PL116228B1 - Process for preparing novel derivatives of 4"-desoxyaminoerythromycin a" - Google Patents
Process for preparing novel derivatives of 4"-desoxyaminoerythromycin a" Download PDFInfo
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- PL116228B1 PL116228B1 PL1978204428A PL20442878A PL116228B1 PL 116228 B1 PL116228 B1 PL 116228B1 PL 1978204428 A PL1978204428 A PL 1978204428A PL 20442878 A PL20442878 A PL 20442878A PL 116228 B1 PL116228 B1 PL 116228B1
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- formula
- compound
- group
- hydrogen atom
- hydrogen
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- 238000004519 manufacturing process Methods 0.000 title description 2
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 67
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 37
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- 238000000034 method Methods 0.000 claims description 28
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- 238000009833 condensation Methods 0.000 claims description 14
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- 238000006722 reduction reaction Methods 0.000 claims description 9
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- 238000010531 catalytic reduction reaction Methods 0.000 claims description 6
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- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
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- OVARTBFNCCXQKS-UHFFFAOYSA-N propan-2-one;hydrate Chemical compound O.CC(C)=O OVARTBFNCCXQKS-UHFFFAOYSA-N 0.000 description 1
- WYVAMUWZEOHJOQ-UHFFFAOYSA-N propionic anhydride Chemical compound CCC(=O)OC(=O)CC WYVAMUWZEOHJOQ-UHFFFAOYSA-N 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000006268 reductive amination reaction Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000010956 selective crystallization Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- CHQMHPLRPQMAMX-UHFFFAOYSA-L sodium persulfate Substances [Na+].[Na+].[O-]S(=O)(=O)OOS([O-])(=O)=O CHQMHPLRPQMAMX-UHFFFAOYSA-L 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76548077A | 1977-02-04 | 1977-02-04 | |
| US05/856,479 US4150220A (en) | 1977-02-04 | 1977-12-01 | Semi-synthetic 4"-erythromycin A derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL204428A1 PL204428A1 (pl) | 1979-06-04 |
| PL116228B1 true PL116228B1 (en) | 1981-05-30 |
Family
ID=27117613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1978204428A PL116228B1 (en) | 1977-02-04 | 1978-02-03 | Process for preparing novel derivatives of 4"-desoxyaminoerythromycin a" |
Country Status (30)
| Country | Link |
|---|---|
| JP (1) | JPS5827798B2 (xx) |
| AR (1) | AR222147A1 (xx) |
| AU (1) | AU501298B1 (xx) |
| BG (2) | BG32718A3 (xx) |
| CA (1) | CA1106367A (xx) |
| CH (1) | CH628906A5 (xx) |
| CS (1) | CS221801B2 (xx) |
| DD (1) | DD140048A5 (xx) |
| DE (1) | DE2804507C2 (xx) |
| DK (1) | DK148036C (xx) |
| ES (2) | ES466057A1 (xx) |
| FI (1) | FI780354A (xx) |
| FR (2) | FR2379550A1 (xx) |
| GB (2) | GB1585316A (xx) |
| GR (1) | GR68691B (xx) |
| HU (1) | HU182559B (xx) |
| IE (1) | IE46661B1 (xx) |
| IL (2) | IL53968A0 (xx) |
| IT (1) | IT1094209B (xx) |
| LU (1) | LU79004A1 (xx) |
| NL (1) | NL176174C (xx) |
| NO (2) | NO146472C (xx) |
| NZ (1) | NZ186385A (xx) |
| PH (2) | PH14421A (xx) |
| PL (1) | PL116228B1 (xx) |
| PT (1) | PT67568B (xx) |
| RO (4) | RO77345A (xx) |
| SE (2) | SE445223B (xx) |
| SU (1) | SU927122A3 (xx) |
| YU (3) | YU40913B (xx) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4124755A (en) * | 1978-01-03 | 1978-11-07 | Pfizer Inc. | 11-Alkanoyl-4"-deoxy-4"-isonitrilo-oleandomycin derivatives |
