PL1673140T3 - Stałoprądowe urządzenie do elektroporacji - Google Patents

Stałoprądowe urządzenie do elektroporacji

Info

Publication number
PL1673140T3
PL1673140T3 PL04788598T PL04788598T PL1673140T3 PL 1673140 T3 PL1673140 T3 PL 1673140T3 PL 04788598 T PL04788598 T PL 04788598T PL 04788598 T PL04788598 T PL 04788598T PL 1673140 T3 PL1673140 T3 PL 1673140T3
Authority
PL
Poland
Prior art keywords
constant current
electroporation device
current electroporation
constant
electroporation
Prior art date
Application number
PL04788598T
Other languages
English (en)
Inventor
Louis C. Smith
Ruxandra Draghia-Akli
Amir S. Khan
Robert H. Carpenter
Jeff Darnell
Original Assignee
Inovio Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inovio Pharmaceuticals, Inc. filed Critical Inovio Pharmaceuticals, Inc.
Publication of PL1673140T3 publication Critical patent/PL1673140T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0412Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0472Structure-related aspects
    • A61N1/0476Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Electrotherapy Devices (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
PL04788598T 2003-09-08 2004-09-03 Stałoprądowe urządzenie do elektroporacji PL1673140T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/657,725 US8209006B2 (en) 2002-03-07 2003-09-08 Constant current electroporation device and methods of use
EP04788598.3A EP1673140B1 (en) 2003-09-08 2004-09-03 Constant current electroporation device
PCT/US2004/028998 WO2005025669A2 (en) 2003-09-08 2004-09-03 Constant current electroporation device and methods of use

Publications (1)

Publication Number Publication Date
PL1673140T3 true PL1673140T3 (pl) 2018-08-31

Family

ID=34312678

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04788598T PL1673140T3 (pl) 2003-09-08 2004-09-03 Stałoprądowe urządzenie do elektroporacji

Country Status (9)

Country Link
US (1) US8209006B2 (pl)
EP (1) EP1673140B1 (pl)
AR (1) AR045603A1 (pl)
CA (1) CA2578847C (pl)
ES (1) ES2668384T3 (pl)
HU (1) HUE038018T2 (pl)
PL (1) PL1673140T3 (pl)
TW (1) TWI246930B (pl)
WO (1) WO2005025669A2 (pl)

