PL147734B1 - Method of obtaining new active polysaccharides capable of lowering trigliceride level - Google Patents
Method of obtaining new active polysaccharides capable of lowering trigliceride level Download PDFInfo
- Publication number
- PL147734B1 PL147734B1 PL1984248970A PL24897084A PL147734B1 PL 147734 B1 PL147734 B1 PL 147734B1 PL 1984248970 A PL1984248970 A PL 1984248970A PL 24897084 A PL24897084 A PL 24897084A PL 147734 B1 PL147734 B1 PL 147734B1
- Authority
- PL
- Poland
- Prior art keywords
- streptococcus
- ferm
- microorganism
- polysaccharide
- separated
- Prior art date
Links
- 229920001282 polysaccharide Polymers 0.000 title claims description 14
- 239000005017 polysaccharide Substances 0.000 title claims description 14
- 238000000034 method Methods 0.000 title claims description 10
- 150000004676 glycans Chemical class 0.000 title claims description 8
- 239000000203 mixture Substances 0.000 claims description 4
- 244000005700 microbiome Species 0.000 claims 7
- 241000194049 Streptococcus equinus Species 0.000 claims 4
- 241001134658 Streptococcus mitis Species 0.000 claims 3
- 229940115921 streptococcus equinus Drugs 0.000 claims 3
- 241001468179 Enterococcus avium Species 0.000 claims 2
- 241000520130 Enterococcus durans Species 0.000 claims 2
- 241000194032 Enterococcus faecalis Species 0.000 claims 2
- 241000194031 Enterococcus faecium Species 0.000 claims 2
- 241000194024 Streptococcus salivarius Species 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 claims 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims 1
- 241000194017 Streptococcus Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 210000004748 cultured cell Anatomy 0.000 claims 1
- 238000000921 elemental analysis Methods 0.000 claims 1
- 238000004817 gas chromatography Methods 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
- 241000700159 Rattus Species 0.000 description 12
- 241000699670 Mus sp. Species 0.000 description 11
- 241001465754 Metazoa Species 0.000 description 9
- 230000037396 body weight Effects 0.000 description 8
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 7
- -1 TRS polysaccharide Chemical class 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000002504 physiological saline solution Substances 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- 239000006188 syrup Substances 0.000 description 3
- 235000020357 syrup Nutrition 0.000 description 3
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
- 229930091371 Fructose Natural products 0.000 description 2
- 239000005715 Fructose Substances 0.000 description 2
- YRKCREAYFQTBPV-UHFFFAOYSA-N acetylacetone Chemical compound CC(=O)CC(C)=O YRKCREAYFQTBPV-UHFFFAOYSA-N 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 229940100445 wheat starch Drugs 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/46—Streptococcus ; Enterococcus; Lactococcus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Materials Engineering (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58135982A JPS6028401A (ja) | 1983-07-27 | 1983-07-27 | トリグリセリド低下活性多糖類 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL248970A1 PL248970A1 (en) | 1985-04-09 |
| PL147734B1 true PL147734B1 (en) | 1989-07-31 |
Family
ID=15164420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1984248970A PL147734B1 (en) | 1983-07-27 | 1984-07-27 | Method of obtaining new active polysaccharides capable of lowering trigliceride level |
