PL116437B1 - Process for preparing novel phthalazine derivatives - Google Patents

Process for preparing novel phthalazine derivatives Download PDF

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Publication number
PL116437B1
PL116437B1 PL1978217897A PL21789778A PL116437B1 PL 116437 B1 PL116437 B1 PL 116437B1 PL 1978217897 A PL1978217897 A PL 1978217897A PL 21789778 A PL21789778 A PL 21789778A PL 116437 B1 PL116437 B1 PL 116437B1
Authority
PL
Poland
Prior art keywords
formula
radical
group
phthalazine
hydrogen atom
Prior art date
Application number
PL1978217897A
Other languages
English (en)
Polish (pl)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL116437B1 publication Critical patent/PL116437B1/pl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL1978217897A 1977-06-03 1978-06-02 Process for preparing novel phthalazine derivatives PL116437B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2358277 1977-06-03

Publications (1)

Publication Number Publication Date
PL116437B1 true PL116437B1 (en) 1981-06-30

Family

ID=10198020

Family Applications (3)

Application Number Title Priority Date Filing Date
PL1978217897A PL116437B1 (en) 1977-06-03 1978-06-02 Process for preparing novel phthalazine derivatives
PL1978207337A PL113208B1 (en) 1977-06-03 1978-06-02 Process for preparing novel phthalazine derivatives
PL1978217896A PL116420B1 (en) 1977-06-03 1978-06-02 Process for preparing novel phthalazine derivatives

Family Applications After (2)

Application Number Title Priority Date Filing Date
PL1978207337A PL113208B1 (en) 1977-06-03 1978-06-02 Process for preparing novel phthalazine derivatives
PL1978217896A PL116420B1 (en) 1977-06-03 1978-06-02 Process for preparing novel phthalazine derivatives

Country Status (29)

Country Link
US (1) US4289772A (Sortimente)
JP (1) JPS5416488A (Sortimente)
AR (2) AR222013A1 (Sortimente)
AT (2) AT362792B (Sortimente)
AU (1) AU505373B1 (Sortimente)
BE (1) BE867727A (Sortimente)
CA (1) CA1111850A (Sortimente)
DD (1) DD137355A5 (Sortimente)
DE (1) DE2824064A1 (Sortimente)
DK (1) DK248078A (Sortimente)
EG (1) EG13527A (Sortimente)
ES (4) ES470470A1 (Sortimente)
FI (1) FI781753A7 (Sortimente)
FR (1) FR2392986A1 (Sortimente)
GB (1) GB2000136B (Sortimente)
GR (1) GR74402B (Sortimente)
HU (1) HU179745B (Sortimente)
IL (1) IL54842A (Sortimente)
IN (3) IN148482B (Sortimente)
IT (1) IT1094944B (Sortimente)
LU (1) LU79761A1 (Sortimente)
NL (1) NL7806016A (Sortimente)
NO (1) NO781935L (Sortimente)
NZ (1) NZ187453A (Sortimente)
PL (3) PL116437B1 (Sortimente)
PT (1) PT68126A (Sortimente)
SE (1) SE7806519L (Sortimente)
SU (2) SU856383A3 (Sortimente)
ZA (1) ZA783183B (Sortimente)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4370328A (en) * 1977-11-03 1983-01-25 Pfizer Inc. Cardiac stimulant 1-(3- or 4-substituted piperidino)phthalazines
IL59619A0 (en) * 1979-03-28 1980-06-30 Pfizer Phthalazine derivatives,their preparation and pharmaceutical compositions containing them
PL135545B1 (en) * 1980-03-01 1985-11-30 Wyeth John & Brother Ltd Process for preparing novel derivatives of piperidine
GB8320958D0 (en) * 1983-08-03 1983-09-07 Pfizer Ltd Quinazoline cardiac stimulants
US5001125A (en) * 1984-03-26 1991-03-19 Janssen Pharmaceutica N.V. Anti-virally active pyridazinamines
US4882354A (en) * 1987-12-16 1989-11-21 Norwich Eaton Pharmaceuticals, Inc. N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents
US5300515A (en) * 1991-01-31 1994-04-05 Kyorin Pharmaceutical Co., Ltd. Carbamic acid derivatives and method for preparing the same
JP3169188B2 (ja) * 1991-01-31 2001-05-21 杏林製薬株式会社 カルバミン酸誘導体及びその製造方法
EP0621267A1 (en) * 1993-04-07 1994-10-26 Shell Internationale Researchmaatschappij B.V. Spiropiperidine derivatives and their use as fungicides
WO1996036611A1 (en) * 1995-05-19 1996-11-21 Chiroscience Limited 3,4-disubstituted-phenylsulphonamides and their therapeutic use
US6288064B1 (en) * 1996-08-20 2001-09-11 Eisai Co., Ltd. Remedy for erection failure comprising fused pyridazine compound
US20030186963A1 (en) 2001-09-14 2003-10-02 Dorwald Florencio Zaragoza Substituted piperidines
US20040224986A1 (en) * 2002-08-16 2004-11-11 Bart De Corte Piperidinyl targeting compounds that selectively bind integrins
BR0313534A (pt) * 2002-08-16 2005-07-12 Janssen Pharmaceutica Nv Antagonistas de integrinade ácido carboxìlico de piperidinoìla
US20060019975A1 (en) * 2004-07-23 2006-01-26 Pfizer Inc Novel piperidyl derivatives of quinazoline and isoquinoline
TW200630337A (en) 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
EP1928437A2 (en) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
WO2007047978A2 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
WO2007053596A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
CA2635439A1 (en) * 2006-01-27 2007-08-02 Pfizer Products Inc. Aminophthalazine derivative compounds
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US8247442B2 (en) 2006-03-29 2012-08-21 Purdue Pharma L.P. Benzenesulfonamide compounds and their use
TW200812963A (en) 2006-04-13 2008-03-16 Euro Celtique Sa Benzenesulfonamide compounds and the use thereof
US8791264B2 (en) 2006-04-13 2014-07-29 Purdue Pharma L.P. Benzenesulfonamide compounds and their use as blockers of calcium channels
JP2009536667A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
EP1903037A1 (de) * 2006-09-07 2008-03-26 Bayer Schering Pharma Aktiengesellschaft 1-(Het)aryl-3-[hetaryl-piperidin-4-yl]-thioharnstoffe als Modulatoren des EP2-Rezeptors
EP1900731A1 (de) * 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
KR20090064418A (ko) 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 4-아실아미노피리딘 유도체 포함 조합물
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2008124118A1 (en) 2007-04-09 2008-10-16 Purdue Pharma L.P. Benzenesulfonyl compounds and the use therof
RU2010106974A (ru) 2007-08-07 2011-09-20 Ф.Хоффманн-Ля Рош Аг (Ch) Ариловые эфиры пирролидина в качестве антагонистов рецепторов nk3
JP2010536818A (ja) 2007-08-22 2010-12-02 エフ．ホフマン−ラ ロシュ アーゲー Ｎｋ３受容体アンタゴニストとしてのピロリジンアリール−エーテル
CA2699464A1 (en) * 2007-09-14 2009-03-19 F. Hoffmann-La Roche Ag Piperidine derivatives as nk3 receptor antagonists
WO2009040659A2 (en) 2007-09-28 2009-04-02 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
AR077014A1 (es) * 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
AU2021360767A1 (en) 2020-10-13 2023-04-27 Endeavor Biomedicines, Inc. Methods of treating fibrosis
CN113087654B (zh) * 2021-04-15 2022-12-23 苏州昊帆生物股份有限公司 哌啶-4-丁胺的制备方法
WO2025188802A1 (en) 2024-03-05 2025-09-12 Endeavor Biomedicines, Inc. Methods of improving lung function