Families Citing this family (155)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080269153A1 (en) * 2002-05-28 2008-10-30 Ruxandra Draghia-Akli Increased stability of a dna formulation by including poly-l-glutamate
US7846720B2 (en) * 2005-01-26 2010-12-07 Vgx Pharmaceuticals, Inc. Optimized high yield synthetic plasmids
CA2604452C (en) * 2005-04-18 2018-03-13 Francine Behar-Cohen Improved methods and devices for delivering a therapeutic product to the ocular sphere of a subject
FR2893256B1 (fr) * 2005-11-14 2008-08-15 Yves Scherman Generateur d'impulsions electriques unipolaires.
EP1981581B1 (en) * 2006-02-11 2016-04-13 Genetronics, Inc. Device for single-needle in vivo electroporation
DE102006009157B4 (de) * 2006-02-24 2015-08-20 Eisenmann Ag Verfahren zum Aufschließen von biologischem Material sowie Vorrichtung zu seiner Durchführung
JP2009528131A (ja) * 2006-03-03 2009-08-06 ジェネトロニクス,インコーポレイティド 外科的切除後の組織に残る微視的残余腫瘍の処置方法及び装置
ATE451067T1 (de) * 2006-06-12 2009-12-15 Region Hovedstaden V Herlev Ho Elektrodeneinführeinrichtung
US7576549B2 (en) * 2006-09-21 2009-08-18 Bio-Rad Laboratories, Inc. Methods for measuring sample resistance in electroporation
PT2066399T (pt) * 2006-10-17 2019-01-11 Inovio Pharmaceuticals Inc Dispositivos de eletroporação e métodos de usar os mesmos para eletroporação de células em mamíferos
EP2799547B1 (en) 2006-11-08 2016-12-21 Veritas Bio, LLC In Vivo Delivery of RNA to a Target Cell
US20100247437A1 (en) * 2007-10-01 2010-09-30 Vgx Pharmaceuticals, Llc Materials and methods for the delivery of biomolecules to cells of an organ
AU2008331673B2 (en) * 2007-11-12 2014-12-11 The Trustees Of The University Of Pennsylvania Novel vaccines against multiple subtypes of influenza virus
CA2702971C (en) * 2007-11-14 2023-03-14 Vgx Pharmaceuticals, Llc Antibody production elicited by a dna vaccine delivered by electroporation
KR101686942B1 (ko) 2008-01-11 2016-12-28 이노비오 파마수티컬즈, 인크. 뎅기 바이러스 다중 서브타입에 대항하는 신규한 백신
WO2009124312A2 (en) * 2008-04-04 2009-10-08 The Trustees Of The University Of Pennsylvania Consensus sequences of chikungunya viral proteins, nucleic acid molecules encoding the same, and compositions and methods for using the same
WO2009124309A2 (en) * 2008-04-04 2009-10-08 The Trustees Of The University Of Pennsylvania Vaccines and immunotherapeutics using il-28 and compositions and methods of using the same
JP5963442B2 (ja) 2008-05-28 2016-08-03 ブイジーエックス ファーマシューティカルズ, エルエルシー 免疫応答を誘発する天然痘dnaワクチンおよびその中の抗原
JP5753090B2 (ja) 2008-10-29 2015-07-22 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 改良型hcvワクチンおよびその使用方法
US8921536B2 (en) 2008-10-29 2014-12-30 The Trustees Of The University Of Pennsylvania HCV vaccines and methods for using the same
EP2358733B1 (en) * 2008-11-17 2015-07-08 Inovio Pharmaceuticals, Inc. Antigens that elicit immune response against flavivirus and methods of using same
TWI423790B (zh) * 2008-11-18 2014-01-21 Univ Nat Chiao Tung 可調式電極植入系統及其可調式電極植入裝置
US9050287B2 (en) 2009-01-23 2015-06-09 The Trustees Of The University Of Pennsylvania Vaccines for human papilloma virus and methods for using the same
CA2653478A1 (en) * 2009-01-23 2010-07-23 Gregg Martin Automated wash system for industrial vehicles
EP2498814B1 (en) 2009-11-02 2015-09-09 The Trustees of the University of Pennsylvania Foot and mouth disease virus (fmdv) consensus proteins, coding sequences therefor and vaccines made therefrom
US8298820B2 (en) 2010-01-26 2012-10-30 The Trustees Of The University Of Pennsylvania Influenza nucleic acid molecules and vaccines made therefrom
AU2011213559B2 (en) 2010-02-08 2015-05-07 The Trustees Of The University Of Pennsylvania Nucleic acid molecules encoding RANTES, and compositions comprising and methods of using the same
CN110195069A (zh) 2010-09-27 2019-09-03 宾夕法尼亚大学托管会 共有抗原构建体和由其制备的疫苗以及使用所述疫苗治疗疟疾的方法
