-18 | 南京工业大学 | 一种合成申嗪霉素方法 |
| US10047034B2 (en) | 2012-05-16 | 2018-08-14 | Prairie Berry Europe Gmbh | Polyhydroxylated pentacyclic triterpene acids as HMG-COA reductase inhibitors |
| KR102370582B1 (ko) | 2015-03-13 | 2022-03-04 | 에스페리온 테라피유틱스 인코포레이티드 | Ｅｔｃ1002 및 에제티미브를 포함하는 고정 용량 조합 및 제형 및 심혈관 질환의 치료 또는 이의 위험의 감소 방법 |
| MA41793A (fr) | 2015-03-16 | 2018-01-23 | Esperion Therapeutics Inc | Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire |
| JP2022537049A (ja) | 2019-06-21 | 2022-08-23 | エスペリオン・セラピューティクス・インコーポレイテッド | ベンペド酸の製造方法及びその組成物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4739073A (en) * | 1983-11-04 | 1988-04-19 | Sandoz Pharmaceuticals Corp. | Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof |
| CA2003478A1 (en) * | 1988-12-12 | 1990-06-12 | Leonard G. Dennick | Combination of an hmg coa reductase inhibitor and other type of serum cholesterol reducing agent and method for lowering serum cholesterol using such combination |
| FI94339C (fi) * | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| CA2048395A1 (en) * | 1990-08-23 | 1992-02-24 | Henry Y. Pan | Method for preventing onset of or treating type iii hyperlipoproteinemia employing pravastatin |
| ATE158789T1 (de) | 1991-07-23 | 1997-10-15 | Schering Corp | Substituierte beta-lactam-verbindungen als hypocholesterolemische mittel und verfahren zu deren herstellung |
| AU5538794A (en) * | 1992-10-26 | 1994-05-24 | Merck & Co., Inc. | Biologically active compounds and process therefor |
| LT3300B (en) | 1992-12-23 | 1995-06-26 | Schering Corp | Combination of a cholesterol biosynhtesis inhibitor and a beta- lactam cholesterol absorbtion inhibitor |
| IL109431A (en) * | 1993-05-14 | 2001-01-11 | Warner Lambert Co | Pharmaceutical compositions containing n-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters), for regulating plasma cholesterol concentration, and certain such novel compounds |
| US5491172A (en) * | 1993-05-14 | 1996-02-13 | Warner-Lambert Company | N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and N-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents |
| WO1995013063A1 (en) * | 1993-11-09 | 1995-05-18 | Merck & Co., Inc. | HMG-CoA REDUCTASE INHIBITORS IN THE NORMALIZATION OF VASCULAR ENDOTHELIAL DYSFUNCTION |
| CN1217656C (zh) * | 1995-11-02 | 2005-09-07 | 沃尼尔·朗伯公司 | 用于调节脂浓度的方法和药物组合物 |
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1996
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- 1996-10-02 AU AU72539/96A patent/AU720853B2/en not_active Ceased
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- 1996-10-02 KR KR10-1998-0703240A patent/KR100449604B1/ko not_active Expired - Fee Related
- 1996-10-02 AT AT96934020T patent/ATE348607T1/de not_active IP Right Cessation
- 1996-10-02 KR KR10-2004-7003107A patent/KR20040029459A/ko not_active Ceased
- 1996-10-02 HU HU9901865A patent/HUP9901865A3/hu unknown
- 1996-10-02 DE DE69636783T patent/DE69636783T2/de not_active Expired - Fee Related
- 1996-10-02 EA EA199800420A patent/EA000514B1/ru not_active IP Right Cessation
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- 1996-10-02 WO PCT/US1996/015854 patent/WO1997016184A1/en not_active Ceased
- 1996-10-02 PL PL96326365A patent/PL186714B1/pl not_active IP Right Cessation
- 1996-10-02 NZ NZ319906A patent/NZ319906A/en unknown
- 1996-10-02 CN CNA2005100517235A patent/CN1679953A/zh active Pending
- 1996-10-02 EP EP96934020A patent/EP0858336B1/en not_active Revoked
- 1996-10-02 UA UA98052811A patent/UA46069C2/uk unknown
- 1996-10-02 BR BR9611410A patent/BR9611410A/pt not_active Application Discontinuation
- 1996-10-02 SK SK557-98A patent/SK284142B6/sk unknown
- 1996-10-31 ZA ZA969187A patent/ZA969187B/xx unknown
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- 1998-04-30 NO NO981961A patent/NO981961L/no unknown
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1999
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| LAPS | Decisions on the lapse of the protection rights |
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