Country Status (12)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5927833A (ja) * | 1982-08-06 | 1984-02-14 | Advance Res & Dev Co Ltd | コレステロール乃至トリグリセリド低下剤 |
| JPS59122428A (ja) * | 1982-12-28 | 1984-07-14 | Advance Res & Dev Co Ltd | コレステロ−ル低下活性蛋白質 |
| JPS61151128A (ja) * | 1984-12-24 | 1986-07-09 | Advance Res & Dev Co Ltd | コレステロ−ル低下活性ｒｎａ画分 |
| JPS625991A (ja) * | 1985-07-03 | 1987-01-12 | Advance Res & Dev Co Ltd | コレステロ−ル乃至トリグリセリド低下活性ｒｎａ画分 |
| US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| US5202431A (en) * | 1985-07-08 | 1993-04-13 | Fidia, S.P.A. | Partial esters of hyaluronic acid |
| US6756361B1 (en) * | 1997-10-14 | 2004-06-29 | Nabi | Enterococcus antigens and vaccines |
| JP2009149523A (ja) * | 2006-03-01 | 2009-07-09 | Ucc Ueshima Coffee Co Ltd | 免疫賦活剤とその製造方法 |
| CN103012615B (zh) * | 2013-01-08 | 2015-02-25 | 广东海洋大学 | 一种高效提取乌贼墨酸性多糖的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS52117492A (en) * | 1975-12-11 | 1977-10-01 | Hayashibara Biochem Lab Inc | Preparation of water-insoluble glucan |
| US4251519A (en) * | 1979-07-30 | 1981-02-17 | Anheuser-Busch, Incorporated | Process for the prevention and reduction of elevated blood cholesterol and triglycerides levels |
| JPS5943929B2 (ja) * | 1979-08-13 | 1984-10-25 | サッポロビール株式会社 | 多糖体ｒｂｓ物質，その製法およびそれを有効成分とする抗腫瘍性剤 |
| JPS601877B2 (ja) * | 1981-01-14 | 1985-01-17 | 明治乳業株式会社 | 高分子多糖類物質ｍｐｓ−８０及びその製造法 |
| DE3305047A1 (de) * | 1982-02-19 | 1983-09-22 | Terumo Kabushiki Kaisha trading as Terumo Corp., Tokyo | Polysaccharide, ihre herstellung und diese enthaltende therapeutische zusammensetzungen |
| JPS5927833A (ja) * | 1982-08-06 | 1984-02-14 | Advance Res & Dev Co Ltd | コレステロール乃至トリグリセリド低下剤 |
-
1983
- 1983-07-27 JP JP58135982A patent/JPS6028401A/ja active Granted
-
1984
- 1984-07-11 AU AU30488/84A patent/AU563995B2/en not_active Ceased
- 1984-07-13 DE DE8484304791T patent/DE3480217D1/de not_active Expired
- 1984-07-13 CA CA000458891A patent/CA1239364A/en not_active Expired
- 1984-07-13 EP EP84304791A patent/EP0132981B1/en not_active Expired
- 1984-07-20 MX MX841039U patent/MX7693E/es unknown
- 1984-07-20 US US06/632,844 patent/US4687764A/en not_active Expired - Fee Related
- 1984-07-26 ES ES534629A patent/ES8505722A1/es not_active Expired
- 1984-07-26 HU HU842873A patent/HU191697B/hu not_active IP Right Cessation
- 1984-07-26 SU SU843770904A patent/SU1732815A3/ru active
- 1984-07-26 DD DD84265684A patent/DD222895A5/de not_active IP Right Cessation
- 1984-07-27 PL PL1984248970A patent/PL147734B1/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU563995B2 (en) | 1987-07-30 |
| EP0132981A3 (en) | 1986-01-29 |
| ES534629A0 (es) | 1985-06-01 |
| ES8505722A1 (es) | 1985-06-01 |
| JPS6028401A (ja) | 1985-02-13 |
| EP0132981B1 (en) | 1989-10-18 |
| EP0132981A2 (en) | 1985-02-13 |
| HUT34773A (en) | 1985-04-28 |
| US4687764A (en) | 1987-08-18 |
| PL248970A1 (en) | 1985-04-09 |
| CA1239364A (en) | 1988-07-19 |
| JPH0365362B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1991-10-11 |
| AU3048884A (en) | 1985-01-31 |
| DE3480217D1 (en) | 1989-11-23 |
| DD222895A5 (de) | 1985-05-29 |
| HU191697B (en) | 1987-03-30 |
| MX7693E (es) | 1990-08-24 |
| SU1732815A3 (ru) | 1992-05-07 |
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