EP3536703B1 (en) 2010-11-12 2021-05-26 The Trustees of the University of Pennsylvania Consensus prostate antigens, nucleic acid molecules encoding the same and uses thereof
TR201904239T4 (tr) 2011-01-28 2019-05-21 Massachusetts Gen Hospital Süreksiz dermabrazyona yönelik yöntem ve aparat.
CN103547226B (zh) 2011-01-28 2018-04-17 通用医疗公司 用于皮肤再表面化的装置
WO2012103483A2 (en) 2011-01-28 2012-08-02 The General Hospital Corporation Apparatus and method for tissue biopsy
US9243041B2 (en) 2011-01-31 2016-01-26 The Trustees Of The University Of Pennsylvania Nucleic acid molecules encoding novel herpes antigens, vaccine comprising the same, and methods of use thereof
CA2827080C (en) 2011-02-11 2022-09-20 The Trustees Of The University Of Pennsylvania Nucleic acid molecule encoding hepatitis b virus core protein and vaccine comprising the same
US9238679B2 (en) 2011-02-11 2016-01-19 The Trustees Of The University Of Pennslyvania Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same
ITTO20110374A1 (it) * 2011-04-29 2012-10-30 Igea S P A Metodo di controllo di un dispositivo di elettro-porazione
AU2012321315B2 (en) 2011-07-11 2016-04-14 Inovio Pharmaceuticals, Inc Cross-protective arenavirus vaccines and their method of use
AU2012321317B2 (en) 2011-07-12 2016-01-28 Inovio Pharmaceuticals, Inc Novel clostridium difficile DNA vaccine
HUE042454T2 (hu) 2011-07-21 2019-07-29 Massachusetts Gen Hospital Berendezés zsír roncsolására és eltávolítására
SG11201400527XA (en) 2011-09-16 2014-04-28 Univ Pennsylvania Rna engineered t cells for the treatment of cancer
US9708384B2 (en) 2011-09-22 2017-07-18 The Trustees Of The University Of Pennsylvania Universal immune receptor expressed by T cells for the targeting of diverse and multiple antigens
EP3443982A1 (en) 2011-10-12 2019-02-20 The Trustees of the University of Pennsylvania Vaccines for human papilloma virus and methods for using the same
KR101913674B1 (ko) 2011-10-24 2018-10-31 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 개선된 hcv 백신 및 이것을 사용하는 방법
US9272002B2 (en) 2011-10-28 2016-03-01 The Trustees Of The University Of Pennsylvania Fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting
BR112014014078A2 (pt) 2011-12-12 2018-10-09 The Trustees Of The University Of Pennsylvania composições compreendendo constructos genéticos il-12 aperfeiçoados e vacinas, imunoterapêuticos e métodos de uso dos mesmos
KR20140116095A (ko) 2011-12-12 2014-10-01 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Mrsa pbp2a 및 이의 단편들을 포함하는 단백질, 이를 인코딩한 핵산, 및 mrsa 감염을 예방 및 치료하기 위한 조성물 및 그의 용도
JP2015509717A (ja) 2012-02-22 2015-04-02 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 抗腫瘍活性およびcar存続性を強化するためのicosベースのcarの使用
CA2864489C (en) 2012-02-22 2023-08-08 The Trustees Of The University Of Pennsylvania Use of the cd2 signaling domain in second-generation chimeric antigen receptors
AU2013245950B2 (en) 2012-04-10 2016-04-21 The Trustees Of The University Of Pennsylvania Human respiratory syncytial virus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same
KR102146904B1 (ko) 2012-04-12 2020-08-24 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 필로바이러스 공통 항원, 이로부터 제조된 핵산 구조체 및 백신, 및 이를 사용하는 방법
CA2876730A1 (en) 2012-07-13 2014-01-16 The Trustees Of The University Of Pennsylvania Enhancing activity of car t cells by co-introducing a bispecific antibody
US9365641B2 (en) 2012-10-01 2016-06-14 The Trustees Of The University Of Pennsylvania Compositions and methods for targeting stromal cells for the treatment of cancer
WO2014055771A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Human alpha-folate receptor chimeric antigen receptor
WO2014055657A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
EP2911736A4 (en) * 2012-10-25 2016-06-15 Oncosec Medical Inc electroporation
WO2014093897A1 (en) 2012-12-13 2014-06-19 The Trustees Of The University Of Pennsylvania Wt1 vaccine