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1094044A (en) * 1965-07-12 1967-12-06 Vantorex Ltd Phthalazine derivatives
GB1199768A (en) 1966-10-31 1970-07-22 Pfizer & Co C Nitrogen Heterocycles and process for their preparation
GB1293565A (en) * 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
GB1460389A (en) 1974-07-25 1977-01-06 Pfizer Ltd 4-substituted quinazoline cardiac stimulants

Also Published As

Publication number Publication date
NO781935L (no) 1978-12-05
PL116420B1 (en) 1981-06-30
NZ187453A (en) 1980-12-19
EG13527A (en) 1981-12-31
JPS5416488A (en) 1979-02-07
FR2392986A1 (fr) 1978-12-29
FR2392986B1 (Sortimente) 1982-07-16
AT362792B (de) 1981-06-10
NL7806016A (nl) 1978-12-05
ZA783183B (en) 1979-06-27
AU505373B1 (en) 1979-11-15
DD137355A5 (de) 1979-08-29
ES478200A1 (es) 1980-01-01
AR222013A1 (es) 1981-04-15
ATA400878A (de) 1980-11-15
SE7806519L (sv) 1978-12-04
PL113208B1 (en) 1980-11-29
DE2824064A1 (de) 1978-12-14
IL54842A (en) 1982-01-31
ES478199A1 (es) 1980-01-16
FI781753A7 (fi) 1978-12-04
GB2000136A (en) 1979-01-04
AT363096B (de) 1981-07-10
SU856383A3 (ru) 1981-08-15
AR223999A1 (es) 1981-10-15
SU862826A3 (ru) 1981-09-07
PL207337A1 (pl) 1979-06-04
ES470470A1 (es) 1979-09-01
JPS5538351B2 (Sortimente) 1980-10-03
DK248078A (da) 1978-12-04
US4289772A (en) 1981-09-15
ES478201A1 (es) 1980-02-01
LU79761A1 (fr) 1980-01-22
BE867727A (fr) 1978-12-01
IN149973B (Sortimente) 1982-06-19
IL54842A0 (en) 1978-08-31
GR74402B (Sortimente) 1984-06-28
IN148482B (Sortimente) 1981-03-07
GB2000136B (en) 1982-01-06
IN149550B (Sortimente) 1982-01-16
HU179745B (en) 1982-12-28
PT68126A (en) 1978-07-01
ATA305080A (de) 1980-12-15
IT7824106A0 (it) 1978-06-01
IT1094944B (it) 1985-08-10
CA1111850A (en) 1981-11-03

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