| US4133950A (en) * | 1978-01-03 | 1979-01-09 | Pfizer Inc. | 4"-Deoxy-4"-carbamate and dithiocarbamate derivatives of oleandomycin and its esters |
| US4382085A (en) * | 1982-03-01 | 1983-05-03 | Pfizer Inc. | 4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents |
| US4518590A (en) * | 1984-04-13 | 1985-05-21 | Pfizer Inc. | 9α-Aza-9α-homoerythromycin compounds, pharmaceutical compositions and therapeutic method |
| HN1998000074A (es) * | 1997-06-11 | 1999-01-08 | Pfizer Prod Inc | Derivados de macrolidos c-4 sustituidos |
| US6407074B1 (en) | 1997-06-11 | 2002-06-18 | Pfizer Inc | C-4″-substituted macrolide derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3836519A (en) * | 1973-05-04 | 1974-09-17 | Abbott Lab | Sulfonyl derivatives of erythromycin |
| US3884903A (en) * | 1973-06-21 | 1975-05-20 | Abbott Lab | 4{41 -Deoxy-4{41 -oxoerythromycin B derivatives |
-
1978
- 1978-01-10 SE SE7800270A patent/SE445223B/sv not_active IP Right Cessation
- 1978-01-13 PH PH20662A patent/PH14421A/en unknown
- 1978-01-17 ES ES466057A patent/ES466057A1/es not_active Expired
- 1978-01-18 YU YU73/78A patent/YU40913B/xx unknown
- 1978-01-18 AR AR270752A patent/AR222147A1/es active
- 1978-01-23 PT PT67568A patent/PT67568B/pt unknown
- 1978-01-31 CH CH106178A patent/CH628906A5/fr not_active IP Right Cessation
- 1978-02-02 GR GR55330A patent/GR68691B/el unknown
- 1978-02-02 RO RO7893080A patent/RO77345A/ro unknown
- 1978-02-02 DE DE2804507A patent/DE2804507C2/de not_active Expired
- 1978-02-02 CS CS78703A patent/CS221801B2/cs unknown
- 1978-02-02 RO RO78101651A patent/RO79687A7/ro unknown
- 1978-02-02 GB GB34309/79A patent/GB1585316A/en not_active Expired
- 1978-02-02 RO RO105255A patent/RO81622B/ro unknown
- 1978-02-02 CA CA296,037A patent/CA1106367A/en not_active Expired
- 1978-02-02 RO RO78101650A patent/RO79686A7/ro unknown
- 1978-02-02 GB GB4165/78A patent/GB1585315A/en not_active Expired
- 1978-02-03 HU HU78PI611A patent/HU182559B/hu not_active IP Right Cessation
- 1978-02-03 DK DK51878A patent/DK148036C/da not_active IP Right Cessation
- 1978-02-03 FR FR7803066A patent/FR2379550A1/fr active Granted
- 1978-02-03 JP JP53011352A patent/JPS5827798B2/ja not_active Expired
- 1978-02-03 NO NO780389A patent/NO146472C/no unknown
- 1978-02-03 AU AU32990/78A patent/AU501298B1/en not_active Expired
- 1978-02-03 NL NLAANVRAGE7801262,A patent/NL176174C/xx not_active IP Right Cessation
- 1978-02-03 BG BG038579A patent/BG32718A3/xx unknown
- 1978-02-03 DD DD78203547A patent/DD140048A5/de unknown
- 1978-02-03 PL PL1978204428A patent/PL116228B1/pl unknown
- 1978-02-03 BG BG040069A patent/BG33159A3/xx unknown
- 1978-02-03 IT IT20005/78A patent/IT1094209B/it active
- 1978-02-03 SU SU782573754A patent/SU927122A3/ru active
- 1978-02-03 FI FI780354A patent/FI780354A/fi not_active Application Discontinuation
- 1978-02-03 LU LU79004A patent/LU79004A1/xx unknown
- 1978-02-03 IL IL53968A patent/IL53968A0/xx not_active IP Right Cessation
- 1978-02-03 NZ NZ186385A patent/NZ186385A/xx unknown
- 1978-02-03 IE IE239/78A patent/IE46661B1/en not_active IP Right Cessation
- 1978-07-07 FR FR7820334A patent/FR2385735A1/fr active Granted
- 1978-08-08 ES ES472429A patent/ES472429A1/es not_active Expired
- 1978-09-01 PH PH21555A patent/PH16675A/en unknown
-
1981
- 1981-01-27 IL IL61997A patent/IL61997A0/xx unknown
- 1981-06-05 NO NO811913A patent/NO150484C/no unknown
-
1983
- 1983-02-07 YU YU265/83A patent/YU40798B/xx unknown
- 1983-02-16 SE SE8300870A patent/SE457086B/xx not_active IP Right Cessation
- 1983-11-21 YU YU2279/83A patent/YU40799B/xx unknown
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