WO2015089492A2 (en) 2013-12-13 2015-06-18 The Trustees Of The University Of Pennsylvania Dna antibody constructs and method of using same
US10543127B2 (en) 2013-02-20 2020-01-28 Cytrellis Biosystems, Inc. Methods and devices for skin tightening
CN105307678A (zh) 2013-03-12 2016-02-03 宾夕法尼亚大学理事会 用于人乳头状瘤病毒的改进疫苗及其使用方法
US11419925B2 (en) 2013-03-15 2022-08-23 The Trustees Of The University Of Pennsylvania Cancer vaccines and methods of treatment using the same
CN114045295A (zh) 2013-03-15 2022-02-15 宾夕法尼亚大学理事会 口蹄疫病毒(fmdv)共有蛋白、其编码序列以及由其制造的疫苗
US11013917B2 (en) 2013-06-21 2021-05-25 Newsouth Innovations Pty Limited Method and apparatus for close-field electroporation
KR102349218B1 (ko) 2013-08-09 2022-01-10 사이트렐리스 바이오시스템즈, 인크. 비-열적 조직 절제를 사용한 피부 치료를 위한 방법 및 기구
CN203451533U (zh) * 2013-08-27 2014-02-26 苏州文曲生物微系统有限公司 一种基于新型微电极芯片的电穿孔系统
WO2015095675A1 (en) 2013-12-19 2015-06-25 Cytrellis Biosystems, Inc. Methods and devices for manipulating subdermal fat
US11028143B2 (en) 2014-01-21 2021-06-08 Novartis Ag Enhanced antigen presenting ability of RNA CAR T cells by co-introduction of costimulatory molecules
ES2910227T3 (es) 2014-10-31 2022-05-12 Univ Pennsylvania Composición y métodos para la estimulación y expansión de células T
MX2017005698A (es) 2014-10-31 2017-06-29 Univ Pennsylvania Alteracion de la expresion genetica en celulas t modificadas con el receptor de antigeno quimerico (cart) y usos de las mismas.
KR102670286B1 (ko) 2014-11-14 2024-05-30 사이트렐리스 바이오시스템즈, 인크. 피부 절제를 위한 디바이스 및 방법
AU2015355126B9 (en) 2014-12-01 2020-03-26 Inovio Pharmaceuticals, Inc. DNA antibody constructs and method of using same
CA2973390A1 (en) 2015-01-09 2016-07-14 Oncosec Medical Incorporated Method for the treatment of malignancies
JP7170394B2 (ja) 2015-01-31 2022-11-14 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 治療用分子のt細胞送達のための組成物および方法
JP6879996B2 (ja) 2015-03-26 2021-06-02 オンコセック メディカル インコーポレイテッド 悪性腫瘍の治療方法
PL3277368T3 (pl) * 2015-03-31 2021-01-25 Oncosec Medical Incorporated Układy do ulepszonej elektroporacji opartej na wykrywaniu tkanek
WO2016178996A1 (en) 2015-05-01 2016-11-10 The Regents Of The University Of California Glycan-dependent immunotherapeutic molecules
WO2016205895A1 (en) * 2015-06-25 2016-12-29 Newsouth Innovations Pty Limited Electroporation system for controlled localized therapeutics delivery
EP3340998B1 (en) 2015-08-28 2023-01-11 The Trustees of the University of Pennsylvania Methods and compositions for cells expressing a chimeric intracellular signaling molecule
KR101788301B1 (ko) * 2015-09-17 2017-10-20 주식회사 엘림텍 전기천공장치 및 그 제어방법
AU2016369608B2 (en) 2015-12-18 2023-02-02 Jean Campbell Plasmid constructs for heterologous protein expression and methods of use
IL260071B2 (en) * 2015-12-22 2023-03-01 Inovio Pharmaceuticals Inc An electroporation device that includes a battery pack with a power switch
BR112018015893A2 (pt) 2016-02-05 2019-03-06 Inovio Pharmaceuticals Inc vacinas de câncer e métodos de tratamento usando as mesmas
EP3432924A1 (en) 2016-03-23 2019-01-30 Novartis AG Cell secreted minibodies and uses thereof
KR20230117470A (ko) 2016-03-29 2023-08-08 사이트렐리스 바이오시스템즈, 인크. 미용 피부 리설페이싱용 디바이스 및 방법
EP3443107A1 (en) 2016-04-13 2019-02-20 Synthetic Genomics, Inc. Recombinant arterivirus replicon systems and uses thereof
JP2018035137A (ja) 2016-07-13 2018-03-08 マブイミューン ダイアグノスティックス エイジーMabimmune Diagnostics Ag 新規な抗線維芽細胞活性化タンパク質(fap)結合薬剤およびその使用
KR102515836B1 (ko) 2016-09-21 2023-03-31 사이트렐리스 바이오시스템즈, 인크. 미용 피부 리설페이싱용 디바이스 및 방법
WO2018075235A1 (en) 2016-10-17 2018-04-26 Synthetic Genomics, Inc. Recombinant virus replicon systems and uses thereof
EP3548625B1 (en) 2016-12-05 2024-06-26 Janssen Pharmaceuticals, Inc. Compositions and methods for enhancing gene expression
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
