CN1217656C - 用于调节脂浓度的方法和药物组合物 - Google Patents

用于调节脂浓度的方法和药物组合物 Download PDF

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Publication number
CN1217656C
CN1217656C CN961980109A CN96198010A CN1217656C CN 1217656 C CN1217656 C CN 1217656C CN 961980109 A CN961980109 A CN 961980109A CN 96198010 A CN96198010 A CN 96198010A CN 1217656 C CN1217656 C CN 1217656C
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CN
China
Prior art keywords
phenyl
methylethyl
atorvastatin
combination
bis
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Expired - Fee Related
Application number
CN961980109A
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English (en)
Chinese (zh)
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CN1201389A (zh
Inventor
T·M·A·博坎
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Warner Lambert Co LLC
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Warner Lambert Co LLC
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Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of CN1201389A publication Critical patent/CN1201389A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN961980109A 1995-11-02 1996-10-02 用于调节脂浓度的方法和药物组合物 Expired - Fee Related CN1217656C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US615595P 1995-11-02 1995-11-02
US60/006,155 1995-11-02

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2005100517235A Division CN1679953A (zh) 1995-11-02 1996-10-02 用于调节脂浓度的联合用药

Publications (2)

Publication Number Publication Date
CN1201389A CN1201389A (zh) 1998-12-09
CN1217656C true CN1217656C (zh) 2005-09-07

Family

ID=21719566

Family Applications (2)

Application Number Title Priority Date Filing Date
CN961980109A Expired - Fee Related CN1217656C (zh) 1995-11-02 1996-10-02 用于调节脂浓度的方法和药物组合物
CNA2005100517235A Pending CN1679953A (zh) 1995-11-02 1996-10-02 用于调节脂浓度的联合用药

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2005100517235A Pending CN1679953A (zh) 1995-11-02 1996-10-02 用于调节脂浓度的联合用药

Country Status (26)

Country Link
US (3) US6124309A (enExample)
EP (1) EP0858336B1 (enExample)
JP (1) JPH11515025A (enExample)
KR (2) KR100449604B1 (enExample)
CN (2) CN1217656C (enExample)
AR (1) AR004527A1 (enExample)
AT (1) ATE348607T1 (enExample)
AU (1) AU720853B2 (enExample)
BG (1) BG64018B1 (enExample)
BR (1) BR9611410A (enExample)
CZ (1) CZ127198A3 (enExample)
DE (1) DE69636783T2 (enExample)
EA (1) EA000514B1 (enExample)
ES (1) ES2279526T3 (enExample)
GE (1) GEP20001898B (enExample)
HU (1) HUP9901865A3 (enExample)
IL (1) IL123902A (enExample)
IS (1) IS4720A (enExample)
NO (1) NO981961L (enExample)
NZ (2) NZ319906A (enExample)
PL (1) PL186714B1 (enExample)
RO (1) RO120816B1 (enExample)
SK (1) SK284142B6 (enExample)
UA (1) UA46069C2 (enExample)
WO (1) WO1997016184A1 (enExample)
ZA (1) ZA969187B (enExample)

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CN1479721A (zh) 2000-10-11 2004-03-03 ͨ��ҽ�ƹ�˾ 用于胆固醇治疗和相关应用的亚砜和双亚砜化合物和组合物
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BG64018B1 (bg) 2003-10-31
WO1997016184A1 (en) 1997-05-09
RO120816B1 (ro) 2006-08-30
IL123902A0 (en) 1998-10-30
BR9611410A (pt) 1999-01-05
EA199800420A1 (ru) 1998-10-29
DE69636783T2 (de) 2007-10-18
NO981961L (no) 1998-05-04
DE69636783D1 (de) 2007-02-01
US6124309A (en) 2000-09-26
NZ319906A (en) 2000-02-28
PL186714B1 (pl) 2004-02-27
KR20040029459A (ko) 2004-04-06
IL123902A (en) 2003-01-12
HK1016509A1 (en) 1999-11-05
EA000514B1 (ru) 1999-10-28
NZ512484A (en) 2003-02-28
GEP20001898B (en) 2000-01-05
KR100449604B1 (ko) 2004-11-16
US6143755A (en) 2000-11-07
UA46069C2 (uk) 2002-05-15
SK284142B6 (sk) 2004-10-05
EP0858336B1 (en) 2006-12-20
ATE348607T1 (de) 2007-01-15
CZ127198A3 (cs) 1998-12-16
PL326365A1 (en) 1998-09-14
EP0858336A1 (en) 1998-08-19
AR004527A1 (es) 1998-12-16
CN1679953A (zh) 2005-10-12
IS4720A (is) 1998-04-17
CN1201389A (zh) 1998-12-09
AU720853B2 (en) 2000-06-15
BG102417A (en) 1999-01-29
KR19990067270A (ko) 1999-08-16
NO981961D0 (no) 1998-04-30
US6093719A (en) 2000-07-25
JPH11515025A (ja) 1999-12-21
HUP9901865A2 (hu) 1999-10-28
HUP9901865A3 (en) 2000-06-28
ES2279526T3 (es) 2007-08-16
SK55798A3 (en) 1999-06-11
ZA969187B (en) 1997-05-29
AU7253996A (en) 1997-05-22

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