PL121664B1 - Process for preparing inclusion compounds of prostacycline and its esters with alkyls of 1 to 4 carbon atoms with cyclodextrinsna i ego alkilovykh ehfirov s 1-4 atomami uglja s ciklogekstrinami - Google Patents

Process for preparing inclusion compounds of prostacycline and its esters with alkyls of 1 to 4 carbon atoms with cyclodextrinsna i ego alkilovykh ehfirov s 1-4 atomami uglja s ciklogekstrinami Download PDF

Info

Publication number
PL121664B1
PL121664B1 PL1978209773A PL20977378A PL121664B1 PL 121664 B1 PL121664 B1 PL 121664B1 PL 1978209773 A PL1978209773 A PL 1978209773A PL 20977378 A PL20977378 A PL 20977378A PL 121664 B1 PL121664 B1 PL 121664B1
Authority
PL
Poland
Prior art keywords
prostacyclin
cyclodextrin
esters
solution
carbon atoms
Prior art date
Application number
PL1978209773A
Other languages
English (en)
Polish (pl)
Other versions
PL209773A1 (pl
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of PL209773A1 publication Critical patent/PL209773A1/xx
Publication of PL121664B1 publication Critical patent/PL121664B1/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
PL1978209773A 1977-09-23 1978-09-22 Process for preparing inclusion compounds of prostacycline and its esters with alkyls of 1 to 4 carbon atoms with cyclodextrinsna i ego alkilovykh ehfirov s 1-4 atomami uglja s ciklogekstrinami PL121664B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU77CI1770A HU179141B (en, 2012) 1977-09-23 1977-09-23

Publications (2)

Publication Number Publication Date
PL209773A1 PL209773A1 (pl) 1979-06-04
PL121664B1 true PL121664B1 (en) 1982-05-31

Family

ID=10994670

Family Applications (1)

Application Number Title Priority Date Filing Date
PL1978209773A PL121664B1 (en) 1977-09-23 1978-09-22 Process for preparing inclusion compounds of prostacycline and its esters with alkyls of 1 to 4 carbon atoms with cyclodextrinsna i ego alkilovykh ehfirov s 1-4 atomami uglja s ciklogekstrinami

Country Status (20)

Country Link
JP (1) JPS5456685A (en, 2012)
AT (1) AT369362B (en, 2012)
BE (1) BE870646A (en, 2012)
CH (1) CH637388A5 (en, 2012)
CS (1) CS200242B2 (en, 2012)
DD (1) DD138600A5 (en, 2012)
DE (1) DE2840142A1 (en, 2012)
DK (1) DK420778A (en, 2012)
FI (1) FI65912C (en, 2012)
FR (1) FR2404006A1 (en, 2012)
GB (1) GB2006193B (en, 2012)
GR (1) GR65001B (en, 2012)
HU (1) HU179141B (en, 2012)
IL (1) IL55569A (en, 2012)
IT (1) IT1160661B (en, 2012)
NL (1) NL7809643A (en, 2012)
PL (1) PL121664B1 (en, 2012)
SE (1) SE447574B (en, 2012)
SU (1) SU847914A3 (en, 2012)
YU (1) YU220678A (en, 2012)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53136513A (en) * 1977-05-06 1978-11-29 Ono Pharmaceut Co Ltd Stabilization of prostaglandin-x-related compounds
US4352793A (en) * 1979-04-26 1982-10-05 Sumitomo Chemical Company, Limited Pharmaceutical composition comprising bencyclane fumarate and cyclodextrin
JPS5920230A (ja) * 1982-07-19 1984-02-01 チバ−ガイギ−・アクチエンゲゼルシヤフト ピルプロフエン含有薬剤
JPS61289034A (ja) * 1985-06-17 1986-12-19 Teijin Ltd イソカルバサイクリン類脂肪乳剤
DE3608088C2 (de) * 1986-03-07 1995-11-16 Schering Ag Pharmazeutische Präparate, enthaltend Cyclodextrinclathrate von Carbacyclinderivaten
DE3740838A1 (de) * 1987-11-27 1989-06-08 Schering Ag Cyclodextrinclathrate von 5-cyano-prostacyclinderivaten und ihre verwendung als arzneimittel
KR20060127946A (ko) 2004-01-29 2006-12-13 에자이 알앤드디 매니지먼트 가부시키가이샤 매크롤라이드계 화합물의 안정화 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS503362B1 (en, 2012) * 1970-06-10 1975-02-04
US3953435A (en) * 1974-01-10 1976-04-27 Ono Pharmaceutical Company Aldehyde derivatives of prostaglandins
JPS5395958A (en) * 1977-01-31 1978-08-22 Ono Pharmaceut Co Ltd Prostaglandin analogues and process for their preparation
US4178367A (en) * 1977-02-21 1979-12-11 Ono Pharmaceutical Co. Ltd. Prostaglandin I2 analogues
JPS53136513A (en) * 1977-05-06 1978-11-29 Ono Pharmaceut Co Ltd Stabilization of prostaglandin-x-related compounds