SE541651C2 (en) 2017-07-28 2019-11-19 Scandinavian Chemotech Ab An electrode device and a needle electrode for use in delivery of electrical pulses to a desired tissue of a mammal
KR20230116954A (ko) 2017-12-13 2023-08-04 이노비오 파마수티컬즈, 인크. Muc16을 표적화하는 암 백신 및 이의 용도
RU2751252C1 (ru) 2017-12-13 2021-07-12 Иновио Фармасьютикалз, Инк. Мезотелин-нацеленные вакцины от рака и их применение
MX2020006216A (es) 2017-12-13 2020-08-31 Inovio Pharmaceuticals Inc Vacunas contra el cancer dirigidas a prame y sus usos.
KR20200100745A (ko) 2017-12-19 2020-08-26 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 B형 간염 바이러스(hbv)에 대한 면역 반응 유도를 위한 방법 및 조성물
KR20200101416A (ko) 2017-12-19 2020-08-27 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 B형 간염 바이러스(hbv) 백신 및 그 용도
EA202091516A1 (ru) 2017-12-19 2020-11-03 Янссен Сайенсиз Айрлэнд Анлимитед Компани Способы и композиции для индукции иммунного ответа против вируса гепатита b (hbv)
US11021692B2 (en) 2017-12-19 2021-06-01 Janssen Sciences Ireland Unlimited Company Hepatitis B virus (HBV) vaccines and uses thereof
US11389531B2 (en) 2017-12-19 2022-07-19 Janssen Sciences Ireland Unlimited Company Methods and apparatus for the delivery of hepatitis B virus (HBV) vaccines
JP7372920B2 (ja) 2017-12-29 2023-11-01 セレクティス Car t細胞の作製を改良するための方法
CN111902163B (zh) 2018-01-19 2024-02-13 杨森制药公司 使用重组复制子系统诱导和增强免疫应答
US20220170097A1 (en) 2018-10-29 2022-06-02 The Broad Institute, Inc. Car t cell transcriptional atlas
US11185692B2 (en) * 2018-10-31 2021-11-30 Emily Ireland Light touch therapeutic headset
US11071860B2 (en) 2019-02-06 2021-07-27 Oncosec Medical Incorporated Systems and methods for detecting fault conditions in electroporation therapy
US20220177863A1 (en) 2019-03-18 2022-06-09 The Broad Institute, Inc. Type vii crispr proteins and systems
TW202042824A (zh) 2019-03-27 2020-12-01 賓夕法尼亞大學董事會 Tn-MUC1嵌合抗原受體(CAR)T細胞療法
US11660139B2 (en) 2019-04-10 2023-05-30 Radioclash Inc. Electroporation probe
CN109999340B (zh) * 2019-04-29 2024-07-16 杭州睿笛生物科技有限公司 一种负载自适应纳秒脉冲产生装置
CA3143679A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and hbv-targeting rnai
US20220324916A1 (en) 2019-06-18 2022-10-13 Janssen Sciences Ireland Unlimited Company Hepatitis B Virus (HBV) Vaccines and Uses Thereof
MA56523A (fr) 2019-06-18 2022-04-27 Janssen Sciences Ireland Unlimited Co Combinaison de vaccins contre le virus de l'hépatite b (vhb) et d'anticorps anti-pd-1 ou anti-pd-l1
WO2020255013A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and capsid assembly modulators being amide derivatives
WO2020255019A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and a quinazoline derivative
WO2020255038A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and pyridopyrimidine derivatives
EP3986562A1 (en) 2019-06-18 2022-04-27 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and hbv-targeting rnai
CA3140588A1 (en) 2019-06-18 2020-12-24 Helen Horton Combination of hepatitis b virus (hbv) vaccines and small molecule pdl1 or pd1 inhibitor
WO2020255014A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Recombinant interleukin 12 construct and uses thereof
WO2020255010A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of recombinant interleukin 12 construct and hepatitis b virus (hbv) vaccines
WO2020255016A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators
WO2020255035A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and pyrimidine derivatives
WO2020254876A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Virus-like particle delivery of hepatitis b virus (hbv) vaccines
US20220233684A1 (en) 2019-06-18 2022-07-28 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and pd-l1 inhibitors
CA3143634A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and anti-pd-1 antibody
US20220241402A1 (en) 2019-06-18 2022-08-04 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and quinazoline derivatives
