KR100449604B1 - 지질농도를 조절하는 제약 조성물 및 방법 - Google Patents

지질농도를 조절하는 제약 조성물 및 방법 Download PDF

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Publication number
KR100449604B1
KR100449604B1 KR10-1998-0703240A KR19980703240A KR100449604B1 KR 100449604 B1 KR100449604 B1 KR 100449604B1 KR 19980703240 A KR19980703240 A KR 19980703240A KR 100449604 B1 KR100449604 B1 KR 100449604B1
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South Korea
Prior art keywords
phenyl
methylethyl
atorvastatin
bis
acetyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR10-1998-0703240A
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English (en)
Korean (ko)
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KR19990067270A (ko
Inventor
토마스 엠. 에이. 보칸
Original Assignee
워너-램버트 캄파니 엘엘씨
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Application filed by 워너-램버트 캄파니 엘엘씨 filed Critical 워너-램버트 캄파니 엘엘씨
Publication of KR19990067270A publication Critical patent/KR19990067270A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR10-1998-0703240A 1995-11-02 1996-10-02 지질농도를 조절하는 제약 조성물 및 방법 Expired - Fee Related KR100449604B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US615595P 1995-11-02 1995-11-02
US60/006.155 1995-11-02

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR10-2004-7003107A Division KR20040029459A (ko) 1995-11-02 1996-10-02 지질 농도를 조절하는 제약 조성물 및 방법

Publications (2)

Publication Number Publication Date
KR19990067270A KR19990067270A (ko) 1999-08-16
KR100449604B1 true KR100449604B1 (ko) 2004-11-16

Family

ID=21719566

Family Applications (2)

Application Number Title Priority Date Filing Date
KR10-1998-0703240A Expired - Fee Related KR100449604B1 (ko) 1995-11-02 1996-10-02 지질농도를 조절하는 제약 조성물 및 방법
KR10-2004-7003107A Ceased KR20040029459A (ko) 1995-11-02 1996-10-02 지질 농도를 조절하는 제약 조성물 및 방법

Family Applications After (1)

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KR10-2004-7003107A Ceased KR20040029459A (ko) 1995-11-02 1996-10-02 지질 농도를 조절하는 제약 조성물 및 방법

Country Status (26)

Country Link
US (3) US6124309A (enExample)
EP (1) EP0858336B1 (enExample)
JP (1) JPH11515025A (enExample)
KR (2) KR100449604B1 (enExample)
CN (2) CN1217656C (enExample)
AR (1) AR004527A1 (enExample)
AT (1) ATE348607T1 (enExample)
AU (1) AU720853B2 (enExample)
BG (1) BG64018B1 (enExample)
BR (1) BR9611410A (enExample)
CZ (1) CZ127198A3 (enExample)
DE (1) DE69636783T2 (enExample)
EA (1) EA000514B1 (enExample)
ES (1) ES2279526T3 (enExample)
GE (1) GEP20001898B (enExample)
HU (1) HUP9901865A3 (enExample)
IL (1) IL123902A (enExample)
IS (1) IS4720A (enExample)
NO (1) NO981961L (enExample)
NZ (2) NZ319906A (enExample)
PL (1) PL186714B1 (enExample)
RO (1) RO120816B1 (enExample)
SK (1) SK284142B6 (enExample)
UA (1) UA46069C2 (enExample)
WO (1) WO1997016184A1 (enExample)
ZA (1) ZA969187B (enExample)

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WO2004067489A2 (en) * 2003-01-23 2004-08-12 Esperion Therapeutics, Inc. Hydroxyl compounds and compositions for cholesterol management and related uses
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Publication number Publication date
BG64018B1 (bg) 2003-10-31
WO1997016184A1 (en) 1997-05-09
RO120816B1 (ro) 2006-08-30
IL123902A0 (en) 1998-10-30
BR9611410A (pt) 1999-01-05
EA199800420A1 (ru) 1998-10-29
DE69636783T2 (de) 2007-10-18
NO981961L (no) 1998-05-04
DE69636783D1 (de) 2007-02-01
US6124309A (en) 2000-09-26
CN1217656C (zh) 2005-09-07
NZ319906A (en) 2000-02-28
PL186714B1 (pl) 2004-02-27
KR20040029459A (ko) 2004-04-06
IL123902A (en) 2003-01-12
HK1016509A1 (en) 1999-11-05
EA000514B1 (ru) 1999-10-28
NZ512484A (en) 2003-02-28
GEP20001898B (en) 2000-01-05
US6143755A (en) 2000-11-07
UA46069C2 (uk) 2002-05-15
SK284142B6 (sk) 2004-10-05
EP0858336B1 (en) 2006-12-20
ATE348607T1 (de) 2007-01-15
CZ127198A3 (cs) 1998-12-16
PL326365A1 (en) 1998-09-14
EP0858336A1 (en) 1998-08-19
AR004527A1 (es) 1998-12-16
CN1679953A (zh) 2005-10-12
IS4720A (is) 1998-04-17
CN1201389A (zh) 1998-12-09
AU720853B2 (en) 2000-06-15
BG102417A (en) 1999-01-29
KR19990067270A (ko) 1999-08-16
NO981961D0 (no) 1998-04-30
US6093719A (en) 2000-07-25
JPH11515025A (ja) 1999-12-21
HUP9901865A2 (hu) 1999-10-28
HUP9901865A3 (en) 2000-06-28
ES2279526T3 (es) 2007-08-16
SK55798A3 (en) 1999-06-11
ZA969187B (en) 1997-05-29
AU7253996A (en) 1997-05-22

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