Also Published As

Publication number Publication date
DK420778A (da) 1979-03-24
IT7869160A0 (it) 1978-09-19
JPS5456685A (en) 1979-05-07
DE2840142A1 (de) 1979-04-05
IL55569A (en) 1981-12-31
IT1160661B (it) 1987-03-11
SE447574B (sv) 1986-11-24
YU220678A (en) 1983-10-31
PL209773A1 (pl) 1979-06-04
FR2404006A1 (fr) 1979-04-20
GR65001B (en) 1980-06-12
AT369362B (de) 1982-12-27
IL55569A0 (en) 1978-12-17
SU847914A3 (ru) 1981-07-15
FI65912B (fi) 1984-04-30
GB2006193A (en) 1979-05-02
NL7809643A (nl) 1979-03-27
BE870646A (fr) 1979-01-15
GB2006193B (en) 1982-05-26
FR2404006B1 (en, 2012) 1981-07-31
CH637388A5 (de) 1983-07-29
HU179141B (en, 2012) 1982-08-28
DD138600A5 (de) 1979-11-14
FI782878A7 (fi) 1979-03-24
CS200242B2 (en) 1980-08-29
FI65912C (fi) 1984-08-10
ATA677478A (de) 1982-05-15
SE7809946L (sv) 1979-03-24

Similar Documents

Publication Publication Date Title
Das et al. Pathophysiology of superoxide radical as potential mediator of reperfusion injury in pig heart
US4113882A (en) Stabilized oral prostaglandin formulation and the process for the preparation thereof
KR860009032A (ko) γ-사이클로 덱스트린 유도체의 제조방법
KR900018129A (ko) 콘드로이틴 황산염, 데르마탄황산염 및 히알루론산의 술포아미노 유도체와 그 약제학적 성질
HK131293A (en) Pharmaceutical compositions containing drugs which are sparingly soluble in water or instable and methods for their preparation
FI67390B (fi) Foerfarande foer framstaellning av en inklusionskomplex av n-(1-fenyletyl)-3,3-difenylpropylamin eller dess hydroklorid me cyklodextrin
Ireland et al. Acetylation of 5-aminosalicylic acid by isolated human colonic epithelial cells
PL121664B1 (en) Process for preparing inclusion compounds of prostacycline and its esters with alkyls of 1 to 4 carbon atoms with cyclodextrinsna i ego alkilovykh ehfirov s 1-4 atomami uglja s ciklogekstrinami
KR920702344A (ko) 과산화산 클라드레트, 그것의 제조방법 및 사용방법
US4058623A (en) Prostaglandin-containing lyophilized powders
FI67483C (fi) Foerfarande foer framstaellning av ett icke adhesivt friflytande farmakologiskt godtagbart gallsyrakomplexbildande adsorbatpreparat
Greengard et al. Yield of oxidative phosphorylation associated with the oxidation of succinate to fumarate
PT705255E (pt) Complexos de inclusao de sin-1a/ciclodextrina
US4128632A (en) Solubilization of Rafoxanide
JPH07157431A (ja) 安定なプロスタグランジンe製剤
Perrissoud et al. The effect of carbon tetrachloride on isolated rat hepatocytes: Early morphological alterations of the plasma membrane
Gale The effects of amphotericin B on yeast metabolism
Murina et al. Antithrombotic activity of N, N-dichlorotaurine on mouse model of thrombosis in vivo
JPS61171421A (ja) 安定なプロスタグランジンe類製剤の製造方法
US4280995A (en) Oral suspension of phenytoin
SK2494A3 (en) Blood plasma substitute composition
CN101370524A (zh) 脂肽组合物
Davey et al. Effects of dimethyl sulphoxide and of vitamin A on human platelets
US20100240606A1 (en) Associations of xanthogenates and cyclodextrins, and their use
Baumann et al. (+)-Cyanidanol-3 as inhibitor of prostaglandin synthetase: Studies on renal medulla and liver of the rat in vitro and in vivo