CA3140702A1 (en) 2019-06-18 2020-12-24 Helen Horton Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators
CA3140690A1 (en) 2019-06-18 2020-12-24 Helen Horton Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators
WO2020255042A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and a pyrimidine derivative
US20220305116A1 (en) 2019-06-18 2022-09-29 Janssen Sciences lreland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and capsid assembly modulators being sulfonamide derivatives
WO2020255022A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and aminopyridine derivatives as hpk1 inhibitors
WO2020255062A1 (en) 2019-06-20 2020-12-24 Janssen Sciences Ireland Unlimited Company Lipid nanoparticle or liposome delivery of hepatitis b virus (hbv) vaccines
WO2020255063A1 (en) 2019-06-20 2020-12-24 Janssen Sciences Ireland Unlimited Company Carbohydrate nanocarrier delivery of hepatitis b virus (hbv) vaccines
CA3149494A1 (en) 2019-08-12 2021-02-18 Purinomia Biotech, Inc. Methods and compositions for promoting and potentiating t-cell mediated immune responses through adcc targeting of cd39 expressing cells
WO2021074695A1 (en) 2019-10-16 2021-04-22 Avacta Life Sciences Limited PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES.
JP2023516080A (ja) 2020-03-06 2023-04-17 ジーオー セラピューティクス,インコーポレイテッド 抗グリコcd44抗体およびその使用
WO2021191870A1 (en) 2020-03-27 2021-09-30 Dcprime B.V. Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
WO2021191871A1 (en) 2020-03-27 2021-09-30 Dcprime B.V. In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
GB202101299D0 (en) 2020-06-09 2021-03-17 Avacta Life Sciences Ltd Diagnostic polypetides and methods
AU2021289600A1 (en) 2020-06-12 2023-01-19 University Of Rochester Encoding and expression of ACE-tRNAs
JP2023533528A (ja) 2020-07-08 2023-08-03 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー Hbvに対するrnaレプリコンワクチン
EP4210832A1 (en) 2020-09-14 2023-07-19 Vor Biopharma, Inc. Chimeric antigen receptors for treatment of cancer
AU2021375493A1 (en) 2020-11-05 2023-06-29 Mendus B.V. Use of tumor-independent antigens in immunotherapies
TW202245809A (zh) 2020-12-18 2022-12-01 美商詹森藥物公司 用於治療b型肝炎病毒感染之組合療法
US20240316090A1 (en) 2020-12-28 2024-09-26 Arcturus Therapeutics, Inc. Transcription activator-like effector nucleases (talens) targeting hbv
JP2024512324A (ja) 2021-03-05 2024-03-19 ジーオー セラピューティクス,インコーポレイテッド 抗グリコcd44抗体およびその使用
JP2024510989A (ja) 2021-03-12 2024-03-12 メンドゥス・ベスローテン・フェンノートシャップ ワクチン接種方法及びcd47遮断薬の使用
US20230001169A1 (en) * 2021-06-30 2023-01-05 Inovio Pharmaceuticals, Inc. Electrode Arrays For Electroporation, and Related Systems and Methods
WO2023010118A1 (en) 2021-07-29 2023-02-02 Vor Biopharma Inc. Nfat-responsive reporter systems for assessing chimeric antigen receptor activation and methods of making and using the same
EP4376877A2 (en) 2021-07-29 2024-06-05 Vor Biopharma Inc. Chimeric antigen receptors for treatment of cancer
EP4380604A1 (en) 2021-08-05 2024-06-12 Go Therapeutics, Inc. Anti-glyco-muc4 antibodies and their uses
TW202328188A (zh) 2021-09-03 2023-07-16 美商Go治療公司 抗醣化-cmet抗體及其用途
CA3230933A1 (en) 2021-09-03 2023-03-09 Go Therapeutics, Inc. Anti-glyco-lamp1 antibodies and their uses
WO2023150753A1 (en) 2022-02-07 2023-08-10 University Of Rochester Optimized sequences for enhanced trna expression or/and nonsense mutation suppression
WO2023215874A1 (en) * 2022-05-05 2023-11-09 Renbio, Inc. Device related to therapeutic dna delivery
US20240002800A1 (en) 2022-05-16 2024-01-04 Mendus B.V. Use of leukemia-derived cells for enhancing natural killer (nk) cell therapy
WO2023233290A1 (en) 2022-05-31 2023-12-07 Janssen Sciences Ireland Unlimited Company Rnai agents targeting pd-l1
WO2024129459A1 (en) 2022-12-16 2024-06-20 University Of Rochester Repairmen! of barrier dysfunction in esophagus

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US578611A (en) 1897-03-09 Thirds to louis f
US2223447A (en) * 1936-07-23 1940-12-03 Rca Corp Short-wave radiotherapy system
US2239432A (en) * 1939-07-12 1941-04-22 Gen Electric Excitation circuit for dynamoelectric machines
US2827851A (en) * 1954-08-13 1958-03-25 Peter B Ferrara Energizer assembly
US2970545A (en) * 1956-01-23 1961-02-07 Magnavox Co Energy converting device
US3060923A (en) * 1959-01-07 1962-10-30 Teca Corp Coaxial electrode structure and a method of fabricating same
US3087486A (en) * 1959-03-05 1963-04-30 Cenco Instr Corp Cardiac electrode means
US3162592A (en) * 1960-04-20 1964-12-22 Pohl Herbert Ackland Materials separation using non-uniform electric fields
US3078850A (en) * 1960-08-26 1963-02-26 Imp Electronics Inc Electrochemotherapeutic cardiac device
US3224436A (en) * 1961-04-10 1965-12-21 Honeywell Regulator Co Hypodermic apparatus for measuring hydrogen ion concentration of blood within a living body
US3313293A (en) * 1964-01-13 1967-04-11 Hewlett Packard Co Multi-electrode needle
US3568660A (en) * 1967-11-20 1971-03-09 Battelle Development Corp Pacemaker catheter
US3682162A (en) * 1968-12-13 1972-08-08 Wellcome Found Combined electrode and hypodermic syringe needle
US3834392A (en) * 1973-02-01 1974-09-10 Kli Inc Laparoscopy system
US3900020A (en) * 1974-05-02 1975-08-19 Chuck Lock Electronic acupuncture device
US4016886A (en) * 1974-11-26 1977-04-12 The United States Of America As Represented By The United States Energy Research And Development Administration Method for localizing heating in tumor tissue
US4119102A (en) * 1975-07-11 1978-10-10 Leveen Harry H Radio frequency treatment of tumors while inducing hypotension
US4141359A (en) * 1976-08-16 1979-02-27 University Of Utah Epidermal iontophoresis device
US4155363A (en) * 1976-08-23 1979-05-22 International Electrolysis Group Inc. Electronically controlled apparatus for electrolytic depilation
DE2800039C2 (de) * 1978-01-02 1984-06-20 Horst Dr.Med. 6700 Ludwigshafen Kief Akupunkturgerät
US4237896A (en) * 1979-08-01 1980-12-09 Senil Nominees Pty. Ltd Immobilizing animals
US4524770A (en) * 1983-01-25 1985-06-25 Ahmad Orandi Endoscope injection needle
US4476004A (en) * 1983-04-08 1984-10-09 D.E.P. Systems, Inc. Apparatus for electrofusion of biological particles
US4663292A (en) * 1984-12-21 1987-05-05 Wong Daniel T High-voltage biological macromolecule transfer and cell fusion system
GB2189698A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
US4969468A (en) * 1986-06-17 1990-11-13 Alfred E. Mann Foundation For Scientific Research Electrode array for use in connection with a living body and method of manufacture
FR2607708B3 (fr) * 1986-12-05 1989-02-24 Bontemps Raymond Dispositif destine au transfert sous-cutane de substances medicinales
US4970154A (en) * 1987-10-09 1990-11-13 Baylor College Of Medicine Method for inserting foreign genes into cells using pulsed radiofrequency
US4822470A (en) * 1987-10-09 1989-04-18 Baylor College Of Medicine Method of and apparatus for cell poration and cell fusion using radiofrequency electrical pulses
JP2798459B2 (ja) * 1988-01-21 1998-09-17 マサチユセツツ・インスチチユート・オブ・テクノロジー エレクトロポレーションを利用した診断装置及び分子の組織内移動装置
US5389069A (en) * 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
US5703055A (en) * 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5137817A (en) * 1990-10-05 1992-08-11 Amoco Corporation Apparatus and method for electroporation
US5545130A (en) * 1992-04-08 1996-08-13 Genetronics, Inc. Flow through electroporation method
US5501662A (en) * 1992-05-22 1996-03-26 Genetronics, Inc. Implantable electroporation method and apparatus for drug and gene delivery
US5507724A (en) * 1992-07-01 1996-04-16 Genetronics, Inc. Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells
US5273525A (en) * 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US5462520A (en) * 1992-08-17 1995-10-31 Genetronics, Inc. Transsurface drug delivery by electrofusion of microbubbles to the tissue surface
US5318514A (en) * 1992-08-17 1994-06-07 Btx, Inc. Applicator for the electroporation of drugs and genes into surface cells
US5464386A (en) * 1992-08-17 1995-11-07 Genetronics, Inc. Transdermal drug delivery by electroincorporation of vesicles
US5688233A (en) * 1992-08-17 1997-11-18 Genetronics, Inc. Electronincorporation enhanced transdermal delivery of molecules
US5468223A (en) * 1992-11-30 1995-11-21 C.N.R.S. Paris Electrochemotherapy
FR2703253B1 (fr) * 1993-03-30 1995-06-23 Centre Nat Rech Scient Applicateur d'impulsions electriques pour traitement de tissus biologiques.
US5439440A (en) 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
EP0774272B1 (en) * 1994-06-17 2004-01-28 Hisamitsu Pharmaceutical Co. Inc. Electrode for iontophoresis and device using the same
US5518264A (en) * 1995-03-14 1996-05-21 Broughton; Timothy C. Free heel/anterior release ski binding
US5810762A (en) * 1995-04-10 1998-09-22 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5628728A (en) * 1995-05-31 1997-05-13 Ekos Corporation Medicine applying tool
US5859327A (en) * 1995-08-22 1999-01-12 Genetronics, Inc. Electroporation-mediated molecular transfer in intact plants
US5944710A (en) * 1996-06-24 1999-08-31 Genetronics, Inc. Electroporation-mediated intravascular delivery
US5869326A (en) * 1996-09-09 1999-02-09 Genetronics, Inc. Electroporation employing user-configured pulsing scheme
US5704908A (en) * 1996-10-10 1998-01-06 Genetronics, Inc. Electroporation and iontophoresis catheter with porous balloon
JP3366548B2 (ja) 1997-02-26 2003-01-14 久光製薬株式会社 イオントフォレーシス用デバイス構造体及びその製造方法
DE69835761T2 (de) 1997-04-03 2007-09-13 Electrofect As. Verfahren zum verabreichen von pharmazeutischen präparaten und nukleinsäuren an den skelettmuskel
US6261281B1 (en) * 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
US5873849A (en) * 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US6241701B1 (en) * 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US6055453A (en) * 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6216034B1 (en) * 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
TW368420B (en) * 1997-11-04 1999-09-01 Genetronics Inc Apparatus and method for transdermal molecular delivery by applying sufficient amplitude of electric field to induce migration of molecules through pores in the stratum corneum
US6208893B1 (en) * 1998-01-27 2001-03-27 Genetronics, Inc. Electroporation apparatus with connective electrode template
US6120493A (en) * 1998-01-27 2000-09-19 Genetronics, Inc. Method for the introduction of therapeutic agents utilizing an electroporation apparatus
AU4219399A (en) * 1998-06-08 1999-12-30 Valentis, Inc. Formulations for electroporation
JP2002520101A (ja) * 1998-07-13 2002-07-09 ジェネトロニクス、インコーポレーテッド 電気的に補助される化粧用薬剤の局部送達法および装置
US6192270B1 (en) * 1998-08-14 2001-02-20 Genetronics, Inc. Apparatus and method for the delivery of drugs and genes into tissue
US6150148A (en) * 1998-10-21 2000-11-21 Genetronics, Inc. Electroporation apparatus for control of temperature during the process
US6314316B1 (en) * 1998-12-17 2001-11-06 University Of South Florida Nonpenetrating electroporation device and method
AU2868200A (en) 1999-02-08 2000-08-25 Chiron Corporation Electrically-mediated enhancement of dna vaccine immunity and efficacy in vivo
US6300108B1 (en) * 1999-07-21 2001-10-09 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes
US6387671B1 (en) * 1999-07-21 2002-05-14 The Regents Of The University Of California Electrical impedance tomography to control electroporation
US6428504B1 (en) 2000-04-06 2002-08-06 Varian Medical Systems, Inc. Multipurpose template and needles for the delivery and monitoring of multiple minimally invasive therapies
AU6475901A (en) * 2000-05-22 2001-12-03 Merck And Company Inc System and method for assessing the performance of a pharmaceutical agent delivery system
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
US6912417B1 (en) 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents

Also Published As

Publication number Publication date
WO2005025669A2 (en) 2005-03-24
TW200510028A (en) 2005-03-16
CA2578847A1 (en) 2005-03-24
US20050052630A1 (en) 2005-03-10
WO2005025669A3 (en) 2005-08-04
HUE038018T2 (hu) 2018-09-28
EP1673140B1 (en) 2018-03-21
US8209006B2 (en) 2012-06-26
CA2578847C (en) 2014-01-28
EP1673140A2 (en) 2006-06-28
TWI246930B (en) 2006-01-11
AR045603A1 (es) 2005-11-02
ES2668384T3 (es) 2018-05-17

Similar Documents

Publication Publication Date Title
PL1673140T3 (pl) Stałoprądowe urządzenie do elektroporacji
AU156617S (en) Stimulation device
AU2003278410A8 (en) Charging device
HK1118131A1 (en) Battery device
EP1621859A4 (en) FORCE DETECTION DEVICE
EP1661596A4 (en) OXYGEN ENRICHMENT DEVICE
EP1630586A4 (en) MICROSCOPE
EP1594295A4 (en) PORTABLE TERMINAL DEVICE
GB0309778D0 (en) Device
EP1617181A4 (en) INVESTMENT DETECTION DEVICE
EP1482315A4 (en) CURRENT MEASUREMENT
EP1626260A4 (en) TORQUE DETECTION DEVICE
EP1811358A4 (en) DEVICE FOR CONTROLLING CONSTANT CURRENTS
EP1589597A4 (en) ELECTROCHEMICAL DEVICE
EP1623834A4 (en) FLUID INJECTION DEVICE
GB0306449D0 (en) Device
GB0300024D0 (en) Device
GB0309779D0 (en) Device
GB0308593D0 (en) Device
EP1603644A4 (en) SET DEVICE
EP1638116A4 (en) DEVICE FOR COLORING ELECTRIC WIRE
HK1066365A1 (en) Portable terminal device
EP1688703A4 (en) SHAPE MEASURING DEVICE
EP1589343A4 (en) ANALAYSATORZUFÜHRUNGSEINRICHTUNG
GB0301384D0 (en) Device